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Melina V. Jones, PhD

Academic Title:

Research Associate

Primary Appointment:

Anesthesiology

Location:

Howard Hall, 660 West Redwood Street, Room 560, Baltimore, MD 21201

Phone (Primary):

410-328-9983

Fax:

410-328-5531

Education and Training

1991-1995     Bachelors of Science , Microbiology, University of Manitoba, Winnipeg, Canada

1995-2002     PhD, Microbiology, University of Kentucky

2002-2004     Postdoctoral Fellowship, Department of Neurology, University of Utah School of Medicine

2004-2006     Postdoctoral Fellowship, Department of Neurology, Division of Neuroimmunology, Johns Hopkins University School of Medicine

Highlighted Publications

1.           Jones M, Olafson K, Del Bigio MR, Peeling J, Nath A. Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. J Neuropathol Exp Neurol. 57(6), 563-70. PMID: 9630236. 1998.

2.           Nath A, Anderson C, Jones M, Maragos W, Booze R, Mactutus C, Bell J, Hauser KF, Mattson M. Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. J Psychopharmacol. 14(3), 222-7. PMID: 11106300. 2000.

3.           Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol. 47(2), 186-94. PMID: 10665489. 2000.

4.           Hudson L, Liu J, Nath A, Jones M, Raghavan R, Narayan O, Male D, Everall I. Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues. J Neurovirol. 6(2), 145-55. PMID: 10822328. 2000.

5.           Jones MV, Bell JE, Nath A. Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia. AIDS. 14(17), 2709-13. PMID: 11125889. 2000.

6.           Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med. 6(12), 1380-7. PMID: 11100124. 2000.

7.           Maragos WF, Tillman P, Jones M, Bruce-Keller AJ, Roth S, Bell JE, Nath A. Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat. Neuroscience. 117(1), 43-53. PMID: 12605891. 2003.

8.           Wang T, Allie R, Conant K, Haughey N, Turchan-Chelowo J, Hahn K, Rosen A, Steiner J, Keswani S, Jones M, Calabresi PA, Nath A. Granzyme B mediates neurotoxicity through a G-protein-coupled receptor. FASEB J. 20(8), 1209-11. PMID: 16636104. 2006.

9.           DeBoy CA, Zhang J, Dike S, Shats I, Jones M, Reich DS, Mori S, Nguyen T, Rothstein B, Miller RH, Griffin JT, Kerr DA, Calabresi PA. High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. Brain. 130(Pt 8), 2199-210. PMID: 17557778. 2007.

10.       Graber JJ, Allie SR, Mullen KM, Jones MV, Wang T, Krishnan C, Kaplin AI, Nath A, Kerr DA, Calabresi PA. Interleukin-17 in transverse myelitis and multiple sclerosis. J Neuroimmunol. 196(1-2), 124-32. PMID: 18417225. 2008.

11.       Jones MV, Nguyen TT, Deboy CA, Griffin JW, Whartenby KA, Kerr DA, Calabresi PA. Behavioral and pathological outcomes in MOG 35-55 experimental autoimmune encephalomyelitis. J Neuroimmunol. 199(1-2), 83-93. PMID: 18582952. 2008.

12.       Nguyen T, Mehta NR, Conant K, Kim KJ, Jones M, Calabresi PA, Melli G, Hoke A, Schnaar RL, Ming GL, Song H, Keswani SC, Griffin JW. Axonal protective effects of the myelin-associated glycoprotein. J Neurosci. 29(3), 630-7. PMID: 19158290. 2009.

13.       Zhang J, Jones M, DeBoy CA, Reich DS, Farrell JA, Hoffman PN, Griffin JW, Sheikh KA, Miller MI, Mori S, Calabresi PA. Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy. J Neurosci. 29(10), 3160-71. PMID: 19279253. 2009.

14.       Farrell JA, Zhang J, Jones MV, Deboy CA, Hoffman PN, Landman BA, Smith SA, Reich DS, Calabresi PA, van Zijl PC. q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy. Magn Reson Med. 63(5), 1323-35. PMID: 20432303. 2010.

15.       DeBoy CA, Rus H, Tegla C, Cudrici C, Jones MV, Pardo CA, Small D, Whartenby KA, Calabresi PA. FLT-3 expression and function on microglia in multiple sclerosis. Exp Mol Pathol. 89(2), 109-16. PMID: 20566414. 2010.

16.       Pathak AP, Kim E, Zhang J, Jones MV. Three-dimensional imaging of the mouse neurovasculature with magnetic resonance microscopy. PLoS One. 6(7), e22643. PMID: 21818357. 2011.

17.       Aggarwal M, Jones MV, Calabresi PA, Mori S, Zhang J. Probing mouse brain microstructure using oscillating gradient diffusion MRI. Magn Reson Med. 67(1), 98-109. PMID: 21590726. 2012.

18.       Zhang J, Jones MV, McMahon MT, Mori S, Calabresi PA. In vivo and ex vivo diffusion tensor imaging of cuprizone-induced demyelination in the mouse corpus callosum. Magn Reson Med. 67(3), 750-9. PMID: 21656567. 2012.

19.       Saini H, Rifkin R, Gorelik M, Huang H, Ferguson Z, Jones MV, Levy M. Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis. BMC Neurol. 13, 104. PMID: 23927715. 2013.

20.       Jones MV, Huang H, Calabresi PA, Levy M. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun. 3, 28. PMID: 25990016. 2015.

21.       Jones MV, Levy M. Effect of CXCR2 Inhibition on Behavioral Outcomes and Pathology in Rat Model of Neuromyelitis Optica. J Immunol Res. 2018, 9034695. PMID: 30648122. 2018.