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Michael A. Mazzeffi, MD

Academic Title:

Associate Professor

Primary Appointment:

Anesthesiology

Administrative Title:

Director for Resident Research Education; Chief, Division of Critical Care Anesthesiology

Email:

mmazzeffi@som.umaryland.edu

Location:

UMMC, S8D

Phone (Primary):

(410) 328-4752

Phone (Secondary):

(410) 328-9813

Fax:

(410) 328-5531

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Education and Training

I completed my undergraduate degree at the University of Notre Dame in 2002.  I then obtained my medical school training and a Master's degree in Public Health at Tulane University in New Orleans.  My residency training was completed at the Mount Sinai School of Medicine in New York City and included one year of a clinical research fellowship with Dr. David Reich.  I then completed two clinical fellowships in cardiothoracic anesthesiology and critical care medicine at Emory University.  In 2016 I completed a Master's Degree in clinical research at the University of Maryland, Baltimore.

Biosketch

I currently work as a cardiothoracic anesthesiologist and critical care physician in the cardiac surgery intensive care unit.  I find caring for critically ill cardiac surgery patients to be an extremely satisfying profession and I take great pride in getting them through one of the most difficult challenges in their life successfully.  In addition I have formal master's level training in Epidemiology.  I use these skills to perform outcomes research related to cardiac surgery.  Much of my research is related to coagulation, transfusion, and ECMO related bleeding.

Research/Clinical Keywords

ECMO Transfusion Coagulation Cardiac surgery outcomes Transfusion associated lung injury Epidemiology

Highlighted Publications

 

