Update Your ProfileAcademic Title:
Assistant Professor
Primary Appointment:
Psychiatry
Email:
Location:
55 Wade Avenue, Catonsville, MD, 21228
Phone (Primary):
410-402-6036
Education and Training
I earned a Bachelor degree in Psychology from Peking University. I then earned my Ph.D in Cognitive neuroscience focusing on TMS, from the Chinese Academy of Sciences under the supervision of Dr. Lin Chen who is one of the leading researchers in psychology in the world, and is also the only Academician of Psychology in the Chinese Academy of Science. During this period, I had cooperation with local psychiatric hospitals about TMS treatment for patients with mental disorders, which strongly boosted my interest in understanding the neural underpinning of mental disorders and their treatment using TMS. To pursue this interest, I applied for and was accepted as a post-doctoral researcher in Dr. Elliot Hong’s lab at the Maryland Psychiatric Research Center (MPRC). I have since created and managed the first TMS Lab at the MPRC.
Biosketch
https://www.xiaomingdu.org
Research/Clinical Keywords
Schizophrenia, auditory hallucination, nicotine addiction, neural modulation, transcranial magnetic stimulation, transcranial direct current stimulation, electroencephalography, functional magnetic resonance imaging
Highlighted Publications
Du, X, Rowland, LM, Summerfelt, A, Choa, F-S, Wittenberg, GF, Wisner, K, Wijtenburg SA, Chiappelli, J, Kochunov P, Hong, LE. Cerebellar-Stimulation Evoked Prefrontal Electrical Synchrony Is Modulated by GABA. The Cerebellum, 2018;1-14.
Du, X, Rowland, LM, Summerfelt, A, Wijtenburg, A, Chiappelli, J, Wisner, K, Kochunov, P, Choa, FS, Hong, LE. TMS evoked N100 reflects local GABA and glutamate balance. Brain Stimul. 2018
Du, X, Kochunov, P, Summerfelt, A, Chiappelli, J, Choa, FS, Hong, LE. The role of white matter microstructure in inhibitory deficits in patients with schizophrenia. Brain Stimul. 2017; 10(2):283-290.
Du, X, Choa, FS, Summerfelt, A, Rowland, LM, Chiappelli, J, Kochunov, P, Hong, LE. N100 as a generic cortical electrophysiological marker based on decomposition of TMS-evoked potentials across five anatomic locations. Experimental Brain Research. 2016.
Du, X, Choa, FS, Summerfelt, A, Tagamets, MA, Rowland, LM, Kochunov, P, Shepard, P, Hong, LE. Neural summation in human motor cortex by subthreshold transcranial magnetic stimulations. Experimental Brain Research. 2015; 233(2):671-677.
Du, X, Summerfelt, A, Chiappelli, J, Holcomb, HH, Hong, LE. Individualized brain inhibition and excitation profile in response to paired-pulse TMS. Journal of Motor Behavior. 2014; 46(1):39-48.
Du, X, Chen, L, Zhou, K. The role of the left posterior parietal lobule in top-down modulation on space-based attention: a transcranial magnetic stimulation study. Human Brain Mapping. 2012; 33(10):2477-2486.
Additional Publication Citations
1. Meng, Q, Jing, L, Badjo, JP, Du, X, Hong, E, Yang, Y, Lu, H, Choa, FS. A novel transcranial magnetic stimulator for focal stimulation of rodent brain. Brain Stimul. 2018; 11(3):663-665.
2. Du, X, Rowland, LM, Summerfelt, A, Wijtenburg, A, Chiappelli, J, Wisner, K, Kochunov, P, Choa, FS, Hong, LE. TMS evoked N100 reflects local GABA and glutamate balance. Brain Stimul. 2018.
3. Ryan, M, Kochunov, P, Rowland, LM, Mitchell, BD, Wijtenburg, SA, Fieremans, E, Veraart, J, Novikov, DS, Du, X, Adhikari, B, Fisseha, F, Bruce, H, Chiappelli, J, Sampath, H, Ament, S, O'Connell, J, Shuldiner, AR, Hong, LE. Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish. Obesity (Silver Spring). 2017.
