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Pranshu Mohindra, MD, MBBS

Academic Title:

Assistant Professor

Primary Appointment:

Radiation Oncology

Administrative Title:

Director of Billing & Compliance

Additional Title:

Asst. Professor, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore Director of Research Internships, Department of Radiation Oncology,

Location:

22 S. Greene St., Baltimore, Maryland-21201

Phone (Primary):

410-328-6080

Phone (Secondary):

410-328-9155

Fax:

410-328-5279

Education and Training

Education

  • 1997 - 2003: M.B.B.S, Dr D Y Patil Medical College, University of Mumbai, India Date of Degree: 12/2003
  • 2004 - 2007: M.D., Tata Memorial Hospital, University of Mumbai, India Date of Degree: 02/2008
    MD Dissertation: Low dose Total Body Irradiation in cases of Low Grade Non-Hodgkin’s Lymphoma: Response evaluation & Immunological-Radiobiological assessment of mechanism.
    Advisor: Dr. Mary Ann Muckaden

Post Graduate Education and Training

  • 2002 - 2003: Internship: Dr D Y Patil Medical College, University of Mumbai, India
  • 2004 - 2007: Residency: Radiation Oncology, Tata Memorial Hospital, University of Mumbai, India
  • 2006 - 2007: Professional Diploma in Clinical Research: Catalyst Clinical Services Pvt. Ltd., India (Correspondence Course)
  • 2007 - 2008: Senior Residency (Fellow): Radiation Oncology Tata Memorial Hospital, India
  • 2009 - 2009: Global Academic Research Associate (Post-doctoral fellow): University of Texas MD. Anderson Cancer Center, Houston, Texas, USA,Supervisor: Dr. S. Krishnan
  • 2009 - 2010: Clinical Fellow: Radiation Oncology (Head and Neck Cancer)Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Canada, Program Director: Dr. Charles Catton
  • 2010 - 2014: Residency: Radiation Oncology University of Wisconsin Hospital and Clinics, Madison, WI, Program Director: Dr. Kristin A Bradley

Certifications

  • 2003 M.B.B.S, University of Mumbai, India
  • 2008 M.D. (Radiotherapy), University of Mumbai, India
  • 2015 American Board of Radiology- Radiation Oncology

Biosketch

Dr. Mohindra's prior training experience includes two radiation oncology residencies (Tata Memorial Centre, Mumbai and University of Wisconsin, Madison), Head-Neck cancer clinical fellowship (Princess Margaret Hospital, University of Toronto) and a post-doctoral Global Academic Research Associate at the U. T. MD Anderson Cancer Center; Houston. He has received several academic excellence, research and travel awards during his residency including the 2014 Radiological Society of North America (RSNA) Roentgen Resident/Fellow Award for outstanding radiologic research and the 2014 American Society for Radiation Oncology (ASTRO) Resident Digital Poster Discussion Award in the Biology category. He also served as the Chief resident, Radiation Oncology, University of Wisconsin, Madison, for the year 2013-14. 

Dr. Mohindra joined the Department of Radiation Oncology at the University of Maryland School of Medicine, Baltimore in July 2014 as an assistant professor in a clinician-scientist role. His primary area of clinical and research interest is in thoracic/lung, gynecological and hemato-lymphoid malignancies. Dr. Mohinda played a key role in the initiation of the department's MRI-guided brachytheapy program for women with cervical cancer. He has helped establish UMMC as a referral center for complex high dose rate (HDR) tandem-ring brachytherapy and interstitial brachytherapy for gynecological cancers. Dr. Mohindra is amongst the select providers in the entire Maryland-DC region who has the expertise in performing these brachytherapy procedures. He is currently working on expanding the use of modern technologies like proton beam therapy for the management of thoracic/lung, gynecological and hemato-lymphoid malignancies.