  1. Judd M, Strauss E, Hasan S, Abuelkasem E, Li J, Deshpande S, Mazzeffi MA, Ogawa S, Tanaka KA. Clotting time results are not interchangeable between EXTEM and FIBTEM on rotational thromboelastometry. J Cardiothorac Vasc Anesth. 34(6), 1467-1473. PMID: 32139339. 2020
  2. Tanaka KA, Reformato VS, Mazzeffi MA. Propofol-Is She Dr. Jekyll or Ms. Hyde?. J Cardiothorac Vasc Anesth. 34(1), 307-308. PMID: 31383596. 2020
  3. Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Anders MG, Rock P, Miller J, Wadhera V, Holzner M, Mandell MS, Pshak TJ, Chang CH, Scovetti JC, Scalea JR, Pai SL, Chad RM, Fukazawa K, Darling CD, Groose M, Kolodzie K, Bokoch M. Corrigendum to “Intravenous fluid management practices in kidney transplant patients: A multicenter observational cohort pilot study. Semin Cardiothorac Vasc Anesth. 24(3), 265. doi: 10.1177/1089253220912853. Epub 2020 Mar 2. PMID: 32114900. 2020
  4. Mazzeffi M, Sari DP, Alejo DE, Fonner CE, Ghorieshi M, Pasrija C, Schena S, Metkus T, Salenger R, Whitman G, Ad N, Higgins RS, Taylor BS. Racial Disparity in Cardiac Surgery Risk and Outcome: Report from a Statewide Quality Initiative. Ann Thorac Surg. 110(2), 531-536. doi: 10.1016/j.athoracsur.2019.11.043. Epub 2020 Jan 18. PMID: 31962111. 2020
  5. Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Society for the Advancement of Transplant Anesthesia Research Committee Writing Group. Intravenous Fluid Management Practices in Kidney Transplant Patients: A Multicenter Observational Cohort Pilot Study. Semin Cardiothorac Vasc Anesth. 24, 1089253220901665. PMID: 31994444. 2020
  6. DiChiacchio L, Boulos FM, Brigante F, Raithel M, Shah A, Pasrija C, Mackowick K, Menaker J, Mazzeffi M, Herr D, Kon ZN, Deatrick KB. Early tracheostomy after initiation of venovenous extracorporeal membrane oxygenation is associated with decreased duration of extracorporeal membrane oxygenation support. Perfusion. 35(6), 509-514. doi: 10.1177/0267659119898327. Epub 2020 Feb 5. PMID: 32020840. 2020
  7. Grazioli A, Athale J, Tanaka K, Madathil R, Rabin J, Kaczorowski D, Mazzeffi M. Perioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review. J Cardiothorac Vasc Anesth. S1053-0770(20)30118-X. doi: 10.1053/j.jvca.2020.01.054. Online ahead of print. PMID: 32147326. 2020
  8. Kim J, Nguyen TT, Li Y, Zhang CO, Cha B, Ke Y, Mazzeffi MA, Tanaka KA, Birukova AA, Birukov KG. Contrasting effects of stored allogeneic red blood cells and their supernatants on permeability and inflammatory responses in human pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 318(3), L533-L548. PMID: 31913681. 2020
  9. Chow JH, Fedeles B, Richards JE, Tanaka KA, Morrison JJ, Rock P, Scalea TM, Mazzeffi MA, TROPIC-Trauma Investigators. Thromboelastography Reaction-Time Thresholds for Optimal Prediction of Coagulation Factor Deficiency in Trauma. J Am Coll Surg. 230(5), 798-808. doi: 10.1016/j.jamcollsurg.2020.01.033. PMID: 32142926. 2020
  10. Chow JH, Mazzeffi MA, Tanaka KA. In Response. Anesth Analg. doi: 10.1213/ANE.0000000000004721. PMID: 32175945. 2020
  11. Chow JH, Mazzeffi MA, McCurdy MT. Angiotensin II for the Treatment of COVID-19-Related Vasodilatory Shock. Anesth Analg. 131(1), 102-105. doi: 10.1213/ANE.0000000000004825. PMID: 32209811. 2020
  12. Heavner MS, McCurdy MT, Mazzeffi MA, Galvagno SM, Tanaka KA, Chow JH. Angiotensin II and Vasopressin for Vasodilatory Shock: A Critical Appraisal of Catecholamine-Sparing Strategies. J Intensive Care Med. 885066620911601. PMID: 32223515. 2020
