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Louis J. DeTolla, VMD, MS, PhD, DACLAM

Director, Program in Comparative Medicine and Chief, Veterinary Resources

Academic Title:


Primary Appointment:


Secondary Appointment(s):

Administration, Medicine, Epidemiology & Public Health

Additional Title:

Director, Comparative Medicine and Chief, Veterinary Resources


MSTF, G-100

Phone (Primary):




Education and Training

  • Temple University, AB,  Psychology, 1970
  • Rutgers University, MS, Microbiology, 1974
  • Rutgers University, PhD, Pathology, Immunology, 1978
  • University of Pennsylvania School of Veterinary Medicine, VMD, 1982
  • Diplomate, American College of Laboratory Animal Medicine, 1992


A senior researcher and pathologist in the field of Comparative Medicine, Dr. DeTolla currently oversees some 300 animal research projects on more than 20,000 animal species, representing over $150 million of funding. Dr. DeTolla utilizes mice and other animals to study cancer treatments and gene therapy of transplanted tumors. He regularly collaborates with a wide range of investigators, especially in the area of infectious diseases, biohazards, biodefense, primatology, and vaccine development.

Through funding from the Maryland Industrial Partnerships Program, Dr. DeTolla has worked with local bio-venture companies to develop new drugs and medical treatments. As Director of the Comparative Medicine Training Program at the University of Maryland, Dr. DeTolla trains residents toward board certification in the American College of Laboratory Animal Medicine (ACLAM). He is also the Director of Transgenic Services and the newly created Germ free Laboratory.

Research/Clinical Keywords

Gnotobiotics, Laboratory Animal Medicine, Medical Primatology, Comparative Medicine, Infectious Diseases, Vaccines, Immunology, Public Health, Transgenics, Pathology, Oncology and Transplantation Biology

Highlighted Publications

L.DeTolla, R. Sanchez, E. Khan, B. Tyler, and M. Guarnieri, “Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice,” Journal of Veterinary Medicine, vol. 2014, Article ID 365673, 8 pages, 2014. Doi:10.1155/2014/365673

G. Beha, L.V. Muscatello, B. Brunetti, P. Asproni, A. Poli, G. Avallone, , L.J. DeTolla, F. Millanta, C. Benazzi and G. Sarli.  Comparison of metastatic phenotypes in mammary tumours of the dog and cat.  Proceedings of the 32nd Meeting of the ESVP-oECVP, Berlin, Germany.  Journal of Comparative Pathology, Vol. 152, Issue 1, p. 45, January 2015.

Muscatello LV, Sarli G, Beha G, Asproni P, Millanta F, Poli A, DeTolla LJ, Benazzi C, and Brunetti B. Validation of Tissue Microarray for Molecular Profiling of Canine and Feline Mammary Tumours.  Journal of Comparative Pathology, April 2015, Vol. 152, Issues 2-3, PP153-160.  doi: 10.1016/j.jcpa.2014.12.014