While continuing to build novel clinical programs and providing expert radiation oncology service, one of his key goals is to represent UMSOM nationally through cutting-edge research. His research efforts include evaluating treatment outcomes through institutional and population-based databases, development of early phase clinical trials evaluating both radiation sensitizers and radiation toxicity mitigators or evaluation of modern radiation techniques including proton beam therapy. He has active involvement in multi-disciplinary collaborative research endeavors including prospective clinical protocols with special emphasis on early phase clinical trials evaluating both radiation sensitizers and radiation toxicity mitigators or evaluation of modern radiation techniques. He is the national PI of two NCI-sponsored phase-I clinical trials; one evaluating VX-970, a novel DNA repair pathway inhibitor with whole brain radiotherapy (WBRT) in patients with brain metastases from NSCLC (CIRB and CTEP approved, NCT02589522, career development project team award) and another evaluating the combination of oral 5-iodo-2-pyrimidinone-2-deoxyribose (IPdR) with WBRT in brain metastases (CIRB and CTEP approved, NCT02993146). He is the Radiation Oncology Co-chair for the Alliance for Clinical Trials in Oncology A041501A study: Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (A Conjugated Anti-Cd22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) with Newly Diagnosed Precursor B-Cell ALL and Alliance Champion for the NRG-sponsored national study: LU002 Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial

Dr. Mohindra represents UMGCCC as the nominated member to the Board of Directors for the Alliance for Clinical Trials in Oncology which comprises nearly 10,000 cancer specialists at hospitals, medical centers, and community clinics across the United States and Canada. He holds committee appointments within Alliance (Radiation Oncology, Respiratory, Symptom Intervention and Cancer in the Older Adults) and American Society for Radiation Oncology (Workforce and Research Grants Evaluation Subcommittee). He was recently also appointed as member of the Advanced Radiation Technology Committee, International Association for the Study of Lung Cancer (IASLC). He is an appointed member of the ACR Radiation Oncology In-Training (TXITTM) Exam committee (Thoracic: 2015-2016 and Gynecology, Lymphoma: 2016) developing examination questions for residents in radiation oncology. Since 2017, he took over as the section chair for Thoracic section of the examination.

Within the Department of Radiation Oncology, UMB, Dr. Mohindra is appointed as Director of Research Internships and oversee the activities of all research-related internships that span more than 30 days. Through 2017 and 2018, this program has awarded $20,000 in awards to five UMSOM medical students for summer fellowships, two medical student research scholarship award and one medical student graduation research award. He has personally mentored medical students and residents on research projects that have led to national awards: Applied Radiation Oncology Clinical Case Contest Winner (Stephanie Rice, MS-4, Univ. Wisconsin, 2014), Medical Student Award for 2017 Alpha Omega Alpha Carolyn Kuckein Fellowship Competition (Jiun Yiing Hu, MS-1, UMSOM, 2017) and Radiation Oncology Institute Excellence Award for a research manuscript (Melissa Vyfhuis, Chief Resident Radiation Oncology, UMSOM, 2017).  He is also the Lead, Scope of Practice, Policy and Procedure Management Workgroup of Quality and Safety Review Council. In this role, he will oversee development of SOPs for various departmental clinical activities and establish uniform procedures system-wise. 

Research/Clinical Keywords

thoracic/lung cancers, gynecological malignancies, hemato-lymphoid malignancies, intensity modulated proton therapy (IMPT)/pencil beam scanning (PBS) proton therapy, intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), stereotactic radiosurgery (SRS), stereotactic body radiation therapy (SBRT), Image-guided Brachytherapy.

Highlighted Publications

CONTRIBUTIONS TO SCIENCE

Contributions in Thoracic-Oncology:

