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Congressionally Directed Medical Research Program

Amyotrophic Lateral Sclerosis Research Program (ALSRP)

Therapeutic Development Award

Pre-application: April 4th, 2016

Invited Application: July 21, 2016

Awarded Amount: $1,000,000 direct costs for 2 years

Eligibility: Independent Investigators at all academic levels

Details: Supports validation of therapeutic leads to Food and Drug Administration (FDA) Investigational New Drug submissions. Studies should be product driven. Examples of activities that will be supported by this award include:

  • Secondary validation of lead compounds obtained from screening or by other means to demonstrate target selectivity and mechanism of action
  • Optimization of potency and pharmacological properties, development of structureactivity maps via synthesis, and testing of derivatives and sister compounds
  • Studies on formulation and stability
  • Development of GMP production methods
  • Collection of data for FDA IND applications, to include compound characterization, absorption, distribution, metabolism, and excretion (ADME) studies, and dose/response and toxicology studies.

Therapeutic Idea Award

Pre-application: April 4th, 2016

Application: July 21, 2016

Awarded Amount: $500,000 direct costs for 2 years

Eligibility: Investigators at all academic levels

New ideas aimed at drug or treatment discovery in early stages of development. Development, modification, and/or validation of preclinical model systems or the application of high through put screens to define or assess lead compounds for ALS treatment.

Details: The Therapeutic Idea Award is designed to promote new ideas aimed at drug or treatment discovery that are still in the early stages of development. Development, modification, and/or validation of preclinical model systems or the application of high-throughput screens to define or assess lead compounds for ALS treatment are of interest.

Autism Research Program (ARP)

Clinical Trial Award

Pre-Application: June 22, 2016

Application: September 29, 2016

Awarded Amount: $1,000,000 direct costs for 4 years

Eligibility: PIs must be at or above the level of Associate Professor

Details: The FY16 ARP Clinical Trial Award seeks applications from all areas of clinical research, and strongly encourages applications that address the critical needs of the ASD community in one or more of the following areas:

  • Behavioral, cognitive, and other non-pharmacological therapies
  • Pharmacological treatments in autism or well-defined subgroups of autism
  • Dissemination/Implementation of efficacious behavioral interventions (including measures of fidelity and outcomes)
  • Therapies to alleviate conditions co-occurring with ASD (e.g., sleep disturbances, gastrointestinal issues, aggression, depression, anxiety, attention deficit)

Idea Development Award

Pre-Application: June 22, 2016

Application: September 29, 2016

Awarded Amount: $377,000 direct costs for 3 years

Eligibility: Investigators at or above the level of Assistant Professor

Details: The FY16 ARP Idea Development Award seeks applications from all areas of basic and preclinical research and strongly encourages applications that address the critical needs of the ASD community in one or more of the following areas:

  • Assessment of novel therapeutics using valid preclinical models
  • Environmental risk factors
  • Mechanisms of heterogeneous clinical expression of ASD
  • Mechanisms underlying conditions co-occurring with ASD (e.g., sleep disturbances, gastrointestinal issues, aggression, depression, anxiety, attention deficit)
  • Factors promoting success in key transitions to independence for individuals living with ASD

Bone Marrow Failure Research Program (BMFRP)

Idea Development Award

Pre-Application: March 29, 2016

Application: July 13, 2016

Awarded Amount: $315,000 direct costs for 2 years

Established Investigator Eligibility: Investigators at or above the level of Associate Professor apply as established investigator

Early Career Investigator Eligibility: Investigators at level of Assistant Professor and less than ten years from terminal degree at the time of application submission deadline apply as early career investigator.

Details: The BMFRP Idea Development Award is intended to support innovative ideas and high-impact approaches based on scientifically sound evidence to move toward the BMFRP vision of understanding and curing BMF syndromes. This award mechanism is designed to support new ideas. Proposed research studies should have a high probability of revealing new avenues of investigation.

Breast Cancer Research Program (BCRP)

BCRP Overarching Challenges to be addressed in a proposal:

  • Prevent breast cancer (primary prevention)
  • Identify determinants of breast cancer initiation, risk, or susceptibility
  • Distinguish deadly from indolent breast cancers
  • Conquer the problems of overdiagnosis and overtreatment
  • Identify what drives breast cancer growth; determine how to stop it
  • Identify why some breast cancers become metastatic
  • Determine why/how breast cancer cells lie dormant for years and then re-emerge (recurrence); determine how to prevent recurrence
  • Revolutionize treatment regimens by replacing them with ones that are more effective and less toxic
  • Eliminate the mortality associated with metastatic breast cancer

Era of Hope Scholar Award

Pre-Application: April 21,2016

Application: May 5, 2016

Awarded Amount: $2,500,000 direct costs for 4 years

Eligibility: Independent investigators within 6 years of his/her last training position (postdoctoral fellowship, medical residency, clinical fellowship)

Details: The Era of Hope Scholar Award supports individuals early in their careers who have demonstrated significant potential to effect meaningful change in breast cancer.


Innovator Award

Pre-Application: April 27, 2016

Invited Application: August 11, 2016

Awarded Amount: $5,000,000 direct costs for 4 years

Eligibility: PIs must be above the level of Associate Professor; previous recipients of BCRP Innovator Award are ineligible

The Innovator Award supports visionary individuals who have demonstrated exceptional creativity, innovative work, and paradigm-shifting leadership in any field including, but not limited to, breast cancer. The Innovator Award will provide these individuals with the funding and freedom to pursue their most novel, visionary, high-risk ideas that could accelerate progress to ending breast cancer.


Breakthrough Award Levels 1 & 2

Pre-Application: April 21, 2016

Application: May 5, 2016

Awarded Amount:

Level 1 - $375,000 direct costs for 3 years

Level 1 with Partnering PI - $600,000 direct costs for 3 years

Level 2 - $750,000 direct costs for 3 years

Level 2 with Partnering PI – 1,000,000 direct costs for 3 years

Eligibility: Investigators at all academic levels; mentorship statements required for postdoctoral fellow applicants

Details: Funding Level 1: Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data required. Funding Level 2: Research that is already supported by preliminary data and has potential to make significant advancements toward clinical translation.


Breakthrough Award Levels 3 & 4

Pre-Application: April 27, 2016

Invited Application: August 11, 2016

Awarded Amount:

Level 3 - $2,500,000 direct costs for 4 years

Level 3 with Partnering PI - $4,000,000 direct costs for 4 years

Level 4 (with or without Partnering PI) - $10,000,000 direct costs plus indirects for 4 years

Eligibility: Independent investigators at all levels

Details: Funding Level 3: Advanced translational studies that have potential for near-term clinical investigation. Small-scale clinical trials may apply. Funding Level 4: Large-scale projects that will transform and revolutionize the clinical management and/or prevention of breast cancer. Near-term clinical impact is expected.


Distinguished Investigator Award

Pre-Application: April 27, 2016

Invited Application: August 11, 2016

Awarded Amount: $3,000,000 direct costs for 4 years

Eligibility: PI must be at or above the level of Assistant Professor and be more than 6 years beyond their last mentored position

Details: The BCRP Distinguished Investigator Award enables established visionary leaders from any field to pursue innovative ideas that could accelerate progress toward ending breast cancer.

Defense Medical Research & Development Program

Military Infectious Diseases Applied Research Award (JPC-2/Military Infectious Diseases Research Program)

Pre-Application: January 26, 2016

Application: May 9, 2016

Awarded Amount: $2,000,000 total costs for 3 years

Eligibility: Independent investigators at all levels

Details: Aims to support research which will improve bacterial, parasitic, viral infection, prevention, screening, diagnosis, and treatment. Focus areas include:

  • Development of new methods for rapid multi-pathogen/multi-phenotype detection of multidrug-resistant organisms (MDROs), nosocomial pathogens, and/or rapid multipathogen/multi-phenotype characterization of antimicrobial resistance patterns.
  • Development of assays for host immune response biomarkers for diagnosis or prognosis (with associated outcomes) of infection to inform clinical infection management decisions (e.g., optimal wound closure time, optimal duration of antibiotic administration for osteomyelitis).
  • Development and preclinical testing of novel chemotypes (chemical classes/materials), biologics as potential therapeutics or prophylactics for wound infection, and/or biofilm formation, maintenance, or propagation. Innovative treatment approaches (e.g., DoD FY17 DMRDP JPC-2/MIDRP Applied Research Award 4 chelators, antibody, phage, antimicrobial peptides, quorum-sensing inhibitors, and host immunoaugmentation, etc.) are encouraged.

