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Joseph S. Friedberg, MD

Charles Reid Edwards, MD Professor in Surgery and Division Head

Academic Title:

Professor

Primary Appointment:

Surgery

Additional Title:

Head, Division of Thoracic Surgery

Location:

Baltimore, MD

Phone (Primary):

410-328-6366

Fax:

410-328-0693

Education and Training

1977 – 1981                        BASc     University of Pennsylvania College of Engineering and Applied Science, summa cum laude (4.0 GPA)

1981 – 1986                        MD        Harvard Medical School, cum laude

1984 – 1985                        Greenebaum Research Fellow (Dr. Judah Folkman, project supervisor), Harvard Medical School, Boston, MA

1986 – 1987                        Surgical Internship, Massachusetts General Hospital, Boston, MA

1987 – 1988                        Resident in Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA

1988 – 1989                        Resident in General Surgery, Massachusetts General Hospital, Boston, MA

1989 – 1991                        Claude Welch Research Fellow, Massachusetts General Hospital, Boston, MA

1991 – 1994                        Resident in General Surgery, Massachusetts General Hospital, Boston, MA

1994 – 1996                        Fellowship in Cardiothoracic Surgery, Brigham and Women’s Hospital (Thoracic Track), Boston, MA

Biosketch

Dr. Joseph Friedberg is the Charles Reid Edwards Professor of Surgery and head of the Division of Thoracic Surgery at the University of Maryland School of Medicine.  Dr. Friedberg received his bachelor’s degree from the University of Pennsylvania College of Engineering and Applied Science and received his M.D. from Harvard Medical School.  He completed a post-doctoral fellowship at Harvard, residencies at Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary, and a fellowship in cardiothoracic surgery at Brigham and Women’s Hospital.  Dr. Friedberg came to the University of Maryland from Penn Presbyterian Medical Center (part of the University of Pennsylvania Health System), where he as Chief of Thoracic Surgery, co-director of the Penn Mesothelioma and Pleural Disease Program and an associate professor of thoracic surgery at the University of Pennsylvania’s Perelman School of Medicine.  Dr. Friedberg was recognized by Best Doctors of America for 2009-10 and 2011-12.

Dr. Friedberg’s translational research his focused on developing new, more effective therapies for various types of lung cancer, including mesothelioma.  Specifically, he is developing a photodynamic therapy (PDT) – generated autologous tumor vaccine that could be used as a postoperative adjuvant or a primary.  PDT involves the use of photosensitizing drug which interacts with a specific type of light to kill cancer cells.

Other areas of Dr. Friedberg’s research include the development of an entirely new type of cancer treatment “photobrachytherapy” that utilizes a combination of radioisotopes, photosensitizers, rare earth nanophosphors, bioabsorbable plasmonic nanovesicles and immunotherapy. 

Clinically, Dr. Friedberg is exploring the development of a system for sealing pulmonary air leaks with an inhaled sealant, the development of a new type of surgical drain, an improved method for airway intubation and a device for minimally invasive control of major blood vessels.

Dr. Friedberg is a member of numerous prestigious medical societies, including the American Association of Thoracic Surgeons, the American College of Chest Physicians and the American Society of Clinical Oncology.   

His Interests include Pleural Mesothelioma, Pleural Malignancies and Disorders, Complex Lung cancer, Chest Wall Tumors, Pulmonary Metastasis, Malignant Pleural effusions, Diaphragm Disorders, Pneumothorax

