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Bhawna Poonia, PhD

Academic Title:

Associate Professor

Primary Appointment:

Medicine

Location:

IHV S521

Phone (Primary):

410-706-4386

Education and Training

CCS Haryana Agricultural University, Haryana, India BVSc&AH(DVM) 1995 Veterinary Sciences
CCS Haryana Agricultural University, Haryana, India MVSc 1997 Veterinary Immunology
CCS Haryana Agricultural University, Haryana, India PhD 2000 Veterinary Microbiology
Johns Hopkins Univ., MD, USA MS 2010 Bioinformatics

Biosketch

 

POSITION TITLE: Assistant Professor

My research aims to identify means for improving immune responses in chronic diseases like HIV/HCV/HBV infections and cancer based on mechanisms of host genetics and immunopathology. I have expertise in studying viral immune evasion mechanisms including the role for Fas:FasL in killing uninfected T cells in HIV/SIV, the impact of Fc gamma receptor variation in HIV disease progression, the poor gamma delta T cells responses in HIV after long-term antiretroviral therapyand and in HCV patients  after cure and the exhaustion phenotype of T cells HBV, HCV and HIV patients treated with antiviral therapy. These research efforts address problems of significance in the immune control of chronic viral infection, problems directly relevant for cure research of chronic infections. 

Positions and Employment

2000-2001, Research Associate, National Research Center on Equines, India

2001-2003, Post-doc fellow, College of Veterinary Medicine, Cornell University, Ithaca, NY

2004-2005, Post-doc Fellow, Tulane National Primate Research Center, Covington, LA

2007-2010, Research Associate, Division of Basic Science and Vaccine Research, IHV, University of Maryland, Baltimore, MD

2010-present, Assistant Professor, Division of Basic Science and Vaccine Research, IHV, University of Maryland, Baltimore, MD

 

Other Experience and Professional Membership

Editorial board member, Journal of Tropical Diseases and Public Health

Editorial board member, Journal of Infectious Diseases and Therapy

Member, American Association for Advancement of Science

Honors

Jawaharlal Nehru Award for best Ph.D. dissertation (2002).

Award of Senior Research Fellowship from Council of Scientific and Industrial Research (ICAR), India (1997-2000)

Award of Junior Research Fellowship from Indian Council of Agricultural Research (ICAR) (1995-1997)

Merit fellowship during BVSc degree from CCSHAU

 

 Selected publications:

  1. Poonia, B. and Charan, S. (2001). T-cell suppression by cyclosporine-A enhances infectious bursal disease virus infection in experimentally infected chickens. Avian Pathology 30 (4): 311-31
  2. Poonia, B, Dunn, P., Lu, H., Jarosinski, K.W. and Schat, K.A. (2006). Isolation and molecular characterization of a new Muscovy Duck Parvovirus from Muscovy ducks in the USA .Avian Pathology :35(6): 435-41. PMID:17121731
  3. Poonia, B., Nelson, S., Bagby, G., Zhang, P., Quniton, L, and Veazey, R.S. (2005) Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Research and Human Retroviruses : October, 21(10): 863-868
  4. Poonia, B., Wang, X. and Veazey, R.S. (2006) Distribution of simian immunodeficiency virus target cells in vaginal tissues of normal rhesus macaques: implications for virus transmission. Journal of  Reproductive Immunology : 72 (1-2): 74-84
  5. Poonia, B., Salvato, M.S., Yagita, H, Maeda, T, Okumura, K and Pauza CD.(2009) Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus. Blood. 2009 Aug 6;114(6):1196-204.
  6. PooniaB and Pauza CD (2012). Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. Cytotherapy. 2012 Feb;14(2):173-81. Epub 2011 Oct 27. PMID: 22029653
  7. Poonia B., Kijak G and Pauza CD. (2010). High affinity allele for the gene of FCGR3A is a risk factor for HIV infection and progression. PLosOne: 20:e15562. PMCID: PMC300496
  8. Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Merigeon EY, Block DS, Zhang  X, Schuze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L and Strome SE.(2013) Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer. Eur J Cancer Oct;49(15):3344-52 PMID: 23871153
  9. Li H, Chaudry S, Poonia B, Shao Y and Pauza CD (2013). Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications. Cellular and Molecular Immunology. 10, 42-49. PMCID: PMC3753036
  10. Poonia B and Pauza CD (2014). Levels of CD56+TIM-3- Effector CD8 T Cells Distinguish HIV Natural Virus Suppressors from Patients Receiving Antiretroviral Therapy. PLoS One Feb 10;9(2):e88884 PMCID: PMC3919829
  11. Poonia B (2016). Adoptive transfer of aminobisphosphonate-expanded Vg9Vd2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy, Vol. 8, No. 5, Pages 5621-52
  12. Poonia, B and Kottilil, S (2016). Newer therapeutics for hepatitis C. Ann Transl Med. Jan;4(2):31. PMCID: PMC4731604
  13. Ward, H, Tang, L, Poonia B and Kottilil S (2016). Treatment of Hepatitis B virus: an update. Future Microbiology 11:1581-1597

