55 Wade Avenue, Baltimore, MD 21228
Education and Training
Sun Yat-Sen University of Medical Sciences, Guangzhou, China
University of North Carolina, Chapel Hill
University of Maryland School of Medicine General Psychiatry Residency
Director, University of Maryland Center for Brain Imaging Research
Director, First Episode Psychosis Clinic, Maryland Psychiatric Research Center
Chief, Neuroimaging Research Program, Maryland Psychiatric Research Center
Professor, Tenured, Department of Psychiatry, University of Maryland School of Medicine
Associate Editor, Schizophrenia Bulletin
Scientific Council Member, Brain and Behavior Research Foundation
Fellow, American College of Neuropsychopharmacology
NARSAD Distinguished Investigator Award
American Board of Psychiatry and Neurology Certificate
State of Maryland, Sate of Pennsylvania Medical Licenses
My research focuses on using neuroimaging, genetics, clinical trials, brain stimulation, and neurophysiological methods to study etiology of and treatment for severe mental illness and addiction.
Contribution to Science (selected peer-reviewed publications from a total of 150)
1. Investigation on roles of brain circuitry contributing to the high rate of smoking in schizophrenia.
Hong LE, Thaker GK, McMahon RP, Summerfelt A, RachBeisel J, Fuller RL, Wonodi I, Buchanan RW, Myers C, Heishman SJ, Yang X, Nye A. Moderate dose varenicline treatment on neurobiological and cognitive biomarkers in schizophrenia smokers and non-smokers. Arch Gen Psychiatry. 2011 Dec;68(12):1195-206.
Hong LE, Hodgkinson CA, Yang Y, Sampath H, Ross TJ, Buchholz B, Salmeron BJ, Thaker GK, Srivastava V, Goldman D, Stein EA. A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13509-14.
Hong LE, Gu, H, Yang YH, Ross TJ, Salmeron BJ, Buchholz B, Thaker GK, Stein EA. Nicotine addiction and Nicotine’s actions are associated with separate cingulate cortex functional circuits. Arch Gen Psychiatry. 2009 Apr;66(4):431-41.
2. Development and refinement of key endophenotypes using state-of-the-art electrophysiology and neurophysiology methods and concepts.
Hong LE, Mitchell BD, Avila MT, McMahon RP, Adami H, Thaker GK. Familial aggregation of eye tracking endophenotypes in schizophrenia families. Arch Gen Psychiatry. 2006 Mar;63(3):259-64.
Hong LE, Summerfelt A, Wonodi I, Adami H, Buchanan RW, Thaker GK. Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval. Am J Psychiatry. 2007;164(1):61-5.
Hong LE, Summerfelt A, Mitchell BD, McMahon RP, Wonodi I, Buchanan RW, Thaker GK. Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate. Arch Gen Psychiatry. 2008 Sep;65(9):1008-16.
Chiappelli J, Pocivavsek A, Nugent KL, Notarangelo FM, Kochunov P, Rowland LM, Schwarcz R, Hong LE. Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. JAMA Psychiatry. 2014 Jul 1;71(7):761-8.
3. Multimodal imaging approach to understand the chemical, functional, and diffusion dysfunctions in the brain of schizophrenia patients.
Rowland LM, Krause BW, Wijtenburg SA, McMahon RP, Chiappelli J, Nugent KL, Nisonger SJ, Korenic SA, Kochunov P, Hong LE. Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study. Mol Psychiatry. 2016 Feb;21(2):198-204
Rowland LM, Summerfelt A, Wijtenburg SA, Du X, Chiappelli JJ, Krishna N, West J, Muellerklein F, Kochunov P, Hong LE. Frontal glutamate and γ-aminobutyric acid levels and their associations with mismatch negativity and digit sequencing task performance in schizophrenia. JAMA Psychiatry. 2016 Feb;73(2):166-74
Kochunov P, Rowland LM, Fieremans E, Veraart J, Jahanshad N, Eskandar G, Du X, Muellerklein F, Savransky A, Shukla D, Sampath H, Thompson PM, Hong LE. Diffusion weighted imaging uncovers likely sources of processing speed deficits in schizophrenia. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13504-13509
Kochunov P, Coyle TR, Rowland LM, Jahanshad N,Thompson PM, Kelly S, Du X, Sampath H, Bruce H, Chiappelli J, Ryan M, FissehaF, Savransky A, Adhikari B, Chen S, Paciga SA, Whelan CD, Xie Z, Hyde CL, ChenX, Schubert CR, O'Donnell P, Hong LE. White matter and core cognitive deficits in schizophrenia. JAMA Psychiatry. 2017 Sep 1;74(9):958-966
4. TMS based brain stimulations to identify electrophysiology - TMS interactions, and TMS-elicited biomarker development in schizophrenia.