Additional Publication Citations

  1. DeTolla, L.J., Passmore, H.C., and Palczuk, N.C. Cardiac allografts in mice congenic at non-H-2 histocompatibility loci. Immunogenetics 5:553-560, 1977
  2. DeTolla, L.J., Semprevivo, L.H., Palczuk, N.C., and Passmore, H.C. Genetic control of acquired resistance to visceral leishmaniasis in mice. Immunogenetics 10:353-361, 1980
  3. Semprevivo, L.H., DeTolla, L.J., Passmore, H.C., and Palczuk, N.C. Spectral model of leishmaniasis in congenic strains of mice. J. Parasitol 67:8-14, 1981
  4. DeTolla, L.J., Scott, P., and Farrell, J.P. Single gene control of resistance to cutaneous leishmaniasis in mice. Immunogenetics 14:29-39, 1982
  5. Zhou, X., DeTolla, L.J., Custer, R., and London, W.T. Iron, ferritin, Hepatitis B surface and core antigens in the livers of Chinese patients with hepatocellular carcinoma. Cancer 59: 1430-1437, 1987
  6. Feitelson, M.A., DeTolla, L.J., and Zhou, X. A chronic carrierlike state is established in nude mice injected with cloned Hepatitis B virus DNA. J Virology 61(4):1408-1415, 1988
  7. Zweerink, H.J., DeTolla, L.J., Hutcheson, C.F., and Puckett, J.M. A human monoclonal antibody that protects mice against pseudomonal pneumonia. J Infect Dis 162:254-257, 1990
  8. DeTolla, L.J. Animal Models of Human Disease, Veterinary Perspectives on Genetically Engineered Animals, American Veterinary Medical Association, Washington, D.C., 1990:26-29, 33-34
  9. DeTolla, L.J. Transgenic Animal Models, Comp. Path. Bulletin XXII, No. 2:1-4, 1990
  10. Panigrahi, P., Tall, B.D., Russell, R.G., DeTolla, L.J., and Morris, G.J., Jr. Development of an in vitro model for study of non-01 Vibrio cholerae virulence using Caco-2 cells. Infect Immun 58(10):3415-3424, 1990
  11. DeTolla, L.J. Overview of Transgenic Systems. In: L.J. DeTolla, H. Chen, K. Chada, R. Hammer, and D. Salter (Eds.): Animal Models: The Production of Transgenic Vertebrates – Am Assoc Lab Animal Science. AALAS Bulletin 30:9-12, 1991
  12. Russell, R.G., Kiehlbauch, J.A., Gebhart, C.J., and DeTolla, L.J. Uncommon Campylobacter species in infant Macaca nemestrina monkeys housed in a nursery. J Clin Microbiol 30(11): 3024-3027, 1992
  13. Sacci, J.B., Schrieter, M.E., Resau, J.H., Wirtz, R.A., DeTolla, L.J., Markham, R.B., and Azad, A.F. Mouse model for exoerythrocytic stages of the falciparum malaria parasite. PNAS 89:3701-3705, 1992
  14. Panigrahi, P., Losonsky, G., DeTolla, L.J., and Morris, J.G. Human immune response to Campylobacter jejuni proteins expressed in vivo. Infect Immun 60(11): 4938-4944, 1992
  15. Russell, R.G., O’Donnoghue, M., Blake, D.C., Zulty, J., and DeTolla, L.J. Early colonic damage and invasion of C. jejuni in experimentally challenged infant M. mulatta monkeys. J Infect Dis 168: 210-215, 1993
  16. Russell, R.G., Wasserman, S.S., O’Donnoghue, J.M., Taylor, D.N., Boslego, J., Moreno, J.G., Hopkins, R.J., DeTolla, L.J., and Morris, J.G. Serologic response to Helicobacter pyloriamong children and teenagers in Northern Chile. Am J Trop Med Hyg 49(2): 189-191, 1993
  17. DeTolla, L.J., Stump, K.C., and Allen, E.D. Transgenic animal care and treatment. Lab Animal 23(1): 24-25, 1994
  18. DeTolla, L.J., Stump, K.C., Russell, R., Viskatis, L.J., Vidal, J.C., Newman, R.A., and Etcheverry, M.A.: Toxicity of the novel animal – derived anticancer agent, VRCTC-310: Acute and subchronic studies in beagle dogs. Toxicology 99: 31-46, 1995
  19. DeTolla, L.J. and Stump, K.C. Protocol Review – Animal Research Assumptions. Lab Animal 24(3): 21-22, 1995