Military Infectious Diseases Clinical Study Award (JPC-2/Military Infectious Diseases Research Program)

Pre-Application: January 26, 2016

Application: May 9, 2016

Awarded Amount: $2,500,000 total costs for 3 years

Eligibility: Independent investigators at all levels

Details: Aims to support research which will improve bacterial, parasitic, viral infection, prevention, screening, diagnosis, and treatment. Focus areas include therapeutics, rapid detection of pathogens and/or anti-microbial drug resistance markers, and rapid detection of biomarkers. Supports military relevant early phase clinical trials and in vitro diagnostic medical device clinical investigations with the potential to have a major impact on the prevention, screening, diagnosis, and/or treatment of combat-related or trauma induced wound infections.


Prolonged Field Care Research Award (PFCRA) (JPC-6/Combat Casualty Care Research Program)

Pre-Application: May 12, 2016

Application: August 18, 2016

Awarded Amount:

Funding Level 1: $1,500,000 directs for 3 years

Funding Level 2: $1,500,000-$3,000,000 directs for 3 years

Eligibility: Independent investigators at all levels

Details: Aims to support research geared toward developing knowledge and materiel solutions for the acute and early management of combat-related trauma-induced injury, including point-of-injury, en-route, and forward surgical care. Focus areas include:

  • Understanding the clinical implications of prolonged field care and prolonged damage control resuscitation
  • Develop next-generation resuscitation and stabilization methods for prolonged field care and prolonged damage control resuscitation
  • Develop enhanced treatment of injuries during prolonged field care and prolonged damage control resuscitation

Predictive Personality & Emotional State Performance Determinants for Training (PREEMPT) Award (JPC-1/Medical Simulation and Informational Sciences Research Program)

Pre-Application: May 11, 2016

Application: August 22, 2016

Awarded Amount: $1,250,000 directs for 2 years

Eligibility: Independent investigators at all levels

Details: PREEMPT aims to fund research that will develop a proof-of-concept task performance assessment tool that combines personality and emotional states as determinant components to predict an individual’s performance and overall stress level under a wide range of potential combat casualty care scenarios, environments, and other stressful situations relevant to patient care.


Inter-professional Team-based Learning in Early Stages of Learning (Team_INTEL) Award (JPC-1/Medical Simulation and Informational Sciences Research Program)

Pre-Application: May 11, 2016

Application: August 22, 2016

Awarded Amount: $1,200,000 direct costs for 2 years

Eligibility: Independent investigators at all levels

Seeking research to determine, define, and validate learning strategies that foster inter-professional team-based learning during the early states. Research will define and use statistical approaches to determine best metrics and evaluation criteria that determine team-based learning training practice guidelines.


Health Information Technologies and Informatics (HITI) Theatre/Operational Medicine Initiative (TOMI) Award (JPC-1/Medical Simulation and Informational Sciences Research Program)

Pre-Application: May 11, 2016

Application: August 22, 2016

Awarded Amount: $2,000,000 direct costs for 2 years

Eligibility: Independent investigators at all levels

Details: The HITI Theater/Operational Medicine Initiative aims to provide technology solutions, software, decision support tools, algorithms, knowledge and HITI services to enhance the efficiency of healthcare operations in combat and operational environments to ensure the delivery of high-quality healthcare services by improving information accessibility and by providing better decision support for clinicians through improved information management and the use of emerging technologies.


Health Information Technologies and Informatics Hands-Free Electronic Health Record Data Entry Initiative (HFEHRI) Award (JPC-1/Medical Simulation and Informational Sciences Research Program)

Pre-Application: May 11, 2016

Application: August 22, 2016

Awarded Amount: $2,000,000 direct costs for 2 years

Eligibility: Independent investigators at all levels

Details: Aims to support research relevant to the Hands-Free Electronic Health Record Initiative to demonstrate and validate technological approaches that enable data entry/data capture to the electronic patient record at point-of-care without the use of hand-operated input devices.


Neuromusculoskeletal Injuries Rehabilitation Research (NMSIRRA) Award

Pre-Application: August 22, 2016

Application: November 16, 2016

Awarded Amount:

Level 1: $600,000 direct costs for 3 years

Level 2: $2,500,000 direct costs for 4 years

Research Level 1/New Investigator Eligibility: at time of pre-application submission the applicant must:

  • Are within 5 years of their last training position
  • Are able to demonstrate the freedom to pursue independent research goals outside of a formal mentorship program or arrangement
  • Can provide evidence of organizational support, such as start-up funds provided by the organization and/or use of a technician, space, facilities, and resources

Research Level 2 Eligibility: Independent investigators at all levels

Details: Supports preclinical research, clinical studies, and clinical trials on the reintegration after injury, functional utility of assistive devices related to the human-device interface, secondary health effects following severe extremity injury, optimizing rehabilitation and device prescription, and standardized assessment metrics for patients with neuromusculoskeletal injury.

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Translational Simulation Research (TRANSfeR) Award

Pre-Application: October 13, 2016

Application: February 2, 2017

Awarded Amount: $1,800,000 total costs for 2 years

Eligibility: Independent investigators at all academic levels

Details: The FY17 JPC-1/MSIS TRANSfeR Award Program Announcement/Funding Opportunity is seeking research to determine whether the medical skill learned on a simulation system has a downstream beneficial effect to patients and/or the MHS in the real clinical world. The application should propose work to develop a model(s) that can measure translational outcomes as a result of a simulation-based program in the following areas:

  • Adverse outcomes, for example, near-misses, harms, morbidity and mortality
  • Return-to-duty rates
  • Task and cognitive workload as it affects clinical performance
  • Improved supervisor satisfaction as reflected in subordinate performance
  • Improved team environment (i.e., inter-professional environments) as reflected in improved team task performance
  • Time to completion (without sacrificing bulleted items listed immediately above) of time-sensitive clinical tasks

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Developing Models for Military Medical Training from Field Data Collected from Sensors (MATADOR) Award

Pre-Application: November 14, 2016

Application: March 1, 2017

Awarded Amount: $750,000 total costs for 2 years

Eligibility: Independent investigators at all academic levels

Details: The FY17 JPC-1/MSIS MATADOR Award seeks to support research for the development and preliminary validation of a conceptual predictive model with the ability to rapidly collect, analyze, and weigh sensor and/or biosurveillance data collected directly from the field (not be limited to a particular type of field environment) via a variety of sensors and/or biosurveillance systems.

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Hearing and Balance Research Award

Pre-Application: December 12, 2016

Application: March 29, 2017

Awarded Amount:

Research Level 1 (Translational Preclinical Research): $2,000,000 total costs for 3 years

Research Level 2 (Observational Studies or Clinical Trials): $4,000,000 total costs for 4 years

Eligibility: Independent investigators at all academic levels

Details: The FY17 JPC-8/CRMRP Hearing and Balance Research Award is intended to support translational preclinical research, observational studies, and early-stage clinical trials addressing auditory and vestibular dysfunction associated with military service.

Lung Cancer Research Program (LCRP)

To be considered for funding, applications for the FY16 LCRP Concept Award must address at least one of the seven Areas of Emphasis listed below:

  • Identify or develop noninvasive or minimally invasive tools to improve the detection of the initial stages of lung cancer.
  • Identify, develop, and/or build upon already existing tools for screening or early detection of lung cancer. Screening may include, but is not limited to, imaging modalities, biomarkers, genetics/genomics/proteomics/metabolomics/transcriptomics, and assessment of risk factors.
  • Understand the molecular mechanisms of initiation and progression to clinically significant lung cancer.
  • Identify innovative strategies for prevention and treatment of early and/or localized lung cancer.
  • Understand predictive and prognostic markers to identify responders and nonresponders.
  • Understand susceptibility or resistance to treatment.
  • Understand contributors to lung cancer development other than tobacco.

