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Eric P. Cohen, MD

Academic Title:

Professor

Primary Appointment:

Medicine

Location:

Baltimore VAMC 5D-148A

Phone (Primary):

410-605-7000

Phone (Secondary):

410-328-5720

Fax:

410-605-7849

Education and Training

  • Université de Liège, Belgium, MD, 1980
  • Residency, Tulane University Program, Medicine, 1980-1982
  • Residency, University of Michigan Program, Neurology, 1982-1983
  • Residency, University of Chicago Program, Medicine, 1983-1984
  • Fellowship, University of Chicago Program, Nephrology, 1984-1986
  • Fellowship, Northwestern University Program, Nephrology, 1986-1987

Biosketch

Dr Cohen is a clinician-investigator whose work has focused on normal tissue radiation injury, with emphasis on radiation nephropathy that can complicate hematopoietic stem cell transplants and is also a risk of accidental or belligerent radiation exposures. He has developed the concept of mitigation, which is the use of a drug or compound after irradiation but before expression of tissue injury, to attenuate the later consequences of irradiation. His laboratory work showed the great benefit of this approach, which he has translated to the clinic.

He has extended this interest to the broader area of Onco-Nephrology, which is the overlap area of those specialties. This includes renal complications of cancer and its treatment, cancers that may damage kidneys, and kidney cancer itself. He has edited a reference text, Cancer and the Kidney.

He has recently developed a new and non-invasive technique to measure renal cortical fibrosis using CT scan images.

His work is currently funded by the DHHS.

Research/Clinical Keywords

Kidney diseases, normal tissue radiation injury, radiation nephropathy, radiation pneumonitis, measurement of renal fibrosis, Onco-Nephrology, radiation nephropathy

Highlighted Publications

Cohen EP, Olson JD, Tooze JA, Bourland JD, Dugan GO, Cline JM. Detection and Quantification of Renal Fibrosis by Computerized Tomography, PlosOne, 2020 Feb 13;15(2): e0228626

Cohen EP, editor, Cancer and the Kidney, 2nd edition, Oxford University Press, 2011

Research Interests

Normal tissue radiation injury, Measurement of renal fibrosis

Clinical Specialty Details

Nephrology, with interest in Onco-Nephrology

Grants and Contracts

Active Grants

07/01/2016 – Current

Role: Co-investigator, 60% UMB effort, 8% overall effort.
PI: I. Lauren Jackson, PhD
Title: Hemostatic dysfunction after total body irradiation in a rabbit model
Type: HHSO100205000091
Source: HHS/ BARDA
Direct costs: $2,000,000 total
Role: Subject matter expert for renal endpoints and for all data analysis


Previous Grants:

03/01/2017 – 1/31/2020

Role: Co-investigator, 10% effort
PI: I. Lauren Jackson, PhD
Title: Development of TP508 as a mitigator of the hematopoietic subsyndrome of the acute radiation syndrome
Type: NIAID-DAIT-NIHAI2015042
Source: NIH
Direct Costs: $2,800,000 total
Role: Subject matter expert for renal endpoints and for all data analysis

07/01/2016 – 06/30/2019

Role: Co-investigator, 63% effort (of UMB)
PI: Thomas MacVittie, PhD
Title: Multi-organ radiation injury in non-human primates
Type: NIH/NIAID subcontract to SRI, HHSN272201500013I
Source: NIH
Direct Costs: $2,000,000 total
Role: Subject matter expert for renal endpoints and for all data analysis

04/01/2013 - 03/31/2018

PI: Cohen (PI)
Title: Mitigation of radiation pneumonitis and fibrosis
Type: CX000569-01A2, Department of Veterans Affairs
Subject: Determine whether enalapril mitigates radiation pneumonitis and fibrosis in patients undergoing radiotherapy of lung cancer and other thoracic cancer

01/01/2014 - 12/31/2017

BX002256-01A1, Department of Veterans Affairs
Role: Cohen (co-investigator)
PI: Mandel (PI)
Title: Afferent arteriolar function and novel small molecules for renal radiation injury
Subject: Determine the role of epoxyeicosatrienoic acid and its synthetic analogs in radiation nephropathy and its mitigation

Links of Interest