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Victor Frenkel, PhD

Academic Title:

Associate Professor

Primary Appointment:

Diagnostic Radiology and Nuclear Medicine

Administrative Title:

Director Of Translational Focused Ultrasound Research

Location:

Health Science Facility I, 618A

Phone (Primary):

410-706-7783

Education and Training

Hebrew University of Jerusalem

Agriculture

B.S., 1991

Tel Aviv University

Life Sciences

M.S., 1995

Technion, Israel Institute of Technology

Agricultural Engineering

Ph.D., 1999

U of MD Biotechnology Institute

Post-doctoral Fellowship

1999 - 2003

Dept. of Radiology, Clinical Center, NIH

Imaging Sciences Training Fellowship

2003 - 2005

Biosketch

I received my PhD in Agricultural Engineering at the Technion, Israel Institute of Technology in Haifa, Israel in 1999. I then spent four years as a post-doctoral fellow at the University of Maryland Biotechnology Institute in Baltimore, MD and two years as an Imaging Sciences Training Program fellow at the Clinical Center, National Institutes of Health. For the next six years I was a staff scientist at the Department of Radiology and Imaging Sciences at the NIH Clinical Center, and headed the focused ultrasound program. Before joining the faculty at the University of Maryland, I was a tenure-track, Associate Professor for three and a half years at the Department of Biomedical Engineering at Catholic University of America in Washington, DC.

Research/Clinical Keywords

Therapeutic ultrasound; Ultrasound mediated drug and gene delivery; Transcranial focused ultrasound

Highlighted Publications

Hersh DS*, Nguyen BA*, Dancy JG*, Adapa AR*, Winkles JA, Woodworth GF, Kim AJ, Frenkel V. Pulsed ultrasound expands the extracellular and perivascular spaces of the brain. Brain Research 2016;1646:543-50.

Krasovitski B, Frenkel V, Shoham S, Kimmel E. Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects. Proceedings of the National Academy of Sciences 2011;108(8):3258-63.

Hancock HA*, Smith LH*, Cuesta J*, Durrani AK*, Angstadt M, Palmeri M, Kimmel E, Frenkel V. Investigations into pulsed-high intensity focused ultrasound enhanced delivery: Preliminary evidence for a novel mechanism. Ultrasound in Medicine and Biology 2009;35(10):1722-36.

Ziadloo A*, Xie J, Frenkel V. Pulsed focused exposures enhance locally administered gene therapy in a murine solid tumor model. Journal of the Acoustical Society 2013;133:1827-34.

Poff J*, Traughber BJ*, Allen C*, Colunga A*, Chen Z, Wood BJ, van Waes C, Li CKP, Frenkel V. Pulsed-high intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts by proteasome inhibitor bortezomib. Radiology 2008;248(2):485-91.

Research Interests

Dr.  Frenkel’s research interests are rooted in a comprehensive understanding of the mechanisms by which ultrasound energy interacts with biological tissues at the macroscopic, cellular and sub-cellular/molecular level. With this knowledge, he and his colleagues have proposed new therapeutic ultrasound applications, as well as ways to improve existing ones in the fields of oncology, cardiovascular disease, physical therapy and cellular homing. A particular focus of his research has involved noninvasively enhancing drug and gene delivery through the skin, in to solid tumors, and in to acute and chronic blood clots.

Dr. Frenkel’s research techniques include mathematical modeling and simulations, as well as multiple modality imaging - from electron microscopy to optical and bioluminescent imaging, ultrasound, and MRI. My projects typically encompass theoretical, mechanistic, and preclinical translational studies, and involve the development of novel in vitro platforms and preclinical models, as well as image-guided focused ultrasound devices.

Dr. Frenkel is a member of the Experimental Therapeutics Program within the University of Maryland Marlene and Stewart Greenebaum Cancer Center Program in Oncology. Experimental Therapeutics researchers collaborate with both basic and clinical research investigators, focusing on the rapid transfer of knowledge from the laboratory to the clinic. Dr. Frenkel’s research centers on developing novel ways that therapeutic ultrasound can be employed for the treatment of solid tumors.