Skip to main content

Jeffrey N. Rottman, MD

Academic Title:

Professor

Primary Appointment:

Medicine

Location:

Baltimore VA Medical Center and University of Maryland School of Medicine

Education and Training

Education

 

Undergraduate

1972-73                 Johns Hopkins University, Baltimore, MD,

 

1973-76        AB    Mathematics, summa cum laude

                              Princeton University, Princeton, NJ,

 

Graduate

1976-78        MA   Mathematics

                              University of California, Berkeley, CA

 

Medical

1978-82        MD   Columbia University, College of Physicians and Surgeons, New York, NY

 

Post Graduate Education and Training

 

Internship and Residency

1982-85           Intern, Resident and Senior Resident in Medicine,

                        Massachusetts General Hospital, Boston, MA

 

Fellowships

1985-87           Clinical and Research Fellow in Medicine (Cardiology)

                        Massachusetts General Hospital, Boston, MA

1987-89           Clinical and Research Fellow in Medicine (Cardiac Electrophysiology)

                        Massachusetts General Hospital, Boston, MA

1988-91           Bugher Research Fellow,

Laboratory of Molecular Cardiology,

                        The Children's Hospital, Boston, MA

                        Dr. Bernardo Nadal-Ginard

1991-92           Post-doctoral Fellow,

Molecular Biology and Pharmacology,

                        Washington University School of Medicine, St. Louis, MO

                        Dr. Jeff Gordon

Highlighted Publications

Montgomery JA, Kanagasundram AN, Clair WK, Rottman JN, Crossley GH. Sudden Cardiac Death Despite a Functional Cardioverter-Defibrillator: The Casee for Early and Aggressive Therapy for Ventricular Teachuycardia in Selected Patients. J Cardiovasc Electrophysiol. (29 Oct 2015) PMID: 26511459

 

Kolek M, Patel N, Clair W, Whalen S, Rottman J, Kanagasundram A, Shen S, Saavedra P, Estrada J, Abraham R, Ellis C. Efficacy of a Bio-absorbable Antibacterial Envelope to Prevent Cardiac Implantable Electronic Device Infections in High-Risk Subjects. J Cardiovasc Electrophysiol 26(10):1111-6 (2015) PMID: 26222980

 

 

Goyal SK, Ellis CR, Ball SK, Ahmad R, Hoff SJ, Whalen SP, Rottman J. High-Risk Lead Removal by Planned Sequential Transvenous Laser Extraction And Minimally Invasive Right Thoracotomy. J Cardiovasc Electrophysiol. 25(6):617-21 (2014) PMID:24446764

 

Hughey CC, James FD, Ma L, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Shearer J. Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart. Am J Physiol Cell Physiol. 306(1):C19-27 (2014) PMID: 24196528

 

Richardson TD, Kolek MJ, Goyal SK, Shoemaker MB, Lewis AA, Rottman JN, Whalen SP, Ellis CR. Comparative outcomes of transvenous extraction of Sprint Fidelis and Riata defibrillator leads: a single center experience. J Cardiovasc Electrophysiol 25(1):36-42 (2014) PMID: 24028661

 

 

Hughey CC, Ma L, James FD, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Hittel DS, Shearer J. Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol 12:128 (2013) PMID: 24007410

 

 

Additional Publication Citations

 

Murray KT, Rottman JN, Arbogast PG, Shemanski L, Primm RK, Campbell WB, Solomon AJ, Olgin JE, Wilson MJ, Dimarco JP, Beckman KJ, Dennish G, Naccarelli GV, Ray WA; the AFFIRM Investigators.Inhibition Of Angiotensin II Signaling And Recurrence Of Atrial Fibrillation In AFFIRM. Heart Rhythm  Heart Rhythm 1:669-75 (2004)

Shearer J, Fueger PT, Rottman JN, Bracy DP, Binas B, Wasserman DH. Heart-Type Fatty Acid Binding Protein Reciprocally Regulates Glucose and Fatty Acid Utilization during Exercise. Am J Physiol Endocrinol Metab. 288:E292-7 (2005)

Yang Z, Shen W, Rottman JN, Wikswo JP, Murray KT. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J Mol Cell Cardiol. 38:299-308 (2005)

Kozlov S, Mounkes L, Cutler D, Sullivan T, Hernandez L, Levy N, Rottman J, Stewart CL. Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy. Novartis Found Symp. 264:246-58; 258-63 (2005).

Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH.Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. J Physiol. 566:533-541 (2005)

Mounkes LC, Kozlov SV, Rottman JN, Stewart CL. Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. Hum Mol Genet 14:2167-2180 (2005)

O’Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valvy-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kB in reovirus-induced apoptosis and disease. J. Clin Invest 115:2341-2350 (2005)

Shearer J, Fueger PT, Bracy DP, Wasserman DH, Rottman JN. Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance. Diabetes 54:3133-9 (2005)

Temple J, Frias P, Rottman J, Yang T, Wu Y, Verheijk EE, Zhang W, Siprachhanh C, Kanki H, Atkinson JB, King P, Anderson ME, Kuperschmidt S, Roden DM. Atrial fibrillation in KCNE1-null mice. Circ Res 97:62-69 (2005)

Exil VJ, Gardner, CD, Rottman JN, Sims H, Bartelds B, Khuchua Z, Sindhal R, Ni G, Strauss AW. Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase. Am J Physiol Heart and Circulatory 290:H1289-97 (2006)

Melcon G, Kozlov S, Cutler DA, Sullivan T, Hernandez L, Zhao P, Mitchell S, Nader G, Bakay M, Rottman JN, Hoffman EP, Stewart CL. Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration. Hum Mol Genet 15: 637-51 (2006)

Rottman JN, Ni G, Brown M. Echocardiographic Evaluation of Ventricular Function in Mice, Echocardiography 24:83-89 (2007)

Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 56:1025-33 (2007)

Fueger PT, Li CY, Ayala JE, Shearer J, Bracy DP, Charron MJ, Rottman JN, Wasserman DH. Glucose Kinetics and Exercise Tolerance in GLUT4 Null C57BL/6 Mice. J Physiol. 582:801-12 (2007)

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High Fat Fed Mice: Studies in Mice with a 50% Reduction of Hexokinase II. Diabetes. 56:2476-84 (2007)

Shearer J, Coenen KR, Pencek RR, Swift LL, Wasserman DH, Rottman JN. Long Chain Fatty Acid Uptake In Vivo: Comparison of [(125)I]-BMIPP and [ (3)H]-Bromopalmitate. Lipids 43:703-11 (2008)

Shearer J, Fueger PT, Wang Z, Bracy DP, Wasserman DH, Rottman JN. Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle. Biochim Biophys Acta. 782:586-92 (2008)

Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA. Treatment of Elderly Hypertensive Patients with Epithelial Sodium Channel Inhibitors Combined with a Thiazide Diuretic Reduces Coronary Mortality and Sudden Cardiac Death. J Am Soc Hypertension 2(5):355-365 (2008)

Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, Young PP. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A. 105:18366-71 (2008).

Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L, RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 361:1139-51. (2009)

Ellis CR, Rottman JN. Increased rate of subacute lead complications with small-caliber implantable cardioverter-defibrillator leads. Heart Rhythm. 6:619-24 (2009)

Monahan K, Storfer-Isser A, Mehra R, Shachar E, Mittleman M, Rottman J, Punjabi N, Sanders M, Quan SF, Resnick H, Redline S. Triggering of nocturnal arrhythmias by sleep-disordered breathing events. J Am Coll Cardiol 54:1797-804 (2009)

Hughey CC, Alfaro MP, Belke DD, Rottman JN, Young PP, Wasserman DH, Shearer J. Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells. Cell Regeneration (2012)

