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James W. Russell, MB,ChB, MS

Academic Title:

Professor

Primary Appointment:

Neurology

Secondary Appointment(s):

Anatomy Neurobiology

Additional Title:

Director Peripheral Neuropathy Center, Director Autonomic Nervous System Disorders Laboratory, Vice Chair Research

Location:

Paca Pratt Building, 110 S Paca Street, 3S-129

Phone (Primary):

(410) 328-3100

Fax:

(410) 328-8981

Education and Training

Dr. James Russell M.B.,Ch.B., M.S. F.R.C.P., F.A.C.P., completed his neurology residency at the University of Iowa and completed training in neuromuscular/peripheral nerve disease at the Mayo Clinic Rochester. After further research training at the Mayo Clinic and the National Institutes of Health, Dr. Russell then joined the faculty at the University of Michigan where he was Associate Professor with tenure, Director of the Veterans Affairs Medical Center (VAMC) Autonomic and Clinical Electrophysiology Laboratory and Associate Chief of Neurology at the VAMC. 

Biosketch

Dr. James Russell is Head of the Neuromuscular Division, Vice for Chair for Research, and Director of the Peripheral Neuropathy Center in the Department of Neurology. He completed his neurology residency at the University of Iowa and completed training in neuromuscular/peripheral nerve disease at the Mayo Clinic Rochester. After further research training at the Mayo Clinic and the National Institutes of Health, Dr. Russell then joined the faculty at the University of Michigan where he was Associate Professor with tenure, Director of the Veterans Affairs Medical Center (VAMC) Autonomic and Clinical Electrophysiology Laboratory. Dr. Russell joined the University of Maryland Medical Center in 2006 where he is Professor of Neurology, Anatomy and Neurobiology and Vice Chair for Research. He is board certified in Neurology and Clinical Neurophysiology, and holds a masters degree in Clinical Research and Trial Design from the University of Michigan. Dr. Russell is a Fellow of the American Neurological Association, the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, the Royal College of Physicians, and the American College of Physicians. He has an active neuromuscular practice as well as research program in peripheral neuropathy.

 

Research/Clinical Keywords

Neuropathy, mitochondrial, diabetes, autonomic`

Highlighted Publications

Publications can be found at the following URL:

http://www.ncbi.nlm.nih.gov/sites/myncbi/18eYtrexEbhQj/bibliography/48143741/public/?sort=date&direction=descending

Dyck PJ, Argyros B, Russell JW, Gahnstrom LE; Nalepa S, Albers JW, Lodermeier KA, Zafft AJ, Dyck PJB, Klein CJ, Litchy WJ, Davies JL, Carter RE, Melton LJ.  Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle and Nerve Vol. 49(5):645-653, May 2014. PMID: 23929701

Choi J, Chandrasekaran K, Inoue T, Muragundla A, Russell JW.  PGC-1alpha regulation of mitochondrial degeneration in experimental diabetic neuropathy.  Neurobiology of Disease Vol. 64; Pages118–130, Apr 2014. PMID: 24423644

Litchy WJ, MD,Albers JW, Wolfe J, Bolton CF, Walsh N, Klein CJ, Zafft AJ, Russell JW, Zwirlein M, Overland CJ, Davies JL, Carter RE, Dyck PJ. Proficiency of Nerve Conduction using Standard Methods and Reference Values (Cl. NPhys Trial 4). Muscle and Nerve. Vol. 50, Issue 6, pages 900–908, Dec 2014. PMID: 24644133

Choi J , Chandrasekaran K, Demarest  T, Kristian T, Xu S,  Vijaykumar K, Dsouza KG, Qi NR, Yarowsky  PJ, Gallipoli R, Koch LG, Fiskum GM, Britton SL and Russell JW.  Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.  Annals of Clinical and Translational Neurology 1(8):589-604, Aug 2014. PMID: 25356430

Choi J, Ravipatia A, Nimmagadda V, Schubert M, Castellani RJ, Russell JW.  Potential role of PINK 1 for increased PGC-1-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.  Mitochondrion Vol. 18C:41-48, Sept 2014. PMID: 25260493

