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Clinical Neurobehavioral Center (CNC)

The Clinical Neurobehavioral Center (CNC) is dedicated to conducting research combining neuroscientific, behavioral-pharmacological, and clinical-psychological methods into an integrated program of human laboratory and clinical outpatient research and treatment studies, which are designed to identify new medications that are effective for the treatment of various subpopulations of drug-addicted individuals. Directed by The Dr. Irving J. Taylor Professor and Chair, Bankole Johnson, DSc, MD, the Center houses state-of-the-art equipment and space that allow investigators to simultaneously conduct numerous clinical trials, ultimately maximizing efficiency and cost-effectiveness. The Center has a portfolio of projects with funding from the National Institute of Alcohol Abuse and Alcoholism (NIAAA) and other competitive funding agencies.

The Clinical Neurobehavioral Center (CNC) is located in Howard County, just south of the main University of Maryland School of Medicine (UMSOM) campus.

FACULTY

Bankole Johnson, DSc, MD

Johnson_BankoleProfessor Johnson is The Dr. Irving J. Taylor Professor and Chair of the Department of Psychiatry; Professor of Pharmacology, Anatomy and Neuro‌biology, and Neurology; and the Director of the Brain Science Research Consortium Unit (BSRCU) at the University of Maryland School of Medicine (UMSOM). He has extensive experience leading research programs that have resulted in scientific breakthroughs in the pharmacological treatment of addiction. He has served on the NIDA Council and the External Advisory Boards of NIDA and NIAAA. Dr. Johnson has provided scientific leadership for the nation, and he has led or been a member of several large multisite research projects that have advanced the field of substance abuse treatment. He is currently a principle investigator on NIH-funded research studies, using neuroimaging, neuropharmacology, and molecular genetics techniques in the study of the psychopharmacology of medications for treating addictions. Professor Johnson’s work incorporates neuroimaging evaluations into studies of drug interaction to identify the site-specific effects of abused drugs and to evaluate the effectiveness of potential medications for the treatment of addiction.

Eric Weintraub, MD

WeintraubDr. Weintraub is an Associate Professor and the Director of the Division of Alcohol and Drug Abuse (ADA) in the Department of Psychiatry at the UMSOM, and the Clinical Directorof the CNC. He is also the Medical Director of the UMMC Methadone Program. Dr. Weintraub has extensive experience and expertise in treating patients who are injecting and non-injecting heroin users, and he has been involved in research to improve the integration of medical and substance abuse care for this specific demographic.

David Gorelick, MD, PhD

Dr. Gorelick is a Professor in the Department of Psychiatry, UMSOM, and Scientific Director of the CNC. He has more than 35 years of experience in addiction psychiatry and clinical pharmacology, which includes designing, conducting, and analyzing phase I and phase II controlled clinical trials of new pharmacological treatments for substance use disorders, as well as working with large clinical teams to develop new treatments. Dr. Gorelick is a national expert in biological treatments for substance use disorders, with experience using brain imaging methods (PET, fMRI) to study the mechanisms of addiction.

Lawrence Adler, MD

adler_lawrenceDr. Adler is an Assistant Clinical Professor in the Department of Psychiatry, UMSOM. He is a psychiatrist who is board-certified in General and Geriatric Psychiatry with expertise in clinical psychopharmacology and alcohol use disorders in older patients. He has been an investigator and a co-investigator on more than 100 clinical trials that are sponsored by the NIMH, in addition to major pharmaceutical companies. Dr. Adler's current research efforts are focused on schizophrenia, tardive dyskinesia, Alzheimer's Disease, and the epidemiology and neurobiology of suicide.

Melanie Bennett, PhD

Bennett_MelanieDr. Bennett is an Associate Professor in the Department of Psychiatry at the UMSOM,  Research Health Scientist at the VA Maryland Healthcare System, and Associate Director for Education at the VA Capitol Healthcare Network MIRECC. Dr. Bennett has expertise in behavioral treatments for addiction and motivation for health behavior change, and has been supported by NIAAA, NIDA, and VA CSR&D for her work in developing behavioral strategies for substance use in individuals with mental health disorders.

Chamindi Seneviratne, MD

Dr. Seneviratne is an Assistant Professor in the Department of Psychiatry, UMSOM, and  geneticist at the Institute for Genome Sciences, with extensive experience in molecular genetics in substance abuse and a primary focus on alcoholism. She has been working in the alcoholism research field for more than ten years and has been involved in several pharmacogenetic clinical trials – first, as a research fellow, and then as a faculty-level investigator. Her training includes conducting genetic experimentations using various genotyping techniques, developing protocols, and analyzing data. Other research interests include characterizing molecular mechanisms of gene regulation, and using molecular cloning and gene expression techniques in in-vitro cell cultures and human blood cells.

Clayton Brown, PhD

Brown_ClaytonDr. Brown is the head of the Biostatistics Core at the MIRECC and Biostatistician in the Departments of Epidemiology and Preventive Medicine and Psychiatry at the UMSOM. He is a biostatistician who has extensive experience in the design and analysis of randomized clinical trials of clinical and health service interventions in the areas of substance abuse and serious mental illness.

CURRENT RESEARCH STUDIES

A Multicenter, Randomized, Double Blind, Placebo Controlled, Phase 2 Pharmacogenetic Study of Ondansetron in Alcohol Use Disorder
(David Gorelick, PI)

This 20-week research study is being conducted to learn whether a medication called ondansetron, combined with brief counseling, is more helpful than placebo (a harmless, inactive substance) in reducing the number of heavy drinking days in people with an alcohol use disorder (AUD) who want to reduce or stop their drinking, and who also have specific genetic characteristics (also called genotypes).

A genotype reflects an individual’s DNA and influences outward appearances, like eye color, which is genetically inherited from a set of parents. We can learn about the genotype by extracting DNA from the blood and testing it. An earlier study showed that, in people with certain genotypes, ondansetron was more helpful than placebo in reducing drinking. In this study, we will use each participant’s genotype to determine whether it helps to determine a response to the study medication, and we will examine a spectrum of genes thought to be involved in the effects of ondansetron.

Biomarkers to Measure Treatment Response for Alcohol Dependence
(Chamindi Seneviratne, PI)

In a series of earlier research studies, investigators reported a genomic biomarker that correlated with amounts of recent drinking in people with alcohol-related problems, and who carry a certain genetic variation. The primary objective of this research study is to further validate the genomic biomarker to explore its potential as a test that can objectively and retrospectively predict amounts of recent heavy drinking. The secondary objective is to explore other novel molecular biomarkers of heavy drinking present in blood. All participants are required to be heavy social drinkers of European descent (without chronic health conditions) and between ages of 21 and 65 years. All genders are welcome.

Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUD
(Bankole Johnson and Melanie Bennett, co-PIs)

The primary objective of this 14-week research study is to determine the efficacy of a medication called pregabalin, administered orally for a period of 12 weeks, in reducing heavy drinking and symptoms of PTSD among individuals who have selected genotypes at the gamma-amino butyric acid transporter and receptor genes. The secondary objective is to assess the safety and tolerability of pregabalin in participants with alcohol use disorder (AUD) and co-occurring PTSD. The investigators will utilize a large and diverse sample of African-American study participants that includes both genders and individuals with different types of trauma.

To learn more about the Clinical Neurobehavioral Center or the studies taking place there, please call (667) 214-2111.

IMPORTANT LINKS

National Institutes of Health

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

National Institute of Mental Health

Substance Abuse and Mental Health Services Administration

VA National Center for PTSD

VA VISN 5 MIRECC