Rytlewski JA, Saavedra P, Rottman JN. Successful ICD Implantation in the Setting of RV Channel Noise, J of Innovations in Cardiac Rhythm Management  2:274-6 (2011)

Palmisano BT, Rottman JN, Wells QS, DiSalvo TG, Hong CC. Familial Evaluation for Diagnosis of Arrhythmogenic Right Ventricular Dysplasia, Cardiology 119:47-53 (2011)

Hughey CC, Johnsen VL, Ma L, James FD, Young PP, Wasserman DH, Rottman JN, Hittel DS, Shearer J. Mesenchymal Stem Cell Transplantation for the Infarcted Heart: A Role in Minimizing Abnormalities in Cardiac-Specific Energy Metabolism. Am J Physiol Endocrin. And Metab. 302:E163-72 (2012)

Ozcan C, Rottman JN, Heist EK, Guy ML, Ellinor PT, Singh J, Milan DJ, Danik SB, Barrett CD, Mansour M, Ruskin JN, Mela T. Unpredictable battery depletion of St Jude Atlas II and Atlas+ II HF implantable cardioverter-defibrillators. Heart Rhythm 9:717-20 (2012)

Dees E, Miller PM, Moynihan KL,, Pooley RD, Hunt RP, Galindo CL, Rottman JN, Bader DM. Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy. Disease Models & Mechanisms. 4:468-80 (2012)

Nagarakanti R, Raj SR, Rottman JN. Pacing output failure after electrocautery during pulse generator replacement. J Innovations in Cardiac Rhythm Management 3:912-6 (2012)

Parvathenani SV, Ellis CR, Rottman JN. High Prevalence of Insulation Failure with Externalized Cables in St Jude Medical Riata Family ICD Leads: Fluoroscopic Grading Scale and Correlation to Extracted Leads. Heart Rhythm 9:1218-24 (2012)

Clinical Specialty Details

Cardiovascular Medicine

Awards and Affiliations

1976                            summa cum laude in mathematics, Princeton University

1976                            Phi Beta Kappa, Princeton University

1981-1982                   NSF Graduate Fellowship in mathematics

1982                            David Scharf Scholarship, N.Y. Academy of Medicine

1982                            Janeway Prize

                                    Columbia University College of Physicians & Surgeons

1982                            Stevelman Award in Cardiology

                                    Columbia University College of P & S

1982                            Bartlestone Award in Pharmacology

                                    Columbia University College of P & S

1982                            Alpha Omega Alpha, Columbia University College of P & S

1988-1990                   Bugher Fellow, American Heart Association

1990-1995                   NIH Physician-Scientist Award

2012, 2013                  USNWR Top Doctors

2014, 2015                  USNWR Top Doctors

Grants and Contracts

09/30/09 – 06/30/16    Jeffrey Rottman (Core Consultant, as needed; PI - Hatzopoulos)          

NHLBI Progenitor Cell Biology Consortium 

Optimizing Cardiovascular Stem Cells for Cardiac Repair and Regeneration

NIH/NHLBI 1U01 HL100398

Institutional participation with a total of nine research hubs to study the biology of blood, lung and heart progenitor cells.

 

2011-2016                   Jeffrey Rottman (Co-Director Cardiovascular Pathophysiology, AN-10%: PI-Wasserman)

Vanderbilt Mouse Metabolic Physiology Centers

NIH/NIDDK U24 DK59637

Annual Direct Costs: 600,000

Total Direct Costs: $2,979,000 (cardiovascular core ~ 25%)

The goal of this program is to provide centers for advanced phenotyping for murine models of metabolic disease, including extensive cardiovascular characterization.

 

2014-present                Jeffrey Rottman (Executive Committee, 6.725%; PI-S Singh)

Safety and Efficacy of ICDs in the Elderly, VA Cooperative Studies Program CSP 592

Annual Direct Costs:  600,000 (pilot phase)

Annual Direct Costs (VA CSP Program, full study): 4,200,000

VA cooperative study evaluating whether ICD's are effective for primary prevention in a specific elderly population.