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Beth A. McNally, PhD

Academic Title:

Research Associate

Primary Appointment:

Physiology

Education and Training

Post-Doctoral Fellow UNIVERSITY OF MARYLAND, BALTIMORE, MD Nov. 2013−present
Performed structure-functions studies on the hERG potassium channel in the lab of Dr. Matthew Trudeau

Post-Doctoral Fellow NORTHWESTERN UNIVERSITY, CHICAGO, IL Aug. 2007−Aug. 2010
Performed structure-function studies on the Calcium Release Activated Calcium Channel (CRAC) in the lab of Dr. Murali Prakriya

Ph.D. Biochemistry UNIVERSITY OF NOTRE DAME, NOTRE DAME, IN Aug. 2002−Aug. 2007
Dissertation Title: “Use of Synthetic Transporters to Facilitate Anion Transport Across Vesicle and Cell Membranes”

Highlighted Publications

McNally, B.A., Somasundaram, A., Jairaman, A., Yamashita, M., Prakriya, M. The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels. J. Physiol. 2013. 591: 2833-2850.  PMCID: PMC3690689

McNally, B.A., Somasundaram, A., Yamashita, M., Prakriya, M. Gated regulation of CRAC channel ion selectivity by STIM1. Nature 2012. 482: 241-245.  PMCID: PMC3276717

McNally, B.A., Yamashita, M., Engh, A., Prakriya, M. Structural determinants of ion permeation in CRAC channels. Proc. Natl. Acad. Sci. U S A 2009. 106: 22516-22521.  PMCID: PMC2792162

Research Interests

My projects work toward uncovering the mechanisms of gating and regulation of voltage- and calcium-activated potassium channels in the KCa1.1 family in heterologous and native cells, and the mechanisms underlying cardiovascular, muscle, and neurological dysfunction associated with these channels.