Concept Award

Pre-Application: July 28, 2016

Application: August 11, 2016

Awarded Amount: $100,000 direct costs for 1 year

Eligibility: All investigators at or above the level of postdoctoral fellow (or equivalent)

Details: This award mechanism supports high-risk studies that have the potential to reveal entirely new avenues for investigation. Applications must describe how the new idea will enhance the existing knowledge of lung cancer or develop an innovative and novel course of investigation.


Career Development Award

Pre-Application: June 9, 2016

Application:September 14, 2016

Awarded Amount: $250,000 direct costs for 2 years

Eligibility: The PI must be an independent investigator at the level of Assistant Professor and be within 5 years of their first faculty appointment by the time of the application submission deadline and meet these requirements:

  • PI must have 40% time of protected time for lung cancer research. Cannot have previously received Career Development Award from any program within CDMRP
  • PI must not have received more than $300,000 in total direct costs for previous or concurrent lung cancer research as PI of one or more Federally or privately funded, non-mentored, peer-reviewed grants
  • Must identify a mentor who is at or above the level of an Assistant Professor (does not have to be at the same institution)

Details: The Career Development Award supports early-career, independent investigators to conduct impactful research under the mentorship of an experienced lung cancer researcher as an DoD FY16 Lung Cancer Research Program Career Development Award 4 opportunity to obtain the funding, mentoring, and experience necessary for productive, independent careers at the forefront of lung cancer research.


Clinical Exploration Award

Pre-Application: June 9, 2016

Application: September 14, 2016

Awarded Amount: $550,000 direct costs for 3 years

Eligibility: PI must be at or above the level of Assistant Professor

Details: The Clinical Exploration Award (CEA) mechanism supports rapid execution of early-phase, proof-of-principle clinical trials to examine hypothesis- based, innovative interventions that have DoD FY16 Lung Cancer Research Program Clinical Exploration Award 4 the potential to resolve current clinical barriers and result in a profound impact on the clinical management of lung cancer. While therapeutic approaches proposed for testing through the CEA must represent novel, hypothesis-based, “outside-the-box” approaches for treating lung cancer, they may include therapies already in clinical use, or undergoing clinical testing for other diseases, provided that the proposed use for lung cancer would lead to a major advancement for treating the disease.


Idea Development Award

Pre-Application:June 9, 2016

Application: September 14, 2016

Awarded Amount: $350,000 direct costs for 2 years

Established Investigator Eligibility: Investigator at or above level of Assistant Professor

New Investigator Eligibility: investigator at or above the level of Assistant Professor and:

  • May not have previously received an LCRP Idea Development Award or LCRP Early Investigator Synergistic Idea Award; and
  • Be within 10 years of first faculty appointment by time of application submission deadline

Details: The Idea Development Award promotes new ideas that are still in the early stages of development and have the potential to yield impactful data and new avenues of investigation. This award supports conceptually innovative, high-risk/high-reward research that could lead to DoD FY16 Lung Cancer Research Program Idea Development Award 4 critical discoveries or major advancements that will accelerate progress toward eradicating deaths from lung cancer.


Investigator Initiated Translational Research Award

Pre-Application: June 9, 2016

Application: September 14, 2016

Awarded Amount: $400,000 direct costs for 2 years

Eligibility: PI must be at the level of Assistant Professor

The Investigator-Initiated Translational Research Award (IITRA) supports translational research that will develop promising ideas in lung cancer into clinical applications. This mechanism is intended to fund a broad range of translational studies, including, but not limited to, the following:

  • Studies advancing/translating in vitro and/or animal studies to applications with human samples/cohorts.
  • Late-stage preclinical work leading to/preparing for a clinical trial, e.g., Investigational New Drug (IND) application submission.
  • Correlative studies that are associated with an ongoing or completed clinical trial and projects that develop endpoints for clinical trials.

Duchenne Muscular Dystrophy Research Program (DMDRP)

All applications for FY16 DMDRP must address one of the following focus areas:

  • cardiac studies including identifying mechanisms of pathology and therapeutic interventions
  • clinical studies and novel interventions that could improve clinical care and quality of life in the following areas (comorbidities, endocrinology, orthopedics, gastrointestinal issues, psychosocial issues, cognitive function, respiratory issues)
  • assessment of clinical trial tools and outcome measures, such as: discovery and qualification of pharmacodynamic, prognostic, and predictive biomarkers, evaluating surrogate markers, evaluating potential composite scores for outcomes assessment, patient-centered outcomes (quality of life, activities of daily living)
  • extension or expansion of existing preclinical translational data in support of specific therapeutic development path

Investigator-Initiated Research Award

Pre-Application: July 19, 2016

Application: October 19, 2016

Awarded Amount: $600,000 direct costs plus indirects for 3 years (without nested trainee), $650,000 direct costs plus indirects for 3 years (nested resident trainee), or $630,000 direct costs for 3 years (nested medical student trainee)

Eligibility: PI must be at or above the level of Assistant Professor. Option for Nested Resident or Medical Student Traineeship with following requirements

  • Resident Trainee must be enrolled in accredited residency program or Medical Student Trainee must be enrolled in a nationally accredited (or equivalent) medical school
  • Trainee must devote minimum of 40% effort to project for 1-year period of performance of traineeship

Details: The DMDRP Investigator-Initiated Research Award (IIRA) supports translational research that will accelerate the movement of promising ideas in Duchenne research into clinical applications. IIRA supports later stage translational research projects, including early-phase, proof-of-principle clinical trials and correlative studies to better inform the development of drugs, devices, and other interventions. Studies proposed under this award should not include target discovery, drug screening, or mechanism of action studies. Projects can include the discovery and qualification of pharmacodynamics, prognostic, and predicative biomarkers.


Career Development Award

Pre-Application: July 19, 2016

Application: October 19, 2016

Awarded Amount: $275,000 direct costs for 2 years (not to be used for mentor salary or clinical trial costs)

Eligibility: PI must be research- or physician-scientist at an early stage (PhD, MD, or equivalent within 5 years). Must meet the following requirements:

  • 30% protected time for Duchenne research require
  • PI must not have received more than $300,000 in total direct costs for previous or concurrent muscular dystrophy research as a PI of Federally or privately funded, non-mentored, peer-reviewed grant
  • Mentor must be at the position of Associate Professor or above, and demonstrate strong funding and publication record in muscular dystrophy research. Mentor does not need to be at the same organization as PI.

Details: The CDA supports early-career investigators in conducting impactful Duchenne research under the mentorship of an experienced muscular dystrophy researcher as an opportunity to obtain the funding, mentoring, and experience necessary for productive, independent careers at the forefront of Duchenne research.

Multiple Sclerosis Research Program (MSRP)

Pilot Clinical Trail Award

Pre-Application: May 26, 2016

Application: August 29, 2016

Awarded Amount: $600,000 direct costs for 3 years

Eligibility: At or above the level of Assistant Professor

Details: All applications submitted for the FY16 MSRP Pilot Clinical Trial Award (PCTA) funding opportunity must address the Focus Area, Treatment of MS Symptoms. Symptoms may include: Pain, Fatigue, Cognitive Dysfunction, Visual Impairment, Motor Impairment, Impaired Mobility, Loss of Bladder Control, Sexual Dysfunction, Depression, and Anxiety. Funding from the PCTA must support a clinical trial and cannot be used for preclinical research or correlative studies.


Investigator Initiated Research Award

Pre-Application: May 26, 2016

Application: August 29, 2016

Awarded Amount: $600,000 direct costs for 3 years

Eligibility: at or above the level of Assistant Professor

Details: All applications submitted for the FY16 MSRP Investigator-Initiated Research Award (IIRA) funding opportunity must address the Focus Area, Obstacles to Remyelination in MS. Examples of acceptable studies include, but are not limited to, the following:

  • Inhibitory factors
  • Trophic factors
  • Axonal pathology
  • Abnormalities in cell-cell interactions

Exploration-Hypothesis Development Award

Pre-Application: May 26, 2016

Application: August 29, 2016

Awarded Amount: $150,000 direct costs for 2 years

Eligibility: at or above the level of Assistant Professor

Details: All applications submitted to the FY16 MSRP Exploration - Hypothesis Development Award (EHDA) funding opportunity must address one or more of the following Focus Areas:

  • Biology of MS Symptoms
  • Measurement of MS Symptoms
  • Treatment of MS Symptoms

Symptoms may include: Pain, Fatigue, Cognitive Dysfunction, Visual Impairment, Motor Impairment, Impaired Mobility, Loss of Bladder Control, Sexual Dysfunction, Depression, and Anxiety.

