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Chiara Orlandi, PhD

Academic Title:

Research Associate

Primary Appointment:

Medicine

Additional Title:

Research Associate

Location:

725 W. Lombard Street, 21201 - Baltimore

Phone (Primary):

410-706-7565

Fax:

410-706-4694

Education and Training

University of Insubria, Italy, B.S. and M.S. in Biological Science, 2005

University of Insubria, Italy, Ph.D in Experimental Medicine and Oncology, 2010

Postdoctoral Fellow, University of Maryland, School of Medicine, Institute of Human Virology, 2011-2017

Research Associate, University of Maryland, School of Medicine, Institute of Human Virology, 2017-present

Research/Clinical Keywords

antibody dependent cellular cytotoxicity (ADCC); Fc-effector functions; Human Fc receptors; HIV-1; antibody

Highlighted Publications

Orlandi C., Forlani G., Tosi G., Accolla RS. Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication, Journal of Translational Medicine, 2011 Jul 7;9:106.

Gohain N, Tolbert WD, Acharya P, Yu L, Liu T, Zhao P, Orlandi C, Visciano ML, Kamin-Lewis R, Sajadi MM, Martin L, Robinson JE, Kwong PD, DeVico AL, Ray K, Lewis GK, Pazgier M (2015) Co-crystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1, J Virol: 1;89(17):8840-54
 
Tolbert WD, Gohain N, Veillette M, Chapleau J-P, Orlandi C., Visciano ML, Ebadi T, DeVico T, Fouts TR, Finzi A, Lewis G, Pazgier M (2016) Paring down HIV-1 Env: Design and Structure of an Independent Inner Domain of gp120 that Stably Expresses the A32 Epitope Sub-region of ADCC Epitope Cluster A, Structure: 24(5):697-709
 
Orlandi C, Flinko R. and G.K. Lewis: A New Cell Line for High Throughput HIV-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) and Cell-to-Cell Virus Transmission Studies. Journal of Immunological Methods, 2016 Jun; 433:51-8.

Gohain N, Tolbert WD, Orlandi C., Richard J , Ding S, Chen X, Bonsor DA, Sundberg EJ, Lu W, Ray K, Finzi A, Lewis GK, Pazgier M. (2016) Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240, Scientific Reports: Nov 9;6:36685. 
 
Tolbert WD, Gohain N, Alsahafi N, Van V, Orlandi C, Ding S, Martin L, Finzi A, Lewis GK, Ray K, Pazgier M (2017) Targeting the Late Stage of HIV-1 Entry for Antibody-dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region, Structure, in press

Additional Publication Citations

Molteni M., Marabella D., Orlandi C. and Rossetti C. Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4, Cancer Letters, 2006 Apr 8; 235(1):75-83.

Pomati F., Orlandi C., Clerici M., Lucani F., and Zuccato E. Effects and interactions in an environmentally relevant mixture of pharmaceuticals, Toxicological Science, 2008 Mar; 102(1):129-37