Highlighted Publications

  1. Friedberg JS, Ryan DP, Driscoll SO, Folkman J. Human small bowel transplants into athymic mice and rats. Surgical Forum 36:375-378, 1985.
  2. Winter HS, Black PR, Bhan AK, Quereshi S, Friedberg JS, Ryan DP, Folkman J:  A model to study development of immune function in the human small intestine.  Advances in Experimental Medicine & Biology 216B:1377-1381, 1987.
  3. Friedberg JS, Tompkins RG, Rakestraw SL, Warren S, Fischmann A, Yarmush ML.  Antibody targeted proteolysis: Bactericidal effects of Sn(IV) chlorine e6-dextran-monoclonal antibody conjugates.  Annals of the New York Academy of Sciences 618:383-393, 1991.
  4. Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA:  Circulating interleukin-1b and tumor necrosis factor-a following burn injury in humans.  Critical Care Medicine 20(10):1414-1419, Oct. 1992.
  5. Dunn JC, Friedberg JS, Tompkins RG, Yarmush ML:  Hepatocytes from rat liver perfusions: Physiochemical effects on polyribosome size.  ASAIO Journal 38(4):841-845, Oct.-Dec. 1992.
  6. Stevens EJ, Ryan CM, Friedberg JS, Barnhill RL, Yarmush ML, Tompkins RG:  A quantitative model of invasive Pseudomonas infection in burn injury.  Journal of Burn Care & Rehabilitation 15(3):232-235, May/June 1994.
  7. Kaiser LR, Friedberg JS:  Adjuvant therapy of lung cancer: Introduction.  Seminars in Thoracic & Cardiovascular Surgery 9(1):55, Jan 1997.
  8. Friedberg JS, Kaiser LR:  Epidemiology of lung cancer.  Seminars in Thoracic & Cardiovascular Surgery 9(1):56-59, Jan 1997.
  9. Miller WT Jr, Tino G, Friedberg JS:  Thoracic CT in the intensive care unit: Assessment of clinical utility.  Seminars in Roentgenology 32(2):117-121, 1997.
  10. Kaiser LR.  Friedberg JS. The role of surgery in the multimodality management of non-small cell lung cancer. Seminars in Thoracic & Cardiovascular Surgery 9(1):60-79, Jan 1997.
  11. Machtay M.  Friedberg JS. The role of radiation therapy in the management of non-small cell lung cancer. [Review] Seminars in Thoracic & Cardiovascular Surgery 9(1):80-89, Jan 1997.
  12. Lennon PF, Hartigan PM, Friedberg JS:  Clinical management of patients undergoing concurrent cardiac surgery and pulmonary resection. Journal of Cardiovascular & Vascular Anesthesia 12(5):587-590, Oct. 1998.
  13. Roberts JR, Bavaria JE, Wahl P, Wurster A, Friedberg JS, Kaiser LR:  Comparison of open and thoracoscopic bilateral volume reduction surgery: Complications analysis.  Annals of Thoracic Surgery 66(5):1759-1765, Nov. 1998.
  14. Miller WT Jr, Tino G, Friedberg JS:  Thoracic CT in the intensive care unit: Assessment of clinical usefulness.  Radiology 209(2):491-498, Nov. 1998.
  15. Lee JH, Machtay M, Kaiser LR, Friedberg JS, Hahn SM, McKenna WG:  Non-small cell lung cancer: Prognostic factors in patients treated with surgery and postoperative radiation therapy.  Radiology 213(3):845-852, Dec. 1999.
  16. Shrager JB, Friedberg JS, Kaiser LR:  Lung volume reduction surgery.  Seminars in Respiratory & Critical Care Medicine 20(5):453-462, 1999.
  17. Friedberg JS:  Clinical presentation of stage IIIA (N2) non-small cell lung cancer:  Role of multimodality therapy. Chest 116(6 Suppl):497S-499S, Dec. 1999.
  18. Shrager JB, Lambright ES, McGrath CM, Wahl PM, Deeb ME, Friedberg JS, Kaiser LR:  Lobectomy with tangential pulmonary artery resection without regard to pulmonary function.  Annals of Thoracic Surgery 70(1):234-239, July 2000.
  19. Greelish JP, Friedberg JS. Secondary pulmonary malignancy. Surgical Clinics of North America 80(2):633-657, Apr. 2000. nb
  20. Hahn SM.  Smith RP.  Friedberg JS. Photodynamic therapy for mesothelioma. Current Treatment Options in Oncology.  2(5):375-83, Oct. 2001.
  21. Metz JM.  Friedberg JS. Endobronchial photodynamic therapy for the treatment of lung cancer. Chest Surgery Clinics of North America 11(4):829-39, Nov 2001.
  22. Yu GH, Soma L, Hahn S, Friedberg JS:  Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining. Diagnostic Cytopathology 24(5):322-327, May 2001.
  23. Wain JC, Kaiser LR, Johnstone DW, Yang SC, Wright CD, Friedberg JS, Feins RH, Heitmiller RF, Mathisen DJ, Selwyn MR:  Trial of a novel synthetic sealant in preventing air leaks after lung resection.  Annals of Thoracic Surgery 71(5):1623-1629, May 2001.
  24. Friedberg JS, Skema C, Baum ED, Burdick J, Vinogradov SA, Wilson DF, Horan AD, Nachamkin I:  In vitro effects of photodynamic therapy on Aspergillus fumigatus.  Journal of Antimicrobial Chemotherapy 48(1):105-107, July 2001.
  25. Shrager JB, Kozyak BW, Roberts JR, Bavaria JE, Friedberg JS, Kaiser LR, Rosengard BR:  Successful experience with simultaneous lung volume reduction and cardiac procedures.  Journal of Thoracic & Cardiovascular Surgery 122(1):196-197, July 2001.
  26. Sanfilippo NJ, Hsi A, DeNittis AS, Ginsberg GG, Kochman ML, Friedberg JS, Hahn SM: Toxicity of photodynamic therapy after combined external beam radiotherapy and intra-luminal brachytherapy for carcinoma of the upper aerodigestive tract. Lasers in Surgery & Medicine 28(3):278-281, 2001.
  27. Marshall MB, Deeb ME, Bleier JI, Kucharczuk JC, Friedberg JS, Kaiser LR, Shrager JB: Suction vs water seal after pulmonary resection: a randomized prospective study.  Chest 121(3):831-835, Mar 2002.
  28. Robnett TJ, Machtay M, Hahn SM, Shrager JB, Friedberg JS, Kaiser LR:  Pathological response to preoperative chemoradiation worsens with anemia in non-small cell lung cancer patients.  Cancer Journal 8(3):263-267, May/June 2002.
  29. Friedberg JS, Mick R, Stevenson J, Metz J, Zhu T, Buyske J, Sterman DH, Pass HI, Glatstein E, Hahn SM:  A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma.   Annals of Thoracic Surgery 75(3):952-959, Mar 2003.
  30. Yom SS, Busch TM, Friedberg JS, Wileyto EP, Smith D, Glatstein E, Hahn SM: Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy.  Photochemistry & Photobiology 78(1):75-81, July 2003.
  31. Singhal S, Wiewrodt R, Malden LD, Amin KM, Matzie K, Friedberg JS, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM:  Gene expression profiling of malignant mesothelioma.  Clinical Cancer Research 9(8):3080-3097, Aug. 1, 2003.
  32. Friedberg JS, Skema C, Burdick J, Yodh AG, Carr SR, Culver JP:  A novel technique for light delivery through branched or bent anatomic structures.  Journal of Thoracic & Cardiovascular Surgery 126(6):1963-1967, Dec 2003.
  33. Sterman DH.  Sztejman E.  Rodriguez E.  Friedberg JS. Diagnosis and staging of "other bronchial tumors". [Review] Chest Surgery Clinics of North America 13(1):79-94, Feb 2003.
  34. Rodriguez E, Baas P, Friedberg JS. Innovative therapies: photodynamic therapy. [Review]Thoracic Surgery Clinics 14(4):557-566, Nov 2004.
  35. Friedberg JS, Mick R, Stevenson JP, Zhu T, Busch TM, Shin D, Smith D, Culligan M, Dimofte A, Glatstein E, Hahn SM:  Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread.  Journal of Clinical Oncology 22(11):2192-2201, June 2004.
  36. O’Brien P, Kucharczuk J, Kaiser LR, Friedberg JS, Shrager J:  Comparative study of subxiphoid versus video-thoracoscopic pericardial “window.” Annals of Thoracic Surgery 80(6):2013-2019, Dec 2005.
  37. Carr SR, Cantor JP, Rao AS, Lakshman TV, Collins JE, Friedberg JS: Peritoneal perfusion with oxygenated perfluorocarbon augments systemic oxygenation. Chest 130: 402-411, Aug 2006.
  38. Berry MF, Friedberg JS.  Chest wall and diaphragmatic complications. Thoracic Surgery Clinics 16(3):277-285, Aug 2006.
  39. Cantor JP, Iliopoulos D, Rao A, Druck T, Semba S, McCorkell KA, Laksman T, Collins J, Washsberger P, Friedberg JS, Hubner K:  Epigentic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorgenicity. International Journal of Cancer 120(1):24-31, Jan. 2007.
