Academic Title:
Associate Professor
Primary Appointment:
Anesthesiology
Administrative Title:
Director for Resident Research Education
Location:
UMMC, S8D
Phone (Primary):
(410) 328-4752
Phone (Secondary):
(410) 328-9813
Fax:
(410) 328-5531
Education and Training
I completed my undergraduate degree at the University of Notre Dame in 2002. I then obtained my medical school training and a Master's degree in Public Health at Tulane University in New Orleans. My residency training was completed at the Mount Sinai School of Medicine in New York City and included one year of a clinical research fellowship with Dr. David Reich. I then completed two clinical fellowships in cardiothoracic anesthesiology and critical care medicine at Emory University. In 2016 I completed a Master's Degree in clinical research at the University of Maryland, Baltimore.
Biosketch
I currently work as a cardiothoracic anesthesiologist and critical care physician in the cardiac surgery intensive care unit. I find caring for critically ill cardiac surgery patients to be an extremely satisfying profession and I take great pride in getting them through one of the most difficult challenges in their life successfully. In addition I have formal master's level training in Epidemiology. I use these skills to perform outcomes research related to cardiac surgery. Much of my research is related to coagulation, transfusion, and ECMO related bleeding.
Research/Clinical Keywords
ECMO Transfusion Coagulation Cardiac surgery outcomes Transfusion associated lung injury Epidemiology
Highlighted Publications
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Judd M, Strauss E, Hasan S, Abuelkasem E, Li J, Deshpande S, Mazzeffi MA, Ogawa S, Tanaka KA. Clotting time results are not interchangeable between EXTEM and FIBTEM on rotational thromboelastometry. J Cardiothorac Vasc Anesth. 34(6), 1467-1473. PMID: 32139339. 2020
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Tanaka KA, Reformato VS, Mazzeffi MA. Propofol-Is She Dr. Jekyll or Ms. Hyde?. J Cardiothorac Vasc Anesth. 34(1), 307-308. PMID: 31383596. 2020
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Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Anders MG, Rock P, Miller J, Wadhera V, Holzner M, Mandell MS, Pshak TJ, Chang CH, Scovetti JC, Scalea JR, Pai SL, Chad RM, Fukazawa K, Darling CD, Groose M, Kolodzie K, Bokoch M. Corrigendum to “Intravenous fluid management practices in kidney transplant patients: A multicenter observational cohort pilot study. Semin Cardiothorac Vasc Anesth. 24(3), 265. doi: 10.1177/1089253220912853. Epub 2020 Mar 2. PMID: 32114900. 2020
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Mazzeffi M, Sari DP, Alejo DE, Fonner CE, Ghorieshi M, Pasrija C, Schena S, Metkus T, Salenger R, Whitman G, Ad N, Higgins RS, Taylor BS. Racial Disparity in Cardiac Surgery Risk and Outcome: Report from a Statewide Quality Initiative. Ann Thorac Surg. 110(2), 531-536. doi: 10.1016/j.athoracsur.2019.11.043. Epub 2020 Jan 18. PMID: 31962111. 2020
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Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Society for the Advancement of Transplant Anesthesia Research Committee Writing Group. Intravenous Fluid Management Practices in Kidney Transplant Patients: A Multicenter Observational Cohort Pilot Study. Semin Cardiothorac Vasc Anesth. 24, 1089253220901665. PMID: 31994444. 2020
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DiChiacchio L, Boulos FM, Brigante F, Raithel M, Shah A, Pasrija C, Mackowick K, Menaker J, Mazzeffi M, Herr D, Kon ZN, Deatrick KB. Early tracheostomy after initiation of venovenous extracorporeal membrane oxygenation is associated with decreased duration of extracorporeal membrane oxygenation support. Perfusion. 35(6), 509-514. doi: 10.1177/0267659119898327. Epub 2020 Feb 5. PMID: 32020840. 2020