  13. Weiner L, Mazzeffi MA, Hines EQ, Gordon D, Herr DL, Kim HK. Clinical Utility of Venoarterial-Extracorporeal Membrane Oxygenation (VA-ECMO) in Patients With Drug-Induced Cardiogenic Shock: A Retrospective Study of the Extracorporeal Life Support Organizations' ECMO Case Registry. Clin Toxicol (Phila). 58(7), 705-710. doi: 10.1080/15563650.2019.1676896. Epub 2019 Oct 16. PMID: 31617764. 2020
  14. Mazzeffi MA, Patel PA, Bolliger D, Erdoes G, Tanaka K. The Year in Coagulation: Selected Highlights From 2019. J Cardiothorac Vasc Anesth. 34(7), S1053-0770(20)30107-5. PMID: 32115363. 2020
  15. Deatrick KB, Galvagno SM, Mazzeffi MA, Kaczoroswki DJ, Herr DL, Rector R, Hochberg E, Rabinowitz RP, Scalea TM, Menaker J. Pilot study evaluating a non-titrating, weight-based anticoagulation scheme for patients on veno-venous extracorporeal membrane oxygenation. Perfusion. 35(1), 13-18. doi: 10.1177/0267659119850024. PMID: 31122144. 2020
  16. Li M, Mazzeffi MA, Gammie JS, Banoub M, Pazhani Y, Herr D, Madathil R, Pousatis S, Bathula A. Characterization of Postoperative Infection Risk in Cardiac Surgery Patients With Delayed Sternal Closure. J Cardiothorac Vasc Anesth. 34(5), 1238-1243. PMID: 32127277. 2020
  17. Tabatabai A, Rabin J, Menaker J, Madathil R, Galvagno S, Menne A, Chow JH, Grazioli A, Herr D, Tanaka K, Scalea T, Mazzeffi M. Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series. A A Pract. 14(7), e01236. PMID: 32539272. 2020
  18. Mazzeffi MA, Petrick KM, Magder L, Greenwald BD, Darwin P, Goldberg EM, Bigeleisen P, Chow JH, Anders M, Boyd CM, Kaplowitz JS, Sun K, Terrin M, Rock P. High-Flow Nasal Cannula Oxygen in Patients Having Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a Randomized Clinical Trial. Anesth Analg. doi: 10.1213/ANE.0000000000004837. Online ahead of print. PMID: 32398433. 2020
  19. Kiefer JJ, Rock P, Augoustides JG, Mazzeffi MA. Critical Care During the Coronavirus Crisis-Reflections on the Roles of Anesthesiologists in Meeting the Challenges of the Pandemic. J Cardiothorac Vasc Anesth. S1053-0770(20)30420-1. doi: 10.1053/j.jvca.2020.04.061. Online ahead of print. PMID: 32507459. 2020
  20. COVIDSurg Collaborative. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg. PMID: 32395848. 2020
  21. Mondal S, Sankova S, Lee K, Sorensen E, Kaczorowski D, Mazzeffi M. Intraoperative and Early Postoperative Management of Patients Undergoing Minimally Invasive Left Ventricular Assist Device Implantation. J Cardiothorac Vasc Anesth. S1053-0770(20)30374-8. doi: 10.1053/j.jvca.2020.04.015. Online ahead of print. PMID: 32505605. 2020
  22. Galvagno SM, Sikorski RA, Floccare DJ, Rock P, Mazzeffi MA, DuBose JJ, Scalea TM, Miller C, Richards JE, O'Connor JV, Mackenzie CF, Hu P. Prehospital Point of Care Testing for the Early Detection of Shock and Prediction of Lifesaving Interventions. Shock. doi: 10.1097/SHK.0000000000001567. Online ahead of print. PMID: 32453248. 2020
  23. Madathil RJ, Tabatabai A, Rabin J, Menne AR, Henderson R, Mazzeffi M, Scalea TM, Tanaka K. Thromboelastometry and D-Dimer Elevation in Coronavirus-2019. J Cardiothorac Vasc Anesth. S1053-0770(20)30481-X. doi: 10.1053/j.jvca.2020.05.020. Online ahead of print. PMID: 32593588. 2020
  24. Chow JH, Mazzeffi MA, McCurdy MT. Justification of the Safety and Efficacy of Angiotensin II for the Treatment of SARS-CoV-Induced Shock. Anesth Analg. 10.1213/ANE.0000000000005047. doi: 10.1213/ANE.0000000000005047. Online ahead of print. PMID: 32502134. 2020