  40. Shan J, Chen J, Meng J, Collins J, Soboyejo W, Friedberg JS, Ju Y:  Biofunctionalization, cytotoxicity, and cell uptake of lanthanide doped hydrophobically ligated NaYF4 upconversion nanophosphors," Journal of Applied Physics 104, 094308, Nov. 2008 (Epub).
  41. Krug LM, Pass H, Rusch V, Kindler H, Sugarbaker DJ, Rosenzweig K, Flores R, Friedberg JS, Pisters K, Monberg M, Obasaju C, Vogelzang N:  Multicenter phase II trial of neoadjuvant pemetrexed plus cisplatin followed by extrapleural pneumonectomy and radiation for malignant pleural mesothelioma.  Journal of Clinical Oncology 27(18):3007-3013, June 2009.
  42. Friedberg JS.  Photodynamic therapy as an innovative treatment for malignant pleural mesothelioma, Seminars in Thoracic & Cardiovascular Surgery 21(2):177-187, Summer 2009.
  43. Hill-Kyser C, Avery S, Mesina C, James P, Friedberg JS, Cengel K, Lin L, Hahn S, Rengan R:  Hemithoracic radiotherapy after extrapleural pneumonectomy for malignant pleural mesothelioma: A dosimetric comparison of two well-described techniques. Journal of Thoracic Oncology 4(11):1431-1437, Nov 2009.
  44. Friedberg JS, Cengel KA:  Pleural malignancies. Seminars in Radiation Oncology 20(3):208-214, July 2010. 
  45. Du KL, Both S, Friedberg JS, Rengan R, Hahn SM, Cengel KA:  Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma. Cancer Biology & Therapy 10(5):425-429, Sept 2010.
  46. Friedberg JS:  Photodynamic therapy for malignant pleural mesothelioma: The future of treatment. Expert Review of Respiratory Medicine 5(1):49-63, Feb. 2011.
  47. Friedberg JS, Mick R, Culligan M, Stevenson J, Fernandes A, Smith D, Glatstein E, Hahn S, Cengel K:  Photodynamic therapy (PDT) and the evolution of a lung sparing surgical treatment for mesothelioma, Annals of Thoracic Surgery 91(6):1738-1745, June 2011.
  48. Sterman DH, Haas A, Moon E, Recio A, Schwed D, Vachani A, Katz SI, Gillespie CT, Cheng G, Sun J, Papasavvas E, Montaner LJ, Heitjan DF, Litzky L, Friedberg JS, Culligan M, June CH, Carroll RG, Albelda SM:  A trial of intrapleural adenoviral-mediated interferon-(alpha)2b gene transfer for malignant pleural mesothelioma. American Journal of Respiratory & Critical Care Medicine 184(12):1395-1399, Dec. 15, 2011 (Epub June 3, 2011).
  49. Berman AT, Litzky L, Livolsi V, Singhal S, Kucharczuk JC, Cooper JD, Friedberg JS, Evans TL, Stevenson JP, Metz JM, Hahn SM, Rengan R:  Adjuvant radiotherapy for completely resected stage 2 thymoma.  Cancer 117(15):3502-3508, Aug. 2011.
  50. Simone CB, Friedberg JS, Glatstein E, Stevenson J, Sterman D, Hahn S, Cengel K: Photodynamic therapy for the treatment of non-small cell lung cancer. Journal of Thoracic Diseases 4(1): 63-75, Feb. 2012.
  51. Rengan R, Mick R, Pryma D, Rosen MA, Lin LL, Maity AM, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Prendergast S, Sharkoski T, Hahn SM:  A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: A report of toxicities and clinical response.  Journal of Thoracic Oncology 7(4):709-715, Apr. 2012.
  52. Lotano V, Friedberg JS:  Role of surgery for small cell lung cancer. Current Problems in Cancer 36:117-130, May/June 2012.
  53. Friedberg JS, Culligan M, Mick R, Stevenson J, Hahn S, Sterman D, Glatstein E, Cengel K.  Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. Annals of Thoracic Surgery 93:1658-1667, May 2012.
  54. Friedberg JS, Nakano T: Disorders of the Pleural Space: Gas, Liquid, and Solid. Pulmonary Medicine (2012) 1-2, June 2012.
  55. Dimofte A, Shanikova A, Meo J, Simone C, Friedberg JS, Zhu T. Light dosimetry and dose verification for pleural PDT. Proc. SPIE 8568 Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 8568OV; March 13, 2013.
  56. Zhu T, Kim M, Liang X, Liu B, Meo J, Finlay J, Dimofte A, Rodriguez C, Simone C, Cengel K, Friedberg JS. Real-time treatment feedback guidance of Pleural PDT. SPIE 8568 Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680O; March 13, 2013.
  57. Friedberg JS. Intraoperative photodynamic therapy for malignant pleural mesothelioma: future or fad? Lung Cancer Management. 2(2):107-119, April 2013.
  58. Friedberg JS. State of the art in the technical performance of lung sparing operations for pleural mesothelioma. Seminars in Thoracic and Cardiothoracic Surgery  25(2):125-143, Summer 2013.
  59. Shah A, Hahn S, Stetson R, Friedberg JS, Pechet T, Sher D. Cost-effectiveness of stereotactic body radiation therapy vs surgical resection for stage I non-small cell lung cancer. Cancer. 119(17):123-132. September 1, 2013.
  60. Friedberg JS, Cengel K, Simone C, Hahn S, et al. Surgery combined with intraoperative photodynamic therapy for stage IVa non-small cell lung cancer. Journal of Clinical Oncology. Submitted 2014.
  61. Friedberg JS, Simone C, Cengel K, et al. Comparison of Three Radiographic Tumor Volume Estimation Techniques for Malignant Pleural mesothelioma: Their Correlation with Each Other, Actual Measures Intraoperative Tumor Volumes and Survival. New England Journal of Medicine. Submitted 2014.
  62. Simone C, Culligan M, Cengel K, Friedberg JS. Patients’ Willingness to participate in a Randomized Controlled Trial for Malignant Pleural Mesothelioma: A New Paradigm to Improve Accrual to Thoracic Oncology Trials. Journal of the American Medical Association. Submitted 2014.
  63. Simone C, Cengel K, Hahn S, Friedberg JS. The role of prophylactic radiotherapy following Radical Pleurectomy for Malignant Pleural Mesothelioma. Journal of Thoracic Oncology. Submitted 2014.
  64. Friedberg JS, Hahn S, Culligan M, Simone C, Cengel K, et al. Photodynamic Therapy for Malignant Pleural Mesothelioma. Journal of Thoracic Disease. Submitted 2014.
  65. Friedberg JS. A New Hybrid Technique For Performing Tracheostomy In The Super Obese Patient, Manuscript in preparation for Journal of Thoracic and Cardiovascular Surgery, 2014.
  66. Friedberg JS, TenutoME, Finlay JC, Darafsheh A, PaikT, ChackoAM, PrymaD, MikitshJ, MurrayCB.  Ultra low (microwatt) intensity light can be used to kill malignant pleural mesothelioma cells with photodynamic therapy. Manuscript in preparation for Photochemistry and Photobiology, 2014.
  67. Friedberg JS, Collins J, Wang E, Bell H, Finlay JC.  Rare earth nanophosphors as an upconverting medium to allow intracorporeal visible light generation for photodynamic therapy from externally delivered infra red light – results of in an in vivo murine mesothelioma model. Manuscript in preparation for Journal of Photodiagnosis and Photodynamic Therapy, 2014.
  68. Friedberg JS, Naselsky W, Tenuto ME, Busch T, Rodriguez C, Darafsheh A, Finlay JC.  Hyperthermia potentiates photodynamic therapy in a murine mesothelioma model, Manuscript in preparation for Journal of Photodiagnosis and Photodynamic Therapy, 2014.
  69. Friedberg JS, Simone C, Culligan MJ, et al.  Posterior intercostal lymph nodes are an independent negative prognosticator in malignant pleural mesothelioma. Manuscript in preparation for Journal of Thoracic Oncology, 2014.
  70. Friedberg JS, Culligan MJ, Simone C, et al.  Radical pleurectomy resulting in a macroscopic complete resection for mesothelioma results in a minimal decrease in pulmonary function. Manuscript in preparation for Annals of Thoracic Surgery, 2014.
  71. Friedberg JS, Haas A, Culligan MJ, et al.  A novel technique for a port-accessed pleural drainage catheter provides patients with another option for palliation of recurrent pleural effusions. Manuscript in preparation for Chest, 2014.
  72. Friedberg JS, Sterman D, Culligan MJ, et al.  A minimally invasive technique to access a fused pleural space for gene therapy or other therapeutics for mesothelioma. Manuscript in preparation for Journal of Thoracic Oncology, 2014.
