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‌SPINlab Hyperpolarizer

Core Facilities

HyperpolarizerSPINlab Hyperpolarizer

Description: Multi-sample DNP hyperpolarizer system

Manufacturer: General Electric Healthcare


Details

Please select a section for more details:

Capabilities

  • Production of hyperpolarized 13C solutions for in vivo and in vitro applications; clinical applications are currently limited to pyruvate
  • Simultaneous polarization of up to 4 samples
  • Liquid-state polarization of approximately 50% for a 1-g pyruvate sample
  • Large volume samples - up to 1mL of concentrated sample production

 Specifications

  • Achieve temperatures of  ≤1.0 K within the polarization region
  • Nominal magnetic field is 5.0 Tesla
  • Motorized sample processing - Mechanical control of multi-sample positioning

Contact

Peripheral equipment

  • Quality Control (QC) module automatically measures pyruvate and residual radical concentrations, pH, temperature, infusion volume, and polarization without compromising the sterile barrier
  • Laser welder for preparation of fluid paths for clinical applications

Template for NIH "Facilities and Other Resources"

This is a template for the SPINlab hyperpolarizer. You can copy & paste this section into the "Facilities and Other Resources" page of NIH applications.

 "Hyperpolarization of 13C-labeled substrates will be performed using a GE SPINlab DNP system within the Center for Metabolic Imaging and Therapeutics on the premises of the University of Maryland Medical Center. The system can simultaneously polarize up to 4 samples and is operating at 5 Tesla and 0.8-1 K. SPINlab, which is fully automated with mechanically controlled vacuum and dissolution systems, can produce, in a sterile manner (using a disposable, sealed sterile fluid path) and after filtering the trityl radical, sample sizes of up to 50 mL of 250-mM 13C-pyruvate suitable for human applications. An important feature, in particular for clinical use, is a quality control module that measures pyruvate and residual radical concentrations, pH, temperature, infusion volume, and polarization without compromising the sterile barrier."