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Monica A. McArthur, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Pediatrics

Location:

HSF1, 480

Phone (Primary):

410-706-5328

Education and Training

Texas A&M University (magna cum laude), B.S., Molecular Biology and Microbiology, 1999

The University of Texas Medical Branch, M.D./Ph.D, 2006

Residency, The University of Texas Medical Branch, 2006-2009

Clinical Fellow, University of Maryland School of Medicine, Pediatric Infectious Diseases and Tropical Pediatrics, 2009-2012

Postdoctoral Fellow, University of Maryland School of Medicine Center for Vaccine Development (CVD), Pediatrics, 2012-2013

Biosketch

Dr. McArthur's research interests include the interactions between pathogens and the human immune system. She is particularly interested in T cell responses against infectious agents affecting children in the developing world.

Currently, Dr. McArthur is leading the Zika vaccine clinical trial at the University of Maryland CVD.

Research/Clinical Keywords

Pathogens, cellular immunology, T cell response, infectious diseases, vaccine development, Zika, flavivirus.

Highlighted Publications

McArthur MA. Zika virus: Recent advances towards the development of vaccines and therapeuticsViruses. 2017 Jun 13;9(6):143.

McArthur MA, Chen WH, Levine MM, Sztein MB. Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-type Enterotoxigenic Escherichia coli in Humans. PLoS Negl Trop Dis. 2017 Jan 19;11(1):e0005291.

McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB. Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model. PLoS Pathog. 2015 May 22;11(5)e1004914.

McArthur MA and MB Sztein. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013 Feb;146(2):140-152.

McArthur MA and MB Sztein. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS One. 2012 Jun 7(6):e38408.

Additional Publication Citations

Fresnay S, McArthur MA, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB. Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. J Transl Med. 2016 Mar 1;14(1):62.

Sztein MB, Salerno-Goncalves R, McArthur MA. Complex adaptive immunity to enteric fevers in humans: Lessons learned and the path forward. Front Immunol. 2014 Oct 27;5:516.

McArthur MA, Sztein MB, Edelman RE. Dengue vaccines: recent developments, ongoing challenges, and current candidates. Expert Rev Vaccines. 2013 Aug;12(8):933-53.

Eloe-Fadrash EA, McArthur MA, Seekatz AM, Drabek EF, Rasko DA, Sztein MB, Fraser CM. Impact of oral typhoid vaccination on the human gut microbiota and correlations with S. Typhi-specific immunological responses. PLoS One. 2013 Apr 24;8(4):e62026.

Research Interests

Dr. McArthur's research interests include cellular immunology, emerging and re-emerging infectious diseases, and vaccine development.

Clinical Specialty Details

Pediatrics and Pediatric Infectious Diseases

Awards and Affiliations

2012: Fellow Research Award, University of Maryland Department of Pediatrics

2009-2011: National Institutes of Health (NIH) T32 Vaccinology Fellowship

Grants and Contracts

Monica McArthur, M.D., Ph.D. (PI)
5/15/2016-5/14/2017
EMMES Corporation
A Phase I/Ib, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of A Zika virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults

Monica McArthur, M.D., Ph.D. (PI)
1/1/2016-12/31/2019
Robert Wood Johnson Foundation Harold Amos Faculty Development Program (AMFDP)  
Role of pathogen-specific T cells in protection from Vibrio cholerae infections in humans

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