  73. Friedberg JS, Simone C, Culligan MJ, et al.  Posterior intercostal lymph nodes are an independent negative prognosticator in malignant pleural mesothelioma. Manuscript in preparation for Journal of Thoracic Oncology, 2014.
  74. Friedberg JS, Simone C, Culligan MJ, et al.  Complications of radical pleurectomy versus extrapleural pneumonectomy in 150 patients undergoing surgery for malignant pleural mesothelioma. Manuscript in preparation for Annals of Thoracic Surgery, 2014.
  75. Paik T, Chacko AM, Mikitsch JL, Friedberg JS, Pryma DA, Murray CB.  Shape-controlled synthesis of isotopic Yttrium-90 labeled rare earth fluoride nanocrystals for multimodal imaging.  Submitted to Nature Materials, 2014.
  76. Comertpay s, Pastorino S, Tanji M, Mezzapelle R, Strianese O, Napalitano A, Baumann F, Weigel T, Friedberg JS, et al. Evaluation of Clonal Origin of Malignant Mesothelioma. Journal of Translational Medicine. Accepted for publication.
  77. Pass H, Rice D, Wolf A, Friedberg JS, Vigneswaran W. The Next Generation of Mesothelioma Surgeons Round Table Discussion. Seminars in Thoracic & Cardiovascular Surgery 20(1), 2016
  78. Friedberg JS, Ryan DP, Driscoll SO, Folkman J. Human small bowel transplants into athymic mice and rats. Surgical Forum, American College of Surgeons meeting, Chicago, IL, 1985.
  79. Buyske J, Friedberg JS, Hahn SM, Kaiser LR: Staging laparoscopy and malignant mesothelioma. Society of American Gastrointestinal Endoscopic Surgeons, San Antonio, Texas, March 25-27, 1999.
  80. Friedberg JS. His RA, Glatstein EJ, and Hahn SM. Plueral Photodynamic Therapy (PDT) as a component of multimodality therapy for Non-Small Cell Lung Cancer: A Phase II Trial. (Presented at ASCO, Annual Meeting, Los Angeles, CA, May 16-19, 1999.)
  81. Machtay M, Lee JR, Shrager JB, Robnett TJ, Algazy KM, Friedberg JS, Hahn SM, Rosenthal 01, Kaiser LR: Chemoradiation with or without Surgery for Stage IlI A Non- Small Cell Lung Cancer: A Comparison of Survival and Patterns of Failure. (Presented at the 41st Annual Meeting of the American Society of Therapeutic Radiology and Oncology, San Antonio, Texas, October 31-November 4, 1999).
  82. Zhu CT, Friedberg JS, Miles J, Metz J, Metz JE, Glatsein E, Hahn S.  The ratio of the spherical and flat detectors at tissue surfaces during pleural photodynamic therapy.  (Presented at the Biomedical Optics Meeting, SPIE, San Jose, CA  2000).
  83. Metz JM, Jones H, Devine P, Hahn SM, Friedberg JS, Glatstein E: Unconventional Medical Therapies Are Used Frequently By Lung Cancer Patients Receiving Radiation Therapy. (Presented in part at the 86th Annual Meeting of the Radiological Society of North America, Chicago, Illinois, November 26 –December 1, 2000).
  84. Metz JM, Tochner Z, Hahn SM, Smith D, Zhu T, Friedberg JS, Fraker D, Glatstein E: Clinical Applications For Photodynamic Therapy In Oncology. Presented in part at the SPIE Meeting (The International Society of Optical Engineering, San Jose, CA, January 20-26, 2001).
  85. Friedberg JS, Metz J, Mick R, Stevenson J, Smith Z, Smith D, Smith J, Aisner J, Glatstein E, Hahn SM.  Multimodality treatment including pleural photodynamic therapy (PDT) for non-small cell lung cancer (NSCLC) patients with pleural carcinomatosis (Abstract #1303).  (Presented at the ASCO 38th Annual Meeting & Exhibition, San Francisco, CA, May 15, 2001).
  86. Friedberg JS, Mick R, Stevenson M, Metz J, Zhu T, Burke J, Smith D, Culligan M, Rodriguez E, Pass IH, Glatstein E, Hahn S.  A phase I study of foscan-mediated photodynamic therapy and surgery in patients with malignant pleural mesothelioma.  (Presented at the 38th Annual Meeting of the Society of Thoracic Surgery, January 28-30, 2002).
  87. Friedberg JS.  Increased survival and local control is observed for patient with stage 3B  non-small cell lung cancer (NSCLC), secondary to malignant pleural effusions and gross pleural carcinomatosis in a phase II trial combining surgery and photodynamic therapy (PDT).  American College of Chest Physicians meeting, 2002.
  88. Friedberg JS, Metz JM, Stevenson J, Carr SR, Zhu T, Mick R, Smith D, Culligan MJ, Miles J, Glatstein E, Hahn SM.  Increased survival and local control is observed for patients with stage 3B non-small cell lung cancer (NSCLC), secondary to malignant pleural effusions and gross pleural carcinomatosis, in a phase II trial combining surgery and photodynamic therapy (PDT).  Chest 2002.  San Diego, CA.  Selected for the ACCP Posters of Distinction. (November 2002)
  89. Friedberg JS, Skema CS, Burdick J, Yodh AG, Horan AD, Carr SR, Culver JP.  Altering the Optical Properties of the Bronchial Tree Permits Illumination of an Entire Lung for Photodynamic Therapy.  Pennsylvania Association of Thoracic Surgeons.  Miami, FL. (October 2002)
  90. Friedberg JS.  Phase II Trial of Pleural PDT and Surgery for patients with NSCLC and pleural spread.  9th World Congress of the International Photodynamic Association.  Miyazaki, Japan (May 2003)
  91. Friedberg JS, Skema CS, Burdick J, Yodh AG, Horan AD, Carr SR, Culver JP.  Altering the Optical Properties of the Bronchial Tree Permits Illumination of an Entire Lung for Photodynamic.  AATS Meeting.  Boston, MA (May 2003)
  92. Carr SR, Cowan SW, Friedberg JS.  Artificial lung in a porcine model - using peritoneal perfusion with perfluorocarbon.  Chest 2003.  Orlando, FL.  Selected for the ACCP Posters of Distinction. (October 2003)
  93. Collins JE, Carr SR, Sims TD, Friedberg JS: Porfimer sodium-mediated photodynamic therapy for aspergillus fumigatus. Presented at the American Society for Laser Medicine and Surgery, Dallas, TX, April 2004.
  94. Friedberg JS, Carr SR, Cantor JP, Collins JE, Sims TD:  Development of a murine model of localized aspergillosis.  Poster Session 3: Basic Science, Surgical Infection Society Meeting, April 30, 2004.
  95. Carr SR, Cantor J, Collins JE, Sims TD, Friedberg JS: Peritoneal perfusion with perfluorocarbon in a large animal model.  Presented as part of the Philadelphia College of Surgeons Meeting, Philadelphia, PA. May 2004.
  96. Carr SR, Cantor J, Friedberg JS:  Utilizing the peritoneum for gas exchange with oxygenated perfluorocarbons.  Presented as part of the American College of Surgeons Meeting, Critical Care Session, New Orleans, LA, Oct. 2004.
  97. Friedberg JS, Cantor JP, Carr SR, Rodriguez E, Stripp D, Stevenson J, Zhu T, Smith D, Culligan M, Dimofte A, Glatstein E, Hahn S: Metastatic non-lung cancer carcinomas and sarcomas treated with photodynamic therapy.  Presented as part of Chest, Seattle, WA, Oct. 2004. 
  98. Cantor JP, Carr SR, Rao AS, Collins JE, Friedberg JS.  Gastric perfusion with perflurocarbon results in significant systemic oxygenation in a large animal model.  Society of Critical Care Medicine, Phoenix, AZ, January 2005.
  99. Cantor JP, Carr SR, Rao AS, Friedberg JS.  Endoscopic techniques to use the stomach and peritoneal cavity as an “artificial lung.”  Society of American Gastrointestinal Endoscopic Surgeons, Fort Lauderdale, FL, April 2005.
  100. Cantor JP, Carr SR, Rao AS, Collins JE, Friedberg JS.  An artificial lung in a large animal model using gastric and peritoneal perfusion with oxygenated perflurocarbons.  American Association for Thoracic Surgery 85th Annual Meeting, San Francisco, CA, April 2005
  101. Cantor JP, Rao AS, Druck T, Wachsberger P, Friedberg JS, Huebner K.  Decreased tumorigenicity of lung cancer cells by minimal Fhit expression. American Association for Cancer Research 2005. Anaheim, CA. April 2005
