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Bhawna Poonia, PhD

Academic Title:

Associate Professor

Primary Appointment:

Medicine

Location:

IHV S521

Phone (Primary):

410-706-4386

Education and Training

BV.SC&AH (DVM), 1995, CCS Haryana Agricultural University, Haryana, India

MVSc (Immunology), 1997, CCS Haryana Agricultural University, Haryana, India

PhD (Microbiology/molecular biology), 2000, CCS Haryana Agricultural University, Haryana, India

MS (Bioinformatics) 2010, Johns Hopkins University, MD

Biosketch

 

POSITION TITLE: Assistant Professor

My lab aims to identify means for improving immune responses in chronic diseases like HBV, HCV and HIV infections and cancer. We investigate immunopathology of chronic diseases and functional cure strategies using clinical samples from well characterized cohorts of patients and from phase 1 and 2 clinical tirals. These research efforts address problems of significance in the immune control of chronic viral infections, problems directly relevant for cure research of these infections. 

Employment

2000-2001, Research Associate, National Research Center on Equines, India

2001-2003, Post-doc fellow, College of Veterinary Medicine, Cornell University, Ithaca, NY

2004-2005, Post-doc Fellow, Tulane National Primate Research Center, Covington, LA

2007-2010, Research Associate, Division of Basic Science and Vaccine Research, IHV, University of Maryland, Baltimore, MD

2010-present, Assistant Professor, Division of Clinical Care and Research, IHV, University of Maryland, Baltimore, MD

 

 Selected publications

  1. Poonia B, Ayithan N, Nandi M, Masur H, Kottilil S. HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis. Sci Rep. 2018 Oct 17;8(1):15296. doi: 10.1038/s41598-018-33719-x.
  2. Mathur P, Emmanuel B, Sneller M, Zhang X,Poonia B, Kottilil S.Recovery of hepatitis C specific T-cell responses after rituximab therapy in hepatitis C mixed cryoglobulinemic vasculitis. J Med Virol. 2018 May;90(5):936-941. doi: 10.1002/jmv.25002. Epub 2018 Jan 4.
  3. Poonia B (2016). Adoptive transfer of aminobisphosphonate-expanded Vg9Vd2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy, Vol. 8, No. 5, Pages 5621-52
  4. Comstock E, Kim CW, Murphy A, Emmanuel B, Zhang X, Sneller M,Poonia B, Kottilil S. Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis. PLoS One. 2017 Dec 11;12(12):e0188314. doi: 10.1371/journal.pone.0188314. eCollection 2017.
  5. Poonia, B and Kottilil, S (2016). Newer therapeutics for hepatitis C. Ann Transl Med. Jan;4(2):31. PMCID: PMC4731604
  6. Ward, H, Tang, L, Poonia B and Kottilil S (2016). Treatment of Hepatitis B virus: an update. Future Microbiology 11:1581-1597
  7. Poonia B and Pauza CD (2014). Levels of CD56+TIM-3- Effector CD8 T Cells Distinguish HIV Natural Virus Suppressors from Patients Receiving Antiretroviral Therapy. PLoS One Feb 10;9(2):e88884 PMCID: PMC3919829
  8. Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Merigeon EY, Block DS, Zhang  X, Schuze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L and Strome SE.(2013) Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer. Eur J Cancer Oct;49(15):3344-52 PMID: 23871153
  9. PooniaB and Pauza CD (2012). Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. 2012 Feb;14(2):173-81. Epub 2011 Oct 27. PMID: 22029653
  10. Poonia, B., Salvato, M.S., Yagita, H, Maeda, T, Okumura, K and Pauza CD.(2009) Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus. 2009 Aug 6;114(6):1196-204.
  11. Poonia, B., Wang, X. and Veazey, R.S. (2006) Distribution of simian immunodeficiency virus target cells in vaginal tissues of normal rhesus macaques: implications for virus transmission. Journal of  Reproductive Immunology : 72 (1-2): 74-84
  12. Poonia, B., Nelson, S., Bagby, G., Zhang, P., Quniton, L, and Veazey, R.S. (2005) Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Research and Human Retroviruses: October, 21(10): 863-868

 

 

 

 

 

 

Research/Clinical Keywords

HBV, HCV, immunity, NUC therapy, DAA therapy, HIV co-infection, nucleosite analogs, functional cure.

