Post Doc Fellow
Education and Training
The University of Georgia, 2010Bachelor of Science in Chemistry
Texas Tech University Health Sciences Center, 2016Doctor of Philosophy of Pharmacology and Neuroscience
The University of Maryland, Baltimore, 2016-2018Postdoctoral Fellowship
Dr. Shannon Dunn received a B.S. (Chemistry) from The University of Georgia in 2010, followed by a Ph.D. (Pharmacology and Neuroscience) from Texas Tech University Health Sciences Center in 2016. During her doctoral research, she studied the effect of thioredoxin (Trx), a redox-damage repair protein that aids cells to recover from an oxidative state, damaging-deficiency in onset of diabetes. Her dissertation details the creation and characterization of novel mouse models of T2D, including transgenic and aged mice on diets with elevated fat and sugar content. Dr. Dunn has a broad background in Pharmacology, with training in Endocrinology and Diabetes. Her first postdoctoral fellowship is at the University of Maryland working with Dr. Simeon Taylor to explore the role of DYRK1B in cardiometabolic physiology. She plans to investigate the effects of Dyrk1B-catalyzed phosphorylation of transcription factors such as FOXO1.
Diabetes, high fat diet, obesity, and metabolic syndrome.
Dunn, S. M., Hilgers, R. and Das, K.C. Decreased EDHF‐mediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged high‐fat sucrose diet. Physiol Rep 5:e13502
Shannon's research interests includes the effects of western diet on vascular function in mice with a type 2 diabetes phenotype, obesity and metabolic syndrome, high fat diet-induced oxidative stress, and the exacerbating effects of high fat diet and aging on the vasculature.
- 2016-present "Diabetes and its metabolic complications"5T32DK098107-02
2014-2016 "Endothelial dysfunction in aged Trx-deficient mice"R01 HL114753
Baltimore Lab School, Baltimore, MD, 2018
Baltimore Underground Science Space (BUGSS), Baltimore, MD, 2018
Ronald McDonald House, Baltimore, MD, 2017
Student Research Week TTUHSC, Lubbock, TX, 2015-2016
Karate Kids, Lubbock, TX, 2013
American Diabetes Association
American Physiological Society
Luciferase assay, western blotting, ELISA, agarose gel electrophoresis, polyacrylamide gel electrophoresis, q real-time PCR, RT-PCR, cell culture, transfection, immunohistochemistry, spectrophotometer, bacterial transformation, plasmid DNA isolation and purification, protein estimation, wire-myography, microscopy, mouse islets isolation, mitochondrion isolation, flux analyzer, mito-tracker red staining, H&E staining, Oil-Red staining, acid-alcohol insulin extraction, protein and RNA isolation.
5+ years’ small animal handling, breeding, weaning, genotyping, tattooing, ear pinching, monitoring body weight, feeding special diet, metabolic testing (GTT, ITT), CODA tail-cuff blood pressure measurement, transgenic animal models, pharmacology behavioral studies (taste aversion, tail flick test, mice fear conditioning studies), sepsis mouse model, kidney blood flow analysis, mouse anesthesia, and sterile rodent surgery.