  102. Cantor JP, Pechet TV, Berd D, Tessonneaud A, Salvat S, Mitra M, Schea H, Rao AS, Lakshman TV, Collins JE, Kuchar J, Culligan M, Shrager J, Friedberg JS.  Generation of an autologous, Hapten-modified non-small cell lung cancer vaccine. American Association of Cancer Research 2005. Anaheim, CA. April 2005
  103. Krug L, Pass H, Rusch V, Bloss, Sugarbaker D, Friedberg JS, Vogelzang.  A multicenter phase II trial of neo-adjuvant pemetrexed plus cisplatin followed by extrapleural pneumonectomy and radiation for pleural mesothelioma. American Association of Clinical Oncology Meeting 2005. Orlando, FL. May 2005.
  104. Krug L, Pass H, Rusch V, Sugarbaker D, Rosenzweig K, Friedberg JS, Bloss L, Obasaju C,Vogelzang N.  A multicenter phase II trial of neo-adjuvant pemetrexed plus cisplatin followed by extrapleural pneumonectomy and radiation for pleural mesothelioma. 11th World Conference on Lung Cancer, Barcelona, Spain, 2005.
  105. Martin N, Deckel G, Smith D, Friedberg JS, Hahn SM. Presence of Metastatic Disease at Diagnosis for Malignant Pleural Mesothelioma; Implications on Survival. American Society for Therapeutic Radiology and Oncology Denver, Colorado, October 2005.
  106. Rao AS, Cantor JP, Lakshman TV, Yu D, Collins JE, Kuchar J, Friedberg JS. “MHC1 Upregulation Increases Immunogenicity of Non-Small Cell Lung Cancer Cells in an Immunocompetent Murine Model.” AACR-NCI-EORTC International Conference – Molecular Targets and Cancer Therapeutics. Philadelphia, PA. Nov, 2005   
  107. Finlay JC, Zhu TC, Dimofte A, Friedberg JS, Hahn SM.  “Diffuse reflectance spectra measured in vivo in human tissues during Photofrin-mediated pleural photodynamic therapy.” The International Society for Optical Engineering – International Symposium. San Jose, CA. Jan 2006  
  108.  Lakshman TV, Cantor JP, Rao AS, Yu D, Collins JE, Carr S, Culligan M, Friedberg JS. “Murine Lung Cancer Cells Transfected with IFNy Provide Enhanced Prophylactic Immunity.” Society of Surgical Oncology Annual Meeting. San Diego, CA. March 2006
  109. Friedberg JS, Culligan MJ, Buyske J, Smith D, Hahn SM.“Invasive Staging for Mesothelioma is required to Reveal Occult Distant Metastatic Disease.” American College of Chest Physicians Annual Meeting. Salt Lake City, Utah, October, 2006
  110. Friedberg JS, Culligan MJ, Smith D, Hahn SM. “Patterns of Recurrence and Survival after Photodynamic Therapy for Stage IIIB Non-Small Cell Lung Cancer.” American College of Chest Physicians Annual Meeting. Salt Lake City, Utah, October 2006.
  111. Collin J, Laksman T, Rao A, Bell H, Friedberg JS. “Infrared Light Can Be Used for Photodynamic Therapy by Using Rare Earth Phosphors for Visible Light Generation”.The International Society for Optical Engineering. January 2007. San Jose, CA
  112. Friedberg JS, Collins J, Nguyen B, Luo J, Culligan MJ, Bell H.  “Nanoparticle Phosphor Intracorporeal Light Generation for “External Beam” Photodynamic Therapy in a Murine Lung Cancer Model. Emerging Technologies Session, 2007 Annual meeting, Society of American Gastrointestinal Endoscopic Surgery, Las Vegas Nevada, 2007.
  113. Friedberg JS, Culligan MJ, Smith D, Hahn SM “Photodynamic Therapy for Stage IIIB Non-Small Cell Lung Cancer.” 2nd International Symposium on Regional Cancer Therapies, San Juan, Puerto Rico, 2007.
  114. Friedberg JS, Buyske J, Huff J.  NOTES Made Easy – Applying Traditional Surgical Principles to an Innovative Technology, 2nd Annual International Conference on NOTES, Boston, MA, 2007.
  115. Friedberg JS, Culligan M, Smith D, Buyske J, Korus G, Hahn S “Routine Staging Laparoscopy and Bronchoscopy Alters Management for Patients with Pleural Mesothelioma.” General Thoracic Surgical Club, Twenty-first Annual Meeting, San Diego, CA, 2008.
  116. Dimofte A, Zhu T, Finlay JC, Culligan M, Edmonds CE, Friedberg JS, CengelK, Hahn S. In-vivo light dosimetry for pleural PDT. Proc SPIE 7164, 7164A, 2009.
  117. Dubroff JG, Alavi A, Friedberg JS, Cengel K. Postsurgical atypical F-18 fluorodeoxy-glucose positron emission tomography uptake. Clinical Nuclear Medicine 34(11):808-810, Nov. 2009.
  118. Friedberg JS, Stevenson J, Hahn SM, Culligan MJ, Smith D, Cengel K.  Photodynamic therapy and the evolution of a lung sparing surgical treatment for malignant mesothelioma.  46th Annual Meeting of Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan. 2010.
  119. Abliz E, Collins J, Friedberg JS, Kumar A, Bell H, Waynant R, Tata D.  Novel applications of diagnostic x-rays in activating photo-agents through x-ray induced visible luminescence from rare-earth particles: An in vitro study.  International Society for Optics and Photonics (SPIE) 7565, San Francisco, CA, Jan. 2010.
  120. Dimofte A, Zhu T, Finlay J, Culligan M, Edmonds C, Friedberg JS, Cengel K, Hahn S. In vivo light dosimetry for HPPH-mediated pleural PDT.  International Society for Optics and Photonics (SPIE) 7565, San Francisco, CA, Jan. 2010.
  121. Hseih Y, Mick R, Culligan M, Cengel K, Hahn S, Cowan S, Friedberg JS.  Radical pleurectomy and photodynamic therapy as a treatment for stage IVA thymic tumors. International Thymic Malignancy Interest Group Meeting, New York, NY, May 2010.
  122. Cengel K, Fernandes A, Mick R, Culligan M, Smith D, Stevenson J, Sterman D, Glatstein E, Hahn S, Friedberg JS.  A multimodality treatment for malignant mesothelioma patients with or without lymph node metastases.  American Society of Clinical Oncology Annual Meeting, Chicago, IL, June 2010.
  123. Culligan M, Sterman D, Stevenson J, Cengel K, Hahn S, Albelda S, Langer C, Hansen-Flashen J, Friedberg JS.  Feasibility of establishing a multidisciplinary program devoted solely to the treatment of pleural diseases.  Poster presentation at the 10th International Conference of International Mesothelioma Interest Group, Kyoto Japan, Aug. 2010.
  124. Friedberg JS, Cengel K, Culligan M, Stevenson J.  Long-term survival of stage IV pleural mesothelioma presenting with retroperitoneal mass following multimodality treatment.  Poster presentation at the 10th International Conference of International Mesothelioma Interest Group, Kyoto Japan, Aug. 2010.
  125. Friedberg JS, Cengel K, Culligan M, Stevenson J, Hahn S, Mick R, Sterman D.  Radical pleurectomy combined with intraoperative photodynamic therapy (PDT) is a safe and effective treatment for malignant pleural mesothelioma.  Society of Thoracic Surgeons 47th Annual Meeting, San Diego, CA, Jan. 2011.
  126. Zhu T, Liang X, Chang C, Sanders J, Finlay J, Dimofte A, Rodrigeus C, Cengel K, Friedberg JS, Glatstein E, Hahn S.  An IR navigation system for real-time treatment guidance of Pleural PDT.  International Society for Optics and Photonics (SPIE) 7886, San Francisco, CA, Jan. 2011.
  127. Dimofte A, Zhu T, Finlay J, Culligan M, Edmonds C, Friedberg JS, Cengel K, Hahn S:  In vivo light dosimetry for HPPH-mediated pleural PDT: An update. [Abstract] Photodiagnosis & Photodynamic Therapy 8(2):199, June 2011.
