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George S.B. Williams, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Physiology

Location:

Mailing Address : BioMET Building, 111 S. Penn St., Suite 104 Office: Pharmacy Hall S544

Education and Training

2001 B.S. The College of William & Mary
2003 M.A. The College of William & Mary
2005 M.S. The College of William & Mary
2008 Ph.D. The College of William & Mary

Biosketch

Dr. Williams has over 15 years of experience performing quantitative measurements and designing computational models. This focus on the quantitative sciences has created 17 peer reviewed publications including 12 as first author and 1 as senior author. Dr. Williams received his quantitative training under the guidance of Drs. Carey K. Bagdassarian and Gregory D. Smith during his graduate and doctoral training at the College of William & Mary. Recently, By combining mathematical modeling with focused experimental tests Dr. Williams has been able to improve the realism of our computational models as well as gain additional insights from experimental findings. Additionally, Dr. Williams has established and maintained numerous collaborations with researchers both local (e.g., Johns Hopkins University) and global (e.g., Göttingen University in Germany). These collaborations have led to new insights into the fields of cardiac calcium homeostasis, heart failure, atrial fibrillation, mitochondrial biology, super resolution imaging, and multi-scale computational modeling. Dr. Williams also has experience guiding younger researchers having served as mentor or co-mentor to several students including a current MD/PhD student (Andrew P. Wescott). Dr. Williams is a current NIH (NHLBI) K awardee.

Research/Clinical Keywords

Calcium Signaling, Calcium Sparks, Calcium-Dependent Arrhythmogenesis, Excitation-Contraction Coupling, Heart Failure, Cardiac Myocytes, Cardiac Mitochondria, Cardiac Cellular Physiology, Computational Biology, Super-Resolution Imaging, Confocal Imaging, Systems Biology

Highlighted Publications

  1. Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS., “Dynamics of calcium sparks and calcium leak in the heart”, Biophysical Journal, 101(6):1287-96, 2011. (PMID: 21943409)
  2. G. S. B. Williams, L. Boyman, A. C. Chikando, R. J. Khairallah, W. J. Lederer, “Mitochondrial calcium uptake”, Proc Natl Acad Sci USA (2013) (PMID: 23759742)
  3. Boyman L, Chikando AC, Williams GSB*, Khairallah RJ, Kettlewell S, Ward CW, et al. (2014), “Calcium movement in cardiac mitochondria Biophys. J., 107(6), 1289–301. PMCID: PMC4167535. *co-first author
  4. Walker M, Williams GSB*, Kohl T, Lehnart S, Jafri MS, Greenstein J, et al. (2014). “Super-Resolution Modeling of Calcium Release in Heart”, Biophys. J., 107(12), 3018–3029. *co-first author
  5. Wescott, AP, Jafri, MS, Lederer, WJ, & Williams, GSB (2016). “Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling.” Journal of Molecular and Cellular Cardiology.

Additional Publication Citations

Patents

  1. Method and system for utilizing Markov chain Monte Carlo simulation.”Mohsin Saleet Jafri, Tuan Minh Hoang-Trong, and George Stuart Blair Williams, Assigned to George Mason University, Fairfax, VA (US), US 9,009,095 B1.