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Grazioli A, Athale J, Tanaka K, Madathil R, Rabin J, Kaczorowski D, Mazzeffi M. Perioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review. J Cardiothorac Vasc Anesth. S1053-0770(20)30118-X. doi: 10.1053/j.jvca.2020.01.054. Online ahead of print. PMID: 32147326. 2020
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Kim J, Nguyen TT, Li Y, Zhang CO, Cha B, Ke Y, Mazzeffi MA, Tanaka KA, Birukova AA, Birukov KG. Contrasting effects of stored allogeneic red blood cells and their supernatants on permeability and inflammatory responses in human pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 318(3), L533-L548. PMID: 31913681. 2020
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Chow JH, Fedeles B, Richards JE, Tanaka KA, Morrison JJ, Rock P, Scalea TM, Mazzeffi MA, TROPIC-Trauma Investigators. Thromboelastography Reaction-Time Thresholds for Optimal Prediction of Coagulation Factor Deficiency in Trauma. J Am Coll Surg. 230(5), 798-808. doi: 10.1016/j.jamcollsurg.2020.01.033. PMID: 32142926. 2020
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Chow JH, Mazzeffi MA, Tanaka KA. In Response. Anesth Analg. doi: 10.1213/ANE.0000000000004721. PMID: 32175945. 2020
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Chow JH, Mazzeffi MA, McCurdy MT. Angiotensin II for the Treatment of COVID-19-Related Vasodilatory Shock. Anesth Analg. 131(1), 102-105. doi: 10.1213/ANE.0000000000004825. PMID: 32209811. 2020
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Heavner MS, McCurdy MT, Mazzeffi MA, Galvagno SM, Tanaka KA, Chow JH. Angiotensin II and Vasopressin for Vasodilatory Shock: A Critical Appraisal of Catecholamine-Sparing Strategies. J Intensive Care Med. 885066620911601. PMID: 32223515. 2020
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Weiner L, Mazzeffi MA, Hines EQ, Gordon D, Herr DL, Kim HK. Clinical Utility of Venoarterial-Extracorporeal Membrane Oxygenation (VA-ECMO) in Patients With Drug-Induced Cardiogenic Shock: A Retrospective Study of the Extracorporeal Life Support Organizations' ECMO Case Registry. Clin Toxicol (Phila). 58(7), 705-710. doi: 10.1080/15563650.2019.1676896. Epub 2019 Oct 16. PMID: 31617764. 2020
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Mazzeffi MA, Patel PA, Bolliger D, Erdoes G, Tanaka K. The Year in Coagulation: Selected Highlights From 2019. J Cardiothorac Vasc Anesth. 34(7), S1053-0770(20)30107-5. PMID: 32115363. 2020
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Deatrick KB, Galvagno SM, Mazzeffi MA, Kaczoroswki DJ, Herr DL, Rector R, Hochberg E, Rabinowitz RP, Scalea TM, Menaker J. Pilot study evaluating a non-titrating, weight-based anticoagulation scheme for patients on veno-venous extracorporeal membrane oxygenation. Perfusion. 35(1), 13-18. doi: 10.1177/0267659119850024. PMID: 31122144. 2020
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Li M, Mazzeffi MA, Gammie JS, Banoub M, Pazhani Y, Herr D, Madathil R, Pousatis S, Bathula A. Characterization of Postoperative Infection Risk in Cardiac Surgery Patients With Delayed Sternal Closure. J Cardiothorac Vasc Anesth. 34(5), 1238-1243. PMID: 32127277. 2020
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Tabatabai A, Rabin J, Menaker J, Madathil R, Galvagno S, Menne A, Chow JH, Grazioli A, Herr D, Tanaka K, Scalea T, Mazzeffi M. Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series. A A Pract. 14(7), e01236. PMID: 32539272. 2020
