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Nrusingh C. Biswal, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Radiation Oncology

Location:

Maryland Proton Treatment Center

Phone (Primary):

(410) 369-5321

Fax:

(410) 347-0870

Education and Training

B.Sc, Physics -- Utkal University Bhubaneswar, India

M.Tech, Laser Technology --  Indian Institute of Technology, Kanpur, India

Ph.D., Electrical Engineering --  University of Connecticut, Storrs, CT

Residency, Therapeutic Medical Physics -- Rush University Medical Center, Chicago, IL

Biosketch

Dr. Biswal received his Ph.D. in Electrical and Biomedical Engineering at University of Connecticut, Storrs, CT in 2010. His research focussed on " Diffuse optical fluorescence tomography for imaging tumor vasculature and hypoxia", under the supervision of Dr. Quing Zhu. Dr. Biswal completed his Therapeutic Medical Physics residency at Rush University Medical Center in 2015. Dr. Biswal joined us, in 2019, from the Rutgers University where he was an Assistant Professor in the Department of Radiation Oncology from 2016 to 2019. 

Research/Clinical Keywords

Molecular Imaging, Image-guided proton therapy, Therapeutic response assessment, Imaging and treatment of tumor Hypoxia, Tumor Hyperthermia.

Highlighted Publications

 

  • Biswal, N. C., Gupta, S., Ghosh, N., Pradhan, A. Recovery of turbidity free fluorescence from measured fluorescence: an experimental approach. Optics Express. 2003 Dec 1; 11 (24): 3320-3331.
  • Gupta, S., Nair, M. S., Pradhan, A., Biswal, N. C., Agarwal, N., Agarwal, A., Panigrahi, P. K. Wavelet based characterization of spectral fluctuations in normal, benign and cancerous human breast tissues. J. of Biomedical Optics. 2005; 10(05): 054012(1-8).
  • Gamelin, J., Yang, Y., Biswal, N. C., Chen, Y., Yan, S., Zhang, X., Karemeddini, M, Brewer, M., Zhu, Q. A prototype hybrid intraoperative probe for ovarian cancer detection; Optics Express. 2009; 17(9): 7245-7258.
  • Biswal, N. C., Gamelin, J. K., Yuan, B., Becker, M. V., Becker, J. M., Zhu, Q. Fluorescence imaging of vascular endothelial growth factor tumors for mice embedded in turbid medium; J. of Biomedical Optics. 2010; 15(1): 016012 (1-11).
  • Yang, Y., Wang, T., Biswal, N. C., Wang, X., Sanders, M., Brewer, M., Zhu, Q. Optical scattering coefficient estimated by OCT correlates with collagen content in ovarian tissue. J. of Biomedical Optics. 2011; 16(9): 090504(1-30).
  • Pavlik, C., Biswal, N. C., Gaenzler, F. C., Morton, M. D., Kuhn, L. T., Claffey K. P., Zhu, Q.,Smith, M. B. Synthesis and fluorescent characteristics of Imidazole-Indocyanine Green conjugates. Dyes and Pigments. 2011; 89(1): 9-15.
  • Yang, Y., Biswal, N. C., Wang, T., Kumavor, P., Karimeddin, M., Vento, J., Sanders, M., Brewer, M., Zhu, Q. Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization; Biomedical Optics Express. 2011; 2(7): 1918-1930.