Neurofibromatosis Research Program (NFRP)

NFRP strongly encourages research applications that specifically address the critical needs of the NF community in one or more of the following Areas of Emphasis:

  • Health services research (see definition below)
    • Evidence-based clinical care pathways
    • Innovative healthcare delivery systems
    • Utilization of technology and informatics
  • Heterogeneity of neurofibromas and other NF-related tumors
  • Nontumor manifestations
    • Sleep, pain, hypotonia, etc., including quality of life measures, self-reported and otherwise
  • Novel disease and treatment response markers using genomics, epigenetics, systems biology, metabolomics, or similar approaches
    • Transition from benign to malignant
  • Nutritional, environmental, and other modifiers of NF
  • Post-adolescent manifestations
  • Preclinical efficacy studies
  • Target identification, drug discovery, targeted and immunotherapies

Clinical Consortium Award

Pre-Application: June 8, 2016

Application: August 1, 2016

Awarded Amount:$5,000,000-9,000,000 total costs for all 4 years

Eligibility: The Operations Center PI must be an independent investigator at or above the level of Associate Professor (or equivalent) with experience in developing and running large scale initiatives such as clinical trials or consortia

Details: The Clinical Consortium Award is intended to support a major goal/product-driven Consortium of exceptional institutions and investigators that will accelerate the clinical translation of basic NF research and ultimately decrease the impact of the disease. The NF Clinical Consortium needs to be a collaboration of multiple organizations and individuals for the purpose of rapidly executing clinical trials. The Consortium must consist of a single Operations Center and a minimum of five Clinical Trial Sites with a demonstrated history of collaborative research. The participants will be jointly responsible for prioritizing, proposing, conducting, and analyzing Phase I and Phase II clinical trials focused on therapeutic interventions for NF1, NF2, and schwannomatosis.


Clinical Trial Award

Pre-Application: July 18, 2016

Application: August 1, 2016

Awarded Amount: $900,000 direct costs for 4 years

Eligibility: at or above the level of Assistant Professor

Details: The NFRP Clinical Trial Award supports research with the potential to have a major impact on the treatment or management of NF. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept (i.e., pilot, first in human, or Phase 0) trials to demonstrate feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations.


Exploration-Hypothesis Development Award

Pre-Application: July 18, 2016

Application: August 1, 2016

Awarded Amount: $100,000 direct costs for 2 years

Eligibility: all academic levels

Details: The NFRP Exploration – Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in NF research. Studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation.


Investigator-Initiated Research Award

Pre-Application: July 18, 2016

Application: August 1, 2016

Awarded Amount: $525,000 direct costs for 3 years (One PI); $575,000 direct costs for 3 years (PI plus Qualified Collaborator)

Eligibility: at or above the level of Assistant Professor. Optional Qualified Collaborator must be at or above level of Assistant Professor and commit at least a 10% level of effort for each budget period through the entirety of the award.

Details: The NFRP Investigator-Initiated Research Award supports highly rigorous, high-impact research projects that have the potential to make an important contribution to NF research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. The rationale for a research idea may be derived from laboratory discovery, population-based studies, a clinician’s firsthand knowledge of patients, or anecdotal data. Applications must include preliminary and/or published data that are relevant to NF and the proposed research project.


New Investigator Award

Pre-Application: July 18, 2016

Application: August 1, 2016

Awarded Amount: $450,000 direct costs for 3 years

Eligibility: Graduate students, postdoctoral fellows, and other “mentored” researchers are not eligible for this award.

PIs must be either:

  • An independent investigator at or below the level of Assistant Professor (or equivalent); or
  • An established independent investigator in an area other than NF at or above the level of Assistant Professor seeking to transition to a career in NF, thereby bringing their expertise to the field. DoD FY16 NFRP New Investigator Award 6 and
  • PIs must not have received more than $300,000 in total direct costs for previous or concurrent NF research as a PI of one or more Federally funded, non-mentored peer reviewed grants;
  • PIs must not have received a New Investigator Award previously from any program within the CDMRP.
  • PIs must commit at least 10% of his/her effort toward the proposed NF research project.

Details: The intent of the NFRP New Investigator Award is to support the continued development of promising independent investigators and/or the transition of established investigators from other research fields into a career in the field of NF research. Prior experience in NF research is not required. However, Principal Investigators (PIs) with a limited background in NF research are strongly encouraged to have a collaborator who is experienced in the NF field.

Orthotics and Prosthetics Outcomes Research Program (OPORP)

The Orthotics and Prosthetics Outcomes Research Programmatic Panel identified the following five focus areas for FY16:

  • Lack of short- and long-term evidence for existing support and reintegration strategies following neuromusculoskeletal injury, and a need for new evidencebased support and reintegration strategies
  • Limited current technologies, including prosthetics and orthotics, for the rehabilitation or replacement of function that optimize patient interaction, usability, and durability
  • Limited ability to predict, prevent, and mitigate development of secondary health deficits following neuromusculoskeletal injury
  • Limited understanding of the management of patient rehabilitation strategies throughout the rehabilitation process following neuromusculoskeletal injury
  • Lack of validated metrics that effectively assess initial presentation, rehabilitation, and reintegration following neuromusculoskeletal injury

Orthotics Outcomes Research Award (OORA)

Pre-Application: August 22, 2016

Application: November 16, 2016

Awarded Amount: $300,000 direct costs for 2 years for research level 1/new investigator, $500,000 direct costs for 3 years for funding level 2, or $2,000,000 direct costs for 3 years for funding level 3

Research Level 1/ New Investigator Eligibility: at the time of pre-application submission must be:

  • within 5 years of last training position
  • demonstrate the freedom to pursue research goals outside of formal mentorship program or arrangement
  • can provide evidence of organizational support, such as start-up funds provided by the institution and/or use of a technician, space, facilities, and resources

Research Level 2 & 3 Eligibility: independent investigators at all academic levels

Details: The OORA is intended to support research that evaluates the comparative effectiveness of orthotic clinical interventions and/or their associated rehabilitation interventions, using patient centric outcomes for Service members and Veterans who have undergone limb impairment.


Prosthetics Outcome Research Award (PORA)

Pre-Application: August 22, 2016

Application: November 16, 2016

Awarded Amount: 300,000 direct costs for 2 years for research level 1/new investigator, $500,000 direct costs for 3 years for funding level 2, or $2,000,000 direct costs for 3 years for funding level 3

Research Level 1/ New Investigator Eligibility: at the time of pre-application submission must be:

  • within 5 years of last training position
  • demonstrate the freedom to pursue research goals outside of formal mentorship program or arrangement
  • can provide evidence of organizational support, such as start-up funds provided by the institution and/or use of a technician, space, facilities, and resources

Research Level 2 & 3 Eligibility: independent investigators at all academic levels

Details: The PORA is intended to support research that evaluates the comparative effectiveness of prosthetic clinical interventions and/or their associated rehabilitation interventions, using patient centric outcomes for Service members and Veterans who have undergone limb amputation.

Ovarian Cancer Research Program (OCRP)

The mission of the OCRP is to support patient-centered research to prevent, detect, treat, and cure ovarian cancer. Although not required, investigators are encouraged to address one of the FY16 Areas of Encouragement in their applications:

  • Treatment resistance
  • Optimizing immunotherapies
  • Etiology, epidemiology and prevention
  • Early detection including rare subtypes
  • Understand host-tumor interactions
  • Assessing early physiological changes of the tumor and the microenvironment in response to therapy

Clinical Development Award

Pre-Application: April 28, 2016

Application: August 10, 2016

Awarded Amount: $600,000 direct costs for 3 years

Eligibility: at or above the level of Assistant Professor

Details: The OCRP Clinical Development Award is intended to provide support for the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life. The goal of this award mechanism is to accelerate the clinical introduction of medical products and technologies that target ovarian cancer biology. Near-term clinical impact is expected


Investigator-Initiated Research Award

Pre-Application: April 28, 2016

Application: August 10, 2016

Awarded Amount: $450,000 direct costs for 3 years

Eligibility: at or above the level of Assistant Professor

Details: The OCRP Investigator-Initiated Research Award is intended to support high-impact research that has the potential to make an important contribution to ovarian cancer or patient/survivor care. Research projects may focus on any phase of research, from basic laboratory research through translational research, excluding clinical trials.


