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Monica A. McArthur, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Pediatrics

Location:

HSF1, 480

Phone (Primary):

410-706-5328

Phone (Secondary):

410-706-0329

Education and Training

Texas A&M University (magna cum laude), B.S., Molecular Biology and Microbiology, 1999

The University of Texas Medical Branch, M.D./Ph.D, 2006

Residency, The University of Texas Medical Branch, 2006-2009

Clinical Fellow, University of Maryland School of Medicine, Pediatric Infectious Diseases and Tropical Pediatrics, 2009-2012

Postdoctoral Fellow, University of Maryland School of Medicine Center for Vaccine Development (CVD), Pediatrics, 2012-2013

Biosketch

Dr. McArthur's primary research interests include the interactions between pathogens and the human immune system. She is particularly interested in T cell responses against infectious agents affecting children in the developing world.  Dr. McArthur performs clinical vaccine trials as well as studying translational human immunology.  She is currently the site PI for an upcoming Phase III COVID-19 Vaccine Trial.

https://www.medschool.umaryland.edu/cvd/trials/ 

Research/Clinical Keywords

Pathogens, cellular immunology, T cell response, infectious diseases, vaccine development, vaccine immunology, Zika, flavivirus, SARS-CoV-2, COVID-19.

Highlighted Publications

McArthur MA, Zhang SL, Li L, Tesh RB, Barrett ADT. Molecular characterization of hamster-adapted yellow fever virus. Vector Borne Zoonotic Dis. Epub ahead of print Dec 2, 2019

McArthur MA. Zika virus: Recent advances towards the development of vaccines and therapeuticsViruses. 2017 Jun 13;9(6):143.

Gaudinski MR, Houser KV, Morabito KM, Hu Z, Yamshchikov G, Rothwell RS, Berkowitz N, Mendoza F, Saunders JG, Novik L, Hendel CS, Holman LA, Gordon IJ, Cox JH, Edupuganti S, McArthur MA, Rouphael NG, Lyke KE,,Cummings GE, Sitar S, Bailer RT, Foreman BM, Burgomaster K, Pelc RS, Gordon DN, DeMaso CR, Dowd KA, Laurencot C, Schwartz RM, Mascola JR,Graham BS, Pierson TC, Ledgerwood JE, Chen GL. Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials.  The Lancet.  2018. Feb 10;391(10120):552-562

McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB. Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model. PLoS Pathog. 2015 May 22;11(5)e1004914.

McArthur MA and MB Sztein. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013 Feb;146(2):140-152.

McArthur MA and MB Sztein. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS One. 2012 Jun 7(6):e38408.

Additional Publication Citations

Fresnay S, McArthur MA, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB. Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. J Transl Med. 2016 Mar 1;14(1):62.

Sztein MB, Salerno-Goncalves R, McArthur MA. Complex adaptive immunity to enteric fevers in humans: Lessons learned and the path forward. Front Immunol. 2014 Oct 27;5:516.

McArthur MA, Sztein MB, Edelman RE. Dengue vaccines: recent developments, ongoing challenges, and current candidates. Expert Rev Vaccines. 2013 Aug;12(8):933-53.

Eloe-Fadrash EA, McArthur MA, Seekatz AM, Drabek EF, Rasko DA, Sztein MB, Fraser CM. Impact of oral typhoid vaccination on the human gut microbiota and correlations with S. Typhi-specific immunological responses. PLoS One. 2013 Apr 24;8(4):e62026.

Research Interests

Dr. McArthur's primary research interests include the interactions between pathogens and the human immune system. She is particularly interested in T cell responses against infectious agents affecting children in the developing world.  Dr. McArthur performs clinical vaccine trials as well as studying translational human immunology.  She is currently the site PI for an upcoming Phase III COVID-19 Vaccine Trial.

 

Clinical Specialty Details

Dr. McArthur is Board Certified in Pediatrics and Pediatric Infectious Diseases.  She provides inpatient and outpatient care to children with complicated infections.

Awards and Affiliations

2012: Fellow Research Award, University of Maryland Department of Pediatrics

2009-2011: National Institutes of Health (NIH) T32 Vaccinology Fellowship

In the News

Links of Interest

https://www.medschool.umaryland.edu/cvd/trials/