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Selen M. Catania, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Physiology

Location:

UMB BioPark I, 240

Education and Training

I received my PhD in Molecular and Cellular Biology in from Institute of Biological Sciences, University of Attila Jozsef, in Szeged, Hungary. My thesis invovled characterizing expression and function of several non-collagenous extracellular matrix protein genes during vertebrate development. My post-doctoral training focused on developmental biology, chromatin remodeling in cancer biology, and the design of improved lentiviral vectors for more effective gene transfer to embryonic stem cells. I joined Dr. Dudley Strickland's laboratory as a post-doctoral fellow in 2008 to work on the role of inflammation in vascular disease. In 2011, I was appointed as Research Associate in Department of Physiology.

Highlighted Publications

Muratoglu, S, Belrave, S, Lillis, A, Migliorini, M, Robinson, S, Smith, E, Zhang, L, and Strickland, D. (2011). Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway PLoS. One. 6(12):e28846 PMCID: PMC3235159

Muratoglu, S, Belgrave, S, Hampton, B, Migliorini, M, Coksaygan, T, Chen, L, Mikhailenko, I, Strickland, D. (2013) LRP1 protects the vasculature by regulating levels of Connective Tissue Growth Factor and HtrA1Arterioscler. Thromb. Vasc. Biol.,2013;33(9):2137–46.  PMCID: PMC3892666

Strickland D, Au D, Cunfer P, Muratoglu S. (2014)  Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrityArterioscler Thromb Vasc Biol. Mar;34(3):487-98.  PMCID: PMC4304649

Davis FM, Rateri DL, Balakrishnan A, Howatt DA, Strickland DK, Muratoglu SC, Haggerty CM, Fornwalt BK, Cassis LA, Daugherty A. (2015) Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor-Related Protein 1 Augments Angiotensin II-Induced Superior Mesenteric Arterial and Ascending Aortic AneurysmsArterioscler Thromb Vasc Biol. 35(1):155-62. doi: 10.1161/ATVBAHA.114.304683. Epub 2014 Nov 13. PMCID: PMC4332619

Lillis AP, Muratoglu SC, Au DT, Migliorini M, Lee MJ, Fried SK, Mikhailenko I, Strickland DK.  LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages.  PLoS One. 2015 Jun 10;10(6):e0128903. doi: 10.1371/journal.pone.0128903. eCollection 2015. PMCID: PMC4463855

Additional Publication Citations

Muratoglu S, Bachrati C, Malpeli M, Szabo P, Neri M, Dozin B, Deak F, Cancedda R, Kiss I. (1995) Expression of the cartilage matrix protein gene at different chondrocyte developmental stagesEur J Cell Biol. Dec; 68(4):411-8.

Szuts V, Mollers U, Bittner K, Schurmann G, Muratoglu S, Deak F, Kiss I, Bruckner P. (1998) Terminal differentiation of chondrocytes is arrested at distinct stages identified by their expression repertoire of marker genesMatrix Biol. Oct; 17(6):435-48.

Piecha D, Muratoglu S, Morgelin M, Hauser N, Studer D, Kiss I, Paulsson M, Deak F. (1999) Matrilin-2, a large, oligomeric matrix protein, is expressed by a great variety of cells and forms fibrillar networksJ Biol Chem. May 7; 274(19):13353-61.

Muratoglu S
, Krysan K, Balazs M, Sheng H, Zakany R, Modis L, Kiss I, Deak F. (2000) Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genesCytogenet Cell Genet. 90(3-4):323-327.

Gangloff YG, Pointud JC, Thuault S, Carre L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I.  (2001) Mammalian TAFII140 and Drosophila BIP2 are novel metazoan TFIID components containing a histone fold and a PHD fingerMol Cell Biol.(15):5109-21. PMCID: PMC87236

Muratoglu S, 
Georgieva S, Papai G, Scheer E, Enunlu I, Komonyi O, Cserpan I, Lebedeva L, Nabirochkina E, Udvardy A, Tora L, Boros I.  (2003) Two different Drosophila ADA2 homologues are present in distinct GCN5 Histone Acetyltransferase-containing complexesMol Cell Biol. Jan 1;23(1):306-321.  PMCID: PMC140672

Fu M, Rao M, Wang C, Sakamaki T, Wang J, Di Vizio D, Zhang X, Albanese C, Balk S, Chang C, Fan S, Rosen E, Palvimo JJ, Janne OA, Muratoglu S, Avantaggiati ML, Pestell RG.  (2003) Acetylation of Androgen Receptor Enhances Coactivator Binding and Promotes Prostate Cancer Cell GrowthMol Cell Biol. Dec 1;23(23):8563-8575. PMCID: PMC262657

Komonyi O, Papai G, Enunlu I, Muratoglu S, Pankotai T, Kopitova D, Maroy P, Udvardy A, Boros I. (2005)  DTL, the Drosophila homolog of PIMT/Tgs1 nuclear receptor coactivator interacting protein/RNA methyltransferase, has an essential role in development. J Biol Chem. 280: 12397-404.

Papai G, Komonyi O, Toth Zsolt, Pankotai T, Muratoglu S, Udvardy A, Boros I. (2005)  Intimate relationship between the genes of two transcriptional co-activators, ADA2a and PIMT of DrosophilaGene 348: 13-23

Pankotai T, Komonyi O, Bodai L, Ujfaludi Z, Muratoglu S, Ciurciu A, Tora L, Szabad J, Boros I. (2005)  The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both requires for normal development but have different functionsMol Cell Biol. 25:82 15-27.  PMCID: PMC1234310

Knights CD, Catania J, Di Giovanni S, Muratoglu S, Perez R, Swartzbeck A, Quong AA, Zhang X, Beerman T, Pestell RG, Avantaggiati ML. (2006)  Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fateJ Cell Biol. 173: 533-44.  PMCID: PMC2063863

Muratoglu S, 
Garratt B, Hyman B, Gajewski K, Schulz RA, Fossett NG. (2006)  Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozenge. Dev. Biol. 296:561-79.

Muratoglu S, 
Hough B, Mon ST, Fossett N. (2007)  The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila hematopoiesis Dev Biol. 311(2):636-49. PMCID: PMC2132443

Frandsen JL, Gunn B, Muratoglu S, Fossett N, Newfeld, S. (2008) Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in DrosophilaSJ.Proc Natl Acad Sci U S A. Sep 30;105(39):14952-7.  PMCID: PMC2553038

Muratoglu, S, 
Mikhailenko, I, Newton, C, Migliorini, M, and Strickland D. (2010) Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway J. Biol Chem. 285:14308-17 PMCID: PMC2863204

Strickland D, Muratoglu S, Antalis T. (2011)  Serpin-Enzyme Receptors LDL Receptor-Related Protein 1Methods Enzymol.499:17-31. PMCID: PMC3189627

Research Interests

My recent work has been focused on the role of inflammation and vascular disease. This work has emphasized the contribution of lipoprotein receptors to regulating inflammation and vascular remodeling. We successfully identified in the role of macrophage LDL receptor related protein 1 (LRP1) in modulating the TGF-beta signaling pathway during vascular injury. Currently, I am focusing on two distinct roles of LRP1: 1. in smooth muscle cell biology and its role in development and protection of vasculature 2. in dyslipidemia and insulin signaling.