Ovarian Cancer Academy Award – Early-Career Investigator

Pre-Application: April 28, 2016

Application: August 10, 2016

Awarded Amount: $725,000 direct costs for 4 years

Eligibility: Early Career Investigator requirements:

  • must be within 3 years of his/her first tenure-track or non-tenure track faculty position (or equivalent, e.g., Staff Scientist)
  • may be a research or physician-scientist
  • must not have a concurrent Career Development-like award at time of award
  • must have institutional commitment of approximately 50% protected time for ovarian cancer research and Academy activities including participation in monthly webinars
  • must commit no less than 25% effort to this award for the first 2 years

Designated Mentor requirements:

  • Should be at the same institution as the Early-Career Investigator; if not at the same institution, another Mentor (“Other Mentor,” who does not have to meet the Designated Mentor’s eligibility requirements) at the Early-Career Investigator’s institution must also be included in the application submission.
  • Must be an independent, established ovarian cancer researcher.
  • Must have ovarian cancer research funding (past and present).
  • Must have a record of ovarian cancer publications in peer reviewed journals.
  • Must demonstrate a commitment (at least 10% effort for mentoring and participating in off-site Academy activities) to develop and sustain the Early-Career Investigator’s independent career in ovarian cancer research. ‒ Mentoring responsibilities include mentoring the designated Early-Career Investigator and an additional Early-Career Investigator within the Academy. ‒ Off-site Academy activities include annual in-person workshops and periodic web-based meetings.

Details: The Ovarian Cancer Academy is a virtual career development and research training platform that consists of Early-Career Investigators and their Designated Mentors from different institutions, and an Academy Dean and Assistant Dean.


Pilot Award

Pre-Application: April 28, 2016

Application: August 10, 2016

Awarded Amount: $250,000 direct costs for 2 years

Eligibility: at or above the postdoctoral level

Details: The OCRP Pilot Award supports the exploration of innovative concepts or theories in ovarian cancer that could ultimately lead to critical discoveries or major advancements that will drive the field forward.

Parkinson’s Research Program (PRP)

Focused Idea Award

Pre-Application: November 9, 2016

Application: November 30, 2016

Awarded Amount: $350,000 direct costs for 3 years

Eligibility: Independent investigators at or above the level of assistant professor

Details: All applications to the FY16 PRP Focused Idea Award Program Announcement/Funding Opportunity MUST address at least one of the following FY16 PRP Focused Idea Award Focus Areas:

  • Studies of the neurovascular unit (including neurons, glia, the microvasculature, and the blood-brain barrier) in Parkinson’s disease and changes associated with its treatment.
  • Identification and evaluation of mechanisms in early Parkinson’s disease involving olfactory, microbiome, gastrointestinal, and/or autonomic nervous systems.
  • Mechanisms of neuroplasticity and compensation in Parkinson’s disease, such as influences of sleep, exercise, and diet.

Impact Award

Pre-Application: September 7, 2016

Application: November 30, 2016

Awarded Amount: $3,000,000 direct costs for 3 years for single PI or $5,000,000 direct costs for 4 years for partnering PI option

Eligibility: Independent investigators at or above the level of assistant professor

Details: All applications to the FY16 PRP Impact Award Program Announcement/Funding Opportunity MUST address at least one of the following

FY16 PRP Impact Award Focus Areas:

  • Studies of the neurovascular unit (including neurons, glia, the microvasculature, and the blood-brain barrier) in Parkinson’s disease and changes associated with its treatment.
  • Identification and evaluation of mechanisms in early Parkinson’s disease involving olfactory, microbiome, gastrointestinal, and/or autonomic nervous systems.
  • Mechanisms of neuroplasticity and compensation in Parkinson’s disease, such as influences of sleep, exercise, and diet.
  • Underlying factors influencing Parkinson’s disease progression in specific community based populations (e.g., Veterans) to identify heterogeneity.

Peer Reviewed Alzheimer’s Research Program (PRARP)

The PRARP’s mission is devoted to (1) understanding the association between traumatic brain injury and Alzheimer’s disease / Alzheimer’s disease-related dementias, and (2) reducing the burden on affected individuals and caregivers, especially in the military and Veteran communities.

Convergence Science Research Award

Pre-Application: August 17, 2016

Application: November 9, 2016

Awarded Amount: $500,000 direct costs for 3 years

Eligibility: independent investigator at or above the level of assistant professor

Details: The intent of the FY16 PRARP CSRA is to support efforts to generate research resources, tools, or novel research efforts for researchers and/or practitioners in health sciences related to the PRARP’s mission. PRARP focus areas include: genomics/proteomics, mechanisms of pathogenesis, diagnostics and biomarkers, novel target identification, epidemiological research.


Quality of Life Research Award

Pre-Application: August 17, 2016

Application: November 9, 2016

Awarded Amount: $500,000 direct costs for 3 years for funding level I or $1,900,000 total costs for 4 years for funding level II

Eligibility: independent investigator at or above the level of assistant professor

Details: The intent of the QUAL mechanism is to support preclinical, basic, epidemiological, or quality-of-life research to alleviate or characterize the common symptoms of traumatic brain injury and Alzheimer’s disease / Alzheimer’s disease-related dementias. Level I is intended to support investigator-initiated research that may be high-risk and/or high-gain. Level II is intended to support advanced studies that may be multidisciplinary in nature, and/or have multiple collaborators.


Epidemiology of Military Risk Factors Award

Pre-Application: August 17, 2016

Application: November 9, 2016

Awarded Amount:$2,500,000 direct costs for 4 years

Eligibility: independent investigator at or above the level of assistant professor

Details: The intent of the FY16 PRARP EMRFA is to investigate the etiology and epidemiology of military-related traumatic brain injury and Alzheimer’s disease / Alzheimer’s disease-related dementias. The research impact will benefit the military, Veteran, and civilian communities. Applications should carefully consider how their studies will characterize the cognitive and behavioral symptoms that result in functional impairments in the proposed identified cohort. Studies that use combinations of measures (e.g., neuropsychological assessments, imaging, genomics, and cerebral spinal fluid biomarkers) are encouraged.


Translational Research Partnership Award

Pre-Application: August 17, 2016

Application: November 9, 2016

Awarded Amount: $1,300,000 direct costs for 3 years

Eligibility: independent investigator at or above the level of assistant professor

Details: The intent of the TRPA is to create an avenue for partnerships between clinicians and research scientists to address a translational research problem or question in a manner that would be unachievable through separate efforts. The research impact will benefit the military, Veteran, and civilian communities. The proposed study must include clearly stated plans for interactions between the partners. The plans must include communication, decision-making, allocation of resources, coordination of research progress and results, and sharing of data among both partners and organizations participating in the project.

Peer Reviewed Cancer Research Program (PRCRP)

PRCRP Topic Areas include: bladder cancer, colorectal cancer, immunotherapy, kidney cancer, Listeria vaccine for cancer, liver cancer, lymphoma, melanoma and other skin cancers, mesothelioma, neuroblastoma, pancreatic cancer, pediatric brain tumors, stomach cancer.

*Research applications in the areas of breast, prostate, lung (excluding mesothelioma), or ovarian cancer will not be accepted.

In addition to addressing at least one of the required Congressionally Directed Topic Areas, applications are encouraged to address at least one of the FY16 PRCRP Military Relevance Focus Areas:

  • Militarily relevant risk factors associated with cancer (e.g., ionizing radiation, chemicals, infectious agents, and environmental carcinogens)
  • Gaps in cancer prevention, early detection/diagnosis, prognosis, treatment, and/or survivorship that may affect the general population but have a particularly profound impact on the health and well-being of military Service members, Veterans, and their beneficiaries

Horizon Award

Pre-Application: August 17, 2016

Application: September 28, 2016

Awarded Amount: $150,000 direct costs for 2 years

Principle Investigator Eligibility: PI must be:

  • predoctoral candidate within two years of completing required coursework, all laboratory rotations, successfully passing qualifying examinations, and is working in their mentor’s laboratory by the time of application submission deadline or
  • postdoctoral fellow within three years of completion of their terminal degree, and working in the mentor’s laboratory at the time of the application submission deadline.

