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Britta Hahn, PhD

Academic Title:

Associate Professor

Primary Appointment:

Psychiatry

Location:

MPRC, Catonsville Campus

Phone (Primary):

(410) 402-6112

Fax:

(410) 402-7198

Education and Training

Diploma, Psychology, Hamburg University, Germany

M.Sc., Neuroscience, Institute of Psychiatry, King’s College London, UK

Ph.D., Behavioral Pharmacology, Institute of Psychiatry, King’s College London, UK

Biosketch

My lab investigates the neural correlates of cognition with particular emphasis on attentional functions, their impairment in people with schizophrenia, and their pharmacological modulation. Of particular interest is the cognitive-enhancing potential of nicotinic compounds, which may possess therapeutic utility in the context of disorders such as schizophrenia and Alzheimer's disease. My research aims at pinpointing the neuroanatomical and pharmacological mechanisms responsible for these effects, finding ways to improve their effect size, and exploiting them to enhance the benefits of cognitive training interventions. We also study mechanisms of nicotine dependence in smokers, including smokers with a diagnosis of schizophrenia. Our work employs behavioral pharmacology, functional Magnetic Resonance Imaging, computerized cognitive task paradigms, and preclinical models of cognition.

Research/Clinical Keywords

cognition, attention, nicotine, nicotinic, schizophrenia, dependence, fMRI, rat

Highlighted Publications

Hahn B, Stolerman IP (2005) Modulation of Nicotine-Induced Attentional Enhance­ment in Rats by Adrenoceptor Antagonists. Psychopharmacology 177: 438-447.

Hahn B, Ross TJ, Yang Y, Kim I, Huestis MA, Stein EA (2007) Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network. Journal of Neuroscience 27: 3477-3489.

Hahn B, Robinson BM, Kaiser ST, Harvey AN, Beck VM, Leonard CJ, Kappenman ES, Luck SJ, Gold JM (2010) Failure of Schizophrenia Patients to Overcome Salient Distractors During Working Memory Encoding. Biological Psychiatry 68: 603-9.

Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Holcomb HH, Gold JM (2013) A Test of the Cognitive Self-Medication Hypothesis of Tobacco Smoking in Schizophrenia. Biological Psychiatry 74: 436–443.

Hahn B, Harvey AN, Gold JM, Fischer BA, Keller WR, Ross TJ, Stein EA (2016) Hyperdeactivation of the Default Mode Network in People with Schizophrenia When Focusing Attention in Space. Schizophrenia Bulletin 42: 1158-66.

Additional Publication Citations

1. Stolerman IP, Mirza NR, Hahn B, Shoaib M (2000) Nicotine in an Animal Model of Attention. European Journal of Pharmacology 393: 147-154.

2.     Hahn B, Stolerman IP, Shoaib M (2000) Kappa-Opioid Receptor Modulation of Nicotine-Induced Behaviour. Neuropharmacology 39: 2848-2855.

3.     Keaney F, Strang J, Gossop M, Marshall EJ, Farrell M, Welch S, Hahn B, Gonzalez A (2001) A Double-Blind Randomized Placebo-Controlled Trial of Lofexidine in Alcohol Withdrawal: Lofexidine is Not a Useful Adjunct to Chlordiazepoxide. Alcohol and Alcoholism 36: 426-430.

4.     Stolerman IP, Childs E, Hahn B, Morley A (2002) Drug trace discrimination with nicotine and morphine in rats. Behavioural Pharmacology 13: 49-58.

5.     Hahn B, Shoaib M, Stolerman IP (2002) Nicotine-Induced Enhancement of Attention in the Five-Choice Serial Reaction Time Task: The Influence of Task-Demands. Psychopharmacology 162: 129-137.

6.     Hahn B, Stolerman IP (2002) Nicotine-Induced Attentional Enhancement in Rats: Effects of Chronic Exposure to Nicotine. Neuropsychopharmacology 27: 712-722.

7.     Hahn B, Shoaib M, Stolerman IP (2002) Effects of Dopamine Receptor Antagonists on Nicotine-Induced Attentional Enhancement. Behavioural Pharmacology 13: 621-632.

