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Technology Development and Translation in Functional Health Resource Core (RC3)

The RC3 provides support, guidance, and mentoring to UM-OAIC investigators using a multi-system approach focused on the whole-body balance, locomotion, and upper limb  activities to address the mechanistic bases upon which the build novel rehabilitation strategies to improve motor function and independence and promote recovery in older people with chronic disease-associated disabilities.  Through this framework, functional activity and exercise-mediated brain and neuromotor plasticity can be identified to guide condition-specific and individual-specific rehabilitation approaches for minimizing disability.  The complementary and collaborative relationship between RC3 and RC2 which focuses on muscle, metabolic, and cardiovascular mechanisms of aging with disability, forges a strong and comprehensive inter-core synergy for understanding the bases for designing and testing effective new rehabilitation programs to restore and sustain functional independence and quality of living among  older individuals. 

To achieve this goal, have implemented the following specific aims:

Develop, enable, and support the investigation and identification of brain and neuromotor mechanisms associated with:

  • functional performance for the development of novel and effective activity and
  • exercise-based rehabilitation interventions to enhance whole-body balance, mobility, and upper limb motor functions and minimize disability among people with chronic health conditions of aging.

Assist, mentor and support trainees, junior faculty and UM-OAIC investigators through:

  • the design and conduct of functional activity and exercise-based rehabilitation interventions that will be translated from the laboratory to the clinic and into the community to improve functional independence in older individuals with chronic disease-associated disability. 

Perform core testing and assessments using:

  • core methodologies to quantify the brain and neuromotor mechanisms of balance, postural control, mobility, upper limb activities;
  • disability phenotype that characterize the processes of adaptive plasticity underlying structured activity; and
  • exercise-derived functional gains across UM-OAIC rehabilitation-based interventions.

The brain and neuromotor changes and accompanying impairments of chronic medical conditions of aging that limit functional performance and lead to disabilities are being investigated in RC3.  This knowledge forms the mechanistic bases for the development and testing of functional activity and exercise-based rehabilitation interventions to improve functional outcomes and alleviate disability.  In collaboration with the other cores, RC3 is advancing the overall UM-OAIC goal to build on the sciences and therapeutic applications of exercise and rehabilitation to restore function and minimize disability due to acute disabling conditions and long-term declines to chronic conditions of older age.

Core Co-Leaders

Richard Macko, MD 
Telephone: 410-605-7063

Li-Qun Zhang, PhD
Telephone: 410-706-2145




Brock Beamer, MD
Telephone: 410-605-7000 ext.54870

Lisa Sulman, MD
Telephone: 410-328-7809