  20. DeTolla, L.J., Srinivas, S., Whitaker, B.R., Reimschuessel, R., Hecker, B., Kane, A., and Andrews, C.: Guidelines for the care and use of fish in research. Institute of Laboratory Animal Resources (ILAR) Journal 37(4): 159-173, 1995
  21. Kapcala, L.P., He, J.R., Pieper, J.O., and DeTolla, L.J.: Subdiaphragmatic vagotomy inhibits intra-abdominal interleukin-1b stimulation of adrenocorticotropin secretion. Brain Research, 728: 247-254, 1996
  22. Xu, M., Kumar, D., Srinivas, S., DeTolla, L.J., Yu, S.F., Stass, S.A., and Mixson, A.J.: Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity. Human Gene Therapy 8:177-185, 1997
  23. Smith, J. and DeTolla, L.J.: Eosinophil response to noise stress. ASLAP Newsletter 30(4): 32-33, 1997
  24. Sulakvelidze, A., Kreger, A., Joseph, A., Robins-Browne, R.M., Fasano, A., Wauters, G., Harnett, N., DeTolla, L.J., and Morris, J.G.: Production of enterotoxin by Yersinia bercovieri, a recently identified Y. enterocolitica-like species. Infect Immun 67(2):968-971, 1999
  25. Jiang, Q., DeTolla, L., Van Rooijen, N., Singh, I.S., Fitzgerald, B., Lipsky, M.M., Kane, A.S., Cross, A.S., and Hasday, J.D.: Febrile range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infect Immun 67(4): 1539-1546, 1999
  26. Jiang, Q., DeTolla, L., Singh, I.S., Gatdula, L.I., Fitzgerald, B., van Rooijen, N., Cross, A.S., and Hasday, J.D. Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. Am J Physiol 276:1653-1660, 1999
  27. Smith, J.S. and DeTolla, L.J. An IACUC guide to reviewing protocols calling for monoclonal antibody production by mouse ascites. Lab Animal pp. 12-17, 1999
  28. DeTolla, L.J. and Smith, J.S. IACUC guidance document and checklist for evaluation of monoclonal antibody production – In vitro vs. ascites. Proceedings of the Production of Monoclonal Antibodies Workshop, Alternatives Research & Development Foundation pp. 58-66, 2000
  29. Ren, S.V., Li, M., Smith, J.M., DeTolla, L.J., Furth, P.A., Low-volume jet injection for intradermal immunization in rabbits, BMC Biotechnology 2002 (, 2:10:1-6
  30. Schreiber, W., Stone, K.D., Strong, M., DeTolla, L.J., Hoppert, M., Donnenberg, M.S., BfpU, a soluble protein essential for type IV pilus biogenesis in enteropathogenic Escherichia coli, Microbiology 148:2507-2518, 2002
  31. Edelman, R., Wasserman, S.S., Bodison, S.A., Perry, J.G., O’Donnoghue, M., DeTolla, L.J., Phase II safety and immunogenicity study of type F botulinum toxoid in adult volunteers, Vaccine, 2003, 21: 4335-4347
  32. Sarli, G., Preziosi, R., DeTolla, L., Brunetti, B., Benazzi, C., E-Caderhin immunoreactivity in canine mammary tumors, Journal of Veterinary Laboratory Investigation, 2004, 16: 542-547
  33. Smith, J.M., Rao, S.S., Stump, K.C., Benazzi, C., Sarli, G., DeTolla, L.J., Mammary ductal carcinoma with comedo pattern in a rhesus macaque, Contemporatory Topics in Laboratory Animal Science, 2005, 44:29-33
  34. Frederick Khachik, , Edra London, Fabiana F. de Moura, Mary Johnson, Scott Steidl, Louis DeTolla, Steven Shipley, Rigoberto Sanchez, B., Xue-Quing Chen, Jodi Flaws, Gerard Lutty, Scott McLeod and Bruce Fowler, Chronic Ingestion of (3R, 3’R,6’R)-Lutein and (3R, 3’R)-Zeaxanthin in Female Rhesus Macaque, Investigative Ophthalmology and Visual Science (IOVS), 2006, 47:5476 – 5486.
  35. Krishnan Kolappaswamy, Edwin H. Kriel, Charles G. McLeod Jr., Louis J. DeTolla. Intermittent Inappetence and Fur Loss in a New Zealand White rabbit. Lab Animal 35, No.4: 19-20, 2006.
  36. Tim Magnus, Turhan Coksaygan, Thomas Korn, Haipeng Xue, Thiruma V. Arumugam, Mohammed Mughal, D. Mark Eckley, Louis DeTolla, Mahendra S. Rao, Riccardo Cassiani-Ingoni, Mark P. Mattson. Evidence that nucleo-cytoplasmic Olig2 translocation mediates brain injury-induced differentiation of glial precursors to astrocytes. Journal of Neuroscience Research, 2007, 85(10): 2126-37