8.     Hahn B, Sharples CGV, Wonnacott S, Shoaib M, Stolerman IP (2003) Attentional Effects of Nicotinic Agonists in Rats. Neuropharmacology 44: 1054-1067.

9.     Hahn B, Shoaib M, Stolerman IP (2003) Involvement of the Prefrontal Cortex but Not the Dorsal Hippocampus in the Attention-Enhancing Effects of Nicotine in Rats. Psychopharmacology 168: 271-279.

10.  Hahn B, Stolerman IP (2005) Modulation of Nicotine-Induced Attentional Enhance­ment in Rats by Adrenoceptor Antagonists. Psychopharmacology 177: 438-447.

11.  Hahn B, Ross TJ, Stein EA (2006) Neuroanatomical Dissociation Between Bottom-up and Top-Down Processes of Visuospatial Selective Attention. Neuroimage 32: 842-853.

12.  Hahn B, Ross TJ, Yang Y, Kim I, Huestis MA, Stein EA (2007) Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network. Journal of Neuroscience 27: 3477-3489.

13.  Hahn B, Ross TJ, Stein EA (2007) Cingulate Activation Increases Dynamically with Response Speed under Stimulus Unpredictability. Cerebral Cortex 17: 1664-1671.

14.  Hahn B, Wolkenberg FA, Ross TJ, Myers CS, HeishmanSJ, SteinDJ, KurupP, Stein EA (2008) Divided Versus Selective Attention: Evidence for Common Processing Mechanisms. Brain Research 1215: 137-146.

15.  Panlilio L, Mazolla C, Drago F, Medalie J, Hahn B, Justinova Z, Cadet J, Yasar S, Goldberg S (2009) Anandamide Induces Behavioral Disruption in an Attention Task in Rats Through a Vanilloid-Dependent Mechanism. Psychopharmacology 203: 529-538.

16.  Hahn B, Ross TJ, Wolkenberg FA, Shakleya DM, Huestis MA, Stein EA (2009) Common and Selective Effects of Nicotine During Stimulus Detection, Selective and Divided Attention: an fMRI Study. Cerebral Cortex 19: 1990-2000.

17.  Gold JM, Hahn B, Strauss GP, Waltz JA (2009) Turning It Upside Down: Areas of Preserved Cognitive Function in Schizophrenia. Neuropsychology Review19: 294-311.

18.  Hahn B, Robinson BM, Kaiser ST, Harvey AN, Beck VM, Leonard CJ, Kappenman ES, Luck SJ, Gold JM (2010) Failure of Schizophrenia Patients to Overcome Salient Distractors During Working Memory Encoding. Biological Psychiatry 68: 603-9.

19.  Gold JM, Hahn B, Zhang W, Robinson BM, Kappenman ES, Beck VM, Luck SJ (2010) Reduced Capacity but Spared Precision and Maintenance of Working Memory Representations in Schizophrenia. Archives of General Psychiatry67: 570-7.

20.  Hahn B, Shoaib M, Stolerman IP (2011) Selective Nicotinic Receptor Antagonists: Effects on Attention and Nicotine-Induced Attentional Enhancement. Psychopharmacology 217: 75-82.

21.  Hahn B, Kappenman ES, Robinson BM, Fuller RL, Luck SJ, Gold JM (2011)Iconic Decay in Schizophrenia. Schizophrenia Bulletin 37: 950-957.

22.  Hahn B, Robinson BM, Harvey AN, Kaiser ST, Leonard CJ, Luck SJ, Gold JM (2012) Visuospatial Attention in Schizophrenia: Deficits in Broad Monitoring. Journal of Abnormal Psychology 12: 119-28.

23.  Kappenman ES, Kaiser ST, Robinson BM, Morris SE­, Hahn B, Beck VM, Leonard CJ, Gold JM, Luck SJ (2012) Response Activation Impairments in Schizophrenia: Evidence from the Lateralized Readiness Potential. Psychophysiology 49: 73-84.

24.  Hahn B, Hollingworth A, Robinson BM, Kaiser ST, Leonard CJ, Beck VM, KappenmanES, Luck SJ, Gold JM (2012) Control of Working Memory Content in Schizophrenia. Schizophrenia Research 134: 70-75.