  25. Mazzeffi M, Chow JH, Amoroso A, Tanaka K. Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?. Anesth Analg. 10.1213/ANE.0000000000005059. doi: 10.1213/ANE.0000000000005059. Online ahead of print. PMID: 32541255. 2020
  26. Deatrick KB, Mazzeffi MA, Galvagno SM, Boswell K, Kaczoroswki DJ, Rabinowitz RP, Madathil RJ, Cornachione CR, Herr DL, Scalea TM, Menaker J. Breathing Life Back Into the Kidney-Continuous Renal Replacement Therapy and Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO J. PMID: 32657829. 2020
  27. Sanford Z, Madathil RJ, Deatrick KB, Tabatabai A, Menaker J, Galvagno SM, Mazzeffi MA, Rabin J, Ghoreishi M, Rector R, Herr DL, Kaczorowski DJ. Extracorporeal Membrane Oxygenation for COVID-19. Innovations (Phila). 1556984520937821. PMID: 32692258. 2020
  28. Boulos FM, Pasrija C, DiChiacchio L, Rouse M, Raithel M, Mackowick K, Rector R, Mazzeffi MA, Griffith BP, Diaz JJ, Kon ZN, Deatrick KB. Early Decompressive Laparotomy for Intra-Abdominal Hypertension Following Initiation of Venovenous Extracorporeal Membrane Oxygenation. ASAIO J. 66(5), 520-523. doi: 10.1097/ MAT.0000000000001045. PMID: 31425255. 2020
  29. Mazzeffi MA, Chow JH, Wu ZJ, Tanaka KA. Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle. Crit Care Med. 48(8), e732-e733. PMID: 32697517. 2020
  30. Coleman PJ, Nissen AP, Kim DE, Ainsworth CR, McCurdy MT, Mazzeffi MA, Chow JH. Angiotensin II in Decompensated Cirrhosis Complicated by Septic Shock. Semin Cardiothorac Vasc Anesth. 24(3), 266-272. doi: 10.1177/1089253219877876. Epub 2019 Sep 20. PMID: 31540560. 2020
  31. McNeil J, Raphael J, Chow JH, Tanaka K, Mazzeffi MA. Antifibrinolytic Drugs and Allogeneic Transfusion In Pediatric Multi-Level Spine Surgery: A Propensity Score Matched Cohort Study. Spine. 45(6), e336-e341. PMID: 31574059. 2020
  32. Mazzeffi MA, Chow JH, Tanaka K. COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management. Shock (Augusta, Ga). DOI: 10.1097/SHK.0000000000001660. 2020
  33. Chow JH, Abuelkasem E, Sankova S, Henderson RA, Mazzeffi MA, Tanaka KA. Reversal of Vasodilatory Shock: Current Perspectives on Conventional, Rescue, and Emerging Vasoactive Agents for the Treatment of Shock. Anesth Analg. 130(1), 15-30. PMID: 31348056. 2020
  34. Barr LF, Boss MJ, Mazzeffi MA, Taylor BS, Salenger R. Postoperative Multimodal Analgesia in Cardiac Surgery. Crit Care Clin. 36(4), 631-651. PMID: 32892818. 2020
  35. Chow JH, Wallis M, Lankford AS, Chancer Z, Barth RN, Scalea JR, LaMattina JC, Mazzeffi MA, McCurdy MT. Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock. Semin Cardiothorac Vasc Anesth. 1089253220949070. PMID: 32787515. 2020
  36. Esposito EC, Jones KM, Galvagno Jr SM, Mazzeffi MA, DiChiacchio L, Deatrick KB, Madathil RJ, Herrold JA, Raninowitz RP, Scalea TM, Menaker J. Incidence of healthcare-associated infections in patients with fever during the first 48 hours after decannulation from veno-venous extracorporeal membrane oxygenation. Perfusion. 267659120948427. PMID: 32820708. 2020
  37. Mazzeffi M, Bathula A, Tabatabai A, Menaker J, Kaczorowski D, Madathil R, Galvagno S, Pasrija C, Rector R, Tanaka K, Herr D. Von Willebrand Factor Concentrate Administration for Acquired Von Willebrand Syndrome- Related Bleeding During Adult Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. S1053-0770(20), 30627-3. PMID: 32758410. 2020
  38. Mazzeffi M, Madathil R, Gutsche JT. In Extracorporeal Cardiopulmonary Resuscitation, It's Great To Be Young. J Cardiothor Vasc Anesth. 34(2), 363-364. doi: 10.1053/j.jvca.2019.08.040. Epub 2019 Aug 30. PMID: 31606279. 2020