  37. Kolappaswamy K, Mahalingam R, Traina-Dorge V, Shipley ST, Gilden DH, Kleinschmidt-Demasters BK, McLeod CG Jr., Hungerford LL, DeTolla LJ. Disseminated Simian Varicella Virus Infection in an Irradiated Rhesus Macaque (Macaca mulatta). Journal of Virology, 2007, 81: 411-415
  38. Silverman, R.P., Banks, N.D., DeTolla, L.J., Shipley, S. T., Panda, A., Sanchez, Azimzadeh, A.M., Pierson, R.N., Wang, D., Rodriguez, E.D., Holton, L.H. and Bartlett, S.T. A Heterotopic Primate Model for Facial Composite Tissue Transplantation. Annals of Plastic Surgery. 2008 ,Volume 60, Number 2, 209-216.
  39. Shipley, S.T., Coksaygan, T., Johnson, D.K., McLeod, C.G., DeTolla, L.J., Diagnosis and Prevention of Dissemination of Tuberculosis in a Recently Imported Rhesus Macaque (Macaca mulatta), Association of Primate Veterinarian Proceedings, Journal of Medical Primatology, February 2008, Vol.37, Supplement 1, 20-24.
  40. Terez Shea-Donohue, Karen Thomas, M. Joshua Cody, Aiping Zhao, Louis J. DeTolla, Karen M. Kopydlowski, Masayuki Futaka, Sergio A. Lira, and Stefanie N. Vogel. Mice Deficient in the CXCR2 Ligand, CXCL1 (KC/GRO-a), Exhibit Increased Susceptibility to Dextran Sodium Sulfate (DSS) – induced Colitis. Innate Immunity, 14(2) 2008, 117-124.
  41. Krishnan Kolappaswamy, Steven T. Shipley, Ivan I. Tatarov, and Louis J. DeTolla. Methicillin-resistant Staphylococcus non-aureus Infection in an Irradiated Rhesus Macaque (Macaca mulatta). Journal of the American Association for Laboratory Animal Science, May 2008, Vol. 47, No 3, 64-67.
  42. Srinivas Rao, Wing-Pui Kong, Chih-Jen Wei, Zhi-Yong Yang, Martha Nason, Carrel Styles, Louis J. DeTolla, Aruna Panda, Erin M. Sorrell, Haichen Song, Hongquan Wan, Gloria C. Ramirez-Nieto, Daniel Perez, Gary J. Nabel. Multivalent HA DNA Vaccination Protects against Highly Pathogenic H5N1 Avian Influenza Infection in Chickens and Mice. PLoS ONE 2008, 3(6): e2432.
  43. Vi Dang, Saran Bao, Alida Ault, Catherine Murray, Joy McFarlane-Mills, Carmelo Chiedi, Marlon Dillon, John-Paul Todd, Louis DeTolla, and Srinivas Rao. Efficacy and Safety of Five Injectable Anesthetic Regimens for Chronic Blood Collection from the Anterior Vena Cava of Guinea Pigs. JAALAS, 2008 November; 47(6): 56-60.
  44. Krishnan Kolappaswamy, Kendra A Williams, Cinzia
    Benazzi, Giuseppe Sarli, Charles G McLeod Jr, Ivana Vucenik, and Louis J DeTolla. Effect of Inositol Hexaphosphate on the Development of UVB-Induced Skin Tumors in SKH1 Hairless Mice. Comparative Medicine, Vol 59, No 2, April 2009, 147-152.
  45. Steven T Shipley, Aruna Panda, Edwin H. Kriel, Louis J. DeTolla, Abdul Q Khan, Sofie Livio, James P. Nataro, Myron M. Levine and Marcelo B. Sztein. A Challenge Model for Shigella dysenteriae 1 in Cynomolgus Monkeys (Macaca fascicularis). Comparative Medicine. 2010 Feb; 60(1):54-61. PubMed PMID: 20158950; PMCID: PMC2826086
  46. Aruna Panda, Ivan Tatarov, Angela R. Melton-Celsa, Krishnan Kolappaswamy, Edwin H. Kriel, Daniel Petkov, Turhan Coksaygan, Sofie Livio, Charles G. McLeod, James P. Nataro, Alison D. O’Brien, and Louis J. DeTolla. (2010). A comparative study of E. coli O157:H7 infection in Dutch Belted and New Zealand White rabbit models.Comparative Medicine. 2010 Feb; 60(1): 31-37. PubMed PMID: 20158946: PMC2826082
  47. George W. Buchman, Matthew E. Cohen, Yuhong Xiao,
    Nicola Richardson-Harman, Peter Silvera, Louis J. DeTolla, Heather L. Davis, Roselyn J. Eisenberg, Gary H. Cohen, Stuart N. Isaacs. A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. Vaccine. 2010 Sept 14; 28(40) 6627-6636. PubMed PMID: 20659519; PMCID: PMC2939220