Additional Publication Citations

Biessels,G.J., Bril,V., Calcutt,N.A., Cameron,N.E., Cotter,M.A., Dobrowsky,R., Feldman,E.L., Fernyhough,P., Jakobsen,J., Malik,R.A., Mizisin,A.P., Oates,P.J., Obrosova,I.G., Pop-Busui,R., Russell JW. Sima,A.A., Stevens,M.J., Schmidt,R.E., Tesfaye,S., Veves,A., Vinik,A.I., Wright,D.E., Yagihashi,S., Yorek,M.A., Ziegler,D., and Zochodne,D.W.  Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab). Journal of the Peripheral Nervous System Vol 19 (2):77-87, June 19, 2014 PMID: 24934510

Russell JW and Zilliox L. Diabetic Neuropathies. Continuum (Minneap Minn) Vol. 20 (5 Peripheral Nervous System Disorders): 1226-1240, Oct 20, 2014. PMID: 25299279

Zilliox LA, Ruby SK, Singh S, Zhan M, Russell JW. Clinical neuropathy scales in neuropathy associated with impaired glucose tolerance. Journal of Diabetes and its Complications, April 2015 Volume 29, Issue 3, Pages 372–377, PMID: 25690405

Chandrasekaran K, Muragundla A, Inoue  T, Choi J, Rao Sagi A, Chen C, Ide T and Russell JW. Mitochondrial Transcription Factor A Regulation of Mitochondrial Degeneration in Experimental Diabetic Neuropathy. American Journal of Physiology - Endocrinology and Metabolism, Jul 15 2015; 309(2):E132-4; (Epub ahead of print) May 5 2015. PMID: 25944881

Bril V, Blanchette CM, Noone JM, Runken C, Gelinas D, Russell JW. The Dilemma of diabetes in chronic inflammatory demyelinating polyneuropathy. Journal of Diabetes and its Complications, May 10, 2016,  PMID: 27389526

Nimmagadda VK, Makar TK, Chandrasekaran K, Sagi AR, Russell JW, Bever CT. SIRT1 and NAD+ Precursors: Therapeutic Targets in Multiple Sclerosis: Journal of Neuroimmunology, (Epub ahead of print) July 17, 2016, PMID: 27474445

Zilliox LA, Chandrasekaran K, Kwan JY, Russell JW. Diabetes and Cognitive Impairment. Current Diabetes Reports, (Epub ahead of print) September 16, 2016, PMID: 27491830

Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. Content Validity of Symptom-based Measures for Diabetic, Chemotherapy, and HIV Peripheral Neuropathy. Muscle & Nerve, July 22, 2016, PMID: 27447116

Research Interests

Dr. Russell's laboratory has as its research focus the understanding of the mechanism/s and treatment of diabetic neuropathy. His laboratory is interested in developing strategies to prevent of reverse neuropathy.  In translational research, the laboratory is currently examining pathways of oxidative and mitochondrial injury in the peripheral nervous system, and mechanisms to prevent or reverse cellular injury. Understanding these basic mechanisms of glucose-induced injury in the peripheral nerve will allow a more a rational design of therapies aimed at ameliorating diabetic neuropathy. In clinical research, the research group is determining the effect of lifestyle interventions on autonomic and somatic neuropathy in subjects with neuropathy associated with pre-diabetes and diabetes.  This research is aimed at developing improved diagnosis and new treatments for peripheral neuropathies.

Clinical Specialty Details

Dr. Russell has clinical research interests in neuromuscular diseases, specifically in the study of peripheral neuropathies. He has active clinical research interests in the pathogenesis and treatment of neuropathy in diabetes and impaired glucose tolerance, and in inflammatory neuropathies. He also has clinical and research interests in autonomic neuropathies. He directs the Autonomic Nervous System Disorders Laboratory at the University of Maryland.

Grants and Contracts

National Institutes of Health (NIDDK) and Department of Veterans Affairs

Lab Techniques and Equipment

* Mitochondrial genetics and proteomics, anatomy and function.
* Electrophysiology in the peripheral nerve.
* Nerve morphometry. Intraepidermal nerve fiber density.
* Autonomic function testing.