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Genomic Resource Center (GRC)


The Genomics Resource Center (GRC) is a high-throughput laboratory and data analysis group supporting the scientific programs of IGS and its collaborators, both across the University of Maryland Baltimore campus and across the globe. The GRC team has been an early-adopter and pioneer in genomic technology development for the past 20 years. Genomic technologies and applications now permeate both basic and clinical research. Using multiple sequencing and analysis platforms, the GRC generates high-quality genomic data in a cost-effective manner.


Led by Dr. Lisa Sadzewicz, Administrative Director, and Mr. Luke Tallon, Scientific Director, who together have more than 40 years’ experience in managing high-throughput sequencing and analysis operations, the multidisciplinary GRC group includes scientists, bioinformatics software engineers, bioinformatics analysts, project managers, and research specialists who have extensive experience in planning and managing projects, ranging in scope from small-scale amplicon and plasmid sequencing to largescale comparative genomic and transcriptome sequencing.

The laboratory services offered by the GRC include sample quality assessment, library construction, sequencing and analysis of a broad range of sample types.

Why the GRC?

Genomic technologies and applications now permeate both basic and clinical research. Personalized medicine is being driven by genomic data. However, transforming the data into medical knowledge is the primary challenge facing researchers today. Led by investigators with more than 40 years of experience at a major genome center, the GRC offers expertise in a compact, nimble, and responsive core. We cultivate long-standing relationships with genomic technology providers to gain early access to new platforms and to maintain our cutting-edge advantage. We offer services using any combination of our sequencing platforms and bioinformatics analysis pipelines.

Who can work with the GRC?

Everyone! We strive to bring the increasing power and decreasing cost of genomic analysis to a continually expanding research community. We provide services to a wide range of researchers – from experienced genomic scientists, to clinicians, to computer scientists. Prior experience with genome sequencing is not required. No matter your experience or expertise, we can guide you through every phase of the process and ensure that your project completes on time and on budget.

What types of projects does the GRC take on?

We routinely work with projects that range from a single sample, to multi-year projects with thousands of samples. On average, we have more than 30 active projects ongoing, and our capacity grows each year. While we have particular expertise in microbial genomics, human microbiome studies, and human genome analysis, if it can be sequenced and analyzed, we can do it! From viral genomes to human genomes, from metagenomes to metatranscriptomes, and everything in between, we have experience sequencing and analyzing a wide variety of samples. Whether you are interested in only sequencing, or a combination of sequencing and analysis, we can customize the project to meet your needs.

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How does it work?

We tailor each project to the needs of the researcher. We conduct an initial consultation to develop a project plan that utilizes the most efficient and effective combination of available platforms and analysis pipelines to accomplish the goals of the project. This customized project plan serves to ensure the services provided by GRC address the underlying scientific question(s) driving the project. As the project commences, we initiate regular project updates, deliver data and quality metrics as they are generated, and conduct a post-project consultation to guide each researcher through the results.


Sequencing Applications

  • DNA/RNA Extraction
  • Library Preparation
  • Genomes/Metagenomes
  • Exomes and Custom Capture
  • Transcriptomes/ Metatranscriptomes
  • Epigenomes
  • Microbiome Amplicons
  • Single Cell Sequencing
  • Custom Amplicons
  • Digital Molecular Profiling
  • Custom Applications

Analysis Services

  • Assembly & Annotation
  • Comparative Genomics
  • Variant Analysis
  • Transcriptome Analysis
  • Epigenome Analysis
  • Microbiome Profiling
  • Pathway & Network Analysis
  • Microarray Analysis
  • Cloud Based Pipelines
  • Customized Analysis


  • Illumina NovaSeq 6000
  • Illumina HiSeq 2500 & 4000
  • Illumina MiSeq and iSeq
  • PacBio Sequel & Sequel II
  • Oxford Nanopore MinION
  • NanoString nCounter MAX
  • 10x Genomics Chromium System


Visit GRC Website

Visit GRC Website


Lisa DeShong Sadzewicz, PhD

Lisa DeShong Sadzewicz, PhD

Administrative Director
(401) 706-6734

Luke J. Tallon, PhD

Scientific Director
(301) 405-7245


BioPark II,
Institute for Genome Sciences
Genomics Resource Center
801 W Baltimore St, Suite 638
Baltimore, MD 21201


Monday through Friday
7:00am - 5:00pm


Office: (410)706-1481

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