Du X, Kochunov P, Summerfelt A, Chiappelli J, Choa FS, Hong LE. The role of white matter microstructure in inhibitory deficits in patients with schizophrenia. Brain Stimulation 2017 Mar - Apr;10(2):283-290
Du X, Rowland LM, Summerfelt A, Wijtenburg A, Chiappelli J, Wisner K, Kochunov P, Choa FS, Hong LE. TMS evoked N100 reflects local GABA and glutamate balance. Brain Stimulation 2018 May 4. pii: S1935-861X(18)30149-9.
Du X, Rowland LM, Summerfelt A, Choa FS, Wittenberg GF, Wisner K, Wijtenberg SA, Chiappelli J, Kochunov P, Hong LE. Cerebellar-Stimulation Evoked Prefrontal Electrical Synchrony Is Modulated by GABA. Cerebellum. Cerebellum. 2018 May 15. doi: 10.1007/s12311-018-0945-2
Du X, Choa FS, Chiappelli J, Wisner KM, Wittenberg G, Adhikari B, Bruce H, Rowland LM, Kochunov P, Hong LE. Aberrant middle prefrontal-motor cortex connectivity mediates motor inhibitory biomarker in schizophrenia. Bio Psychiatry June 2018 DOI: 10.1016/j.biopsych.2018.06.007
Hong LE, Choa FS. Methods and systems for controlling magnetic fields and magnetic field induced current. PCT/US15/24054, PCT/US16/40019 (TMS related patents)
Active Grant Support (Updated August 2018)
9/10/2015 to 6/30/2020 (PI)
“Amish Connectome Project on Mental Illness”
01/01/2017 to 1/31/2022 (PI)
"The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia Spectrum"
08/1/2018 to 7/30/2023 (PI)
“Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum”
5/1/2014 to 4/30/2019 (Project 3 PI)
"Project 3: Brain biomarker and clinical implication of kynurenine pathway dysfunction"
NIMH P50 MH103222 (Silvio O. Conte Centers; Overall PI: R. Schwarcz)
7/1/2017 to 12/30/2019 (PI)
Distinguished Investigator Award
"Active Electrical-Glutamatergic Interaction Mapping"
Brain & Behavior Research Foundation, NY
7/1/2018 to 6/30/2021 (PI)
“Takeda - UMB Multi-Stage Clinical Biomarker Evaluations”
Takeda Pharmaceuticals, Inc
8/1/2012 to 8/24/2020 (co-I; PI: P. Kochunov)
“Solar-eclipse Computational Tools for Imaging Genetics”
NIBIB R01 EB015611
2013 to current (co-I; PI: R. Buchanan)
"Maryland Early Intervention Program"
State of Maryland DHMH annual research contract
1/1/2017 to 12/30/2021 (Primary Mentor; PI: J. Chiappelli)
"Biomarkers and Mechanisms of Stress Pathophysiology in Early Schizophrenia"
6/1/2018 to 5/30/2019 (Primary Mentor; PI: J. Chiappelli)
Kempt Fund Award
"A Translational Model of Anticipatory Anxiety to Study Neurobiological Basis of Paranoia Formation in Schizophrenia"
American Psychiatric Association, DC
7/1/2018 to 6/30/2020 (Co-PI; PI: S. Ament)
Dean’s Challenge Award to Accelerate Innovation and Discovery in Medicine (ACCEL-Med)
“Convergent Neuroscience of Processing Speed Deficits in Severe Mental Ilness”
University of Maryland School of Medicine