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Abulkalam Shamsuddin, MBBS, PhD

Academic Title:

Professor

Primary Appointment:

Pathology

Location:

MSTF 637

Phone (Primary):

(410) 706-4874

Fax:

(410) 706-8414

Education and Training

Education:

  • 1965: H.Sc. Notre Dame College, Dhaka, Bangladesh
  • 1972: M.B., B.S. University of Dhaka, Dhaka, Bangladesh (M.D)
  • 1980: Ph.D. University of Maryland, Baltimore, MD

Major area: Carcinogenesis.

Training:

Internship (Rotating)

  • 1972-1973: Lawrence General Hospital, Lawrence, Massachusetts

Residency: (Anatomic Pathology)

  • 1973-1975: Baltimore City Hospitals, Baltimore, MD
    Post-Doctoral Fellow, Department of Pathology, Johns Hopkins
    University School of Medicine, Baltimore, MD
  • 1975-1977: University of Maryland Hospitals, Baltimore, MD

Biosketch

Dr Shamsuddin graduated Dhaka Medical College, University of Dhaka in 1972. Following Internship in Massachusetts and Residency training in pathology in Maryland, he was certified by the American Board of Pathology in 1977. In 1980, he received Ph.D. degree from the University of Maryland for his work on colon carcinogenesis. He joined the faculty of the University of Maryland as an Instructor in 1977, and rose through the ranks of Assistant Professor and Associate Professor to become a full Professor in 1988. For his excellence in teaching he received the Best Teacher award from the medical students many times, including the coveted "Golden Apple Award" by the American Medical Students' Association in 1999.

Dr. Shamsuddin has been studying the process of cancer formation and the prevention of cancer since 1975. His research in the steps of colon cancer formation resulted in the development of a very simple and accurate screening test for colon cancer. This rather inexpensive test detects cancers at a very early stage, and even before they have formed; in other words, it can also detect precancerous polyps and other precancerous lesions and conditions. The test has been in use in China since the early 1990's often referred to as "Shams' Test." He further discovered that the colon cancer marker Gal-GalNAc is a common cancer marker expressed through a similar "field-effect" phenomenon; thus forming the basis for a general cancer screening test such as for cancer of the lungs and breast, and possibly prostate and uterine cervix. His book on the subject "Diagnostic Assays for Colon Cancer" by CRC Press (1991) was written for health-care professionals.

In mid 1985, Dr. Shamsuddin started his pioneering experiments on the anti-cancer property of inositol and inositol hexaphosphate (IP-6) - natural constituents of cereals and legumes such as rice, corn, beans etc. For the next two decades, he has reconfirmed and expanded his groundbreaking studies to show the efficacy of IP-6 and inositol against different cancers in various experimental models. Dr. Shamsuddin has published two books on the subject for the general public, and one for professionals and researchers. Aside from these Dr. Shamsuddin has contributed numerous book-chapters and published over 200 scientific papers.

 

Research/Clinical Keywords

Carcinogenesis - Tumor Markers - Cancer Screening Tests - Cancer Chemoprevention - Inositol Hexaphosphate - IP6

Highlighted Publications

Shamsuddin, A.K.M., Barrett, L.A., Autrup, H., Harris, C.C., and Trump, B.F.: Long-term organ culture of adult rat colon. Pathology Research and Practice, 163: 362-372, 1978.

Shamsuddin, A.M., and Elsayed, A.M.: A test for detection of colorectal cancer. Human Pathology 19: 7-10, 1988.

Shamsuddin, A.M., Ullah, A., and Chakravarthy, A.K.: Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice. Carcinogenesis 10: 1461-1463, 1989.

Shamsuddin, A. M.: A simple mucus test for cancer screening. Anticancer Research 16: 2193-2200, 1996.

