HSF II, S316
Education and Training
University of Chittagong, Bangladesh, B.Sc. (Honors), Chemistry, 2000
University of Chittagong, Bangladesh, M.Sc., Organic Chemistry, 2002
Saitama University, Japan, Ph.D., Carbohydrate Chemistry, 2007
Researcher, RIKEN (The Institute of Physical & Chemical Research), Japan, 2007-2008
Postdoctoral Researcher, University of Maryland School of Medicine, Institute of Human Virology, 2008-2015
Postdoctoral Associate, University of Maryland College Park, Chemistry and Biochemistry, 2015
Postdoctoral Researcher, University of Maryland School of Medicine, Center for Vaccine Development (CVD), 2015-2016
Dr. Amin's current research at CVD involves the synthesis and analysis of novel carbohydrate vaccine constructs and analysis of the binding characteristics of vaccine-induced antibodies. He works on the development of vaccines to prevent invasive infections with bacterial pathogens, including Salmonella enterica , Klebsiella pneumonia, and Pseudomonas sp. Dr. Amin has a strong background in chemistry and biochemistry, essential components of vaccine research.
Dr. Amin began working with oligosaccharide synthesis in RIKEN, Japan's largest comprehensive research institution. He worked under the supervision of Dr. Yukishige Ito as a doctoral student and researcher. In 2008, Dr. Amin joined the Institute of Human Virology (IHV) at the University of Maryland School of Medicine. At the IHV, he continued his research in the field of glycobiology with Dr. Lai-Xi Wang, where his research focused on the chemical and enzymatic synthesis of homogeneous glycoconjugates for deciphering functions such as protein quality control and identifying glycopeptides epitope for HIV antibodies. Dr. Amin currently works closely with Dr. Simon, Dr. Tennant, and Dr. Cross.
Carbohydrate chemistry, polysaccharide conjugate vaccine, bio-conjugation, glycan isolation, characterization and modification, chemical and enzymatic synthesis of glycopeptides and glycoproteins, glycopeptides epitope for HIV antibodies, glycobiology.
A full list of Dr. Amin's publications.
Wang LX, Amin MN. Chemical and chemoenzymatic synthesis of glycoproteins for deciphering functions. Chemistry & Biology. 2014;21(1):51–66.
Amin MN, McLellan JM, Huang W, Orwenyo J, Kwong PD, Wang LX. Synthetic HIV-1 glycopeptides enable characterization of fine epitopes of broadly neutralizing antibodies PG9 and PG16. Nature Chemical Biology. 2013 9(8):521-526.
Amin MN, Huang W, Rahman MM, Wang LX. Convergent synthesis of homogeneous Glc1Man9GlcNAc2-protein and derivatives as ligands of molecular chaperones in protein quality control. J Am Chem Soc. 2011;133:14404-14417.
Amin MN, Ishiwata A, Ito Y. Synthesis of N-linked glycan derived from Gram-negative bacterium, Campylobacter jejuni. Tetrahedron. 2007;63:8181-8198.
Lab Techniques and Equipment
HPLC, UPLC, FPLC, HPAEC-PAD; routinely use NMR, mass spectrometry for characterizations
Surface Plasmon Resonance techniques for kinetic data, characterization of epitope, binding studies between antibodies and vaccine/drug candidates and receptors etc. polysaccharide protein conjugation, biotinylations etc.
Glycan isolation, analysis, synthesis and modifications
Polysaccharide-protein conjugates for better immunological assay