  128. Friedberg JS, Culligan M, Korus G, Buyske J, Cengel K, Simone CB, Stevenson J Wang EJ, Sterman D, Kuhns K, Hahn S. Routine laparoscopic and selective contralateral thoracoscopic staging in 151 patients undergoing surgery for malignant pleural mesothelioma. Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  129. Friedberg JS, Culligan M, Cengel K, Simone CB, Stevenson J, Alley E, Wang EJ, Hahn S. Complications associated with radical pleurectomy for malignant pleural mesothelioma in 77 patients. Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  130. Friedberg JS, Culligan M, Putt M, French B, Hahn S, Simone CB, Stevenson J, Alley E, Sterman D, EJ Wang, Cengel K. Posterior intercostal lymph nodes and malignant pleural mesothelioma – what are they, where are they and what do they mean? Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  131. Friedberg JS, Culligan M, Putt M, French B, Hahn S, Simone CB, Alley E, Stevenson J, Sterman D, Wang EJ, Cengel K. Tumor volume as prognostic factor for patients undergoing radical pleurectomy for malignant pleural mesothelioma. Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  132. Friedberg JS, Culligan M, Putt M, French B, Hahn S, Simone CB, Stevenson J, Alley E, Cengel K, Wang EJ, Sterman D. The impact of macroscopic complete resection radical pleurectomy for mesothelioma on pulmonary function. Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  133. Culligan M, Friedberg JS, Recio A, Jacobs-Small M, Mudrick K, Albelda S, Haas A, Cengel K, Hahn S, Stevenson J, Simone CB, Langer C, Alley E, Sterman D. A dedicated multidisciplinary mesothelioma program fosters enrollment in clinical trials. Poster presentation at the 11th International Conference of International Mesothelioma Interest Group, Boston, MA, September 2012.
  134. Friedberg JS, Simone C, Culligan M, Hahn S, Alley E, Sterman D, Glatstein E, McNulty S, Shin M, Hagan S, Cengel K. Extended Survival Following Recurrence for Patients with Malignant Pleural Mesothelioma Treated with Radical Pleurectomy, Photodynamic Therapy and Chemotherapy: The potential role of STAT3. Poster presentation at the 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  135. Friedberg JS, Albelda S, Haas A, Metzger S, Culligan M, Sterman D. A New Minimally Invasive Surgical Technique to Access a Fused Pleural Space for Biopsy, Gene Therapy or Other Novel Intrapleural Therapies – A Report of 34 patients. Poster presentation at the 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  136. Friedberg JS, Haas A, Culligan M, Sterman D. A Novel Technique for Palliating Recurrent Pleural Effusions with a Port-Accessed Tunneled Catheter. Poster presentation at the 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  137. Simone C, Shah A, Culligan M, Friedberg JS, Sterman D, Alley E, Stevenson J, Cengel K, Hahn S. Patients’ Willingness to participate in a Randomized Controlled Trial for Malignant Pleural Mesothelioma: A New Paradigm to Improve Accrual to Thoracic Oncology Trials. Poster presentation at the 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  138. Simone C, McKay K, Culligan M, Sterman D, Alley E, Busch T, Glatstein E, Hahn S, Cengel K, Friedberg JS. Prospective Study of Surgery with Curative Intent and Intraoperative Photodynamic Therapy to Achieve Long-term Pleural Control and Improve Overall Survival for patient with Non-Small Cell Lung Cancer with Pleural Dissemination. 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  139. Friedberg, JS, Culligan M, Katz S, et al. Comparison of Three Radiographic Tumor Volume Estimation Techniques for Malignant Pleural mesothelioma: Their Correlation with Each Other, Actual Measures Intraoperative Tumor Volumes and Survival. 15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  140. Sterman D, Alley E, Recio A, Stevenson J, Metzger S, Moon E, Haas A, Vachani A, Katz S, Litzky L, Cengel K, Simone C, Friedberg JS, Culligan M, Albelda S. A Pilot and Feasibility Trial Evaluating Two Different Chemotherapy Regimens in Combination with Intrapleural Adenoviral-mediated Interferon-Alpha (SCH 721015, Ad.hIFN-alpha2b) Gene Transfer for Malignant Pleural Mesothelioma.  15th World Conference on Lung Cancer, Sydney Australia, October 2013.
  141. Culligan M, Metzger S, Sterman D, Friedberg JS. A Dedicated Multidisciplinary Program Fosters Enrollment into Clinical Trials for Malignant Pleural mesothelioma Patients. Poster presentation at 2014 Oncology Nurse Society Congress, Anaheim, CA. May 1-4, 2014.
  142. Barsky AR, Buckley JP, Friedberg JS, Culligan M, et al. Prophylactic Irradiation of Surgical Tract Sites in the Era of Radical Pleurectomy for Malignant Pleural Mesothelioma. Abstract submission – American Society for Radiation Oncology” 56th Annual Meeting, Moscone Center, San Francisco, September 2014.
  143. Simone C, Heskel M, Xanthopoulos E, Corradetti M, Singhal S, Friedberg JS, Pechet T, Kucharczuk J, Christodouleas JP, Levin W, Cengel K, Rengan R, Hahn S. Stereotactic Body Radiotherapy (SBRT) for Stage I Non-small Cell Lung Cancer (NSCLC): Outcomes by Fractionation, Tumor Stage and Location, and Patient Operability. Abstract submission – American Society for Radiation Oncology” 56th Annual Meeting, Moscone Center, San Francisco, September 2014.
  144. Barsky AR, Buckley JP, Friedberg JS, Culligan M, Simone C, et al. Radiation-induced Malignant Mesothelioma: Frequency and Prognosis. Abstract submission – American Society for Radiation Oncology” 56th Annual Meeting, Moscone Center, San Francisco, September 2014.
  145. Friedberg JS, TenutoME, Finlay JC, Darafsheh A, PaikT, ChackoAM, PrymaD, MikitshJ, MurrayCB.  Ultra low (microwatt) intensity light can be used to kill malignant pleural mesothelioma cells with photodynamic therapy. Submitted for American Society of Photobiology meeting, San Diego, CA, June2014.
  146. Friedberg JS, Culligan M, Putt M, Barsky A, French B, Hahn SM, Alley E, Sterman D, Cengel KA, Simone CB II. Posterior Intercostal Lymph Nodes and Malignant Pleural Mesothelioma – What Are They, Where Are They and What Do They Mean? 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  147. Barsky AR, Buckley JP, Friedberg JS, Culligan M, Simone C, et al. Radiation-induced Malignant Mesothelioma: Frequency and Prognosis. 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  148. Friedberg JS, Culligan M, Simone C, Mick R, Sterman D, Alley E, Hahn S, Cengel K. Extended Pleurectomy-Decortication and Intraoperative Photodynamic Therapy for Epithelial Malignant Pleural Mesothelioma.12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  149. Friedberg JS, Grillo, H,Culligan M. Effects on air leak and chest tube management with the use of a lung sealant at the time of radical pleurectomy for malignant pleural mesothelioma.  Poster presentation at the 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  150. Barsky A, Friedberg JS, Culligan M, Sterman D, Alley E, Lanfranco A, Litzky L, Glatstein E, Hahn S, Cengel K, Simone C. Frequency and Prognosis of Radiation-induced Malignant Pleural Mesothelioma. Poster presentation at the 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  151. Friedberg JS, Naselsky W, Tenuto M, Finlay J, Culligan M, Busch T. Hyperthermia is not effective and does not augment photodynamic therapy in a murine mesothelioma model. Poster presentation at the 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  152. Friedberg JS, Tenuto M, Finlay J, Darafsheh A, Naselsky W, Paik T, Murray C, Busch T, Pryma D, Culligan M, Chacko, AM Nanowatt range photodynamic therapy unexpectedly kills mesothelioma cells in vitro. Poster presentation at the 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  153. Katz S, Culligan M, Friedberg JS, et al. CT for detection of posterior intercostal lymph nodes in patients with malignant pleural mesothelioma. Poster presentation at the 12th International Conference of the Mesothelioma Interest Group, Cape Town, South Africa, October 2014.
  154. Friedberg JS, Tenuto M, Finlay J, Darafsheh A, Paik T, Najmr S, Murray C. Phosphor-based fiber optic microprobes for ionizing beam radiation dosimetry. SPIE Photonic West 2015, San Francisco, CA, February 2015.
  155. Friedberg JS, Tenuto M, Finlay J, Darafsheh A, Najmr S, Paik T, Murray C. Characterization of rare-earth-doped Nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams. Poster presentation at the SPIE Photonic West 2015, San Francisco, CA, February 2015.