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Mazzeffi MA, Petrick KM, Magder L, Greenwald BD, Darwin P, Goldberg EM, Bigeleisen P, Chow JH, Anders M, Boyd CM, Kaplowitz JS, Sun K, Terrin M, Rock P. High-Flow Nasal Cannula Oxygen in Patients Having Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a Randomized Clinical Trial. Anesth Analg. doi: 10.1213/ANE.0000000000004837. Online ahead of print. PMID: 32398433. 2020
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Kiefer JJ, Rock P, Augoustides JG, Mazzeffi MA. Critical Care During the Coronavirus Crisis-Reflections on the Roles of Anesthesiologists in Meeting the Challenges of the Pandemic. J Cardiothorac Vasc Anesth. S1053-0770(20)30420-1. doi: 10.1053/j.jvca.2020.04.061. Online ahead of print. PMID: 32507459. 2020
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COVIDSurg Collaborative. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg. PMID: 32395848. 2020
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Mondal S, Sankova S, Lee K, Sorensen E, Kaczorowski D, Mazzeffi M. Intraoperative and Early Postoperative Management of Patients Undergoing Minimally Invasive Left Ventricular Assist Device Implantation. J Cardiothorac Vasc Anesth. S1053-0770(20)30374-8. doi: 10.1053/j.jvca.2020.04.015. Online ahead of print. PMID: 32505605. 2020
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Galvagno SM, Sikorski RA, Floccare DJ, Rock P, Mazzeffi MA, DuBose JJ, Scalea TM, Miller C, Richards JE, O'Connor JV, Mackenzie CF, Hu P. Prehospital Point of Care Testing for the Early Detection of Shock and Prediction of Lifesaving Interventions. Shock. doi: 10.1097/SHK.0000000000001567. Online ahead of print. PMID: 32453248. 2020
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Madathil RJ, Tabatabai A, Rabin J, Menne AR, Henderson R, Mazzeffi M, Scalea TM, Tanaka K. Thromboelastometry and D-Dimer Elevation in Coronavirus-2019. J Cardiothorac Vasc Anesth. S1053-0770(20)30481-X. doi: 10.1053/j.jvca.2020.05.020. Online ahead of print. PMID: 32593588. 2020
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Chow JH, Mazzeffi MA, McCurdy MT. Justification of the Safety and Efficacy of Angiotensin II for the Treatment of SARS-CoV-Induced Shock. Anesth Analg. 10.1213/ANE.0000000000005047. doi: 10.1213/ANE.0000000000005047. Online ahead of print. PMID: 32502134. 2020
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Mazzeffi M, Chow JH, Amoroso A, Tanaka K. Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?. Anesth Analg. 10.1213/ANE.0000000000005059. doi: 10.1213/ANE.0000000000005059. Online ahead of print. PMID: 32541255. 2020
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Deatrick KB, Mazzeffi MA, Galvagno SM, Boswell K, Kaczoroswki DJ, Rabinowitz RP, Madathil RJ, Cornachione CR, Herr DL, Scalea TM, Menaker J. Breathing Life Back Into the Kidney-Continuous Renal Replacement Therapy and Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO J. PMID: 32657829. 2020
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Sanford Z, Madathil RJ, Deatrick KB, Tabatabai A, Menaker J, Galvagno SM, Mazzeffi MA, Rabin J, Ghoreishi M, Rector R, Herr DL, Kaczorowski DJ. Extracorporeal Membrane Oxygenation for COVID-19. Innovations (Phila). 1556984520937821. PMID: 32692258. 2020
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Boulos FM, Pasrija C, DiChiacchio L, Rouse M, Raithel M, Mackowick K, Rector R, Mazzeffi MA, Griffith BP, Diaz JJ, Kon ZN, Deatrick KB. Early Decompressive Laparotomy for Intra-Abdominal Hypertension Following Initiation of Venovenous Extracorporeal Membrane Oxygenation. ASAIO J. 66(5), 520-523. doi: 10.1097/ MAT.0000000000001045. PMID: 31425255. 2020
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Mazzeffi MA, Chow JH, Wu ZJ, Tanaka KA. Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle. Crit Care Med. 48(8), e732-e733. PMID: 32697517. 2020
