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Terez Shea-Donohue, PhD

Academic Title:

Professor

Primary Appointment:

Radiation Oncology

Secondary Appointment(s):

Physiology, Medicine

Location:

MSTF, 7-00C

Phone (Primary):

410-706-5503

Phone (Secondary):

410-706-5515

Fax:

410-706-5508

Education and Training

I received my Ph.D.  in Physiology and Biophysics from Georgetown University,  I was a post-doctoral Fellow at the Uniformed Services Univesrity of the Health Sciences in the laboratory of Dr. Andre Dubois.  I joined the faculty at Uniformed Services Univesrity of the Health Sciences where I rose to the rank of Professor of Medicine.  In 2004, I moved to the University of Maryland School of Medicine as Professor of Medicine and currently Professor of Radiation Oncology and Medicine.  

Biosketch

Dr. Shea-Donohue's rearch is focused on investigation of the mechanisms of the interactions between hematopoietic and non-hematopoietic cells in acute and chronic pathologies of the gastrointestinal.  She has focused the impact of these interactions on gastrointestinal function in the context of irradiation, obesity, host-pathogen interactions, and inflammatory bowel disease.  Her current projects include identification of novel therapeutic targets for medical countermeasures to treat the gastrointestinal syndrome, development and testing of a novel therapeutic for type 2 diabetes, the therapeutic potential of pathogen derived products for the treatment of chronic gastrointestinal inflammatory pathologies, and brain gut function following traumatic brain injury.  In 1997 she received the recipient for the Janssen Award for Outstanding Research in Basic Science.  She was a member of the Varenna Group (2004-2007), which developed teaching materials for gastrointestinal motility and its control in health and disease.  She is currently member of the Rome IV Committee (2014-2017), which is sponsored by the Rome Foundation, a non-profit organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of functional gastrointestinal disorders (FGIDs).  She is an Associate Editor of Gut Microbes, and serves on the editorial board of the American Journal of Physiology (former Associate Editor) and Infection and Immunity.   

Research/Clinical Keywords

Th2 cytokines, mucosal barrier function, obesity and diabetes, chronic GI irradiation syndrome.

Highlighted Publications

  1. Zhao A, Urban JF, Anthony AM, Sun R, Stiltz J, van Rooijen N, Wynn T, Gause WC, and Shea-Donohue T. Th2 cytokine-induced alterations in intestinal smooth muscle function are dependent on alternatively activated macrophages. Gastroenterology, 2008, 135(1):217-225.
  2. Zhao A., Urban JF, Sun R, Stiltz J, Morimoto M, Notari L, Madden KB, Yang Z, Grinchuk V, Ramalingam TR, Wynn T, Shea-Donohue T.  Critical role of IL-25 in nematode infection-induced alterations in intestinal function.  J Immunology 2010, 185(11):6921-9.
  3. Notari L, Riera D, Sun R, Bohl J, Sullivan C,  Madden K , van RooijenN, Vanuytsel T, Urban JF,  Zhao A, Shea-Donohue T.  Role of macrophages in altered epithelial function during a type 2 immune response induced by enteric nematode infection. PLoS One. 2014 Jan 23;9(1):e8476
  4. McLean, L, Smith A, Chung L, Sun R, Grinchuk V, Vanuytsel T, Desai N, Urban JF, Zhao A,   Raufman JP, Shea-Donohue T. Type 3 Muscarinic Receptors   and Contribute  Clearance of Citrobacter rodentium.  Inflamm Bowel Dis. 2015 21:1860-1871.
  5. Sun R, Notari L, Vanuystsel, T, Madden K, Bohl JA, Ramalingam T, Wynn J, Urban JF, Zhao A, Shea-Donohue T.  IL-13Rα1-dependent responses in the intestine are critical to parasite clearance. Infection and Immunity 2016 84(4):1032-44

Research Interests