Skip to main content

William T. Regenold, MDCM

Academic Title:

Associate Professor

Primary Appointment:


Administrative Title:

Division Head, Geriatric Psychiatry; Acting Division Head, Adult Psychiatry

Additional Title:

Director, Division of Geriatric Psychiatry, Adult Inpatient Service and Electroconvulsive Therapy Service


UMMC, S12A09

Phone (Primary):

(410) 328-6511

Phone (Secondary):

(410) 328-4169


(410) 328-2672

Education and Training

1977-1981, Miami University, BA, Philosophy

1985-1989, McGill University, MDCM               

1989-1990, Johns Hopkins Bayview Medical Center, Internship

1990-1993, Johns Hopkins Hospital, Psychiatry Residency

1992, Maudsley Hospital, Old Age Psychiatry training



I am a psychiatrist who is certified in general adult psychiatry and geriatric psychiatry by the American Board of Psychiatry and Neurology. My clinical work mostly involves older adults and adult inpatients. Although I see patients with a variety of psychiatric problems, I am particularly interested in patients whose psychiatric problems are associated with medical or neurological disorders. I also consult on patients of any age who are considering electroconvulsive therapy (ECT), and I perform ECT at the University of Maryland Medical Center.

My current areas of research interest include: the mechanisms of action of ECT; brain energy metabolism in neuropsychiatric disorders, including bipolar disorder, schizophrenia, and major depression; white matter disease in neuropsychiatric disorders, and biological markers and novel treatments for neuropsychiatric disorders, including major depression, bipolar disorder and Alzheimer's disease.

Research/Clinical Keywords

old age, geriatric, electroconvulsive therapy, bioenergetics, mitochondrial disorders, white matter disease, Alzheimer's disease, dementia, neurocognitive disorders, bipolar disorder, major depression, vitamin B12

Highlighted Publications

Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T, Fiskum G: Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling. J Psychiatr Res, 46 (1): 95-104, 2012.

Lachner C, Steinle N, Regenold WT: The Neuropsychiatry of Vitamin B12 Deficiency in the Elderly. J Neuropsychiatry Clin Neurosci, 24 (1): 5-15, 2012.

Klinedinst NJ and Regenold WT: A mitochondrial bioenergetic basis of depression.  J Bioenerg Biomembr, 47(1-2):155-71, 2015.

Regenold WT, Noorani RJ, Piez D, Patel P: Nonconvulsive electrotherapy for treatment resistant unipolar and bipolar major depressive disorder: a proof-of-concept trial. Brain Stimul, 8(5):855-61, 2015.

Regenold WT, Blumenthal JB, Loreck DJ, Mordecai KL, Scarinzi G MS, Doddi SR, Adler L: Elevated plasma Aβ42 in cognitively impaired individuals taking ACE inhibitor antihypertensives. Am J Alzheimers Dis Other Demen, doi: 10.1177/1533317517707288, 2017



Additional Publication Citations

A list of all publications can be found here: