Linda Chang, MD, MS
Professor and Vice Chair of Faculty Development,
Department of Diagnostic Radiology and Nuclear Medicine
Dr. Chang's research interests include the application of advanced neuroimaging techniques and genetics to study neurological disorders of HIV infection, substance use disorders, and other brain disorders during brain development and brain aging.
Please select a project title to learn more:
Neural Correlates of Working Memory Training for HIV
This research project is a clinical trial to evaluate the efficacy of the computerized working memory training program “Cogmed®”.
Multimodal MRI (sMRI, DTI, functional MRI), CSF cytokines and LMX1A genotypes are used to evaluate and assess treatment effects
We are actively recruiting HIV-positive and HIV-negative individuals.
Funded by NIDA / NIH (7R01-DA035659)
Adolescent Brain Cognitive Development Study (ABCD Study)
The University of Maryland is one of 21 institutions nationwide participating in the ABCD Study. Researchers have enrolled almost 12,000 children ages 9-10 years, whose biological and behavioral development will be tracked through adolescence into young adulthood.
The ABCD Study at the University of Maryland is conducted in the new HSF-III research building and the Maryland Psychiatric Research Center.
Although HIV-infected individuals can be treated and have normal life expectancies, up to half continue to suffer from cognitive problems that are often difficult to evaluate. This exploratory study aims to use machine learning to combine different types of brain imaging and clinical data to generate an objective and reproducible approach to assess brain injury associated with HIV-infection. Our approach may provide a useful biomarker to evaluate brain injury and monitor treatments in these patients in both research and clinical settings.
PIs: Linda Chang, MD and Edward H. Herskovits, MD, PhD
Funding NIH: "Machine Learning to Generate a Multivariate Model of Brain Injury in HIV Patients" (1R21NS108811-01).
Funding: NIH / NIDA: "Neural correlates of working memory training for HIV Patients" (Co-investigator, R01 DA035659)
The goal of this study is to evaluate the efficacy of computerized working memory training program in HIV-positive individuals, using multimodal MRI.
Note: the picture on the left shows the chemical structure of Methamphetamine, a commonly used drug.
I have a long-standing interest in developing and applying advanced MRI and MRS techniques to study the developing brain in neonates and young children. It is fascinating to observe the rapid and dramatic changes occuring in infants with MRI.
For instance, the image on the left shows early myelination of the motor tract (hyperintense signal) in a newborn, which mirrors the rapid improvements in motor skills in neonates.
Linda Chang, MD, MS, FAAN
Dr. Chang joined the University of Maryland School of Medicine in 2017. She previously worked at UCLA, Brookhaven National Laboratory, and the University of Hawaii.
Christine Cloak, PhD
ABCD Site coordinator
Christine holds a PhD in Neuroscience from UCLA. She is primary site coordinator for the ABCD study.
Muhammad Saleh, PhD
Active Grants and Proposals
|PI/MPI||Grant Title||Total Project Period||Funding Source||Total Costs|
|Linda Chang/ Thomas Ernst||2/21 ABCD-USA Consortium: Research Project Site at UMB||04/15/20 - 03/31/27||NIDA/NIAAA||$13,098,568.00|
|Linda Chang/ Thomas Ernst||ABCD Diversity Supplement (Julian Baptiste, MD)||04/15/20 - 03/31/22||NIDA||$203,394.00|
|Linda Chang/ Edward Herskovits||Machine Learning to Generate a Multivariate Model of Brain Injury in HIV Patients||08/01/18 - 07/31/20 (NCE)||NINDS||$424,875.00|
|Linda Chang||ABCD Social Development Substudy (U. Pitt Sub K)||01/01/18 - 12/21/20||NIJ (DOJ)||$600,000.00|
|Linda Chang/ Thomas Ernst||ABCD-Brain MRS-GABA Substudy (U. Utah Sub K)||06/15/19 - 05/31/21||NIDA||$154,500.00|
Please refer Dr. Chang's faculty profile for highlighted publications.