Shamsuddin, A. K. M. & Yang, G-Y: Inositol & Its Phosphates: Basic Science to Practical Applications. eISBN: 9781681080079 ISBN: 9781681080086  Bentham e-Book, Bentham Science Publishers, Sharjah, UAE 2015. DOI: 10.2174/97816810800791150101 http://ebooks.benthamscience.com/book/9781681080079/

Additional Publication Citations

Baten, A., Ullah, A., Tomazic, V.J., and Shamsuddin, A.M.: Inositol phosphate induced enhancement of natural killer cell activity correlates with tumor suppression. Carcinogenesis 10: 1595-1598, 1989.

Shamsuddin, A. M., and Yang, G-Y: Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells, Carcinogenesis 16: 1975-1979, 1995.

Yang, G-Y., and Shamsuddin, A. M.: IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: Involvement of intracellular inositol phosphates, Anticancer Research 15: 2479-2488, 1995.

Shamsuddin, A. M.: A simple mucus test for cancer screening. Anticancer Research 16: 2193-2200, 1996.

Shamsuddin, A. M., and Vucenik, I.: IP6 & Inositol in cancer prevention and therapy. Current Cancer Therapy Reviews 1:259-269, 2005.

Vucenik, I., and Shamsuddin, A. M.: Protection against cancer by dietary inositol and IP6. Nutrition & Cancer 55: 109-125, 2006.

Vlaicu, S.I., Tegla, C.A., Cudrici, C.D., Fosbrink, M., Nguyen, V., Azimzadeh, P., Rus, V., Chen, H., Mircea, P.A., Shamsuddin, A., Rus, H.: Epigenetic modifications induced by RGC-32 in colon cancer Experimental and Molecular Pathology. 88:67-76, 2010. Epub 2009 Oct 31.

Matejuk, A., and Shamsuddin, A. M.: IP6 in cancer therapy: Past, present and future. Current Cancer Therapy Reviews 6: 1-12, 2010.

Shamsuddin, A. K., and Bose, S.: IP6 (inositol hexaphosphate) as a signaling molecule, Current Signal Transduction Therapy 7: 291-306, 2012.

Shamsuddin, A.M.:  Diagnostic Assays for Colon Can­cer. ISBN 0-8493-6540-6, CRC Press, Boca Raton, Florida; 1991.

Shamsuddin, A.M.IP6: Nature’s Revolutionary Cancer-Fighter., ISBN 1-57566-357-0, Kensington Publishing Corp, New York, NY; 1998­.

Shamsuddin, A.M.IP6 + Inositol: Nature’s Medicine for the Millennium. ISBN 978-984-33-2708-6 IP-6 Research, Inc. Baltimore, Maryland 2011.  http://www.amazon.com/IP6-Inositol-Medicine-Millennium-Molecules/dp/984332708X/ref=sr_1_2?s=books&ie=UTF8&qid=1331137244&sr=1-2.

Research Interests

Cancer Screening:

Carbohydrate tumor markers such as D-galactose-N-Acetyl-D-galactosamine in early detection of cancer and precancerous lesions through screening tests.

Cancer Prevention and Therapy:

Myo-inositol and inositol hexaphosphate (IP6) abundant in cereals and legumes in prevention and treatment of cancer. Mechanisms of the various actions of IP6, its application in human and animal health as well as in other technologies. New IP6 compounds such as IP6-citrate.