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Coleman PJ, Nissen AP, Kim DE, Ainsworth CR, McCurdy MT, Mazzeffi MA, Chow JH. Angiotensin II in Decompensated Cirrhosis Complicated by Septic Shock. Semin Cardiothorac Vasc Anesth. 24(3), 266-272. doi: 10.1177/1089253219877876. Epub 2019 Sep 20. PMID: 31540560. 2020
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McNeil J, Raphael J, Chow JH, Tanaka K, Mazzeffi MA. Antifibrinolytic Drugs and Allogeneic Transfusion In Pediatric Multi-Level Spine Surgery: A Propensity Score Matched Cohort Study. Spine. 45(6), e336-e341. PMID: 31574059. 2020
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Mazzeffi MA, Chow JH, Tanaka K. COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management. Shock (Augusta, Ga). DOI: 10.1097/SHK.0000000000001660. 2020
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Chow JH, Abuelkasem E, Sankova S, Henderson RA, Mazzeffi MA, Tanaka KA. Reversal of Vasodilatory Shock: Current Perspectives on Conventional, Rescue, and Emerging Vasoactive Agents for the Treatment of Shock. Anesth Analg. 130(1), 15-30. PMID: 31348056. 2020
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Barr LF, Boss MJ, Mazzeffi MA, Taylor BS, Salenger R. Postoperative Multimodal Analgesia in Cardiac Surgery. Crit Care Clin. 36(4), 631-651. PMID: 32892818. 2020
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Chow JH, Wallis M, Lankford AS, Chancer Z, Barth RN, Scalea JR, LaMattina JC, Mazzeffi MA, McCurdy MT. Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock. Semin Cardiothorac Vasc Anesth. 1089253220949070. PMID: 32787515. 2020
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Esposito EC, Jones KM, Galvagno Jr SM, Mazzeffi MA, DiChiacchio L, Deatrick KB, Madathil RJ, Herrold JA, Raninowitz RP, Scalea TM, Menaker J. Incidence of healthcare-associated infections in patients with fever during the first 48 hours after decannulation from veno-venous extracorporeal membrane oxygenation. Perfusion. 267659120948427. PMID: 32820708. 2020
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Mazzeffi M, Bathula A, Tabatabai A, Menaker J, Kaczorowski D, Madathil R, Galvagno S, Pasrija C, Rector R, Tanaka K, Herr D. Von Willebrand Factor Concentrate Administration for Acquired Von Willebrand Syndrome- Related Bleeding During Adult Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. S1053-0770(20), 30627-3. PMID: 32758410. 2020
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Mazzeffi M, Madathil R, Gutsche JT. In Extracorporeal Cardiopulmonary Resuscitation, It's Great To Be Young. J Cardiothor Vasc Anesth. 34(2), 363-364. doi: 10.1053/j.jvca.2019.08.040. Epub 2019 Aug 30. PMID: 31606279. 2020
Clinical Specialty Details
Awards and Affiliations
Society of Cardiovascular Anesthesiologists
Society of Critical Care Medicine
American Society of Anesthesiologists
International Anesthesia Research Society
Grants and Contracts
Active
July 2016-current Society for Cardiovascular Anesthesiologists Starter Grant
Procoagulant and anticoagulant factor levels, thrombin
generation, and bleeding during veno-arterial ECMO.
PI: Michael Mazzeffi
Total award: $50,000
Completed
September 2014-June 2016 Department of Defense grant
Prolongation of platelet storage time by protection against
mitochondrial energy failure.
US Air Force FA8650-14-2-6D17
PI: Gary Fiskum
Role: 0.05% FTE, sub-investigator
Total award: $281,000
July 2014-June 2015 Departmental seed grant
Effect of cardiopulmonary bypass on platelet mitochondrial respiration.
PI: Michael Mazzeffi
Total award: $10,000
Community Service
International Service
03/2006-04/2006 Volunteer, Bwindi Community Health Center, Bwindi, Uganda
01/2009 Volunteer, JFK Memorial Hospital, Monrovia, Liberia
01/2010 Volunteer, Phoebe Hospital, Liberia
10/2014 Volunteer, Kien Gang Hospital, Rach Gia, Vietnam