 

 

Clinical Specialty Details

University of Maryland School of Medicine
Expertise: Transesophageal echocardiography: 50-60 perioperative echocardiograms per year in the cardiac surgery ORs and cardiac surgery ICU. Special ventilation techniques applied in ICU for patients with ARDS, acute and severe lung injury and mechanical ventilation: airway pressure release ventilation (APRV), high frequency oscillatory ventilation (HFOV), and veno-venous ECMO. Perioperative management of post-sternotomy pain for 40-50 patients/yr in cardiac OR and 200 patients/yr in cardiac ICU. Coagulation management for 40-50 cardiac patients per/yr in OR, and 200 in cardiac ICU): thromboelastography, platelet function analysis, and resuscitation for bleeding after cardiac surgery. Critical care for 200 cardiac surgery patients/yr in cardiac ICU. Currently only anesthesiologist who is board certified in both critical care and perioperative echocardiography, providing expertise in airway management, venous access, and echocardiography. Adult Extracorporeal Membrane Oxygenation (ECMO), for 30-40 patients/yr in cardiac ICU. Critical Care for 20 recipients/yr of Solid Organ Transplants of heart or lungs. Vascular Anesthesiology (50 patients/yr) for high-risk vascular procedures including aortic endovascular stent graphing and arterial bypass surgery. Thoracic Anesthesiology for 10-20 patients/yr undergoing thoracic surgery, needing bronchial blocker or double lumen tube placement.
Role: Cardiothoracic anesthesiologist in the operating room (OR) and intensive care unit (ICU)
 
Time Spent: Clinical Duties are divided between the OR (40-50 hrs/wk, 38 wks/yr) and the ICU (70-80 hrs/wk, 14 wks/yr)
 
Patients: All patient numbers are approximate
 
Description: Currently the only anesthesiologist who is board certified in both critical care and perioperative echocardiography, providing expertise in airway management, venous access, and echocardiography.

Awards and Affiliations

Society of Cardiovascular Anesthesiologists

Society of Critical Care Medicine

American Society of Anesthesiologists

International Anesthesia Research Society

Grants and Contracts

Active

July 2016-current  Society for Cardiovascular Anesthesiologists Starter Grant

Procoagulant and anticoagulant factor levels, thrombin

generation, and bleeding during veno-arterial ECMO.

PI: Michael Mazzeffi

Total award: $50,000

 

Completed   

September 2014-June 2016 Department of Defense grant

Prolongation of platelet storage time by protection against

mitochondrial energy failure.

US Air Force FA8650-14-2-6D17

PI: Gary Fiskum

Role: 0.05% FTE, sub-investigator

Total award: $281,000

 

July 2014-June 2015  Departmental seed grant

Effect of cardiopulmonary bypass on platelet mitochondrial respiration.

PI: Michael Mazzeffi

Total award: $10,000

 

 

Community Service

International Service

03/2006-04/2006  Volunteer, Bwindi Community Health Center, Bwindi, Uganda

01/2009               Volunteer, JFK Memorial Hospital, Monrovia, Liberia

01/2010               Volunteer, Phoebe Hospital, Liberia

10/2014               Volunteer, Kien Gang Hospital, Rach Gia, Vietnam

Professional Activity

2005-2006        Member, Alpha Omega Alpha
2008-present     Member, American Society of Anesthesiologists
2008-2012         Member, International Anesthesia Research Society
2011-2012         Member, Society of Cardiovascular Anesthesiologists
2012-2013         Member, Society of Critical Care Anesthesiologists
2013-present     Member, International Anesthesia Research Society
2014-present     Member, Society of Cardiovascular Anesthesiologists
2014-present     Member, Maryland Society of Anesthesiologists
2016-present     Member, Scientific Committee, Society for Advancement in Transplant Anesthesia
2017-present     Member, Society of Cardiovascular Anesthesiologists, Kaplan Leadership Award Selection Committee
2017-2019        Member, Society of Cardiovascular Anesthesiologists Fellowship Program Directors Committee
2017-2019        Member, Society of Cardiovascular Anesthesiologists, Fellowship Program Directors' Committee
2018-present     Member, Safety, Quality, and Leadership Committee Society of Cardiovascular Anesthesiologists
2018-present     Member, Editorial Board, Journal of Cardiothoracic and Vascular Anesthesia
2019-present     Chair, ECMO Subcommittee Society of Cardiovascular Anesthesiologists
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