Additional Publication Citations

  1. Friedberg JS, Kaiser LR:  The role of video-assisted thoracic surgery management of pulmonary cancer and tumors of the mediastinum.  Chapter 7 in Geraghty JG, Young HL, Sackier JM, Stoldt HS, Audisio RA (eds):  Minimal Access Surgery in Oncology.  London: Greenwich Medical Media, 1998, 83-98.
  2. Friedberg JS, Lanuti M:  The esophagus.  Chap. 12 in Kreisel K, Krupnick AS, Kaiser LR (eds.):  The Surgical Review: An Integrated Basic and Clinical Science Study Guide.  Philadelphia: Lippincott Williams & Wilkins, 2001, 185-196.
  3. Friedberg JS, Deeb M:  Treatment of esophageal perforation.  In Baker RJ (ed.): Mastery of Surgery, Fourth Edition.  Philadelphia: Lippincott Williams & Wilkins, 2001, 843-853.
  4. Friedberg JS:  The pleura: Anatomy, physiology and disorders.  In Norton JA, Bollinger RR, Chang AE, Lowry SF, Mulvihill SJ, Pass HI, Thompson RW, Li M (eds.):  Essential Practice of Surgery.  New York: Springer Verlag, 2003, 1243-1264.
  5. Rodriguez E, Park P, Cowan S, Weinstein M, Kaulback K, Friedberg JS, Diehl JT, Mannion JD, Cohen M:  Complicated management of a traumatic aortoesophageal fistula in a patient with a right-sided aortic arch. [Case Report] Journal of Trauma 56(3):691-693, Mar 2004.
  6. Friedberg JS, Hahn S: Foscan-mediated photodynamic therapy and operation for malignant pleural mesothelioma.  [Editorial] Ann Thorac Surg 78:388-389, June 2004.
  1. Awsare M, Coben R, Friedberg JS, Primary melanoma of the esophagus. [Case Report] Clinical Gastroenterology & Hepatology 3(7):xxvii, July 2005.
  2. Friedberg JS, Cohn H, Rodriguez E: Secondary lung tumors.  In Selke F, Swanson S., del Nido PJ (eds.): Sabiston 

Research Interests

2008 – 2013 - PO1 CA-087971-06A1, NIH-CA [NCI], Principal Investigator for Project 1 - Photodynamic Therapy for Pleural Malignancies.  $131,658/yr (5 year renewal scored high enough to pass for review by Dr. Harold Varmus, NCI Director)

2013 - present - Dr. and Mrs. James Brock Endowment for Mesothelioma Research $1,000,000 lump sum donation to Penn Mesothelioma and Pleural Program, Program Director

2013 – present - Recipient of Penn Presbyterian Medical Center Fund Raiser with matching funds from Shein Foundation for Humanity, Development of Patient Education Materials for the Penn Mesothelioma and Pleural Program, Program Director, $50,000 with matching funds ($100,000)

2012 – 2017 - Cuthbert Cancer Foundation donation for mesothelioma research and patient care, Co-PI with Dr. Stephen Hahn, initial gift of $50,000/year for five years ($250,000)                                                       

2012 -  Daniel Sullivan Fund, Donation for scholarly activities related to pleural malignancies, sole recipient,  $343,000 lump sum donation

2011 - 2014 - Shein Foundation for Humanity, Donation for scholarly activities related to malignant pleural mesothelioma, sole recipient, $167, 000.00/year for three years

2010 – 2013 - Simon’s Foundation for Mesothelioma, Donation for establishment and development of the Penn Mesothelioma and Pleural Program, Program Director, $250,000/year for three years ($750,000)

Past funding

2010 - BACH Fund Award, Principal Investigator, Use of Upconverting Nanophosphors for Diagnosis of Malignant Pleural Effusions, $10,000

2008 – 2011- Sunstones BioScience Sponsored Research Agreement, Principal Investigator, Bio-application & Validation of Nanophosphor Compounds $200,000/year for three years ($600,000)

2008 – 2009 - NIH STTR – Phase I Small Business Technology Transfer Grant, Principal Investigator, RBC typing antibodies labeled with rare earth phosphor upconverting nanoparticles, $260,000

2008 – 2011- Nanotechnology Institute (NTI) of Pennsylvania Sponsored Research Grant, Principal Investigator, Bioapplications of rare earth nanophosphors $50,000/year for three years ($150,000)

2007- BACH Fund Award, Principal Investigator, Preoperative Teaching Tools Will Have a Positive Impact on Patients’ Thoracic Surgical Experience at Penn-Presbyterian Medical Center, $9,400

2006 - Abramson Cancer Center Lung Cancer Research Grant, Prinicipal Investigator, Utilizing Photodynamic Therapy to Generate Anti-Tumor Vaccines in an Immunocompetent Murine Non-Small Cell Lung Cancer Model, $25,000

2006 - SAGES Research Grant, Principal investigator, Supplemental Oxygenation Utilizing Minimally Invasive Techniques of Peritoneal and Gastric perfusion with Oxygenated Perfluorocarbons, $14,866

2006 - BACH Fund Award,  Photodynamic Therapy as a Treatment for Bronchoalveolar Carcinoma, Principal investigator, $15,000