  48. Krishnan Kolappaswamy, Steven Shipley, Mark A Reynolds,
    Charles McLeod, and Louis DeTolla. Recurrent Idiopathic Gingival Enlargement in an Olive Baboon (Papio anubis). Journal of the American Association for Laboratory Animal Science (JAALAS). 2010 Nov; 49(6): 860-2. PubMed PMID: 21205454; PMCID: PMC2994056
  49. Kendra A Williams, Krishnan Kolappaswamy, Louis J DeTolla, and Ivana Vucenik. Protective Effect of Inositol Hexaphosphate Against UVB Damage in HaCaT Cells and Skin Carcinogenesis in SKH1 Hairless Mice. Comparative Medicine. 2011 Feb; 61(1): 39-44. PubMed PMID: 21819680; PMCID: PMC3060432
  50. Benvenga S, Itri E, Hauser P, DeTolla L, Yu SF, testa G, Pappalardo MA, Trimarchi F, Amato A. Gender differences in locomotor and stereotypic behavior associated with I-carnitine treatment in mice. Gender Medicine. 2011 Feb; 8(1): 1-13. PubMed PMID: 21497767
  51. Svetlana P. Chapoval, Preeta Dasgupta, Elizabeth P.
    Smith, Louis J. DeTolla, Michael M. Lipsky, Ann E. Kelly-Welch, and Achsah D. Keegan. STAT6 Expression in Multiple Cell Types Mediates the Cooperative Development of Allergic Airway Disease. The Journal of Immunology. 2011 Feb.15; 186 (4): 2571-2583. PubMed PMID: 21242523; PMCID: PMC3139332
  52. Elizabeth P Smith, Kathleen Shanks, Michael M Lipsky, Louis J DeTolla, Achsah D Keegan and Svetlana P Chapoval. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. BMC Immunology, 2011, May 19:12 (1):30, pp 1-17, doi: 10.1186/1471-2172-12-30. PMID: 21595947; PMCID: PMC3118960
  53. Eusebius Henry Nkyimbeng-Takwi, Kathleen Shangs, Elizabeth Smith, Apoorva lyer, Michael Lipsky, Louis DeTolla, Hitoshi Kikutani, Achsah Keegan, Svetlana Chapoval. A critical functional role for neuroimmune semaphoring 4A in the experimental asthma severity. The Journal of Immunology, 2011, 186, 103.7.
  54. Ivan Tatarov, Aruna Panda, Daniel Petkov, Krishnan Kolappaswamy, Keyata Thompson, Anoop Kavirayani, Michael M Lipsky, Edward Elson, Christorpher C Davis, Stuart S Martin, andLouis J DeTolla. Effect of Magnetic Fields on Tumor Growth and Viability. Comparative Medicine. 2011 Aug: 61(4):339-45. PubMed PMID: 22330249; PMCID: PMC3155400
  55. E H Nkyimbeng-Takwi, K Shanks, E Smith, A Iyer, LJ DeTolla, H Kikutani, A D Keegan and S P Chapoval. Neuroimmune semaphoring 4A downregulates the severity of allergic response. Mucosal Immunology, 2012 July: 5(4): 409-19. Doi: 10.1038/mi.2012.18. PMID: 22472774: PMCID: PMC3378810
  56. Michael Guarnieri, Cory Brayton, Louis DeTolla, Nadine Forbes-McBean, Rachel Sarabia-Estrada and Patrica Zadnik. Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats. Lab Animal, 2012 November; 41(11): 337-43. Doi: 10.1038/laban.152. PMID: 23079917.
  57. Tonia Zangari, Angela R. Melton-Celsa, Aruna Panda, Nadia boisen, Mark A. Smith, Ivan Tatarov, Louis J. DeTolla, James P. Nataro and Alison D. O’Brien. Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli 0104:H4 German Outbreak Isolate in Two Animal Models. Infection and Immunity, 2013 May, 81(5): 1562-1574. PMID: 23439303; PMCID: PMC3647979
  58. Girish Ramachandran, Mohan E Tulapurkar, Kristina M Harris, Gila Arad, Anat Shirvan, Ronen Shemesh, Louis J DeTolla, Cinzia Benazzi, Steven M Opal, Raymond Kaempfer and Alan S Cross. A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft tissue infection induced by Streptococcus pyogenes. Journal of Infectious Diseases. 2013 Jun 15; 207(12): 1869-77. PMID: 23493729; PMC3654752
  59. Anna M. Seekatz, Aruna Panda, David A. Rasko,Franklin R. Toapanta, Emiley A. Eloe-Fadrosh, Abdul Q. Khan, Zhenqiu Liu,