4. Puvvada, KC, Summerfelt, A, Du, X, Krishna, N, Kochunov, P, Rowland, LM, Simon, JZ, Hong, LE. Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia. Schizophrenia Bulletin. 2017.
5. Kochunov, P, Coyle, TR, Rowland, LM, Jahanshad, N, Thompson, PM, Kelly, S, Du, X, Sampath, H, Bruce, H, Chiappelli, J, Ryan, M, Fisseha, F, Savransky, A, Adhikari, B, Chen, S, Paciga, SA, Whelan, CD, Xie, Z, Hyde, CL, Chen, X, Schubert, CR, O'Donnell, P, Hong, LE. Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia. JAMA Psychiatry. 2017; 74(9):958-966.
6. Du, X, Kochunov, P, Summerfelt, A, Chiappelli, J, Choa, FS, Hong, LE. The role of white matter microstructure in inhibitory deficits in patients with schizophrenia. Brain Stimul. 2017; 10(2):283-290.
7. Chiappelli, J, Kochunov, P, Savransky, A, Fisseha, F, Wisner, K, Du, X, Rowland, LM, Hong, LE. Allostatic load and reduced cortical thickness in schizophrenia. Psychoneuroendocrinology. 2017; 77105-111.
8. Bruce, HA, Kochunov, P, Paciga, SA, Hyde, CL, Chen, X, Xie, Z, Zhang, B, Xi, HS, O'Donnell, P, Whelan, C, Schubert, CR, Bellon, A, Ament, SA, Shukla, DK, Du, X, Rowland, LM, O'Neill, H, Elliot Hong, L. Potassium Channel Gene Associations with Joint Processing Speed and White Matter Impairments in Schizophrenia. Genes Brain Behav. 2017.
9. Wijtenburg, SA, Wright, SN, Korenic, SA, Gaston, FE, Ndubuizu, N, Chiappelli, J, McMahon, R, Chen, H, Savransky, A, Du, X, Wang, DJ, Kochunov, P, Hong, LE, Rowland, LM. Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL Study. Neuropsychopharmacology. 2016.
10. Rowland, LM, Summerfelt, A, Wijtenburg, SA, Du, X, Chiappelli, JJ, Krishna, N, West, J, Muellerklein, F, Kochunov, P, Hong, LE. Frontal Glutamate and gamma-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia. JAMA Psychiatry. 2016; 73(2):166-174.
11. Kochunov, P, Thompson, PM, Winkler, A, Morrissey, M, Fu, M, Coyle, TR, Du, X, Muellerklein, F, Savransky, A, Gaudiot, C, Sampath, H, Eskandar, G, Jahanshad, N, Patel, B, Rowland, L, Nichols, TE, O'Connell, JR, Shuldiner, AR, Mitchell, BD, Hong, LE. The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. NeuroImage. 2016a; 125189-197.
12. Kochunov, P, Rowland, LM, Fieremans, E, Veraart, J, Jahanshad, N, Eskandar, G, Du, X, Muellerklein, F, Savransky, A, Shukla, D, Sampath, H, Thompson, PM, Hong, LE. Diffusion-weighted imaging uncovers likely sources of processing-speed deficits in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2016b; 113(47):13504-13509.
13. Kochunov, P, Ganjgahi, H, Winkler, A, Kelly, S, Shukla, DK, Du, X, Jahanshad, N, Rowland, L, Sampath, H, Patel, B, O'Donnell, P, Xie, Z, Paciga, SA, Schubert, CR, Chen, J, Zhang, G, Thompson, PM, Nichols, TE, Hong, LE. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping. 2016c.
14. Kochunov, P, Fu, M, Nugent, K, Wright, SN, Du, X, Muellerklein, F, Morrissey, M, Eskandar, G, Shukla, DK, Jahanshad, N, Thompson, PM, Patel, B, Postolache, TT, Strauss, KA, Shuldiner, AR, Mitchell, BD, Hong, LE. Heritability of complex white matter diffusion traits assessed in a population isolate. Human Brain Mapping. 2016d; 37(2):525-535.
