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Shannon M. Dunn, PhD

Academic Title:

Post Doc Fellow

Primary Appointment:

Medicine

Additional Title:

Postdoctoral Fellow

Phone (Primary):

(410) 706-6947

Education and Training

  • The University of Georgia, 2010
    Bachelor of Science in Chemistry
  • Texas Tech University Health Sciences Center, 2016
    Doctor of Philosophy of Pharmacology and Neuroscience
  • The University of Maryland, Baltimore, 2016-2018
    Postdoctoral Fellowship

Biosketch

Dr. Shannon Dunn received a B.S. (Chemistry) from The University of Georgia in 2010, followed by a Ph.D. (Pharmacology and Neuroscience) from Texas Tech University Health Sciences Center in 2016. During her doctoral research, she studied the effect of thioredoxin (Trx), a redox-damage repair protein that aids cells to recover from an oxidative state, damaging-deficiency in onset of diabetes. Her dissertation details the creation and characterization of novel mouse models of T2D, including transgenic and aged mice on diets with elevated fat and sugar content. Dr. Dunn has a broad background in Pharmacology, with training in Endocrinology and Diabetes. Her first postdoctoral fellowship is at the University of Maryland working with Dr. Simeon Taylor to explore the role of DYRK1B in cardiometabolic physiology. She plans to investigate the effects of Dyrk1B-catalyzed phosphorylation of transcription factors such as FOXO1.

Research/Clinical Keywords

Diabetes, high fat diet, obesity, and metabolic syndrome.

Highlighted Publications

Dunn, S. M., Hilgers, R. and Das, K.C. Decreased EDHFmediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged highfat sucrose diet. Physiol Rep 5:e13502

Research Interests

Shannon's research interests includes the effects of western diet on vascular function in mice with a type 2 diabetes phenotype, obesity and metabolic syndrome, high fat diet-induced oxidative stress, and the exacerbating effects of high fat diet and aging on the vasculature.

Grants and Contracts

  • 2016-present "Diabetes and its metabolic complications"5T32DK098107-02
  • 2014-2016 "Endothelial dysfunction in aged Trx-deficient mice"R01 HL114753

Community Service

Baltimore Lab School, Baltimore, MD, 2018

Baltimore Underground Science Space (BUGSS), Baltimore, MD, 2018

Ronald McDonald House, Baltimore, MD, 2017

Student Research Week TTUHSC, Lubbock, TX, 2015-2016

Karate Kids, Lubbock, TX, 2013

Professional Activity

Toastmasters Club

American Diabetes Association

American Physiological Society

Lab Techniques and Equipment

Laboratory experience:

Luciferase assay, western blotting, ELISA, agarose gel electrophoresis, polyacrylamide gel electrophoresis, q real-time PCR, RT-PCR, cell culture, transfection, immunohistochemistry, spectrophotometer, bacterial transformation, plasmid DNA isolation and purification, protein estimation, wire-myography, microscopy, mouse islets isolation, mitochondrion isolation, flux analyzer, mito-tracker red staining, H&E staining, Oil-Red staining, acid-alcohol insulin extraction, protein and RNA isolation.

Animal experience:

5+ years’ small animal handling, breeding, weaning, genotyping, tattooing, ear pinching, monitoring body weight, feeding special diet, metabolic testing (GTT, ITT), CODA tail-cuff blood pressure measurement, transgenic animal models, pharmacology behavioral studies (taste aversion, tail flick test, mice fear conditioning studies), sepsis mouse model, kidney blood flow analysis, mouse anesthesia, and sterile rodent surgery.