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Biraj Shrestha

Contact Information:

bshrestha@som.umaryland.edu

Training Program:

Graduate Program in Life Sciences , MS in Cellular and Molecular Biomedical Sciences

Mentor(s):

Shannon Takala Harrison, PhD

Publications >


Brief Summary of Research Project:

I am currently characterizing the role of specific P. falciparum mutations in resistance to the artemisinin partner drug piperaquine. Specifically, I am using gene editing approaches to remove a mutation from the P. falciparum chloroquine resistance transporter to understand the impact of this mutation on piperaquine susceptibility in parasites collected from an area of emerging multidrug resistance in Cambodia.

Education:

Bachelor of Science in Biotechnology, Northeastern University, Boston, MA, USA.

About me:

I am passionate about my work. I love what I do, and that motivates me to do my best. I have a keen interest in understanding the molecular mechanisms underlying drug resistance in P. falciparum and other organisms, using gene-editing approaches based on zinc finger nucleases and CRISPR-Cas9. Understanding the molecular mechanisms contributing to drug resistance will not only aid in identification of molecular markers for use in surveillance, but also may provide important insights for drug discovery and development and design of new combination therapies. In the future, I would like to use machine learning and other genotype-phenotype association analyses to identify polymorphisms associated with resistance to drugs used to treat malaria and other diseases.