    Steven T. Shipley, Louis J. DeTolla, Marcelo B. Sztein, Claire M. Fraser. Differential Response of the Cynomolgus Macaque Gut Microbiota to Shigella Infection. PLoS One. 2013 June 5; 8(6); e64212. Doi: 10.1371/journal.pone.0064212. PMID: 23755118; PMC3673915
  60. Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP. Neuroimmune semaphoring 4A as a drug and drug target for asthma. International immunopharmacology. 2013Nov; 17(3): 568-75. PubMed PMID: 23994348; PMCID: PMC3818409
  61. Shanks K, Nkyimbeng-Takwi EH, Smith E, Lispky, MM, DeTolla LJ, Scott DW, Keegan AD, Chapoval SP. Neuroimmune semaphoring 4D is necessary for optimal lung allergic inflammation. Molecular Immunology. 2013 Dec; 56(4): 480-7. PubMed PMID: 23911404; PMCID: PMC3783523
  62. Schildhaus N, Trink E, Poison C, DeTolla L, Tyler BM, Jallo GI, Tok S, Guarnieri M. Thermal latency studies in opiate-treated mice. Journal of Pharmacy & Bioallied Sciences. 2014 Jan; 6(1): 43-7. PubMed PMID: 24459403; PMCID: PMC3895293
  63. Barbara Brunetti, Germana Beha, Cinzia Benazzi, Louis J DeTolla and Giuseppe Sarli. CD117 expression influences proliferation, but not survival in canine mammary tumours. Journal of Comparative Pathology. January 2014, Vol, 1-5. DOI: 10.1016/j.jcpa.2014.04.018 ISSN: 0021-9975
  64. Guarnieri M, Tyler BM, DeTolla L, Zhao M, Kobrin B. Subcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs. JPharm Bioall Sci March 2014; 6:38-42. PMID: 24459402; PMCID: PMC3895292
  65. Eugene N Ateh, Toshie Nata, Marco Goicochea, Harry Davis, Janine Davenport, Louis J DeTolla, Tagaya Yutaka, Joseph L Bryant. The HIV-1 Transgenic Nude Rat: A model of Pneumocystis Pneumonia. International Research Journal of Biological Sciences,Vol.3(5), 10-18, May 2014. ISSN: 2278-3202
  66. Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, Coksaygan T, DeTolla L, Marugan JJ, Austin CP, McKew JC, Gong DW, Zheng W. Niemann-Pick Disease type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. J Biomol Screen. 2014 Jun 6; 19(8): 1164-1173. PMID: 24907126
  67. Pereira,EF, Aracava,Y, DeTolla, LJ Jr, Beecham, EJ, Basinger, GW Jr, Wakayama, EJ, Albuquerque, EX. Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds. Journal of Pharmacology and Experimental Therapeutics, 2014 Aug: 350(2): 313-21. PubMed PMID: 24907067: PMC4109493
  68. Brunetti B, Beha G, Benazzi C, Bondin V, DeTolla L, Sarli G. CD117 expression influences proliferation but not survival in canine mammary tumours. Journal of Comparative Pathology. 2014 Aug-Oct; 151 (2-3):202-6. PubMed PMID: 25027114
  69. Panda, A.,Tatarov, I., Masek, B.J., Hardick, J., Crusan, A., Wakefield, T., Carroll, K., Yang, S., Hsieh, Y.H., Lipsky, M.M., McLeod, C.G., Levine, M.M., Rothman, R.E., Gaydos, C.A. and DeTolla, L.J. A rabbit model of non-typhoidal Salmonella bacteremia. Comparative Immunology, Microbiology and Infectious Diseases. 2014 Sep: 37 (4): 211-220. PMID: 25033732: PMCID: PMC4167468
  70. Zangari, T, Melton-Celsa, A., Panda, A., Smith, M., Tatarov, I., DeTolla, L.J. and O’Brien, A.D. Enhanced Virulence of the Escherichia coli 0157:H7 Spinach-Associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin. Infection and Immunity. 2014 Dec; 82(12): 4968-4977. Doi: 10.1128/1A1.02361 – 14 PubMed PMID: 25225244; PMCID: PMC4249278
  71. Karl A Traul, Jennell B Romero, Cory Brayton, Louis DeTolla, NadineForbes-McBean, Matthew Halquist, H Thomas Karnes, Rachel Sarabia-Estrada, Michael J Tomlinson, Betty M Tyler, Xiaobu Ye, Patricia Zadnik, Michael Guarnieri. Safety Studies of Postsurgical Buprenorphine Therapy for Mice. Laboratory Animals 2015, Vol. 49(2) 100-110. DOI: 10.1177/0023677214554216