  1. Cannon DM, Mehta MP, Adkison JB, Khuntia D, Traynor AM, Tomé WA, Chappell RJ, Tolakanahalli R, Mohindra P, Bentzen SM, Cannon GM.Dose Limiting Toxicity Following Hypofractionated Dose-Escalated Radiotherapy in Non-Small Cell Lung Cancer. JCO 2013 Oct. 21. PMID: 24145340
  2. Murigi FN, Mohindra P, Hung C, Salimi S, Goetz W, Pavlovic R, Jackson IL, Vujaskovic Z. Dose Optimization Study of AEOL 10150 as a Mitigator of Radiation-Induced Lung Injury in CBA/J Mice. Radiat Res. 2015 Oct;184(4):422-32. Epub 2015 Sep 28. PMID: 26414508
  3. Mohindra P, Barrow K, Kieta KM, Parker J, De Faria E, Taylor-Howell C, Dobbin T, Gibbs A, Farese AM, MacVittie TJ. Use of Computed Tomography (CT) scan to Assess Efficacy of Mitigators of Radiation-induced Lung Injury (RILI): A Rhesus Macaque Whole Thoracic Lung Irradiation (WTLI) Model. IJROBP, 2015:93(3), Supplement, Page E512. Abstract only.
  4. de Faria EB, Barrow KR, Ruehle BT, Parker JT, Swartz E, Taylor-Howell C, Kieta KM, Lees CJ, Sleeper MM, Dobbin T, Baron AD, Mohindra P, MacVittie TJ. The Evolving Mcart Multimodal Imaging Core: Establishing a Protocol for Computed Tomography and Echocardiography in the Rhesus Macaque to Perform Longitudinal Analysis of Radiation-Induced Organ Injury. Health Phys. 2015 Nov;109(5):479-92. PMID: 26425907
  5. Lam VK, Bentzen SM, Mohindra P, Nichols EM, Bhooshan N, Vyfhuis M, Scilla KA, Feigenberg SJ, Edelman MJ, Feliciano JL. Obesity is associated with long-term improved survival in definitively treated locally advanced non-small cell lung cancer (NSCLC). Lung Cancer. 2017 Feb;104:52-57. PMID: 28213000.
  6. Diwanji TP, Mohindra P, Vyfhuis M, Snider JW, Kalavagunta C, Mossahebi S, Yu J, Feigenberg S, Badiyan S. Advances in Radiotherapy Techniques and Delivery for NSCLC: Benefits of IMRT, Proton Therapy, and SBRT. Transl Lung Cancer Res. 2017 Apr;6(2):131-147. PMID: 28529896.
  7. Scilla KA, Bentzen SM, Lam VK, Mohindra P, Nichols EM, Vyfhuis MA, Bhooshan N, Feigenberg SJ, Edelman MJ, Feliciano JL. Neutrophil-Lymphocyte Ratio Is a Prognostic Marker in Patients with Locally Advanced (Stage IIIA and IIIB) Non-Small Cell Lung Cancer Treated with Combined Modality Therapy. Oncologist. 2017 Jun;22(6):737-742. PMID: 28533476.
  8. Vyfhuis MA, Bhooshan N, Burrows WM, Turner M, Suntharalingam M, Donahue J, Nichols EM, Feliciano J, Bentzen S, Badiyan S, Carr, SR, Friedberg J, Simone CB, Edelman MJ, Feigenberg S, Mohindra P. Oncological outcomes from trimodality therapy receiving definitive doses of neoadjuvant chemoradiation (≥60 gy) and factors influencing consideration for surgery in stage III non-small cell lung cancer. Adv Radiat Oncol (2017). 2017 Sept;2(3):259-269.
  9. Vyfhuis M AL, Bhooshan N, Molitoris J, Bentzen SM, Feliciano JF, Edelman M, Burrows WM, Nichols EM, Suntharalingam M, Donahue J, Nagib M, Carr SR, Friedberg J, Badiyan S, Simone CB, Feigenberg SJ, Mohindra P. Clinical outcomes of black vs. non-black patients with locally advanced non–small cell lung cancer. Lung Cancer. 2017; 114:44-49, DOI: 10.1016/j.lungcan.2017.10.016.
  10. Vyfhuis M AL, Burrows WM, Bhooshan N, Suntharalingam M, Donahue J, Feliciano JF, Badiyan S, Nichols EM, Edelman MJ, Carr SR, Friedberg J, Henry G, Stewart S, Sachdeva A, Pickering EM, Simone CB, Feigenberg SJ, Mohindra P. Implications of Pathological Complete Response (pCR) Beyond Mediastinal Nodal Clearance with High-dose Neoadjuvant Chemoradiotherapy (CRT) in Locally Advanced, Non-Small Cell Lung Cancer (LA-NSCLC). Article in press. IJROBP. DOI: 10.1016/j.ijrobp.2018.02.003
  11. Vyfhuis MAL, Rice S, Remick J, Mossahebi S, Badiyan S, Mohindra P, Simone CB. Reirradiation for locoregionally recurrent non-small cell lung cancer. Accepted. J Thorac Dis. 2018.
  12. Molitoris JK, Diwanji T, Snider JW, Mossahebi S, Samanta S, Badiyan SN, Simone CB, Mohindra P. Advances in the Use of Motion Management and Image Guidance in Radiation Therapy Treatment for Lung Cancer. Accepted. J Thorac Dis. 2018.