Highlighted Publications

Poonia B, Ayithan N, Nandi M, Masur H, Kottilil S. HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis. Sci Rep. 2018 Oct 17;8(1):15296. doi: 10.1038/s41598-018-33719-x.

Mathur P, Emmanuel B, Sneller M, Zhang X,Poonia B, Kottilil S.Recovery of hepatitis C specific T-cell responses after rituximab therapy in hepatitis C mixed cryoglobulinemic vasculitis. J Med Virol. 2018 May;90(5):936-941. doi: 10.1002/jmv.25002. Epub 2018 Jan 4.

Shrivastava S, Wilson E, Poonia B, Tang L, Osinusi A, Kohli A, Kottilil S. Augmentation of hepatitis C virus-specific immunity and sustained virologic response. J Viral Hepat. 2017 Sep;24(9):742-749. doi: 10.1111/jvh.12702.

Poonia B (2016). Adoptive transfer of aminobisphosphonate-expanded Vg9Vd2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy, Vol. 8, No. 5, Pages 5621-52

Poonia, B and Kottilil, S (2016). Newer therapeutics for hepatitis C. Ann Transl Med. Jan;4(2):31. PMCID: PMC4731604

Poonia B and Pauza CD (2014). Levels of CD56+TIM-3- Effector CD8 T Cells Distinguish HIV Natural Virus Suppressors from Patients Receiving Antiretroviral Therapy. PLoS One Feb 10;9(2):e88884 PMCID: PMC3919829

Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Merigeon EY, Block DS, Zhang  X, Schuze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L and Strome SE.(2013) Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer. Eur J Cancer Oct;49(15):3344-52 PMID: 23871153

PooniaB and Pauza CD (2012). Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. 2012 Feb;14(2):173-81. Epub 2011 Oct 27. PMID: 2202965

Poonia, B., Salvato, M.S., Yagita, H, Maeda, T, Okumura, K and Pauza CD.(2009) Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus. Blood 2009 Aug 6;114(6):1196-204.

 

 

Research Interests

Mechanisms of immune dysfunction during chronic virus infections, including HBV, HCV and HIV.

Lymphocyte immune phenotypes, transcriptional profiles, and functional states that underlie HBV persistence.

HBV functional cure strategies.

Role of adaptive immunity in clearance of chronic HCV infection treated with interferon-free DAA therapy.

Immune recovery following HCV cure: relevance for preventing re-infection in high-risk populations such as HIV co-infected and/or injection drug users. 

Grants and Contracts

  1. 1 R01 DA043396-01A1 Poonia (PI) 2017-2022. Immune correlates of long-term success with DAA therapy in HCV/HIV infected people who  inject drugs. Role: Principal Investigator

  2.  

     CCT 2016-6240 Poonia (PI) 10/01/2018-09/30/2020

    Arbutus Biopharma .A Prospective Study to Determine Immunophenotypes in the Setting of Chronic Hepatitis B Infection                     Role: Principal Investigator

  3.  

      1802150 Poonia (PI) 6/27/2017-06/26/2019 Gilead SciencesTLR8 agonist in healthy volunteers Role: Principal Investigator

  4.   Poonia (PI) 6/27/2018-06/26/2020 Gilead SciencesTLR8 agonist in chronic HBV Role: Principal Investigator

             Completed Research Support

  1.      1R03AI110229-01Poonia (PI)  2014-2017

             Genetic Polymorphisms in Rhesus Macaque FcRn and Association with IgG Levels. Role: Principal Investigator

               2. CCT 2016-6240 Poonia (PI) 10/01/2016-09/30/2017

                 Sponsor: Arbutus Biopharma. Title: A Prospective Study to Determine Immunophenotypes in the Setting of Chronic Hepatitis B Infection                   Role: Principal Investigator

              3. 00240382Poonia (PI)12/5/2016-11/4/2017

                 Sponsor: Gilead Sciences. Title: Immune Correlates of Chronic Hepatitis B. Role: Principal Investigator

               4. 00190856 Poonia (PI) 09/01/2015-12/31/2016

              Sponsor: MedImmune Inc. Title: Immunophenotypes and Cellular Responses in Chronic Hepatitis B Infection. Role: Principal Investigator