B.S., Biology, Villanova University, 1973
Ph.D., Experimental Pathology, University of Maryland School of Medicine, 1979
Registered Quality Assurance Professional-GLP (SQA) Certification, 2012
I recieved my B.S. in Biology from Villanova University in 1973 and my Ph.D. in experimental pathology from the University of Maryland School of Medicine in 1979. The focus of my research has been chemical carcinogenesis and the toxicologic effects of chemical carcinogens in a variety of animal models and in vitro model systems. Much of this research involved environmentally relevant chemical contaminants. We established and maintained a laboratory in environmental pathology, including aquatic pathology, for a number of years. Subsequent research efforts focused on the use on isolated human cells maintained in vitro for comparison to animal models. In the past few years we have become involved in quality assurance, especially in pursuing "Good Labortory Practices" models for work requiring FDA approval. We achieved RQAP-GLP certification through the Society of Quality Assurance. I am currently the Director of the Pathologist's Assistant Program in the Department of Pathology, University of Maryland School of Medicine.
Toxicology, chemical carcinogenesis, aquatic pathology and toxicology, toxicologic pathology,quality assurance, in vitro toxicology, hepatocarcinogenesis, renal carcinogenesis
Kari Ann Shirey1, Wendy Lai1, Michael Lipsky1, Kevin Yim2, Christopher Karp3, Jaclyn McAlees3, Daniel P Rossignol4,5, Fabian Gusovsky4, Jorge C. Blanco2, Stefanie N. Vogel1. TLR4 Antagonist, Eritoran, Protects Mice from Lethal Influenza Infection. Nature, 497:498-502, 2013
Pennini, M, Perkins DJ, Salazar, AS, Lipsky, M and Vogel, SN. Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and I ncreased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice: J Immunol. Jan 1, 190: 307-316, 2013.
Silvestri A, Calvert V, Belluco C, Lipsky M, De Maria R, Deng J, Colombatti A, De Marchi F, Nitti D,Liotta L, Petricoin E, Pierobon M.Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations. Clin Exp Metastasis. Mar;30(3):309-16. 2013.
Lipsky, M.M., Hinton, D.E., Klaunig, J.E., and Trump, B.F.: Biology of hepatocellular neoplasia in the mouse. I. The histogenesis of safrole induced hepatocellular carcinoma. JNCI 67: 365 376, 1981.
Hsu, I.C., Harris, C.C., Lipsky, M.M., Snyder, S., and Trump, B.F.: Cell and species differences in metabolic activation of chemical carcinogens. Mutat. Res. 177: 1 7, 1987.
Pfeifer, A., M., Mace, K., Tromvoukis, Y. and Lipsky, M.M. High efficiency establishment of immortalized cells from adult human liver. Meth. Cell Sci. 17:83-89, 1995.
Whittaker, M, Wang, G, Chen, XQ, Lipsky M, Smith, D, Gwiazda, R and Fowler B. Exposure to Pb, Cd and As Mixtures Potentiates the Production of Oxidative Stress Precursors: 30 Day, 90 Day and 180 Day Drinking Water Studies in Rats. Toxicol. Appl. Pharmacol. 254: 154-166, 2011
The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence. Thompson, K.N., Whipple, R.A., Yoon, J.R., Lipsky, M., Charpentier, M.S.,Boggs, A.E., Chakrabarti, K.R., Bhandary, L., Hessler, L., Martin, S.S., and Vitolo, M.I. Oncotarget: Nov 3;6(34):35231-46. 2015
Director Pathologist's Assistant Program
Society of Quality Assurance 2012- present