Contributions in Gynecology-Oncology: 

  1. Mishra S, Laskar S, Muckaden MA, Mohindra P, Shrivastava SK, Dinshaw KA. Monthly palliative pelvic radiotherapy in advanced carcinoma of uterine cervix. Journal of Cancer Research & Therapeutics. 2005 Oct; 1(4): 208-212. PMID: 17998655.
  2. Mohindra P, Kruser TJ, Gondi V, Thomas SR, McHaffie DR, Bradley KA. Papillary serous and clear cell adenocarcinoma of the uterus: A 10-year single-institution experience. IJROBP, 2011;81(2):Supplement, Pages S471-S472. Poster Presentation- ASTRO 53rd Annual Meeting 2011; Miami.
  3. Mohindra P, Bentzen SM, Scartoni D, Giacomelli I, Rao G, Roque DM, Hanna N, Nichols EM. Adjuvant Therapy for Locoregionally Advanced Endometrioid Adenocarcinoma (EA): Upfront Chemotherapy (UC) or Upfront Radiotherapy (UR)? IJROBP, 2016:96(2), Supplement, Page E289-290.Abstract only.
  4. Mohindra P, Bentzen SM, Giacomelli I, Scartoni D, Roque DM, Rao G, Hanna N, Nichols EM. Adjuvant Whole Pelvic Radiation Therapy (WPRT) for Endometrioid Adenocarcinoma (EA): 45 Gy or 50/50.4 Gy? IJROBP, 2016:96(2), Supplement, Page E300. Abstract only.
  5. Nichols EM, Bentzen SM, Scartoni D, Giacomelli I, Rao G, Roque DM, Hanna N, Mohindra P. Positive impact of radiation therapy in the management of uterine carcinosarcoma. IJROBP, 2016:96(2), Supplement, Page S49. Abstract only.
  6. Cohen J, Harper A, Nichols E M, Rao GG, Mohindra P, Roque DM. Barriers to Timely Completion of Radiation Therapy in Patients with Cervical Cancer in an Urban Tertiary Care Center. Cureus 2017 Sep; 9(9): e1681. doi:10.7759/cureus.1681
  7. Molitoris JK, Diwanji T, Samanta S, Lamichhane N, Chhabra A, Roque D, Rao G, Amin P, Nichols E, Mohindra P. Improving Outcomes through Immune System Modulation in the Treatment of Gynecological Malignancies. Reproductive Immunol Open Acc, 2017;2:34.
  8. Fowler KG, Mohindra P, Kim A, Gomez-Lobo V Foley Catheter As Vaginal Stent In A Toddler With Vaginal Rhabdomyosarcoma. J Pediatr Adolesc Gynecol. 2017 Dec 9. doi: 10.1016/j.jpag.2017.12.003. [Epub ahead of print] 

 

Contributions in Head-Neck Oncology:  

  1. Mohindra P, Urban E, Pagan JD, Geye HM, Patel VB, Bayliss RA, Bender ET, Harari PM. Selective omission of level V nodal coverage for patients with oropharynx cancer: Clinical validation of intensity modulated radiotherapy experience and dosimetric significance. Head Neck. 2014 Dec 1. [Epub ahead of print]. PMID: 25445257
  2. Morris ZS, Mohindra P, Kruser TJ. Combined chemo-radiation therapy in the treatment of squamous cell carcinoma of the head and neck; an evolving paradigm. Oncol Hematol Rev(US)., 2014;9:109-114.
  3. Hoffman MR, McCulloch TM, Mohindra P, Das R, Geurts M, Harari PM. Simulation study of high-dose-rate brachytherapy for early glottic cancer.  Brachytherapy. 2016 Jan-Feb;15(1):94-101, PMID: 26614234
  4. Barasch S, Mohindra P, Hennrick K, Hartig GK, Harari PM, Yang DT. Assessing p16 Status of Oropharyngeal Squamous Cell Carcinoma by Combined Assessment of the Number of Cells Stained and the Confluence of p16 Staining: A Validation by Clinical Outcomes. Am J Surg Pathol. 2016 Sep;40(9):1261-9, PMID: 27186851.