2006 - Donald Perry Foundations for Cancer Research, For scholarly pursuits related to cancer research, sole recipient, $77,257

2005 – 2008 - AVAX Technologies, Inc,  Sponsored Research Agreement, Principal Investigator, L-VAX: A Feasibility Study using a DNP-Modified Autologous Tumor Cell Vaccine as Therapy in Patients with Stage I or II Non-small Cell Lung Cancer, $100,000

2005 - BACH Fund Award, Principal Investigator, Autologous Tumor Vaccine Production for NSCLC, $4,500

2004 – 2007 - Sponsored Research Agreement, Eli Lilly and Company, Principal Investigator, A Multicenter Phase II Trial of Neo-Adjuvant ALIMTA plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma, $50,000

2003 - Gifted approximately $500,000 worth of neat perfluorocarbon by Dr. Jewel Osterholm of Neuron Therapeutics for nonpulmonary supplemental oxygenation research, recipient and prinicipal investigator

2002 - American Society of Lasers in Medicine and Surgery. Summer research grant:  In vitrodose rate response of Photofrin for Aspergillus fumigatus. Award winner – Josh Collins.  PI – Joseph S. Friedberg, MD, $2,000

1996 - Thomas B. and Jeannette E. Laws McCabe Fund Fellow and Pilot Award. Photodynamic Therapy for cancer, Principal Investigator, $50,000.

Awards and Affiliations

1971-1977                          Allentown City Tennis Champion in respective age bracket 6 out 7 consecutive years from ages 12-18

1977                                    Emmaus High School Varsity Tennis Team, Captain

1977                                    Emmaus High School Faculty Award, Most Outstanding Chemistry Student

1977                                    Emmaus High School Lions Club Award, Most Outstanding Science Student

1978                                    Elected “Most Inspirational Freshman Oarsman,” University of Pennsylvania Heavyweight Crew

1981                                    Pennsylvania Electorate, Regional Finalist for Rhodes Scholarship

1981                                    Captain University of Pennsylvania Heavyweight Crew

1981                                    Elected “Most Inspirational Varsity Oarsman,” University of Pennsylvania Heavyweight Crew

1981                                    University of Pennsylvania Wreath Hopkins Award Recipient

1981                                    University of Pennsylvania BASc, Summa Cum Laude (4.0 GPA)

1981 - 1986                        Boston Marathon finisher, five consecutive years

1981                                    United States Maccabiah Team, Rowing, 2 Gold Medals

1985                                    United States Maccabiah Team, Rowing, 1 Gold, 1 Silver Medal

1986                                    Harvard Medical School Soma Weiss Research Award recipient (Dr. Judah Folkman, research advisor)

1986                                    Harvard Medical School MD, Cum Laude

1998                                    Association for Academic Surgery Medical Student Research Award (Mentor to student recipient, Eric Baum)

2001                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2002                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2003                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2004                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2005                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2006                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2007                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2008                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2009                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2010                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2011                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2012                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2013                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2014                                    Philadelphia Magazine – Thoracic Surgery “Top Doc”

2002                                    Poster of Distinction, Thoracic Oncology Category, Chest Meeting

2003                                    Poster of Distinction, Critical Care Category, Chest Meeting

2004                                    Society for Artificial Internal Organs Fellowship Award (Research mentor to fellow recipient, Shamus Carr)

2005                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2006                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2007                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2008                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2009                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2010                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2011                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2012                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2013                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2014                                    Castle Connolly – America’s Top Doctors, Thoracic Surgery

2006                                    Castle Connolly – America’s Top Doctors for Cancer

2007                                    Castle Connolly – America’s Top Doctors for Cancer

2008                                    Castle Connolly – America’s Top Doctors for Cancer

2009                                    Castle Connolly – America’s Top Doctors for Cancer

2010                                    Castle Connolly – America’s Top Doctors for Cancer

2011                                    Castle Connolly – America’s Top Doctors for Cancer

2012                                    Castle Connolly – America’s Top Doctors for Cancer

2013                                    Castle Connolly – America’s Top Doctors for Cancer

2014                                    Castle Connolly – America’s Top Doctors for Cancer

2015                                    Castle Connolly – America’s Top Doctors for Cancer

2009                                    Consumers’ Research Council of America “Guide to America’s Top Surgeons”

2009                                    Marquis Who’s Who in America

2010                                    Marquis Who’s Who in America

2011                                    Marquis Who’s Who in America

2012                                    Marquis Who’s Who in America

2013                                    Marquis Who’s Who in America

2009                                    Marquis Who’s Who in Medicine and Healthcare

2010                                    Marquis Who’s Who in Medicine and Healthcare

2011                                    Marquis Who’s Who in Medicine and Healthcare

2012                                    Marquis Who’s Who in Medicine and Healthcare

2013                                    Marquis Who’s Who in Medicine and Healthcare

2009                                    Marquis Who’s Who in Medicine and Healthcare

2009                                    Marquis Who’s Who in the World

2010                                    Marquis Who’s Who in the World

2011                                    Marquis Who’s Who in the World

2012                                    Marquis Who’s Who in the World

2013                                    Marquis Who’s Who in the World

2010                                    Marquis Who’s Who in Science and Engineering

2011                                    Marquis Who’s Who in Science and Engineering

2012                                    Marquis Who’s Who in Science and Engineering

2013                                    Marquis Who’s Who in Science and Engineering

2012                                    US News and World Report, “Top Cardiac and Thoracic Surgeons.”

2013                                    US News and World Report, “Top Cardiac and Thoracic Surgeons.”

2009                                    Listed in “Best Doctors” (www.Bestdoctors.com)

2010                                    Listed in “Best Doctors” (www.Bestdoctors.com)

2011                                    Listed in “Best Doctors” (www.Bestdoctors.com)

2012                                    Listed in “Best Doctors” (www.Bestdoctors.com)

2013                                    Listed in “Best Doctors” (www.Bestdoctors.com)

In the News

  1. Friedberg JS, Pechet TV:  Video mediastinoscopy and surgical advances for treating lung cancer.  Live WebCast, Thomas Jefferson University Hospital, Philadelphia, PA, 2002.
  2. Friedberg JS:  Surgical treatment of lung cancer and photodynamic therapy in the treatment of advanced lung cancer.  Rowan University Radio Station “Your Health Matters,” Oct. 2004.
  3. Friedberg JS, Hahn SM: International photodynamic therapy program. Comcast Newsmakers / CN8 Television, Jan. 2007.
  4. Friedberg JS: Photodynamic therapy for advanced lung cancer. CNN Headline News Feb. 2007.
  5. Friedberg JS:  Photodynamic therapy treatment of a patient with mesothelioma.  Featured in Discovery Channel Series: Notes from the Edge of Life, filmed 2007.
  6. Friedberg JS: Pleural Disease,Decision Support in Medicine, LLC. Robert Kotloff, Editor, 2012.
  7. Friedberg JS, Cowan S:  Mediastinal Masses, Decision Support in Medicine, LLC. Barry Fuchs, Editor, 2012.
  8. Friedberg JS. New Frontiers in Surgery for Mesothelioma. Teleconference – Mesothelioma Applied Research Foundation. January 2014.

 

Professional Activity

2003 - present                    American Association of Thoracic Surgeons

2003 - present                    American College of Surgeons (Fellow)

2001-  present                    Massachusetts General Hospital Alumni Society

2001 - present                    Society of Thoracic Surgeons

1998 - present                    General Thoracic Surgical Club