Clinical Specialty Details

Anatomic Pathology, Diagnostic Electron Microscopy

Awards and Affiliations

  • 1977: Student Council Faculty Award (Best Teacher): University of MarylandSchool of Medicine - Class of 1979.
  • 1979: Student Council Faculty Award (Best Teacher): University of MarylandSchool of Medicine - Class of 1981.
  • 1982: International Union Against Cancer (Geneva) - ICRETT Award, Visiting Scientist, Cancer Institute (JFCR), Tokyo, Japan.
  • 1984: Foundation for Promotion of Cancer Research (Tokyo) Fellowship; Guest Scientist, National CancerCenter Research Institute, Tokyo,
  • 1989: Research Fellow, The University of Tokyo, Institute of Medical Sciences, Tokyo, Japan.
  • 1991: Student Council Faculty Award (Best Teacher): University of Maryland School of Medicine - Class of 1993.
  • 1994: Student Council Faculty Award (Best Teacher): University of Maryland School of Medicine - Class of 1996.
  • 1995: Student Council Faculty Award (Best Teacher): University of Maryland School of Medicine - Class of 1997.
  • 1996: Visiting Professor, University of Tokyo; Government of Japan Ministry of Education (Monbusho) Distinguished Foreign Scholar Program. August - September 1996.
  • 1996: Tokyo Society of Medical Sciences and Faculty of Medicine University of Tokyo Lectureship, August 27
  • 1997: Student Council Faculty Award (Teacher of The Year): University of Maryland School of Medicine - Class of 1999.
  • 1998: Inductee - 1st Annual Teaching Wall of Fame (Best Teacher): University of Maryland School of Medicine Class of 2000.
  • 1998: Visiting Professor, The First Military Medical University, Guangzhou, P. R. China, November 1998 - November 2001.
  • 1999: Student Marshall [elected by the Class of 1999], Pre-Commencement Convocation, University of Maryland School of Medicine.
  • 1999: American Medical Student Association "Golden Apple Award" Class of 1999, University of Maryland School of Medicine

In the News

Community Service

Editorial Tasks:

  • 1981 - 2005: Reviewer, Archives of Pathology and Laboratory Medicine
  • 1982 - 2005: Reviewer, American Journal of Pathology
  • 1992 - 2006: Reviewer, Cancer
  • 1991 - 1995: Reviewer, Cancer Epidemiology, Biomarkers and Prevention
  • 1983 - 2010: Reviewer, Cancer Research
  • 1983 - 2010: Reviewer, Carcinogenesis
  • 1992: Reviewer, Chemico-Biological Interactions
  • 1993: Reviewer, Critical Reviews in Food Science and Nutrition
  • 1996: Reviewer, Digestive Diseases and Science
  • 1991: Reviewer, Drug Development Research
  • 1993: Reviewer, Ethnicity and Disease
  • 1981 - 2008: Reviewer, Gastroenterology
  • 1983 - 2008: Reviewer, International Journal of Cancer
  • 1987- 1988: Reviewer, Journal of Investigative Dermatology
  • 1982 - 1993: Reviewer, Journal of the National Cancer Institute
  • 1991 - 2001: Reviewer, Laboratory Investigation
  • 1992: Reviewer, Nutrition & Cancer
  • 1998: Reviewer, Proceedings of the Soc. of Experimental Biology & Medicine
  • 1998 - 1999: Special Issue Editor, Anticancer Research Vol. 19 #5A, 1999
  • 1999 - 2004: Member, Editorial Board, Anticancer Research
  • 1999 - 2005: Reviewer, Cancer Letters
  • 2000 - Present: Associate Editor, Nutrition and Cancer
  • 2001 – 2003: Reviewer, Leukemia
  • 2001 – 2004: Reviewer, Cell Biology International
  • 2002 - Present: Reviewer, Complementary Therapies in Medicine
  • 2002 - Present: Reviewer, Food and Chemical Toxicology
  • 2004: Reviewer, British Journal of Dermatology
  • 2004: Reviewer, Cellular and Molecular Life Sciences
  • 2004: Reviewer, Mechanisms of Ageing and Development
  • 2004 - Present: Member, Editorial Board, Current Cancer Therapy Reviews
  • 2004 – 2006: Reviewer, Digestive Diseases Science
  • 2005: Reviewer, FEBS Letters
  • 2005: Reviewer, Veterinary Pathology
  • 2007 – Present: Member, Editorial Board, Open Cancer Journal
  • 2008: Reviewer, Journal of Medicinal Food
  • 2008: Reviewer, Nutrition Research

Please see CV for other National and International Major Consultant & Membership Activities

Links of Interest