 

Complete list of published work in My Bibliography:

 

https://www.ncbi.nlm.nih.gov/sites/myncbi/1J7899CDf9iAc/bibliography/40431977/public/?sort=date&direction=descending

Research/Clinical Keywords

HBV, HCV, immunity, DAA therapy, HIV co-infection, nucleosite analogs, functional cure

Highlighted Publications

  1. Poonia, B., Nelson, S., Bagby, G., Zhang, P., Quniton, L, and Veazey, R.S. (2005) Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Research and Human Retroviruses:October, 21(10): 863-868. PMID:16796534
  2. Poonia, B, Salvato, MS, Yagita, H, Maeda, T, Okumura, K, Pauza,CD. (2009). Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus. Blood:114(6):1196-204. PMCID: PMC2723015
  3. Poonia, B and Pauza CD (2012). Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. Cytotherapy. 2012 Feb;14(2):173-81. Epub 2011 Oct 27. PMID: 22029653
  4. Poonia, B and Pauza, CD (2014). Levels of CD56+TIM-3- Effector CD8 T Cells Distinguish HIV Natural Virus Suppressors from Patients Receiving Antiretroviral Therapy. PLoS One Feb 10;9(2):e88884 PMCID: PMC3919829
  5. Poonia, B (2016). Adoptive transfer of aminobisphosphonate-expanded Vg9d2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy. May;8(5):521-6. PMID: 27140407.
  6. Poonia, B and Kottilil, S (2016). Newer therapeutics for hepatitis C. Ann Transl Med. Jan;4(2):31. PMCID: PMC4731604

Additional Publication Citations

1:
Emmanuel B, Sidique N, Zhang X, Poonia B, Sneller MC, Kottilil S. Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. J Viral Hepat. 2017 Feb;24(2):128-131. doi: 10.1111/jvh.12618. PubMed PMID: 27666584

 

             
2: 
Ward H, Tang L, Poonia B, Kottilil S. Treatment of hepatitis B virus: an update. Future Microbiol. 2016 Dec;11:1581-1597. PubMed PMID: 27855500.

 

 

             
3: 
Shrivastava S, Meissner EG, Funk E, Poonia S, Shokeen V, Thakur A, Poonia B, Sarin SK, Trehanpati N, Kottilil S. Elevated hepatic lipid and interferon stimulated gene expression in HCV GT3 patients relative to non-alcoholic steatohepatitis. Hepatol Int. 2016 Nov;10(6):937-946. PubMed PMID: 27193023

 

             
4: 
Poonia B. Adoptive transfer of aminobisphonate-expanded Vγ9Vδ2+ T cells does not control HIV replication in a humanized mouse model. Immunotherapy. 2016 May;8(5):521-6. doi: 10.2217/imt-2015-0003. PubMed PMID: 27140407.

 

 

             
5: 
Poonia B, Kottilil S. Newer therapeutics for hepatitis C. Ann Transl Med. 2016 Jan;4(2):31. doi: 10.3978/j.issn.2305-5839.2015.10.06. PubMed PMID: 26889484; PubMed Central PMCID: PMC4731604.

 

             
6: 
Pauza CD, Poonia B, Li H, Cairo C, Chaudhry S. γδ T Cells in HIV Disease: Past, Present, and Future. Front Immunol. 2015 Jan 30;5:687. doi: 10.3389/fimmu.2014.00687. Review. PubMed PMID: 25688241; PubMed Central PMCID: PMC4311680.