Peer Reviewed Publications 

  1. George S. B. Williams, Aftab M. Hossain, Shiying Shang, David E. Kranbuehl, and Carey K. Bagdassarian, “Evolution of a catalytically effective model enzyme: The importance of tuned conformational fluctuations”, Journal of Theoretical and Computational Chemistry, 2(3):323-331, 2003.
  2. George S. B. Williams, Aftab M. Hossain, David E. Kranbuehl, and Carey K. Bagdassarian, “Evolution of rate-promoting oscillations in a model enzyme”, Journal of Physical Chemistry, 107(1):12527-12533, 2003.
  3. George S. B. Williams, Marco A. Huertas, Eric A. Sobie, M. Saleet Jafri, and Gregory D. Smith, “A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes”, Biophysical Journal, 92(7):2311-28, 2007. (PMID: 17237200)
  4. George S. B. Williams, Evan J. Molinelli, and Gregory D. Smith, “Modeling local and global intracellular calcium responses mediated by diffusely distributed inositol 1,4,5-trisphosphate receptors”, Journal of Theoretical Biology, 253(1):170-88, 2008. (PMID: 18405920)
  5. George S. B. Williams, Marco A. Huertas, Eric A. Sobie, M. Saleet Jafri, and Gregory D. Smith, “Moment closure for local control models of calcium-induced calcium release in cardiac myocytes”, Biophysical Journal, 95(4):1689-703, 2008. (PMID: 18487291)
  6. George S. B. Williams, Gregory D. Smith, Eric A. Sobie, and M. Saleet Jafri, “Models of cardiac excitation-contraction coupling in ventricular myocytes”, Journal of Mathematical Biosciences, 226:1-15, 2010. (PMID: 20346962)
  7. Tuan HT, Williams GS, Chikando AC, Sobie EA, Lederer WJ, Jafri MS, “Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves”, Conf Proc IEEE Eng Med Biol Soc., 2011:4677-80, 2011. (PMID: 22255381)
  8. Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS., “Dynamics of calcium sparks and calcium leak in the heart”, Biophysical Journal, 101(6):1287-96, 2011. (PMID: 21943409)
  9. Chikando AC, Kettlewell S, Williams GS, Smith G, Lederer WJ., “Ca2+ dynamics in the mitochondria - state of the art”, Journal Molecular Cell Cardiology, 51(5):627-31, 2011. (PMID: 21864537)
  10. Wagner, E., Lauterbach, M. A., Kohl, T., Westphal, V., Williams, G. S. B., Steinbrecher, J. H., et al., STED Live Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction, Circulation Research, (2012). (PMID: 22723297)
  11. L. Boyman, G. S. B. Williams*, D. Khananshvili, I. Sekler, W. J. Lederer, “NCLX: The mitochondrial sodium calcium exchanger”, J Mol Cell Cardiol (In Press) (2013). (PMID: 23538132) *co-first author
  12. G. S. B. Williams, L. Boyman, A. C. Chikando, R. J. Khairallah, W. J. Lederer, “Mitochondrial calcium uptake”, Proc Natl Acad Sci USA (2013) (PMID: 23759742)
  13. Boyman L, Chikando AC, Williams GSB*, Khairallah RJ, Kettlewell S, Ward CW, et al. (2014), “Calcium movement in cardiac mitochondria Biophys. J., 107(6), 1289–301. PMCID: PMC4167535. *co-first author
  14. Greiser M, Kerfant B-G, Williams GSB, Voigt N, Harks E, Dibb KM, et al. (2014). “Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes” J Clin Invest, 124(11), 4759–72.
  15. Walker M, Williams GSB*, Kohl T, Lehnart S, Jafri MS, Greenstein J, et al. (2014). “Super-Resolution Modeling of Calcium Release in Heart”, Biophys. J., 107(12), 3018–3029. *co-first author
  16. Williams GSB, Boyman L, Lederer WJ (2014), “Mitochondrial Calcium and the Regulation of Metabolism in Heart” Journal of Molecular and Cellular Cardiology, 78C, 35–45.
  17. Boyman L, Williams GSB, Lederer WJ. (2015). “The growing importance of mitochondrial calcium in health and disease.” Proc Natl Acad Sci USA National Acad Sciences;, 112(36), 11150–1. PMCID: PMC4568708
  18. Wescott, AP, Jafri, MS, Lederer, WJ, & Williams, GSB (2016). “Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling.” Journal of Molecular and Cellular Cardiology.

Other Publications

  1. George S. B. Williams, “Evolution and analysis of a catalytically effective model enzyme: The importance of active site orientation and tuned conformational fluctuations” The Department of Chemistry, Roger’s Hall, The College of William & Mary, 2003. (M.A. Thesis)
  2. George S. B. Williams, “Probability density methods for modeling local and global aspects of intracellular calcium signaling”, The Department of Applied Science, McGlothlin Street Hall, The College of William & Mary, 2008. (Ph.D. Dissertation) 

Book Chapters

  1.  Boyman, L., Williams, G.S., Lederer, W.J., “Mitochondrial Calcium and Ischemia Reperfusion Injury in Heart”, Mitochondria and Cell Death, Springer Science, 2015. (In press)

Awards and Affiliations

2008-2011  Postdoctoral Fellow, George Mason University

2009-2011  Affiliate Postdoctoral Fellow, University of Maryland School of Medicine

2011-Present  Postdoctoral Fellow, University of Maryland School of Medicine

 

1997 Graduated Co-Valedictorian, Wilson Memorial High School, Fishersville, VA

1997-2001Monroe Scholar, The College of William & Mary, Williamsburg, VA

2002-2003 Graduate Student Research Stipend, The College of William & Mary, Williamsburg, VA.

2003-2008Graduate Student Research Assistantship, The College of William & Mary, Williamsburg, VA.

2011-2014NRSA Fellowship Awardee, National Institutes of Heath, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD

2015-PresentK Awardee, National Institutes of Heath, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD

 

Grants and Contracts

Current Funding

 

06/30/2015-Present (PI, 100%)

“Mitochondrial Calcium Signaling in Heart”

Mentored Quantitative Research Development Award

NHLBI K25HL125762

Annual Direct Costs: $132,435

Total Direct Costs: $662,175

 

Past Funding

 

04/11/2011 - 04/11/2014 (PI, 100%)

“Molecular Basis of Ca2+ Leak in Heart”

National Research Service Award Fellowship

NHLBI F32HL108604 

Annual Direct Costs: $51,015

Total Direct Costs: $156,979