  • Biswal, N. C., Pavlik, C., Smith, M. B., Aguirre, A., Xu, Y., Zanganeh, S., Kuhn, L. T., Claffey, K. P., Zhu, Q. Imaging tumor hypoxia by near-infrared fluorescence tomography. J. Biomedical Optics. 2011; 16(6): 066009 (1-8).
  • Ardeshirpour, Y., Biswal, N. C., Aguirre, A., Zhu, Q. Artifact reduction method in diffuse optical tomography using exogenous contrast agents. J. Biomedical Optics. 2011; 16(4): 046015 (1-11).
  • Biswal, N.C., Xu, Y., Zhu, Q. Imaging tumor oxyhemoglobin and deoxyhemoglobin concentrations with ultrasound-guided diffuse optical tomography. Technology in Cancer Research and Treatment. 2011; 10(5): 417-429.
  • Biswal, N. C., Ayala-Orozco, C., Halas, N. J., Joshi, A. Calibrating the photo-thermal response of magneto-fluorescent gold nanoshells. IEEE Engineering in Medicine and Biology Society (EMBC). 2011; FrA19.5: 4776-4779.
  • Gharekhan, A., Biswal, N. C., Gupta, S., Panigrahi, P. K., Pradhan, A. Characteristic spectral features of the polarized fluorescence of breast cancer in the wavelet domain. Applied Spectroscopy. 2012; 66(7): 820-827.
  • Chen, W., Ayala-Orozco, C., Biswal N. C., Perez-Torres, C., Bartels, M., Bardhan, R., Stinnet, G., Liu, X., Ji, B., Deorukhkar, A., Brown, L. V., Guha, S., Pautler, R. G., Krishnan, S., Halas, N.J., Joshi, A. Targeting of pancreatic cancer with magneto-fluorescent theranostic gold nanoshells. Nanomedicine. 2013; 9(8): 1209-1222.
  • Abuteen, A., Zanganeh, S., Akhigbe, J. Samankumara, L., Aguirre, A., Biswal, N.C., Braune, M. Vollrtsen, A. Roder, B., Bruckner, C., Zhu, Q. The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging. Physical Chemistry Chemical Physics. 2013; 15: 18502-18509.
  • Fu, X., Creighton, C. J., Biswal, N. C., Kumar, V., Shea, M., Herrera, S., Contreras, A., Gutierrez, C., Wang, T., Nanda, S., Giuliano, M., Morrison, G., Nardone, A., Karlin, K., Westbrook, T., Heiser, L., Anur, P., Spellman, P, Guichard, S., Smith, P., Davies, B., Klinowska, T., Lee, A., Mills, G., Rimawi, M., Hilsenbeck, S., Gray, J., Joshi, A., Osborne, C., Schiff, R.. Overcoming endocrine resistance due to reduced PTEN levels in ER-positive breast cancer by cotargeting mTOR, AKT, or MEK. Breast Cancer Research. 2014; 16:430 (1-17).
  • Biswal, N. C., Swan, B., McKenna, M., Singh, R. UroLift as a surrogate for fiducial markers in IGRT planning of prostate cancer in BPH patient. Practical Radiation Oncology. 2018; 8(4): e231- e233.
  • Zhang, A., Deek, M. P., Kim, S., Sayan, M., Grann, A., Wagman, R. T., Malhotra, U., Hathout, L., Biswal, N. C., Zhang, Y., Langenfeld, J., Kennedy, T., August, D. A., Jabbour, S. K. Vertebral body irradiation during chemoradiation therapy for esophageal cancer contributes to acute bone marrow toxicity. Journal of Gastrointestinal Oncology. 2019. Doi: 10.21037/jgo.2019.01.20

 

Additional Publication Citations

 