15. Du, X, Choa, FS, Summerfelt, A, Rowland, LM, Chiappelli, J, Kochunov, P, Hong, LE. N100 as a generic cortical electrophysiological marker based on decomposition of TMS-evoked potentials across five anatomic locations. Experimental Brain Research. 2016.
16. Chiappelli, J, Postolache, TT, Kochunov, P, Rowland, LM, Wijtenburg, SA, Shukla, DK, Tagamets, M, Du, X, Savransky, A, Lowry, CA, Can, A, Fuchs, D, Hong, LE. Tryptophan Metabolism and White Matter Integrity in Schizophrenia. Neuropsychopharmacology. 2016; 41(10):2587-2595.
17. Wright, SN, Hong, LE, Winkler, AM, Chiappelli, J, Nugent, K, Muellerklein, F, Du, X, Rowland, LM, Wang, DJ, Kochunov, P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Human Brain Mapping. 2015; 36(10):3793-3804.
18. Nugent, KL, Chiappelli, J, Sampath, H, Rowland, LM, Thangavelu, K, Davis, B, Du, X, Muellerklein, F, Daughters, S, Kochunov, P, Hong, LE. Cortisol Reactivity to Stress and Its Association With White Matter Integrity in Adults With Schizophrenia. Psychosomatic Medicine. 2015; 77(7):733-742.
19. Du, X, Choa, FS, Summerfelt, A, Tagamets, MA, Rowland, LM, Kochunov, P, Shepard, P, Hong, LE. Neural summation in human motor cortex by subthreshold transcranial magnetic stimulations. Experimental Brain Research. 2015; 233(2):671-677.
20. Chiappelli, J, Hong, LE, Wijtenburg, SA, Du, X, Gaston, F, Kochunov, P, Rowland, LM. Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation. Transl Psychiatry. 2015; 5e548.
21. Du, X, Summerfelt, A, Chiappelli, J, Holcomb, HH, Hong, LE. Individualized brain inhibition and excitation profile in response to paired-pulse TMS. Journal of Motor Behavior. 2014; 46(1):39-48.
22. Kochunov, P, Du, X, Moran, LV, Sampath, H, Wijtenburg, SA, Yang, Y, Rowland, LM, Stein, EA, Hong, LE. Acute nicotine administration effects on fractional anisotropy of cerebral white matter and associated attention performance. Frontiers in Pharmacology. 2013; 4117.
23. Ballesteros, A, Summerfelt, A, Du, X, Jiang, P, Chiappelli, J, Tagamets, M, O'Donnell, P, Kochunov, P, Hong, LE. Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clinical Neurophysiology. 2013a; 124(11):2209-2215.
24. Ballesteros, A, Jiang, P, Summerfelt, A, Du, X, Chiappelli, J, O'Donnell, P, Kochunov, P, Hong, LE. No evidence of exogenous origin for the abnormal glutathione redox state in schizophrenia. Schizophrenia Research. 2013b; 146(1-3):184-189.
25. Hong, LE, Moran, LV, Du, X, O'Donnell, P, Summerfelt, A. Mismatch negativity and low frequency oscillations in schizophrenia families. Clinical Neurophysiology. 2012; 123(10):1980-1988.
26. Du, X, Chen, L, Zhou, K. The role of the left posterior parietal lobule in top-down modulation on space-based attention: a transcranial magnetic stimulation study. Human Brain Mapping. 2012; 33(10):2477-2486.
Research Interests
My career goal is to make significant contributions to the understanding of the mechanism and etiology of schizophrenia that will one day lead to more robust treatments of the illness. Transcranial magnetic stimulation (TMS), approved by FDA for depression treatment, is one of the most advanced techniques that can noninvasively modulate the activation in the brain and may benefit the treatment of schizophrenia as well.