Contributions in Neuro-Oncology: 

  1. Mohindra P, Sinha RN, Andrews RJ, Khuntia D. Non-cytotoxic radiosensitizers in brain radiotherapy: Journey till the first decade of this millennium. Curr Cancer Drug Targets., 2012;12:260-278. PMID: 22268387.
  2. Mohindra P, Robins HI, Tomé WA, Hayes L, Howard S. Wide-field pulsed-reduced-dose-rate radiotherapy (PRDR) for recurrent ependymoma in pediatric and young adult patients. Anticancer Res., 2013;33:2611-2618. PMID: 23749916
  3. Magnuson W, Robins HI, Mohindra P, Howard S. Large volume reirradiation as salvage therapy for glioblastoma after progression on bevacizumab. J Neurooncol., 2014;117:133-139. PMID: 24469853
  4. Diwanji T, Snider JW, Lin JY, Engelman A, Mohindra P, Kwok Y., Mehta MP. Volumetric Analysis of the Hippocampus in Long Term (∼1 year) Survivors of Whole Brain-Radiation Therapy for Brain Metastasis. Int J Radiat Oncol Biol Phys. 2015;93(3):Supp 1, E69.  Abstract only.
  5. Koroulakis A, Diwanji T, Lin J, Mohindra P, Mehta M. Subcortical Volumetric Changes in Patients Receiving Whole-Brain Radiation Therapy for Brain Metastases. American College of Radiation Oncology (ACRO) Annual Meeting, In: Orlando, FL; 2016. Abstract only.
  6. Diwanji T, Snider JW, Koroulakis A, Feigenberg SJ, Mohindra P, Kwok Y., Mehta MP. Interobserver Variability in Atlas-Based, Manual Segmentation of the Hippocampus in Patients With Brain Metastases. Int J Radiat Oncol Biol Phys. 2016;96(2):Supp 1, E130. Abstract only.
  7. Diwanji TP, Engelman A, Snider JW, Mohindra P. Epidemiology, diagnosis, and optimal management of glioma in adolescents and young adults. Adolesc Health Med Ther 2017 Sep,8:99-113

Contributions towards education in radiation oncology: Dr. Mohindra was involved in publication of the first ever report that described the factors assessed by MS4s during the process of radiation oncoloy residency selection. As one of the founding members of the education sub-committee of the Association of Residents in Radiation Oncology (ARRO), he was involved in a unique study assessing the factors involved in the job search and career planning both from the perspective of graduating residents and the hiring physicians. He developed multiple peer-reviewed educational presentations for the online educational resource through the ARRO. Further, he served as the institutional co-investigator for a multi-institutional introductory structured didactic radiation oncology curriculum for medical students pursuing a career in radiation oncology. These efforts have led to multiple publications.  

  1. Brower J, Mohindra P, Golden D, Bradley K. Radiation oncology residency selection: A targeted assessment of factor importance among fourth year medical students. Int J Radiat Oncol Biol Phys., 2014;88:967-968. PMID: 24606856
  2. Ye JC, Mohindra P, Spektor A, Krishnan MS, Chmura SJ, Howard AR, Viswanathan AN, MacDonald SM, Thaker NG, Das P, Mancini BR, Higgins SA, Braunstein S, Haas-Kogan D, Bradley KA, Hung AY, Thomas CR Jr, Kharofa J, Wheatley M, Currey A, Parashar B, Du K, Jimenez RB, Golden DW. Medical Student Perspectives on a Multi-institutional Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group. Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):217-9, PMID: 25968822
  3. Nabavizadeh N, Burt LM, Mancini BR, Morris ZS, Walker AJ, Miller SM, Bhavsar S, Mohindra P, Kim MB, Kharofa J; ARRO Executive Committee. Results of the 2013-2015 Association of Residents in Radiation Oncology Survey of Chief Residents in the United States. Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):228-34. Epub 2015 Oct 22.PMID: 26853332
  4. Oskvarek JJ, Brower JV, Mohindra P, Raleigh DR, Chmura SJ, Golden DW. Educational Impact of a Structured Radiation Oncology Clerkship Curriculum: An Interinstitutional Comparison. J Am Coll Radiol. 2017 Jan;14(1):96-102, PMID: 27652570
  5. Pranshu Mohindra, Steven P. Howard. ARROContour- Glioblastoma multiforme. Assoiation of Residents in Radiation Oncology (ARRO) Educational Resource.                                                                         https://www.astro.org/ARRO/Resident-Resources/Educational-Resources/ARROCase/index.aspx

