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Flaubert Tchantchou, PhD

Academic Title:

Research Associate

Primary Appointment:

Anesthesiology

Location:

MSTF, 5-34

Phone (Primary):

(410) 706-3418

Fax:

(410) 706-2550

Education and Training

Ph.D,  Biochemistry and Molecular Biology, University of Massachusetts, Lowell

M.Sc,  Medical and Pharmaceutical Research, Free University of Brussels, Belgium

Research/Clinical Keywords

Traumatic brain injury, Alzheimer's disease, Pathophysiology, Neuroprotection, Experimental therapeutics

Highlighted Publications

Tchantchou F., Fourney W.L, Leiste U.H, Vaughan J., Rangghran P. Puche A., Fiskum G. (2017). Neuropathology and neurobehavioral alterations in a rat model of traumatic brain injury to occupants of vehicles targeted by underbody blasts. Exp. Neurol. 289:9-20

Loane D.J, Stoica B.A, Tchantchou F., Kumar A., Akintola T., Xue F., Conn J.P, Faden A.I (2014).Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration,   and alters microglial polarization after experimental TBI. Neurotherapeutics, 1(4):857-69

Tchantchou F., Tucker L.B, Fu A.H, Bluet R.J, McCabe J.T, Patel S., Zhang Y. (2014).  The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and  improves functional recovery in mice with traumatic brain injury. Neuropharmacology, 85:427-39

Tchantchou F., Zhang Y. (2013).  Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain   barrier breakdown and improves functional recovery in a mouse model of traumatic brain injury. J. Neurotrauma. 30(7):565-79 (Cover page)

Tchantchou F, Lacor PF, Cao Z, HouY, CuiC,KleinWL, Luo Y (2009). Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in    Hippocampal Neurons. J Alzheimer’s Dis; 18(4):787-98

Chan A, Tchantchou F, Rogers EJ, Shea TB. (2009). Dietary deficiency increases presenilin expression, gamma- activity and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine. J. Neurochem. 110(3):831-6

Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007). EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J. 21(10):2400-8

Tchantchou F, Graves M, Ortiz D, Chan A., Rogers E, and Shea TB (2006). S-adenosyl methionine: a connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer’s disease. J. Nutri, Health Aging 10(6):541-4

Tchantchou F. (2006, Review). Homocysteine metabolism and various consequences of folate deficiency.  J. Alz Dis. 9(4):421-427

Tchantchou F, Graves M and Shea TB, (2006). Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: Modulation by apolipoprotein E-deficiency. Nutritional Neurosci., 9 (1):17-24 

Additional Publication Citations

Book Chapters

Tchantchou F and Shea TB (2008). Folate deprivation, the methionine cycle and Alzheimer's disease, In Litwack G., Eds. Folic Acid and Folates; Vitamins and Hormones, Vol. 79:83-97

Tchantchou F and Shea TB (2005). Interaction between Dietary and Genetic Deficiencies in the Modulation of Homocysteine Elimination, In Luo Y. and Packer L., Eds. Oxidative Stress and Age-Related Neurodegeneration. CRC Press: 443-456

 

Grants and Contracts

US-DOD-FA8650-17-2-6H10 (01/23/2017-12/31/2021)

Co-Principal Investigator: F. Tchantchou