Mentor Eligibility: must be at the level of Assistant professor and must have a proven publication and active funding record in cancer research

Details: The Horizon Award supports junior-level scientists in conducting impactful research with the mentorship of an experienced cancer researcher (i.e., Mentor). The Horizon Award challenges junior scientists to develop and implement research in the cancer field.


Career Development Award

Pre-Application: June 8, 2016

Application: September 13, 2016

Awarded Amount: $360,000 direct costs for 3 years

PI Eligibility: PI must be independent, early-career investigator within 10 years after completion of terminal degree.

Designated Mentor Eligibility: mentor must hold position at or above the level of an Associated Professor and have proven publication and funding record in cancer research.

Details: The PRCRP Career Development Award supports independent, early-career investigators to conduct impactful research with the mentorship of an experienced cancer researcher (i.e., the Designated Mentor) as an opportunity to obtain the funding, guidance, and experience necessary for productive, independent careers at the forefront of cancer research. This award supports impactful research projects with an emphasis on discovery.


Idea Award with Special Focus

Pre-Application: June 8, 2016

Application: September 13, 2016

Awarded Amount: $400,000 direct costs for 2 years

Eligibility: PI must have faculty level appointment

Details: The Idea Award with Special Focus supports innovative, untested, high-risk/potentially highreward concepts, theories, paradigms, and/or methods in cancer research that are relevant to Service members, their families, Veterans, and other military beneficiaries. The “Special Focus” of this award mechanism is on exposures, conditions, or circumstances that are unique to the military, disproportionately represented in a military beneficiary population, or may affect mission readiness.


Translational Team Science Award

Pre-Application: June 8, 2016

Application: September 13, 2016

Awarded Amount: $1,000,000 direct costs for 3 years

Eligibility: PI should be at or above the level of Assistant Professor. Partnering PI(s) must be at or above the level of Assistant Professor. It is encouraged that at least one of the PIs be a military or VA investigator.

Details: The Translational Team Science Award supports hypothesis-driven translational studies associated with an ongoing or completed clinical trial that could lead to a next-phase clinical trial or future clinical application. By leveraging information from ongoing or completed clinical trials, research projects funded by the TTSA should address critical knowledge gaps in outcomes, validate key research and expand upon potential transformative results, or investigate novel findings. Observations from ongoing or completed clinical trials may be utilized to formulate a new hypothesis to move to the next research stage or step of implementation of the clinical outcomes. The TTSA is not intended to fund the ongoing clinical trial. Applications associated with a clinical trial not yet started are discouraged.

Peer Reviewed Medical Research Program (PRMRP)

PRMRP Topic Areas include:

• Acute Lung Injury • Antimicrobial Resistance • Chronic Migraine and PostTraumatic Headache • Congenital Heart Disease • Constrictive Bronchiolitis • Diabetes • Dystonia • Emerging Infectious Diseases • Focal Segmental Glomerulosclerosis • Fragile X Syndrome • Hepatitis B • Hereditary Angioedema • Hydrocephalus • Inflammatory Bowel Disease • Influenza • Integrative Medicine • Interstitial Cystitis • Lupus • Malaria DoD FY16 PRMRP Clinical Trial Award 4 • Metals Toxicology • Mitochondrial Disease • Nanomaterials for Bone Regeneration • Non-Opioid Pain Management • Pancreatitis • Pathogen-Inactivated Dried Plasma • Polycystic Kidney Disease • Post-Traumatic Osteoarthritis • Psychotropic Medications • Pulmonary Fibrosis • Respiratory Health • Rett Syndrome • Rheumatoid Arthritis • Scleroderma • Sleep Disorders • Tinnitus • Tuberculosis • Vaccine Development for Infectious Disease • Vascular Malformations • Women’s Heart Disease

Clinical Trial Award

Pre-Application: June 29, 2016

Application: October 26, 2016

Awarded Amount: no predetermined cost limit for 4 years

Eligibility: PIs at or above the level of Assistant Professor

Details: The PRMRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on a disease or condition addressed in at least one of the Congressionally directed FY16 PRMRP Topic Areas. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first in human, Phase 0) to demonstrate feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations.


Discovery Award

Pre-Application: July 7, 2016

Application: July 21, 2016

Awarded Amount: $200,000 direct costs for 18 months

Eligibility: Investigators at all levels are eligible to submit applications

Details: The intent of the PRMRP Discovery Award is to support innovative, non-incremental, highrisk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications


Focused Program Award

Pre-Application: June 29, 2016

Application: October 26, 2016

Awarded Amount: $10,000,000 direct costs for 4 years

Eligibility: PI must be an independent investigator at or above the level of Full Professor

Details: The PRMRP Focused Program Award mechanism is intended to optimize research and accelerate the solution for a critical question related to at least one of the Congressionally directed FY16 PRMRP Topic Areas through a synergistic, multidisciplinary research program.


Investigator-Initiated Research Award

Pre-Application: June 23, 2016

Application: October 19, 2016

Awarded Amount: $1,200,000 direct costs for 3 years or $1,500,000 direct costs for 3 years for Partnering PI Option

Eligibility: Investigators at or above the level of Assistant professor

Details: The PRMRP Investigator-Initiated Research Award is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to at least one of the Congressionally directed FY16 PRMRP Topic Areas. The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinician’s first-hand knowledge of patients, or anecdotal data.


Technology/Therapeutic Development Award

Pre-Application: June 23, 2016

Application: October 19, 2016

Awarded Amount: $3,000,000 direct costs for 3 years

Eligibility: PI at or above the level of Assistant Professor

Details: The PRMRP Technology/Therapeutic Development Award is a product-driven award mechanism intended to provide support for the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life, in at least one of the Congressionally directed FY16 PRMRP Topic Areas. Products in development should be responsive to the healthcare needs of military Service members, Veterans, and/or beneficiaries.

Peer Reviewed Orthopaedic Research Program (PRORP)

All applications must address one and only one of the following FY16 PRORP Focus Areas. The Focus Area addressed should be one from either the Surgical Care category or the Rehabilitation category. Surgical care focus areas include: peripheral nerve injuries, prevention of heterotopic ossification, volumetric muscle loss, extremity fractures, pelvic ring injuries, compartment syndrome, gaps in clinical practice guidelines, surgical techniques to optimize gait, soft tissue trauma. Rehabilitation focus areas include: post-operative pain management, prosthetic and/or orthotic device function, secondary physical health effects, physical or occupational therapy, barriers to successful therapy outcomes, rehabilitation outcomes.

Applied Research Award

Pre-Application: September 7, 2016

Application: December 7, 2016

Awarded Amount: $500,000 direct costs for 3 years

Eligibility: independent investigators at all academic levels

Details: The PRORP ARA seeks applied research applications focused on advancing optimal treatment and restoration of function for military personnel with musculoskeletal injuries sustained during combat or combat-related activities


Clinical Trial Award

Pre-Application: September 7, 2016

Application: December 7, 2016

Awarded Amount: $3,000,000 direct costs for 4 years

Eligibility: Independent investigators at all academic levels

Details: The PRORP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a major impact on military combat- related orthopaedic injuries or non-battle injuries that significantly impact unit readiness and return-to-duty/work rates. Funding from this award mechanism must support a clinical trial and may not be used for preclinical research studies


Integrated Clinical Trial Award

Pre-Application: September 7, 2016

Application: December 7, 2016

Awarded Amount: $4,500,000 total costs for 4 years

Eligibility: Independent investigator at or above the level of Assistant Professor

Details: The PRORP ICTA supports the rapid implementation of an interdisciplinary clinical trial that integrates both surgical and rehabilitation strategies and has the potential to have a major impact on both the treatment of combat-related orthopaedic injuries, as well as the treatment of non-battle injuries that significantly impact unit readiness and return-to-duty/work rates.