 

 

             
7: 
Poonia B, Pauza CD. Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy. PLoS One. 2014 Feb 10;9(2):e88884. doi: 10.1371/journal.pone.0088884. PubMed PMID: 24520422; PubMed Central PMCID: PMC3919829.

 

             
8: 
Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Mérigeon EY, Block DS, Zhang X, Schulze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L, Strome SE. Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer. Eur J Cancer. 2013 Oct;49(15):3344-52. doi: 10.1016/j.ejca.2013.06.009. PubMed PMID: 23871153.

 

 

             
9: 
Zapata JC, Carrion R Jr, Patterson JL, Crasta O, Zhang Y, Mani S, Jett M, Poonia B, Djavani M, White DM, Lukashevich IS, Salvato MS. Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate. PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2406. doi: 10.1371/journal.pntd.0002406. PubMed PMID: 24069471; PubMed Central PMCID: PMC3772037.

             
10: 
Zapata JC, Poonia B, Bryant J, Davis H, Ateh E, George L, Crasta O, Zhang Y, Slezak T, Jaing C, Pauza CD, Goicochea M, Moshkoff D, Lukashevich IS, Salvato MS. An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity. Virol J. 2013 Feb 12;10:52. doi: 10.1186/1743-422X-10-52. PubMed PMID: 23402317; PubMed Central PMCID: PMC3602176.

 

             
11: 
Li H, Chaudhry S, Poonia B, Shao Y, Pauza CD. Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications. Cell Mol Immunol. 2013 Jan;10(1):42-9. doi: 10.1038/cmi.2012.50. Review. Erratum in: Cell Mol Immunol. 2013 May;10(3):283. Chaudry, Suchita [corrected to Chaudhry, Suchita]. PubMed PMID: 23241900; PubMed Central PMCID: PMC3753036.

 

 

             
12: 
Poonia B, Pauza CD. Gamma delta T cells from HIV+ donors can be expanded in vitro by zoledronate/interleukin-2 to become cytotoxic effectors for antibody-dependent cellular cytotoxicity. Cytotherapy. 2012 Feb;14(2):173-81. doi: 10.3109/14653249.2011.623693. PubMed PMID: 22029653.

 

             
13: 
Poonia B, Kijak GH, Pauza CD. High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression. PLoS One. 2010 Dec 20;5(12):e15562. doi: 10.1371/journal.pone.0015562. PubMed PMID: 21187939; PubMed Central PMCID: PMC3004964.

 

 

             
14: 
Poonia B, Pauza CD, Salvato MS. Role of the Fas/FasL pathway in HIV or SIV disease. Retrovirology. 2009 Oct 15;6:91. doi: 10.1186/1742-4690-6-91. Review. PubMed PMID: 19832988; PubMed Central PMCID: PMC2772842.

 

             
15: 
Poonia B, Salvato MS, Yagita H, Maeda T, Okumura K, Pauza CD. Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus. Blood. 2009 Aug 6;114(6):1196-204. doi: 10.1182/blood-2009-02-202655. PubMed PMID: 19498020; PubMed Central PMCID: PMC2723015. 


 

 

             
16: 
Poonia BS, Sasmal D, Mazumdar PM. Anti-diarrheal activity of methanol extract of Litsea polyantha bark in mice. Fitoterapia. 2007 Apr;78(3):171-4. PubMed PMID: 17275209.

             
17: 
Wang X, Rasmussen T, Pahar B, Poonia B, Alvarez X, Lackner AA, Veazey RS. Massive infection and loss of CD4+ T cells occurs in the intestinal tract of neonatal rhesus macaques in acute SIV infection. Blood. 2007 Feb 1;109(3):1174-81. PubMed PMID: 17047153; PubMed Central PMCID: PMC1785148.

 

             
18: 
Poonia B, Wang X, Veazey RS. Distribution of simian immunodeficiency virus target cells in vaginal tissues of normal rhesus macaques: implications for virus transmission. J Reprod Immunol. 2006 Dec;72(1-2):74-84. PubMed PMID: 16956666.

 

 

             
19: 
Poonia B, Dunn PA, Lu H, Jarosinski KW, Schat KA. Isolation and molecular characterization of a new Muscovy duck parvovirus from Muscovy ducks in the USA. Avian Pathol. 2006 Dec;35(6):435-41. PubMed PMID: 17121731.

