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Rebecca M. Brotman, PhD, MPH

Academic Title:

Associate Professor

Primary Appointment:

Epidemiology & Public Health

Location:

Institute for Genome Sciences, BioPark II, 801 W. Baltimore Street, Room 627

Phone (Primary):

410-706-6767

Fax:

410-706-1482

Education and Training

Education

1996                           

B.A., Washington University                      

St. Louis, MO                                       

 

2001                           

M.P.H., Johns Hopkins University Bloomberg School of Public Health

Focus: Reproductive Epidemiology

Baltimore, MD

 

2007                           

Ph.D.,  Johns Hopkins University Bloomberg School of Public Health

Department of Epidemiology; Infectious Diseases Program

Baltimore, MD

 

Post Graduate Education and Training                

2005 - 2007                

Predoctoral fellow, Intramural Research Training Award (IRTA)

Longitudinal Study of Vaginal Flora

National Institutes of Health

National Institute of Child Health and Human Development

Division of Epidemiology, Statistics and Prevention Research (DESPR)

Rockville, MD

                                  

2007 - 2008                

Postdoctoral fellow, Institute for Genome Sciences

University of Maryland School of Medicine

Baltimore, MD

 

 

Biosketch

Academic Appointments     

2016 - present            

Associate Professor          

University of Maryland School of Medicine                         

Department of Epidemiology and Public Health

Institute for Genome Sciences

 

2008 - 2016                

Assistant Professor

University of Maryland School of Medicine                         

Department of Epidemiology and Public Health

Institute for Genome Sciences

 