Clinical Translational Research Award

Pre-Application: September 7, 2016

Application: December 7, 2016

Awarded Amount: $2,000,000 total costs for 4 years

Eligibility: Independent investigators at all academic levels

Details: It is intended to support high-impact and/or new/emerging research that may or may not be ready for a full-scale randomized controlled clinical trial. Projects should include translational research that evaluates the effectiveness of health care practices and/or interventions in neuromusculoskeletal injuries rehabilitation.

Prostate Cancer Research Program (PCRP)

PCRP Focus Areas include: biomarker development, genetics, imaging, mechanisms of resistance and response, survivorship and palliative care, therapy, tumor and microenvironment biology. Applicants are highly encouraged to address one of the PCRP overarching challenges, and are expected to address at least one of the PCRP focus areas.

Impact Award

Pre-Application: June 9, 2016

Application: August 25, 2016

Awarded Amount: $750,000 direct costs for 3 years for single PI or $2,000,000 directs costs for 3 years for partnering PI option

Eligibility: PIs at or above the level of Assistant Professor; Partnering PI must be at or above the level of Assistant Professor

Details: The Impact Award encourages applications that support the full spectrum of research projects or ideas that specifically focus on scientific and clinical prostate cancer issues, which, if successfully addressed, have the potential to make a major impact in eliminating death from prostate cancer and enhancing the well-being of men experiencing the impact of the disease.


Health Disparity Research Award

Pre-Application: June 9, 2016

Application: August 25, 2016

Awarded Amount: $450,000 direct costs for 3 years for single PI, $600,000 direct costs for 3 years for qualified collaborator option, $92,500 direct costs for predoctoral investigator for 3 years, or $115,000 direct costs for postdoctoral investigator for 3 years

Established PI Eligibility: at or above the level of Assistant Professor

New Investigator Eligibility:

  • must have freedom to pursue independent research goals without formal mentorship
  • Not previously received a PCRP Health Disparity Research Award and/or Idea Development Award
  • Either completed at least 3 years of postdoctoral training or fellowship (if never held an independent faculty position), or been in an independent faculty position (or equivalent) for less than 5 years.

Qualified Collaborator Eligibility: at or above the level of Assistant Professor

Nested Young Investigator Option Eligibility:

  • Predoctoral Ph.D., M.D., and M.D./Ph.D. investigators enrolled in full-time accredited doctoral program and have met candidacy requirements by March 31, 2017
  • Postdoctoral Ph.D., M.D. and M.D/Ph.D. investigators who have successfully defended a doctoral thesis or possess an M.D. degree by March 31, 2017, and will have 3 years or less of postdoctoral experience by March 31, 2017

Details: Studies proposed for this award mechanism are expected to improve the understanding of, and ultimately contribute to eliminating disparities in prostate cancer incidence, morbidity, mortality, and survivorship. Applicants for this award must explicitly state how the proposed research is related to an area of prostate cancer health disparity. Appropriate health disparity areas include, but are not limited to: race and ethnicity; socioeconomic status; access to health care; differing standards of health care; insurance status; age; geography; sexual orientation; gender identity; and cultural beliefs.


Idea Development Award

Pre-Application: June 23, 2016

Application: October 6, 2016

Awarded Amount: $275,000 direct costs for 3 years for New Investigators, $600,000 direct costs for 3 years for an Established Investigator, $1,000,000 direct costs for 3 years Partnering PI option

New Investigator Eligibility:

  • must have freedom to pursue independent research goals without formal mentorship
  • Not previously received a PCRP Health Disparity Research Award and/or Idea Development Award
  • Either completed at least 3 years of postdoctoral training or fellowship (if never held an independent faculty position), or been in an independent faculty position (or equivalent) for less than 5 years.

Established PI Eligibility: at or above the level of Assistant Professor

Partnering PI Eligibility: at or above the level of Assistant Professor. PIs categorized as a New Investigator are not eligible to apply for the partnering PI option

Details: The Idea Development Award supports new ideas that represent innovative approaches to prostate cancer research and have the potential to make an important contribution to the PCRP mission. Although groundbreaking research often involves a degree of risk, applications should be based on a sound scientific rationale that is established through logical reasoning and/or critical review and analysis of the literature. To maximize the potential for impact, investigators are strongly encouraged to incorporate the following components into their study design where appropriate: authentication of proposed cell lines; statistical rigor of preclinical animal experiments; incorporation of experiments to assess clinical relevance and translatability of findings.


Physician Research Award

Pre-Application: July 7, 2016

Application: July 21, 2016

Awarded Amount: $520,000 direct costs for 4 years

Eligibility: PI must be a physician with clinical duties and/or responsibilities who:

  • is in the last year of an accredited graduate medical education program, as a resident or a fellow
  • within 3 years of having initiated his/her first appointment as an Instructor, Assistant Professor, or equivalent

Details: The Physician Research Award supports a mentored research experience to prepare physicians with clinical duties and/or responsibilities for productive careers in prostate cancer research. This award emphasizes equally the quality of the proposed research project and the career development of the PI, which should prepare physicians for careers in basic, population science, translational, or clinical prostate cancer research.


Early Investigator Research Award

Pre-Application: July 7, 2016

Application: July 22, 2016

Awarded Amount: $60,000 direct costs for 2 years for Predoctoral PIs, and $125,000 direct costs for 2 years for Postdoctoral PIs.

Predoctoral PI Eligibility: must be enrolled full-time in an accredited doctoral program and must have met pre-dissertation requirements by March 31, 2017

Postdoctoral PI Eligibility: must have successfully defended doctoral thesis or possess an M.D. degree by March 31, 2017, be involved in an accredited training or residency program, and have 3 years or less of postdoctoral research experience by March 31, 2017.

Details: The Early Investigator Research Award supports prostate cancer-focused research opportunities for individuals in the early stages of their careers, under the guidance of a designated Mentor. This opportunity allows for young investigators to develop a research project, investigate a problem or question in prostate cancer research, and further their intellectual development as a prostate cancer researcher of the future.


Clinical Consortium Research Site

Pre-Application: September 15, 2016

Application: October 6, 2016

Awarded Amount: $800,000 direct costs for 4 years

Eligibility: Independent investigators at Assistant Professor level or higher

Details: The Clinical Consortium Research Site Award provides the support to develop and enhance collaborations and resources necessary for a network of organizations to rapidly execute Phase II or Phase II-linked Phase I (Phase I/II) prostate cancer clinical trials. These trials will include investigations of high-impact, novel therapeutic agents or approaches for the management or treatment of prostate cancer, especially as pertaining to the FY16 PCRP overarching challenges.

Psychological Health/Traumatic Brain Injury Research Program (PH/TBIRP)

Cognitive Resilience and Readiness Research Award

Pre-Application: June 27, 2016

Application: September 7, 2016

Awarded Amount: $2,500,000 direct costs for 3 years

Eligibility: Independent investigators at all academic levels

Details: The application must address one or more of the topics:

  • Cognitive resilience: tools and strategies to confer robustness and adaptability in cognitive performance.
  • Cognitive readiness: Translating cognitive resilience to military operational performance and Service member health

Complex Traumatic Brain Injury Rehabilitation Research Award

Pre-Application: August 17, 2016

Application: November 30, 2016

Awarded Amount: $2,000,000 total costs for 3 years for Funding Level 1 or $5,000,000 total costs for 4 years for Funding Level 2

Eligibility: Independent investigators at all academic levels

Details: Funding Level 1 is for epidemiological and etiological studies comparing patients with complex TBI responsive versus refractory to treatments. Funding level 2 is for interventional studies to evaluate emerging or existing treatment and rehabilitation strategies.

