Shien Hu, MD

1994 - 2002     B.S. & M.D. (7/12/2002), Peking Union Medical College, Beijing, China              

2003 - 2008     Postdoctoral fellowship.  Martin Boyer Lab, University of Chicago School of Medicine

2010 - 2013     Residency, Internal Medicine. University of Nevada School of Medicine, Reno 

2013 - 2017     Fellowship, Gastroenterology & Hepatology, T32 Research Track. University of Maryland School of Medicine

After graduating from Peking Union Medical College in 2002, Dr. Hu received research training as a Postdoctoral Fellow and then Research Associate in the laboratory of Dr. Eugene B. Chang at the University of Chicago School of Medicine (2003-2010). In Chicago, his projects focused on translational regulation of protective heat shock proteins in active colitis and the regulatory effects of butyrate on microRNAs in colon cancer. For this work, he was awarded support from the CCFA, GIRF and DDRCC that enabled me to publish nine peer-reviewed research papers (including five first-author scientific publications in Gastroenterology, the American Journal of Physiology, and PLoS One).

After the Internal Medicine Residency Training at the University of Nevada School of Medicine in Reno (2010-2013), Dr. Hu became an NIDDK T32-sponsored post-doctoral fellow in the Division of Gastroenterology & Hepatology at the University of Maryland School of Medicine. At Maryland, he was co-mentored by two productive, senior investigators, Dr. Jean-Pierre Raufman, Head of the Division of Gastroenterology & Hepatology, and Dr. Jian-Ying Wang, Vice-Chair for Research in the Department of Surgery, on a project recently published in Molecular Cancer which continued his study of the regulatory effects of butyrate on microRNAs and cell proliferation in colon cancer. 

With a proven track record of commended performance, Dr. Hu joined the faculty of University of Maryland School of Medicine in 7/2017 to continue his clinical service and basic science research in the field of gastroenterology. 

Colon cancer, inflammatory bowel disease, microRNAs, translational regulation.

• Said A, Hu S (co-first), Abutaleb A, Watkins T, Cheng K, Chahdi A, Kuppusamy P, Saxena N,  Xie G, Raufman JP.  Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochemical Journal 2017 Mar,474(5)647-665
• Hu S, Liu L, Chang EB, Wang JY, Raufman JP. Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. Mol Cancer. 2015 Oct 13;14:180.
• Raufman JP, Dawson PA, Rao A, Drachenberg CB, Heath J, Shang AC, Hu S, Zhan M, Polli JE, Cheng K. Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids. Carcinogenesis. 2015 Jul 25.
• Hu S, Dong TS, Dalal SR, Wu F, Bissonnette M, Kwon JH, Chang EB. The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer. PLoS One. 2011 Jan 20;6(1):e16221.
• Liedel JL, Guo Y, Yu Y, Shiou SR, Chen S, Petrof EO, Hu S, Musch MW, Claud EC. Mother's Milk-Induced Hsp70 Expression Preserves Intestinal Epithelial Barrier Function in an Immature Rat Pup Model. Pediatr Res. 2011 May;69(5 Pt 1):395-400.
• Hu S, Wang Y, Lichtenstein L, Tao Y, Musch MW, Jabri B, Antonopoulos D, Claud EC, Chang EB. Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins. Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1266-75.
• Fujiya M, Inaba Y, Musch MW, Hu S, Kohgo Y, Chang EB. Cytokine regulation of OCTN2 expression and activity in small and large intestine. Inflamm Bowel Dis. 2011 Apr;17(4):907-16.
• Hu S, Claud EC, Musch MW, Chang EB. Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G481-92. Erratum in: 2010 May;298(5):G795-6.
• Hu S, Zhu X, Triggs JR, Tao Y, Wang Y, Lichtenstein L, Bissonnette M, Musch MW, Chang EB. Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1003-11.
• Tao Y, Hart J, Lichtenstein L, Joseph LJ, Ciancio MJ, Hu S, Chang EB, Bissonnette M. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009 Jan;30(1):175-82.
• Hu S, Ciancio MJ, Lahav M, Fujiya M, Lichtenstein L, Anant S, Musch MW, Chang EB. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology. 2007 Dec;133(6):1893-904.
• Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14;1(4):299-308.