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Small Animal MRI: 9.4T Biospec

Core Facilities

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9.4 Tesla Biospec 94/30 USR MRI Scanner‌

Description: Small animal scanner, 30cm open bore

Manufacturer: Bruker Corporation

Click here for manufacturer website


Details

Please select a section for more details:

Contact

Rao Gullapalli, PhD
Phone: 410-328-2099
rgullapalli@umm.edu


Su Xu, PhD
Phone: 410-706-6384
sxu@umm.edu

Template for NIH "Facilities and Other Resources"

UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE

 

The University of Maryland houses the Core for Translational Research in Imaging @ Maryland (C-TRIM) which is operated by faculty associated with the Center for Advanced Imaging Research (CAIR) within the Department of Diagnostic Radiology & Nuclear Medicine of the University of Maryland School of Medicine.  Within the core, both Animal and Human imaging facilities are available.  Below are the animal imaging equipment that investigators on campus can have access to

 

Core for Translational Research in Imaging @ Maryland (C-TRIM): The facilities of C-TRIM are located in two buildings.  One is located in Howard Hall 6th floor where the 7 Tesla Bruker small Animal MRI, Siemens Inveon microPET/CT, Xenogen, MR guided Focused Ultrasound (MRgFUS) and wet lab for tissue processing are available.  The other location is in the basement of the new Health Sciences Research Facilities III building where a 9.4 Tesla Bruker system is available.  This location also hosts the human imaging arm of C-TRIM where a research dedicated 3.0 Tesla PRISMA FIT scanner and a state of the art Siemens 3.0 Tesla mMR biograph system (combined PET/MR) are located.

 

Animal Imaging at C-TRIM:    C-TRIM provides cross-sectional imaging services to various investigators on campus. Certain aspects of animal imaging within C-TRIM are available within HSF-III and the rest of the equipment are located in a nearly 3000 square foot facility that provides animal imaging services including MRI, PET, CT, SPECT, MR guided focused-ultrasound (MRgFUS), fluorescence and bioluminescence imaging  The location is also conveniently close to the animal imaging facilities.  Currently the core houses a NCRR funded 7 Tesla 30 cm MRI scanner from Bruker Biospin that operates on Avance VI software system.   Two sets of gradient coils are available to facilitate optimal imaging of larger and smaller rodents operating at slew rates of 800 T/m/s with a peak gradient strength of 200 mT/m and the second one operating at a slew rate of 5000 T/m/s with a peak gradient of 400 mT/m respectively.  The scanner has multi-nuclear capabilities.  Parallel imaging is available with 4-receive and 4 transmit channels available with the system.  Several RF coils, including P-31, C-13 and Na-23 are available to fit the anatomy of various rodents. Two volumetric quadrature coils, 30mm and 40 mm diameter respectively are available to accommodate various size animals.    In addition a 4 channel receive coil is available for optimal reception of signals regardless of the transmit coil used. A large animal body coil is also available to image with the larger diameter gradient. Physiology monitoring systems are available to monitor the animals along with the safe delivery of anesthesia.

 

Along with the 7.0 Tesla scanner, we recently acquired a 9.4 Tesla 30 cm system which is located in HSFIII.  This system also has two gradient coils to accommodate both large and small rodents.  For the relatively large rodents there is a 20 cm gradient coil operating at 640T/m/s with a peak gradient strength of 20mT/m.  The smaller bore gradient operates at a max slew rate of 3,440 T/ms with a peak gradient of 440 mT/m.  Similar coils as for the 7 Tesla are available and this system also has the broad-band capability.  In addition, the system is also equipped with a 2 channel cryo-coil for mouse imaging.The system has the same capabilities as the 7.0 Tesla and more including a cryocoil for mouse imaging.

 

A small animal Inveon Micro-PET/CT from Siemens Molecular Imaging is installed, also through a grant from NCRR and the Marlene and Stewart Greenebaum Cancer Center.   This equipment is to mainly facilitate several metabolic, flow and anatomic studies pertaining to cancer and TBI projects.  This system was chosen because of its versatility to operate as independent single units or as a combined unit. The PET aspect of this unit provides high spatial resolution, sensitivity and count rate performance and has transmission imaging capability. The CT aspect of this instrument will provide high resolution anatomical images at a large field of view and will allow for PET attenuation and scatter correction. 

 

In addition to the above C-TRIM has access to a small animal ultrasound system from Visual Sonics (Vevo 770) is available for various cardiovascular and cancer applications with probe heads ranging from 15-55 MHz. 

 

2D Bioluminescence and fluorescence imaging is facilitated by Perkin Elmer IVIS Spectrum which enables imaging of five rodents simultaneous including mice, rats and rabbits.  The system has wide range of fluorescence excitation and emission filters.

 

A small animal high intensity focused ultrasound (HIFU) for neuro and body applications was recently added to this core to facilitate neuro and body interventions.  The small animal HIFU consists of 8-element phased array transducer and can be used for thermal therapies, and for performing blood-brain barrier manipulations for drug delivery.

 

Two SurgiVet MR-conditional animal anesthesia systems and an SA Instruments model 1030 gating and monitoring system for use with a clinical MR scanner are available for delivery of isoflurane anesthesia and to monitor physiological parameters (ECG, respiration, temperature, heart rate, and blood oxygen saturation).