  • Biswal, N. C., Gupta, S., Pradhan, A.; Extraction of biochemical information from intrinsic fluorescence; National Laser Symposium, IIT Kharagpur, WB, India, 12/22/2003; #621-622
  • Gupta, S., Biswal, N. C., Ghosh, N., Pradhan, A.; Detection of milk adulteration using fluorescence spectroscopy; National Laser Symposium, IIT Kharagpur, WB, India, 12/22/2003; #619-620
  • Gharekhan, A. H., Biswal, N. C., Gupta, S., Pradhan, A., Bhaskaran, S. M., Panigrahi, P. K.; Characterization of cancer and normal tissue fluorescence through wavelet transform and singular value decomposition; SPIE Photonics West, San Jose, CA, 01/19/2008; #6853.
  • Biswal, N. C., Yuan, B., Gamelin, J., Zhu, Q.; In-vivo small animal near infrared fluorescence imaging with prior anatomical information; Era of Hope Department of Defense Breast Cancer Research Program Meeting, Baltimore, MD, 06/25/2008; #P8-16
  • Biswal, N. C., Gamelin, J., Yuan, B., Becker, J. M., Zhu, Q.; Near infrared fluorescence imaging of small animals with simultaneously estimated structural information; SPIE Photonics West, San Jose, CA, 01/24/2009; #717416
  • Yang, Y., Biswal, N. C., Kumavor, P., Wang, T., Karimeddini, M., Sanders, M., Brewer, M., Zhu, Q.; A miniature prototype hybrid intraoperative probe for ovarian cancer detection; OSA Biomedical Optics Topical Meeting, Miami, FL, 04/10/2010; #BSuC7.
  • Ardeshirpour, Y., Biswal, N. C., Zhu, Q.; Improvement of NIR diffuse optical tomography in patients with a small amount breast tissue by using contrast agents; OSA Biomedical Optics Topical Meeting, Miami, FL, 04/10/2010; #JMA79
  • Biswal, N. C., Pavlik, C., Smith, M. B., Kuhn, L. T. , Claffey, K. P., Zhu, Q.; Nitroimidazoleindocyanine Green conjugates for breast cancer hypoxia imaging; Optical Society of America (OSA) Biomedical Optics Topical Meeting, Miami, FL, 04/10/2010; #JMA92.
  • Biswal, N. C., Zhu, Q.; Diffuse optical imaging for mapping tumor hypoxia; 2nd North American International Optical Society of America (OSA) Network of Students Conference, Tucson, AZ, 09/2010
  • Biswal, N. C., Bartels, M., Chen, W., Ayala-Orozco, C., Bardhan, R., Schiff, R., Deorukhkar, A., Krishnan, S., Joshi, A.; Dynamic pharmacokinetics of breast cancer theranostic nanoparticles; 8th Annual Duncan Cancer Center Symposium, Baylor College of Medicine, Houston, TX, 11/05/2010
  • Zanganeh, S. Aguirre, A., Biswal, N. C., Pavlik, C., Smith, M. B., Alqasemi, U., Li, H., Zhu, Q.;Hypoxia targeted carbon nanotubes as a sensitive contrast agent for photoacoustic imaging of tumors; SPIE Photonics West, San Francisco, CA, 01/22/2011, #78991S.
  • Yang, Y., Biswal, N. C., Wang, T., Kumavor, P., Karimeddini, M., Sanders, M., Brewer, M., Zhu,Q.; A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization; SPIE Photonics West, San Francisco, CA, 01/22/2011; #7892DY.
  • Biswal, N. C., Pavlik, C., Smith, M. B., Aguirre, A., Zanganeh, S., Xu, Y., Kuhn, L. T., Claffey, K. P., Zhu, Q.; Tumor hypoxia fluorescence imaging using 2-nitroimidazole bis-carboxylic acid indocyanine dye conjugate; SPIE Photonics West, San Francisco, CA, 01/22/2011; #78962R.
  • Biswal, N. C., Xu, Y., Zhu, Q.; Breast tumor hypoxia mapping using ultrasound guided diffuse optical tomography; SPIE Photonics West, San Francisco, CA, 01/22/2011; #78962N
  • Biswal, N. C., Xu, Y., Zhu, Q.; Breast tumor hemoglobin oxygenation measurement and hypoxia mapping by diffuse optical and diffuse fluorescence imaging; Era of Hope DOD Breast Cancer Program Meeting, Orlando, FL, 08/02/2011; #P17-18