 

             
20: 
Poonia B, Walter L, Dufour J, Harrison R, Marx PA, Veazey RS. Cyclic changes in the vaginal epithelium of normal rhesus macaques. J Endocrinol. 2006 Sep;190(3):829-35. PubMed PMID: 17003283.

 

 

             
21: 
Poonia B, Nelson S, Bagby GJ, Zhang P, Quniton L, Veazey RS. Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Res Hum Retroviruses. 2006 Jun;22(6):589-94. PubMed PMID: 16796534.

 

             
22: 
Poonia B, Nelson S, Bagby GJ, Veazey RS. Intestinal lymphocyte subsets and turnover are affected by chronic alcohol consumption: implications for SIV/HIV infection. J Acquir Immune Defic Syndr. 2006 Apr 15;41(5):537-47. PubMed PMID: 16652027.

 

 

             
23: 
Poonia B, Nelson S, Bagby GJ, Zhang P, Quniton L, Veazey RS. Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Res Hum Retroviruses. 2005 Oct;21(10):863-8. Erratum in: AIDS Res Hum Retroviruses. 2006 Aug;22(8):824. Corrected and republished in: AIDS Res Hum Retroviruses. 2006 Jun;22(6):589-94. PubMed PMID: 16225413.  

     


          24: 
Poonia B, Charan S. Early and transient induction of nitric oxide (NO) in infectious bursal disease virus infection is T-cell dependent: a study in cyclosporin-A treated chicken-model. Indian J Exp Biol. 2005 Feb;43(2):192-6. PubMed PMID: 15782823.

 

             
25: 
Poonia B, Charan S. Infiltration by CD4+ and CD8+ lymphocytes in bursa of chickens infected with Infectious Bursal Disease Virus (IBDV): strain-specific differences. Indian J Exp Biol. 2004 Aug;42(8):823-9. PubMed PMID: 15573535.

 

 

             
26: 
Poonia B, Charan S. T-Cell suppression by cyclosporin-A enhances infectious bursal disease virus infection in experimentally infected chickens. Avian Pathol. 2001 Aug;30(4):311-9. doi: 10.1080/03079450120066313. PubMed PMID: 19184916.

 

                         
27: 
Poonia B, Sharma AK. Modulation of lympho-proliferative responses of ovine peripheral blood mononuclear cells by Mycoplasma mycoides ssp. mycoides (LC type). Vet Immunol Immunopathol. 1998 Aug 31;64(4):323-35. PubMed PMID: 9764725.

Research Interests

Major research focus of my lab is investigation into mechanisms of immune dysfunction during chronic virus infections.

Current projects in the lab investigate lymphocyte immune phenotypes, transcriptional profiles, and functional states that underlie HBV persistence.

We are also investigating the role of adaptive immunity in clearance of chronic HCV infection treated with interferon-free DAA therapy as well as relevance of immunity in preventing re-infection in high-risk populations such as HIV co-infected and/or injection drug users. 

Grants and Contracts

  1.      1R03AI110229-01Poonia (PI)  2014-2017

             Genetic Polymorphisms in Rhesus Macaque FcRn and Association with IgG Levels

             Role: Principal Investigator

 

              2. CCT 2016-6240 Poonia (PI) 10/01/2016-09/30/2017

                 Arbutus Biopharma

                 A Prospective Study to Determine Immunophenotypes in the Setting of Chronic Hepatitis B Infection                     

                 Role: Principal Investigator

 

              3. 00240382Poonia (PI)12/5/2016-11/4/2017

                 Gilead Sciences

                 Immune Correlates of Chronic Hepatitis B

                 Role: Principal Investigator

 

 

             Completed Research Support

             1. Poonia (2010-2012)                   

             Institutional Grant

             Institute of Human Virology of the University of Maryland Baltimore School of Medicine

             This study investigates CD8 T cell immune responses relevant for HIV control and

             their recovery with natural or therapeutic infection control

             Role: Principal Investigator

 

              2. 00190856 Poonia (PI) 09/01/2015-12/31/2016

              MedImmune Inc

              Immunophenotypes and Cellular Responses in Chronic Hepatitis B Infection                       

              Role: Principal Investigator