 

Additional Publication Citations

Other peer-reviewed publications (total 41 peer-reviewed publications, 4 peer-reviewed online educational presentations, multiple oral and poster conference presentations, published abstracts, 1 book chapter):

Google Scholar: 328 citations, h-index 10, i10-index 10

https://scholar.google.com/citations?user=qSgqHtIAAAAJ&hl=en

Research Gate: RG score 36.71

https://www.researchgate.net/profile/Pranshu_Mohindra

Research Interests

See Biosketch

Clinical Specialty Details

Dr. Mohindra provides patient care service for patients with thoracic/lung, gynecological and hemato-lymphoid malignancies. Dr. Mohindra is experienced in the latest radiation modalities including intensity modulated proton therapy (IMPT)/pencil beam scanning (PBS) proton therapy, intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), stereotactic radiosurgery (SRS), stereotactic body radiation therapy (SBRT) and Image-guided Brachytherapy.  

Awards and Affiliations

Professional Society Membership

  • 2005-present: Life Member, Association of Radiation Oncologists of India (AROI), ID: LM 883
  • 2006-2014: Member-in-training, ASTRO; ID 35192732
  • 2010-2014: Member-in-training, RSNA; ID 00435019
  • 2010-2014: Member-in-training, ACR; ID 05089204
  • 2010-2014: Member-in-training, ACRO; ID 28311
  • 2011-2014: Member-in-training, ASCO; ID 146438
  • 2012-2014: Associate Member, AACR; ID 251301
  • 2014-2015: Full Member, RRS
  • 2014-present: Affiliate Member, ASTRO; ID 35192732
  • 2015-present: Full Member, IASLC
  • 2015-present: Full Member, ACRO
  • 2016-present: Full Member, ABS

Honors And Awards

  • 1995: National top 0.1% merit list in ‘Science’ subject at All India Secondary School Examination
  • 1995: National Talent Search Examination Scholarship, India
  • 2000: Distinction [score more than 75%] in ‘Human Pathology’ in Board examinations of Medical school, University of Mumbai.
  • 2005: Best Poster, ESTRO International Symposium: ESTRO / TMH Evidence Based Medicine, Mumbai
  • 2006: All-India First Rank, Professional Diploma in Clinical Research, Class of October- 2006
  • 2007: Winner, Quiz; National Conference of Indian Cooperative Oncology Network (ICON), India
  • 2007: Invited Symposium Speaker at International Congress of Radiation Research [ICRR], San Francisco
  • 2007: Best thesis award, Indian Cooperative Oncology Network (ICON), India
  • 2008: UICC World Cancer Congress Travel Grant, Geneva, Switzerland
  • 2012: Fellowship Grant: AACR/ASCO Workshop on Methods in Clinical Cancer Research
  • 2014: ASTRO Spring Refresher Course Travel Grant, New Orleans, USA
  • 2013-14: Chief Resident, University of Wisconsin School of Medicine, Radiation Oncology, Wisconsin, USA
  • 2014: RSNA Roentgen Resident/Fellow Research Award, USA
  • 2014: ASTRO Resident Digital Poster Discussion Award (Biology Category), San Francisco, USA
  • 2014: Clinical Case Contest Winner (Senior Author). Applied Radiation Oncology, September 2014
  • 2014: Selection for the NCI’s Experimental Therapeutics Clinical Trials Network Career Development Project Team Member (VX-970 Brain Metastases). Principal Investigator on a NCI-sponsored multi-institutional study (Protocol # 9952) titled: “Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of VX-970 When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Non-Small Cell Lung Cancer (NSCLC)”. CTEP “Approval on Hold” status, CIRB: Approval Pending Modification of Initial Review.
  • 2016: Research Abstract as Senior Author selected for 2016 Best of Astro
  • 2017: Mentor for Medical Student Awardee for 2017 Alpha Omega Alpha (AOA), Carolyn Kuckein Fellowship Competition
  • 2017: Moderator, News Briefing: Treatment Considerations for Focused Populations, 2017 Multidisciplinary Thoracic Cancers Symposium, San Francisco, 2017 Mar.
  • 2017: Moderator, Miscellaneous Proferred Papers, 2017 Annual Conference American Brachytherapy Society, Boston, 2017 Apr.
  • 2017: Senior Author on resident research manuscript selected for Radiation Oncology Institute (ROI) Excellence Award
  • 2017: Medical Student Research Day Mentor Recognition- Transformational Impact, University of Maryland School of Medicine
  • 2017: Guest editor for an upcoming focused issue on "Advances in Radiation Oncology for Thoracic Malignancies” in The Journal of Thoracic Disease, a quarterly published journal indexed in pubmed and distributed worldwide.