Spinal Cord Injury Research Program (SCIRP)

The FY16 SCIRP encourages applications that specifically address one or more of the following areas:

  • Pre-hospital, en route care, and early hospital management of SCI
  • Development, validation, and timing of promising interventions to address consequences of SCI and to improve recovery, including, but not limited to:
    • Bladder, bowel, and autonomic dysfunction
    • Cardiometabolic dysfunction
    • Neuropathic pain and sensory dysfunction
    • Pressure ulcers ○ Respiratory dysfunction
    • Sexual dysfunction
  • Identification and validation of best practices in SCI care, including, but not limited to:
    • Critical care interventions
    • Interventions for musculoskeletal health
    • Rehabilitation interventions
    • Surgical interventions
    • Psychosocial and behavioral interventions in military/Veteran populations

Clinical Trail Award

Pre-Application: June 21, 2016

Application: September 21, 2016

Awarded Amount: $2,000,000 direct costs for 4 years

Eligibility: Independent investigators at all academic levels

Details: The SCIRP Clinical Trial Award supports human subjects research with the potential to have a major impact on the treatment or management of SCI and its consequences in military Service members, Veterans, or o2,500,000ther individuals. Funding from this award mechanism must support a clinical trial and may not be used for preclinical research studies.


Investigator-Initiated Research Award

Pre-Application: June 21, 2016

Application: September 21, 2016

Awarded Amount: $500,000 direct costs for 3 years

Eligibility: Independent investigators at all academic levels

Details: The SCIRP Investigator-Initiated Research Award is intended to support studies that have the potential to make an important contribution to SCI research, patient care, and/or quality of life. Investigator-Initiated Research Award applications may focus on any phase of research from basic through translational, including preclinical studies in animal models or human subjects, as well as correlative studies associated with an existing clinical trial. Clinical trials are not allowed under this funding opportunity.


Qualitative Research Award

Pre-Application: June 21, 2016

Application: September 21, 2016

Awarded Amount: $500,000 direct costs for 3 years

Eligibility: Independent investigators at all academic levels

Details: The intent of the Qualitative Research Award is to support qualitative research studies that will help researchers and clinicians better understand the experiences of individuals with SCI and thereby identify the most effective paths for adjusting to disability and/or improving overall quality of life, health, and functional status after SCI. Appropriate qualitative research topics include, but are not limited to, the explorative, descriptive, predictive, or explanatory study of the:

  • Barriers preventing Service members with SCI from returning to active duty, returning home, or reintegrating into the community.
  • Impact of personal factors and co-morbid medical conditions that influence or mediate a patient’s health or quality of life during hospitalization following SCI.
  • Impact of cultural values and beliefs on the success of rehabilitation and community reintegration.
  • Impact of medical care decisions (e.g., choice of civilian, VA, or military facility, treatment type) on the success of rehabilitation and community reintegration.
  • Impact of care provision on the spouse and/or families of the spinal cord injured to include career issues, emotional stress, physical strain and injury, intimacy, etc.
  • Factors and strategies for improving psychosocial adjustment and adjustment to disability for people with SCI and their family and friends, including the influence of family and friends’ involvement in the individual’s life experiences on quality of life and health outcomes.
  • Impact of perceived access to care and care coordination on effectiveness of care delivery and success of rehabilitation.
  • Impact of aging and age-related changes in social support that may limit one’s ability to become and remain more fully integrated into society.

Translational Research Award

Pre-Application: June 21, 2016

Application: September 21, 2016

Awarded Amount: $1,250,000 direct costs for 3 years

Eligibility: Independent investigators at all academic levels

Details: The SCIRP TRA is intended to support translational research that will accelerate the movement of promising ideas in SCI research into clinical applications. Although not all-inclusive, some examples include demonstration studies of pharmaceuticals and medical devices in preclinical systems, and/or clinical research on therapeutics, devices, or practice using human tissues or resources. The SCIRP TRA may include a pilot clinical trial where limited clinical testing of a novel intervention or device is necessary to inform the next step in the continuum of translational research. Such pilot clinical trial studies should be small, represent only a portion of the proposed Statement of Work, and be utilized to establish feasibility of a potential approach or to aid in device or intervention refinement.


Clinical Research Development Award

Pre-Application: September 7, 2016

Application: September 21, 2016

Awarded Amount: $100,000 direct costs for 1 year

Eligibility: Independent investigators at all academic levels

Details: The SCIRP Clinical Research Development Award (CRDA) is intended to support the planning and development activities necessary to initiate a future clinical research study with military and/or Veteran populations and with the potential to have a significant impact on spinal cord injuries.

Tuberous Sclerosis Complex Research Program (TSCRP)

The mission of the FY16 TSCRP is to encourage innovative research aimed at understanding the pathogenesis, and preventing and treating the manifestations of TSC. Focus Areas include:

  • Understanding phenotypic heterogeneity in TSC
  • Gaining a deeper knowledge of TSC signaling pathways and the cellular consequences of TSC deficiency
  • Improving TSC disease models
  • Developing clinical biomarkers for TSC
  • Facilitating therapeutics and clinical trials research

Exploration Hypothesis Development Award

Pre-Application: July 1, 2016

Application: July 18, 2016

Awarded Amount: $200,000 direct costs for 2 years

Eligibility: Investigators at all academic levels, including postdoctoral fellows

Details: The EHDA supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the TSC research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation.


Idea Development Award

Pre-Application: July 1, 2016

Application: July 18, 2016

Awarded Amount: $450,000 direct costs for 3 years

Established Investigator Eligibility: PI must be independent investigator at or above the level of Assistant Professor

New Investigator Eligibility: By application submission deadline, PI must be either:

  • an independent investigator at or below the level of Assistant Professor or an established investigator in an area other than TSC at or above the level of Assistant Professor
  • must not have received more than $300,000 total direct costs for previous or concurrent TSC research as a PI of one or more Federally funded, non-mentored peer reviewed grant
  • must not have received a New Investigator Award previously from any program within the CDMRP.
  • PIs must commit at least 10% of his/her effort toward the proposed TSC research project.
  • Graduate students, postdoctoral fellows, and other “mentored” researchers are not eligible for this award.

Details: The Idea Development Award promotes ideas that have the potential to yield high-impact findings and new avenues of investigation. This award mechanism supports conceptually innovative research that could ultimately lead to critical discoveries in TSC research and/or improvements in patient care.


Pilot Clinical Trial Award

Pre-Application: July 1, 2016

Application: July 18, 2016

Awarded Amount: $300,000 direct costs for 2 years

Eligibility: PI at or above the level of Assistant Professor

Details: The PCTA mechanism supports exploratory studies involving limited human exposure (e.g., small sample size) that produce information on diagnostic or therapeutic effectiveness, safety, tolerability, or mechanisms of action. Preclinical studies will not be supported by this mechanism. Examples of acceptable studies include, but are not limited to the following:

  • Studies designed to identify an appropriate population or subpopulation for future clinical trials
  • Identification of the dosage, duration, and/or delivery strategy of an intervention
  • Evaluation of the feasibility of the intervention in TSC
  • Evaluation of efficacy and safety

Postdoctoral Development Award

Pre-Application: July 1, 2016

Application: July 18, 2016

Awarded Amount: $150,000 direct costs for 2 years

Postdoctoral Eligibility: As of the application deadline PI must:

  • Have successfully completed the requirements for a doctoral and/or medical degree
  • Be a postdoctoral fellow in the Mentor’s laboratory, and
  • Have a total of 3 years or less postdoctoral research experience

Mentor Eligibility: at or above the level of Assistant professor and must be an experienced TSC researcher with strong record of active peer reviewed funding and recent publications in the TSC field.

Details: The Postdoctoral Development Award supports recent doctoral or medical graduates to conduct impactful research with the mentorship of an experienced TSC researcher (i.e., Mentor). This opportunity allows for junior investigators to develop and investigate a TSC research project and further their intellectual development as a TSC researcher of the future. Under this award mechanism, the junior investigator is considered the Principal Investigator (PI), and the application should focus on the PI’s research and TSC career development.


Synergistic Idea Development Award

Pre-Application: July 1, 2016

Application: July 18, 2016

Awarded Amount: $750,000 direct costs for 3 years

Eligibility: Each PI must be at or above the level of Assistant Professor

Details: The Synergistic Idea Development Award supports new or existing partnerships between two or three Principal Investigators (PIs) who should utilize their complementary and synergistic perspectives to significantly accelerate advances in TSC research to support the TSCRP vision to lessen the impact of TSC. The Synergistic Idea Development Award mechanism requires multiple investigators in a wide spectrum of disciplines including, but not limited to, basic science, engineering, bioinformatics, population science, translational research, and clinical research to jointly design a single project.