Research Interests

Dr. DeTolla is a veterinarian with a PhD in Pathology and is currently Professor of Pathology in our Department of Pathology. He regularly reviews gross and microscopic histopathology for a wide range of species and especially mice. In addition, Dr. DeTolla is the Chief of Veterinary Resources and the Director of Comparative Medicine and oversees a group of other faculty veterinarians that are a part of his team, including Aruna Panda, DVM, PhD, Assistant Professor of Pathology, Michael Lipsky, PhD, Professor Pathology and Charles McLeod, DVM, DACVP, Chief of Veterinary Pathology, Turhan Coksaygan, DVM, PhD, DACLAM, Assistant Professor of Pathology and Chief, Comparative Medical Research. Dr. DeTolla regularly collaborates with a wide range of investigators utilizing animal models, especially in the area of infectious diseases and transgenics and  biohazards, biodefense, primatology, vaccine development and gnotobiology. He is funded by NIH, DOD and industry.

Awards and Affiliations

  • Teaching Excellence, Virginia/Maryland Regional College of Veterinary Medicine, 1990
  • Research Fellow, National Aquarium, Baltimore, MD, 1999
  • Research Scientist, Mystic Aquarium, Mystic, CT, 2005
  • Fellow, National Academy of Veterinary Sciences (India), 2007
  • Senior Editor, Journal of Infectious Diseases and Immunity (2010-present)
  • Recipient of the John M’Fadyean medal sponsored by The Journal of Comparative Pathology, 2016

Previous Positions

  • Chief Attending Veterinarian, Gerontology Research Center, National Institute on Aging (NIA), Baltimore, Md., 1993-1998
  • Research Veterinarian and Co-Director, Laboratory Animal Resources, Merck, Sharp & Dohme Research Laboratories, Merck Institute for Therapeutic Research, Rahway, NJ