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Tibor Kristian, PhD

The goal of Dr. Kegan’s laboratory is to understand the mechanisms, regulation, and functional outcomes of inflammation and vascular growth response in the pulmonary vasculature during the development of cardiovascular diseases such as pulmonary hypertension. We use in vivo pathophysiology, in vitro cellular and molecular biology, and genetic and biochemical approaches. Clinical samples from patients with pulmonary hypertension also are utilized to uncover the relevant signaling pathways that might reveal new therapeutic targets.

Dr. Kegan has strong expertise in vascular biology and has focused on the role of inflammatory mediators in cardio-pulmonary angiogenesis, vasculogenesis, and remodeling, particularly under hypoxic conditions.

Our laboratory is currently working to determine the mechanisms by which vascular injury and the subsequent immune response by inflammatory cells, particularly macrophages, contribute to disease progression in pulmonary hypertension.

Currently, Postdoctoral/graduate student positions are available in Dr. Kegan’s laboratory. Under the mentorship of Dr. Kegan, you can expect to apply basic science approaches to address clinically relevant issues in a multidisciplinary team and gain experience with highly specialized techniques in cardio-pulmonary vascular and macrophage biology.