2014 - present            

Full Member, Population Research Program

University of Maryland Marlene and Stewart Greenebaum Cancer Center 

Highlighted Publications

  1. Stekler J, Bachmann L, Brotman RM, Erbelding EJ, Lloyd LV, Rietmeijer CA, Handsfield HH, Holmes KK, Golden MR: Concurrent sexually transmitted infections (STIs) in sex partners of patients with selected STIs: implications for patient-delivered partner therapy. Clin Infect Dis 40:787-793, 2005. PMCID: N/A.
  2. Klebanoff MA, Andrews WW, Yu KF, Brotman RM, Nansel TR, Zhang J, Cliver SP, Schwebke JR: A pilot study of vaginal flora changes with randomization to cessation of douching. Sex Transm Dis 33:610-613, 2006. PMCID: N/A.
  3. Brotman RM, Erbelding EJ, Jamshidi RM, Klebanoff MA, Zenilman JM, Ghanem KG: Findings Associated with Recurrence of Bacterial Vaginosis among Adolescents Attending Sexually Transmitted Diseases Clinics. Journal of pediatric and adolescent gynecology 20:225-231, 2007. PMCID: PMC3647449.
  4. Brotman RM, Klebanoff MA, Nansel T, Zhang J, Schwebke JR, Yu KF, Zenilman JM, Andrews WW: Why Do Women Douche? A Longitudinal Study with Two Analytic Approaches. Ann Epidemiol 18:65-73, 2008. PMCID: N/A.
  5. Brotman RM, Ghanem KG, Klebanoff MA, Taha TE, Scharfstein DO, Zenilman JM: The effect of vaginal douching cessation on bacterial vaginosis: a pilot study. Am. J. Obstet. Gynecol. 2008 Jun;198(6):628.e1-7. PMCID: PMC2494605.
  6. Brotman RM, Klebanoff MA, Nansel TR, Andrews WW, Schwebke JR, Zhang J, Yu KF, Zenilman JM, Scharfstein DO. A longitudinal study of vaginal douching and bacterial vaginosis — A marginal structural modeling analysis. Am J Epidemiol. 2008 Jul 15;168(2):188-96. PMCID: PMC2574994.
  7. Brotman RM, Ravel J. [Invited Commentary] Ready or not: The molecular diagnosis of bacterial vaginosis. Clin Infect Dis. 2008 Jul 1;47(1):44-6. PMCID: N/A.
  8. Rifkin SB, Smith MR, Brotman RM, Gindi RM, Erbelding EJ: Hormonal contraception and risk of bacterial vaginosis diagnosis in an observational study of women attending STD clinics in Baltimore, MD. Contraception 80:63-67, 2009. PMCID: N/A.
  9. Klebanoff MA, Nansel TR, Brotman RM,  Zhang J, Yu K, Schwebke JR, Andrews WW. Personal hygienic behaviors and bacterial vaginosis, Sex Transm Dis, 2010 Feb;37(2):94-9. PMCID: PMC2811217.
  10. Klebanoff MA, Andrews WW, Zhang J, Brotman RM, Nansel TR, Yu K, Schwebke JR. Race of male sexual partners and occurrence of bacterial vaginosis, Sex Transm Dis. 2010 Mar;37(3):184-190. PMCID: PMC2828507.
  11. Brotman RM, Melendez JH, Smith TD, Galai N, Zenilman JM. Effect of Menses on Clearance of Y-Chromosome in Vaginal Fluid: Implications for a Biomarker of Recent Sexual Activity, Sex Transm Dis, 37(1):1-4, 2010. PMCID: PMC3551347.
  12. Forney LJ, Gajer P, Williams CJ, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Brotman RM, Davis CC, Ault K, Ravel J: Comparison of self-collected and physician-collected vaginal swabs for microbiome analysis. J Clin Microbiol 48:1741-1748, 2010. PMCID: PMC2863907.
  13. Brotman RM, Ravel J, Cone RA, Zenilman JM: Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis. Sex Transm Infect 86:297-302, 2010 PMCID: PMC3534767.
  14. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault K, Peralta L, Forney LJ: Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A 108 Suppl 1:4680-4687, 2011. PMCID: PMC3063603.
  15. Brotman RM, Klebanoff MA, Nansel TR, Yu KF, Andrews WW, Zhang J, Schwebke JR: Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection. J Infect Dis 202:1907-1915, 2010. PMCID: PMC3053135.
  16. Zhou X, Brotman RM, Gajer P, Abdo Z, Schuette U, Ma S, Ravel J, Forney LJ: Recent Advances in Understanding the Microbiology of the Female Reproductive Tract and the Causes of Premature Birth. Infectious Diseases in Obstetrics & Gynecology 2010:1-10, 2010. PMCID: PMC3004384.
  17. Brotman RM, Melendez J, Ghanem KG: A case control study of anovaginal distance and bacterial vaginosis. Int J STD AIDS. 2011 Apr;22(4):231-3. PMCID: PMC3528012.
  18. Brotman RM: Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest 121:4610-4617, 2011. PMCID: PMC3225992.
  19. Gajer P*, Brotman RM*, Bai G, Sakamoto J, Schutte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, Abdo Z, Forney LJ, Ravel J: Temporal dynamics of the human vaginal microbiota. Sci Transl Med 4:132ra52, 2012. *contributed equally as first author PMCID: PMC3722878.
  20. Bai G, Gajer P, Nandy M, Ma B, Yang H, Sakamoto J, Blanchard MH, Ravel J, Brotman RM: Comparison of storage conditions for human vaginal microbiome studies. PLoS ONE 7:e36934, 2012. PMCID: PMC3360033.
  21. Brotman RM, Bradford LL, Conrad M, Gajer P, Ault K, Peralta L, Forney LJ, Carlton JM, Abdo Z, Ravel J: Association Between Trichomonas vaginalis and Vaginal Bacterial Community Composition Among Reproductive-Age Women. Sex Transm Dis 2012; 39(10):807-812. PMCID: PMC3458234.
  22. Liu S, BrotmanRM, Zenilman JM, Gravitt PE, Cummings DAT: Menstrual Cycle and Detectable Human Papillomavirus in Reproductive Age Women: A Time Series Study. J Infect Dis. 2013 Nov; 208(9):1404-15.  PMCID: PMC3789568.
  23. Ravel J, Brotman RM, Gajer P, Ma B, Nandy M, Fadrosh DW, Sakamoto J, Koenig SS, Fu L, Zhou X, Hickey RJ, Schwebke JR, Forney LJ. Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis. Microbiome 2013;1:29. PMCID: PMC3968321.
  24. Brotman RM, Shardell MD, Gajer P, Fadrosh D, Chang K, Silver M, Viscidi RP, Burke AE, Ravel J, Gravitt PG. Association between the vaginal microbiota, menopausal status, and vulvovaginal symptoms. Menopause. 2014 May;21(5):450-8. PMCID: PMC3994184.
  25. Brotman RM, Ravel J, Bavoil PM, Gravitt PE, Ghanem KG.Microbiome, Sex Hormones, and Immune Responses in the Reproductive Tract: Challenges for Vaccine Development Against Sexually Transmitted Infections. Vaccine. 2014 Mar 20;32(14):1543-52. PMCID: PMC3964794.
  26. Liu S, Cummings D, Zenilman JM, Gravitt P, Brotman RM. Characterizing the Temporal Dynamics of Human Papillomavirus DNA Detectability Using Short-Interval Sampling. Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):200-8. PMCID: PMC3947138.
  27. Fadrosh DW, Ma B, Gajer P, Sengamalay N, Ott S, Brotman RM, Ravel J. An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform. Microbiome 2014;2:6. PMCID: PMC3940169.
  28. Brotman RM, Shardell MD, Gajer P, Tracy JK, Zenilman JM, Ravel J, Gravitt PE. Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection. J Infect Dis. 2014 Dec 1;210(11):1723-33. PMCID:PMC4296189.
  29. Brotman RM, He X, Gajer P, Fadrosh D, Mongodin EF, Ravel J, Glover ED, Rath JM. Association between cigarette smoking and the vaginal microbiota: A Pilot study. BMC Infect Dis. 2014 Aug 28;14:471. PMCID: PMC4161850.
  30. Huttenhower C, Knight R,  Brown CT, Caporaso JG, Clemente JC,  Gevers D, Franzosa EA, Kelley ST, Knights D, Ley RE, Mahurkar A,  Ravel J, The Scientists for Advancement of Microbiome Research*, and White O. Advancing the Microbiome Research Community. Cell 2014, 159(2):227-230. PMCID: PMC4221798. *listed in consortium.
  31. Dareng EO , Ma B , Famooto AO , Akarolo-Anthony SN, Offiong RA, Olaniyan O, Dakum PS ,  Wheeler CM, Fadrosh D,  Yang H,  Gajer P,  Brotman RM, Ravel  J, Adebamowo  CA. Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women. Epidemiol Infect 2016 Jan;144(1):123-37. PMCID: PMC4659743.
  32. Bradshaw CS, Brotman RM. Making inroads into improving treatment of bacterial vaginosis - striving for long-term cure. BMC Infect Dis 2015, 15(1):292. PMCID: PMC4518586.
  33. Nelson TM, Borgogna JL, Brotman RM, Ravel J, Walk ST, Yeoman CJ: Vaginal biogenic amines: biomarkers of bacterial vaginosis or precursors to vaginal dysbiosis? Frontiers in physiology 2015, 6:253.  PMCID: PMC4586437.
  34. Ravel J, Brotman RM. Translating the vaginal microbiome: gaps and challenges. Genome Med. 2016 Apr 1;8(1):35. PMCID: PMC4818402.
  35. Robinson CK, Brotman RM, Ravel J: Intricacies of assessing the human microbiome in epidemiologic studies. Ann Epidemiol 2016, 26(5):311-321. PMCID: PMC4892937.
  36. Kenyon CR, Buyze J, Klebanoff MA, Brotman RM. Association between incident bacterial vaginosis and partner concurrency: a longitudinal study. Sex Trans Infec. 2016;0:1–3. Epub ahead of print. PMCID: pending.