Grants and Contracts

Grants

--ACTIVE

2016-2017                   Department of Radiation Oncology Seed grant, University of Maryland, Baltimore, Peer Reviewed (Modiri), Total Amount: $12,000 (all direct costs, no salary support), Project Title: Non-uniform spatiotemporal fractionation for SAbR IMPT in central lung lesions, Role: Co-Investigator

2017-current                R01CA169102, Sawant (PI), NIH/NCI: $383,801, 0.36 CME, Project Title: Personalized Motion Management for truly 4D Lung Stereotactic Body Radiotherapy, Role: Co-Investigator

--COMPLETED

2013-2014                   Department of Radiation Oncology R&D Seed grant, University of Wisconsin, Peer Reviewed (Harari), collaborative interdepartmental project with Department of Pathology, Total amount: $8,725 (all direct costs, no salary support), Project Title: Assessment of Human Papillomavirus (HPV) Status in Archived Tissue from Oropharyngeal Cancer Biopsies, Role: Study Chair (Primary contributor)/ Co-Investigator  

2010-2013                   Department of Radiation Oncology R&D Seed grant, University of Wisconsin, Peer Reviewed, Total Amount: $15,885 (all direct costs, no salary support), Project Title (Bentzen): SEER-medicare database analysis, Role: Co-investigator   

2015-2016                   Department of Radiation Oncology Seed grant, University of Maryland, Baltimore, Peer Reviewed, Total Amount: $10,764 (all direct costs, no salary support), Project Title: Pediococcus–based Probiotics: A Murine Model to Assess Prevention and Mitigation of Radiation Induced Intestinal Toxicity (RiIT), Role: PI, Mentor for Radiation Oncology Resident (Lin)

 

IRB approved prospective clinical protocols

ACTIVE ROLE- INSTITUTIONAL:

2017-current                University of Maryland School of Medicine, Baltimore, MD, USA, Title: NRG LU001 Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC, Role: Institutional PI of this NRG-sponsored national study 

2017-current                University of Maryland School of Medicine, Baltimore, MD, USA, Title: NRG CC001 A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases, Role: Institutional PI of this NRG-sponsored national study 

2017-current                University of Maryland School of Medicine, Baltimore, MD, USA, Title: NRG CC003 Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer, Role: Institutional PI of this NRG-sponsored national study 

2018-current                University of Maryland School of Medicine, Baltimore, MD, USA, Title: NRG LU002 Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial, Role: Institutional PI of this NRG-sponsored national study, Study Champion-Alliance for Clinical Trials in Oncology

ACTIVE ROLE- NATIONAL:

2016-current                Experimental Therapeutics Clinical Trials Network (ETCTN), Title: # 9952 Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of VX-970 When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Non-Small Cell Lung Cancer (NSCLC), Role: National PI, Project Team Member- Career Development Award

2016-current                Experimental Therapeutics Clinical Trials Network (ETCTN), Title: # 9979 Phase 1 and Pharmacology Study of Oral 5-iodo-2-pyrimidinone-2-deoxyribose (IPdR) as a Prodrug for IUdR-Mediated Tumor Radiosensitization in Brain Metastases, Role: National PI

2017-current                Alliance for Clinical Trials in Oncology, Title: ALLIANCE A041501A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (A Conjugated Anti-Cd22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) with Newly Diagnosed Precursor B-Cell ALL, Role: Radiation Oncology Co-chair

2018-current                Alliance for Clinical Trials in Oncology, Title: NRG LU002 Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial, Role: Study Champion of this NRG-sponsored national study in which Alliance is also participating

 

