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Eric P. Cohen, MD

Academic Title:

Professor

Primary Appointment:

Medicine

Location:

Baltimore VAMC 5D-148A

Phone (Primary):

410-605-7000

Phone (Secondary):

410-328-5720

Fax:

410-605-7849

Education and Training

  • Université de Liège, Belgium, MD, 1980
  • Residency, Tulane University Program, Medicine, 1980-1982
  • Residency, University of Michigan Program, Neurology, 1982-1983
  • Residency, University of Chicago Program, Medicine, 1983-1984
  • Fellowship, University of Chicago Program, Nephrology, 1984-1986
  • Fellowship, Northwestern University Program, Nephrology, 1986-1987

Biosketch

Dr Cohen is a clinician-investigator whose work has focused on normal tissue radiation injury, with emphasis on radiation nephropathy that can complicate hematopoietic stem cell transplants and is also a risk of accidental or belligerent radiation exposures. He has developed the concept of mitigation, which is the use of a drug or compound after irradiation but before expression of tissue injury, to attenuate the later consequences of irradiation. His laboratory work showed the great benefit of this approach, which he has translated to the clinic.

He has extended this interest to the broader area of Onco-Nephrology, which is the overlap area of those specialties. This includes renal complications of cancer and its treatment, cancers that may damage kidneys, and kidney cancer itself. He has edited a reference text, Cancer and the Kidney.

He has also had a longstanding clinical interest in mechanisms and measurement of urinary acidification, and was the first to show the molecular defect of H+ATPase in acquired distal renal tubular acidosis.

His work is currently funded by the NIH and the DHHS.

Research/Clinical Keywords

Kidney diseases, Onco-Nephrology, normal tissue radiation injury, radiation nephropathy, radiation pneumonitis

Highlighted Publications

Epoxyeicosatrienoic acid analog mitigates kidney injury in a rat model of radiation nephropathy. Khan MAH, Fish B, Wahl G, Sharma A, Falck JR, Paudyal MP, Moulder JE, Imig JD, Cohen EP. Clin Sci, 130(8):587-99, 2016

Cohen EP, editor, Cancer and the Kidney, 2nd edition, Oxford University Press, 2011

Absence of H+-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. J Am Soc Nephrol. 3:264-271, 1992

Research Interests

Normal tissue radiation injury, with emphasis on kidney and lung

Clinical Specialty Details

Nephrology, with interest in Onco-Nephrology

Grants and Contracts

Current Grants:

07/01/2016 – 12/31/2019

Role: Co-investigator, 2% effort
PI: I. Lauren Jackson, PhD
Title: Hemostatic dysfunction after total body irradiation in a rabbit model
Type: HHSO100205000091
Source: HHS
Direct costs: $2,000,000 total
Role: Subject matter expert for renal endpoints and for all data analysis

03/01/2017 – 1/31/2020

Role: Co-investigator, 10 % effort
PI: I. Lauren Jackson, PhD
Title: Development of TP508 as a mitigator of the hematopoietic subsyndrome of the acute radiation syndrome
Type: NIAID-DAIT-NIHAI2015042
Source: NIH
Direct Costs: $2,800,000 total
Role: Subject matter expert for renal endpoints and for all data analysis

07/01/2016 – 06/30/2019

Role: Co-investigator, 63% effort (of UMB)
PI: Thomas MacVittie, PhD
Title: Multi-organ radiation injury in non-human primates
Type: NIH/NIAID subcontract to SRI, HHSN272201500013I
Source: NIH
Direct Costs: $2,000,000 total
Role: Subject matter expert for renal endpoints and for all data analysis

Previous Grants:

04/01/2013 - 03/31/2018

PI: Cohen (PI)
Title: Mitigation of radiation pneumonitis and fibrosis
Type: CX000569-01A2, Department of Veterans Affairs
Subject: Determine whether enalapril mitigates radiation pneumonitis and fibrosis in patients undergoing radiotherapy of lung cancer and other thoracic cancer

01/01/2014 - 12/31/2017

BX002256-01A1, Department of Veterans Affairs
Role: Cohen (co-investigator)
PI: Mandel (PI)
Title: Afferent arteriolar function and novel small molecules for renal radiation injury
Subject: Determine the role of epoxyeicosatrienoic acid and its synthetic analogs in radiation nephropathy and its mitigation

07/01/2016 – 03/31/2017

HHSN272201500013I, NIH/NIAID, subcontract to SRI
Role: Cohen (co-investigator)
PI: MacVittie (PI)
Title: Multi-organ radiation injury in non-human primates
Subject: Establish the roles of acute and chronic renal radiation injury after prompt radiation exposure in a primate model

Links of Interest