25.  Hahn B, Robinson BM, Kaiser ST, Matveeva TM, Harvey AN, Luck SJ, Gold JM (2012) Kraepelin and Bleuler Had It Right: People With Schizophrenia Have Deficits Sustaining Attention Over Time. Journal of Abnormal Psychology 121: 641-648.

26.  Hahn B, Gold JM, Buchanan RW (2013) The Potential of Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia. Neuropharmacology 64:185-90.

27.  Johnson M, McMahon RP, Robinson BM, Harvey AN, Hahn B, Leonard CJ, Luck SJ, Gold JM (2013) The Relationship Between Working Memory Capacity and Broad Measures of Cognitive Ability in Healthy Adults and People with Schizophrenia. Neuropsychology 27: 220-229.

28.  Leonard CJ, Kaiser ST, Robinson BM, Kappenman ES, Hahn B, Gold JM, Luck SJ (2013) Toward the Neural Mechanisms of Reduced Working Memory Capacity in Schizophrenia. Cerebral Cortex 23: 1582-1592.

29.  Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Holcomb HH, Gold JM (2013) A Test of the Cognitive Self-Medication Hypothesis of Tobacco Smoking in Schizophrenia. Biological Psychiatry 74: 436–443.

30.  Leonard CJ, Robinson BM, Kaiser ST, Hahn B, McClenon C, Harvey AN, Luck SJ, Gold JM (2013) Testing Sensory and Cognitive Explanations of the Antisaccade Deficit in Schizophrenia. Journal of Abnormal Psychology122: 1111-20.

31.  Leonard CJ, Robinson BM, Hahn B, Gold JM, Luck SJ (2014) Enhanced Distraction by Magnocellular Salience Signals in Schizophrenia. Neuropsychologia 56: 359-66.

32.  Gray BE, Hahn B, Robinson BM, Harvey AN, Leonard CJ, Luck SJ, Gold JM (2014) Relationships Between Divided Attention and Working Memory Impairment in People with Schizophrenia. Schizophrenia Bulletin 40: 1462-1471.

33.  Luck SJ, McClenon C, Beck VM, Hollingworth A, Leonard CJ, Hahn B, Robinson BM, Gold JM (2014) Hyperfocusing in Schizophrenia: Evidence from Interactions Between Working Memory and Eye Movements. Journal of Abnormal Psychology 123: 783-95.

34.  Erickson MA, Hahn B, Leonard CJ, Robinson BM, Luck SJ, Gold JM (2014) Enhanced Vulnerability to Distraction Does Not Account for Working Memory Capacity Reduction in People with Schizophrenia. Schizophrenia Research: Cognition 1: 149-154.

35.  Erickson, MA, Hahn B, Leonard CJ, Robinson BM, Gray BE, Luck SJ, Gold JM (2015) Impaired Working Memory Capacity Is Not Caused by Failures of Selective Attention in Schizophrenia. Schizophrenia Bulletin 41: 366-373.

36.  Hahn B, Riegger KE, Elmer GI (2016) Strain Dependency of the Effects of Nicotine and Mecamylamine in a Rat Model of Attention. Psychopharmacology 233: 1427-1434.

37.  Hahn B, Harvey AN, Gold JM, Fischer BA, Keller WR, Ross TJ, Stein EA (2016) Hyperdeactivation of the Default Mode Network in People with Schizophrenia When Focusing Attention in Space. Schizophrenia Bulletin 42: 1158-66.

38.  Sawaki R, Kreither J, LeonardCJ, Kaiser ST, Hahn B, Gold JM, Luck SJ (in press) Hyperfocusing of Attention on Goal-Related Information in Schizophrenia: Evidence from Electrophysiology. Journal of Abnormal Psychology

39.  Yuille MB, Olmstead CK, Wells AK, Hahn B (in press) A Test of the Cognitive-Enhancing Potential of Low-Dose Mecamylamine in Healthy Non-Smokers. Psychopharmacology1.     Hahn B, Wolkenberg FA, Ross TJ, Myers CS, HeishmanSJ, SteinDJ, KurupP, Stein EA (2008) Divided Versus Selective Attention: Evidence for Common Processing Mechanisms. Brain Research 1215: 137-146.