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Michael A. Mazzeffi, MD

Academic Title:

Associate Professor

Primary Appointment:


Administrative Title:

Director for Resident Research Education; Chief, Division of Critical Care Anesthesiology



Phone (Primary):

(410) 328-4752


(410) 328-5531

Education and Training

I completed my undergraduate degree at the University of Notre Dame in 2002.  I then obtained my medical school training and a Master's degree in Public Health at Tulane University in New Orleans.  My residency training was completed at the Mount Sinai School of Medicine in New York City and included one year of a clinical research fellowship with Dr. David Reich.  I then completed two clinical fellowships in cardiothoracic anesthesiology and critical care medicine at Emory University.  In 2016 I completed a Master's Degree in clinical research at the University of Maryland, Baltimore.


I currently work as a cardiothoracic anesthesiologist and critical care physician in the cardiac surgery intensive care unit.  I find caring for critically ill cardiac surgery patients to be an extremely satisfying profession and I take great pride in getting them through one of the most difficult challenges in their life successfully.  In addition I have formal master's level training in Epidemiology.  I use these skills to perform outcomes research related to cardiac surgery.  Much of my research is related to coagulation, transfusion, and ECMO related bleeding.

Research/Clinical Keywords

ECMO Transfusion Coagulation Cardiac surgery outcomes Transfusion associated lung injury Epidemiology

Highlighted Publications

1.  Mazzeffi M, Sanchez PG, Herr D, Krause E, Evans CF, Rector R, McCormick B, Pham S, Taylor B, Griffith B, Kon Z.  Outcomes of extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest in adult cardiac surgery patients.  J Thorac Cardiovasc Surg.  2016; In press  PMID: 27422361


2.  Mazzeffi M, Greenwood J, Tanaka K, Menaker J, Rector R, Herr D, Kon Z, Lee J, Griffith B, Rajagopal K, Pham S.  Bleeding, transfusion, and mortality on extracorporeal life support: ECLS working group on thrombosis and hemostasis.  Ann Thorac Surg. 2015;  4975(15): 1250-3.  PMID:  26443879


3.  Mazzeffi M, Kassa W, Gammie J, Tanaka K, Roman P, Zhan M, Griffith B, Rock P.  Preoperative aspirin use and lung injury after aortic valve replacement surgery: a retrospective cohort study.  Anesth Analg.  2015; 121 (2): 271-7.  PMID:  25993389


4.  Mazzeffi M, Zivot J, Buchman T, Halkos M:  In hospital mortality after cardiac surgery:  patient characteristics, timing, and association with postoperative length of intensive care unit and hospital stay.  Ann Thorac Surg; 97 (4): 1220-5.  PMID:  24360878


5.  Mazzeffi M, Flynn B, Bodian C, Bronheim D:  Preoperative Pulse Pressure has No Apparent Association with Perioperative Mortality after Lower Extremity Arterial Bypass.  Anesth Analg 2012; 114 (6): 1170-6.  PMID:  21642608

Awards and Affiliations

Society of Cardiovascular Anesthesiologists

Society of Critical Care Medicine

American Society of Anesthesiologists

International Anesthesia Research Society

Grants and Contracts


July 2016-current  Society for Cardiovascular Anesthesiologists Starter Grant

Procoagulant and anticoagulant factor levels, thrombin

generation, and bleeding during veno-arterial ECMO.

PI: Michael Mazzeffi

Total award: $50,000



September 2014-June 2016 Department of Defense grant

Prolongation of platelet storage time by protection against

mitochondrial energy failure.

US Air Force FA8650-14-2-6D17

PI: Gary Fiskum

Role: 0.05% FTE, sub-investigator

Total award: $281,000


July 2014-June 2015  Departmental seed grant

Effect of cardiopulmonary bypass on platelet mitochondrial respiration.

PI: Michael Mazzeffi

Total award: $10,000



Community Service

International Service


03/2006-04/2006  Volunteer

Bwindi Community Health Center

Bwindi, Uganda


01/2009   Volunteer

JFK Memorial Hospital

Monrovia, Liberia


01/2010   Volunteer

Phoebe Hospital



10/2014   Volunteer

Kien Gang Hospital

Rach Gia, Vietnam