  • Chen, W., Ayala-Orozco, C., Biswal, N. C., Krishnan, S., Schiff, R., Halas, N., Joshi, A.; Magneto-fluorescent gold nanoshells for pancreatic cancer imaging and therapy; World Molecular Imaging Congress (WMIC), San Diego, CA, 09/07/2011, #T094
  • Biswal, N. C., Fu, X., Shea, M. J., Westbrook, T. F., Schiff, R., Joshi, A.; In vivo imaging of RNAi induced endocrine therapy resistance in breast cancer; World Molecular Imaging Congress (WMIC), San Diego, CA, 09/07/2011; #P290
  • Biswal, N. C., Ayala-Orozco, C., Halas, N., Joshi, A.; Calibration of theranostic response of magneto-fluorescent gold nanoshells embedded in scattering medium; World Molecular ImagingCongress (WMIC), San Diego, CA, 09/07/2011; #T085
  • Biswal, N. C., Fu, X., Shea, M., Roy, R., Lords, T., Westbrook, T. F., Schiff R., Joshi, A.; Sensitive in-vivo fluorescence imaging of endocrine therapy resistance in breast cancer; 9th Annual Duncan Cancer Center Symposium, Houston, TX, 11/04/2011
  • Biswal, N. C., Ayala-Orozco, C., Dowell, A. E., Halas, N. J., Joshi, A.; Theranostic responses of magneto-fluorescent gold nanoshells in breast cancer models; 9th Annual Duncan Cancer Center Symposium, Houston, TX, 11/04/2011
  • Fu, X., Shea, M., Biswal, N. C., Mitchell, T., Giuliano, M., Healy, N. A., Meerbrey, K. L., Joshi, A., Westbrook, T., Hilsenbeck, S., Osborne, C. K., Schiff, R.; Establishment and characterization of endocrine resistance model in vitro and in vivo by inducible PTEN knockdown; San Antonio Breast Cancer Symposium, San Antonio, TX, 12/06/2011; P4-01-03
  • Dowell, A. E., Chen, W., Biswal, N. C., Ayala-Orozco, C., Giuliano, M., Schiff, R., Halas, N., Joshi, A.; Calibrating the imaging and therapy performance of magneto-fluorescent gold nanoshells for breast cancer; SPIE Photonics West, San Francisco, CA, 01/21/2012; #8233.
  • Yang, Y., Wang, T., Biswal, N. C., Kumavor, P., Wang, X., Karimeddini, M., Vento, J., Sanders, M., Brewer, M., Zhu, Q.; An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization; Proc. SPIE Photonics West, San Francisco, CA; 2012; #8220-13
  • Y., Wang, T., Biswal, N. C., Wang, X., Sanders, M., Brewer, M., Zhu, Q.; Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images;Proc. SPIE Photonics West, San Francisco, CA; 2012; #8213 (82130C)
  • Biswal, N. C., Ayala-Orozco, C., Halas, N., Joshi, A.; Molecularly targeted theranostics of aberrant vasculature in pancreatic cancer; World Molecular Imaging Congress (WMIC), Dublin,Ireland, 09/05/2012
  • Biswal, N. C., Fu, X., Shea, M., Mitchel, T., Schiff, R., Joshi, A.; Longitudinal imaging of RNAi induced endocrine therapy resistance in breast cancer; World Molecular Imaging Congress (WMIC), Dublin, Ireland, 09/05/2012
  • Biswal, N. C., Anderson, J., Sun, J., Bernard, D, Jegier, B., Wu, Z., Dandekar, V., Yao, R., Darwish, N., Woloschak, G. E., Griem, K. L., Chu, J. C. H.; Early detection of radiation skin reactions by changes in thermal effusivity; AAPM Midwest Chapter Spring Meeting (Young Investigator’s Symposium), Chicago, IL, 04/27/2013, #2
  • Chu, J.C.H., Biswal, N. C., Anderson, J., Darwish, N., Sun,J., Bernard, D., Woloschak, G., Gegier, B., Wu, Z., Dandekar, V., Griem, K.; Three-Dimensional Thermal Tomography as Predictor for Radiation-induced Skin Reactions;, EPR 2013 Conference Proceedings, Dartmouth College, Hanover, NH, June 22-28, 2013
  • Darwish, N., Biswal, N. C., Sun, J., Bernard, D., Dandekar, V., Yao, R., Jegier, B. J., Woloschak, G. E., Griem, K. L., Chu, J. C. H.; Blood perfusion of the skin as an indicator of radiationinduced skin reaction; AAPM 55th Annual Meeting, Indianapolis, IN, 08/04/2013; TH-A-WAB-10. Medical Physics, 40:522, 2013