Professional Activity

Academic Administrative Roles

Institutional

  • 2013-2014: Chief Resident, Dept. of Radiation Oncology, University of Wisconsin Hospital and Clinics
  • 2013-2014: Peer-nominated member, Resident Quality and Safety Council, University of Wisconsin Hospital and Clinics
  • 2016-Present: Director of Research Internships, Department of Radiation Oncology, University of Maryland School of Medicine
  • 2017-Present: Medical Student Elective Course Director, Department of Radiation Oncology, University of Maryland School of Medicine
  • 2018-Present: Lead, Scope of Practice, Policy and Procedure Management Workgroup of Quality and Safety Review Council, Dept. of Radiation Oncology
  • 2018: Course Co-Director, First Annual University of Maryland Mock Orals Course in Radiation Oncology

National/ International

  • 2013-2016: Appointed member, American Society for Radiation Oncology (ASTRO): Funding Advocacy and Clinical Trials Committee [FACT] [formerly NIH Clinical Trials Committee]
  • 2015-Present: Appointed member, ACR Radiation Oncology In-Training (TXITTM) Exam- Thoracic section (2015-Present), Lymphoma and Gynecology section (2016) and Section Chair Thoracic section (2017-Present)
  • 2016-Present: Appointed member, Alliance for Clinical Trials in Oncology-Symptom Intervention Committee (2016-Present), Radiation Oncology Committee (2016-Present), Leukemia Committee (2016-Present), Respiratory (2017-Present) and Cancer in the Older Adult Committee (2018-Present)
  • 2016-Present: Member, NCI Brain Metastases Working Group
  • 2016-Present: Appointed member, American Society for Radiation Oncology (ASTRO):Research Grants Evaluation Subcommittee and Workforce Subcommittee
  • 2017-Present: Nominated Member, Board of Directors, Alliance for Clinical Trials in Oncology
  • 2018-PResent: Appointed member, Advanced Radiation Technology Committee, International Association for the Study of Lung Cancer (IASLC)

Reviewer Roles

Institutional

  • 2014: Judge (poster presentation), Medical Student Research Day, Office of Student Research, Alpha Omega Alpha Honor Society, University of Maryland School of Medicine
  • 2014-present: Residency Interview Selection Committee, Radiation Oncology, University of Maryland School of Medicine, Baltimore
  • 2014: Radiation Oncology Faculty Candidate Interview, University of Maryland School of Medicine, Baltimore
  • 2014: Nephrology Faculty Candidate Interview, University of Maryland School of Medicine, Baltimore
  • 2015: Cancer Review Committee (CRC) member, University of Maryland Greenebaum Cancer Center, Baltimore
  • 2016: Dosimetry Student Interview Selection Committee, Radiation Oncology, University of Maryland School of Medicine, Baltimore
  • 2016: Technology Research Review Committee (TRRC), Radiation Oncology, University of Maryland School of Medicine, Baltimore
  • 2017-current: GCRC Advisory Committee (GAC) member, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore
  • 2017-current: Full member, Clinical Research Committee (CRC), University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore

National/ International

  • 2011-2014: Selected member and peer reviewer, Education Subcommittee, Association of Residents in Radiation Oncology (ARRO)
  • 2012-2014: Appointed member, Radiation Oncology panel, Education Exhibits Committee for RSNA Annual Meeting
  • 2013-Present: Invited honorary editorial board member, Journal of Brain and Spinal Cancer
  • 2013-Present: Journal reviewer, The Journal of Neurosciences in Rural Practice
  • 2014-Present: Journalreviewer, RadioGraphics
  • 2014-Present: Journalreviewer, International Journal of Radiation Oncology Biology Physics
  • 2015-Present: Journalreviewer, Lung Cancer
  • 2016: Dutch Cancer Society (KWF) and Dutch Technology Foundation (STW): Partnership Research Programme-Technology in Oncology Reviewer of Grant Proposal
  • 2016: Abstract Reviewer, 2017 Multidisciplinary Thoracic Cancers Symposium
  • 2017: Abstract Reviewer, 2017 Annual Meeting American Brachytherapy Society, Boston
  • 2017-Present: Ad Hoc Reviewer, Brachytherapy
  • 2017-PresentAd Hoc Reviewer, Clinical Lung Cancer
  • 2017-Present: Ad Hoc Reviewer, Advances in Radiation Oncology
  • 2018: Abstract Reviewer, 2018 ASTRO Annual Meeting Abstract Review- Biology Track