  • Biswal, N. C., Sun, J., Anderson, J., Bernard, D., Dandekar, V., Yao, R., Darwish, N., Wu, Z., Jegier, B. J., Woloschak, G. E., Griem, K. L., Chu, J. C. H.; Thermal effusivity changes predict radiation exposure; AAPM 55th Annual Meeting, Indianapolis, IN, 08/04/2013; #SU-E-CAMPUSJ-03. Medical Physics, 40:378, 2013.
  • Anderson, J., Kiel, K., Yao, R., Liao, Y., Bernard, D., Biswal, N. C., Turian J., Chu, J.C.H.,; PET Image-Guided Dose Escalation Study for Cervical Cancer Patients Receiving HDR Brachytherapy; AAPM 55th Annual Meeting, Indianapolis, IN, 08/04/2013. Medical Physics, 40:309, 2013
  • Biswal, N. C., Wu, Z., Sun, J., Anderson, J., Bernard, D., Dandekar, V., Jegier, B., Woloschak, G., Griem, K. L., Chu, J. C. H.; Skin thermal effusivity changes as predictor for radiation exposure; 60th Annual meeting of Radiation Research Society (RRS), Las Vegas, NV, 09/21/2014; #399.
  • Biswal, N. C., Zhen, H., Chu, J. C. H., Turian, J.; Commissioning aS1000 electronic portal imaging device, EPID, for patient specific IMRT QA on a Varian Trilogy machine; AAPM Midwest Chapter Spring Meeting (Young Investigator’s Symposium), Chicago, IL, 04/25/2015; #1
  • Biswal, N. C., Wu, Z., Sun, J., Chu, J. C. H.; Skin temperature recovery rate and thermal effusivity as predictors for radiation-induced skin reactions; AAPM 57th Annual Meeting, Anaheim, CA, 07/11/2015; #SU-E-J-273. Medical Physics, 42:3329, June 2015.
  • Biswal, N. C., Cifter, G., Sun, J., Sen, D., Wang, D., Diaz, A., Griem, K., Chu, J. C. H.; Early prediction of radiotherapy induced skin reactions using dynamic infrared imaging; AAPM 58th Annual Meeting, Washnigton, DC, 08/03/2016; WE-FG-202-1. Medical Physics, 43:3826, June 2016.
  • Zhang, A., Deek, M.P., Kim, S., Grann, A., Wagman, R.T., Malhotra, U., Hathout, L., Biswal, N.C., Zhang, Y., Langenfeld J., Kennedy T., August, D. A., Jabbour, S.; Vertebral Body Irradiation During Chemoradiation Therapy for Esophageal Cancer can Promote Acute Bone Marrow Toxicity; ASTRO Annual Meeting 2017, San Diego, CA, 09/26/2017. Presentation No. 2492.
  • Liu, B., Biswal, N. C., Wang, X., Nie, K., Zhang, A., Yue, N., Jabbour, S., Zhang, Y.; Dosimetric Comparison of radiotherapy Plans Using Proton Therapy, VMAT and Static IMRT for Chemoradiation Therapy of Esophageal Cancer; AAPM Annual Meeting 2018, Nashville, TN, 07/29/2018. Presentation No. SU-I-GPD-T-124.
  • Biswal, N.C., Swann, B., McKenna, M., Singh, R.; Implanted UroLift Device Works as Fiducial Markers in IGRT Planning of Patients with Benign Prostatic Hyperplasia: A Case Study; AAPM Annual Meeting 2018, Nashville, TN, 07/29/2018. Presentation No. SU-I-GPD-J-13.
  • Biswal, N.C., Zhang, A., Jabbour, S.; Assessment of Radiation Therapy Response in Esophageal Cancer Using Weekly CBCT Data; AAPM Annual Meeting 2018, Nashville, TN, 07/29/2018. Presentation No. SU-I-GPD-J-69.

Grants and Contracts

2006 - 2007       (PI, 50%)

                          “Fluorescence Imaging of Near Infrared Diffusive Light with the Localization of Ultrasound

                          Department of Defense-US Army Breast Cancer Research Program Predoctoral Award.

                          Annual Direct Costs: $32,000

                          Total Direct Costs: $32,000

2010 - 2012       (Co-Inv 25%)

                          “Targeted Probes for Breast Tumor Hypoxia Imaging”

                          Connecticut Department of Public Health Research Grant

                          Annual Direct Costs: $100,000

                          Annual Indirect Costs: $155,000