 

Research Interests

I am an infectious diseases epidemiologist who has integrated the study of genomics into public health research. Over the past 10 years, I have developed a research career in various aspects of the human microbiome with an emphasis on women's health. My research has ranged between the role of the vaginal microbiome in susceptibility to sexually transmitted infections (STIs) and the behavioral and biological factors associated with the development of bacterial vaginosis (BV), a common dysbiosis of the vaginal microbiota. 

Awards and Affiliations

2001 - 2003                

Ruth L. Kirschstein National Research Service Award (T32)

 

2005 - 2007                

Intramural Research Training Award (NIH)

 

2007                           

NIH Fellows Award for Research Excellence (travel award)

 

2011                           

American Sexually Transmitted Diseases Association (ASTDA) Young Investigator Award

http://depts.washington.edu/astda/about/awards.html

 

2013                           

GenomeWeb Young Investigator Award

http://www.genomeweb.com/genomeweb-feature-eighth-annual-young-investigators

 

2013                           

The North American Menopause Society (NAMS) New Investigator Award

http://www.menopause.org/annual-meetings/2013-meeting/award-scholarship-recipients

 

2013                           

The Infectious Diseases Society for Obstetrics and Gynecology Young Investigator Award

 

2015                           

Best Paper Award, North American Menopause Society/Lippincott Williams & Wilkins Menopause Journal

Grants and Contracts

Active grants

1/1/2017 – 12/31/2917          

“Health disparities in STI incidence and the vaginal microbiome: the role of psychosocial stress and socioeconomic position”

MPI: Brotman RM, Slopen N

 

10/1/2016 – 9/31/2017          

“Cervical dysplasia and the vaginal microbiota”

Department of Obstetrics, Gynecology and Reproductive Sciences

University of Maryland School of Medicine

MPI: Brotman RM, Mark K

 

05/13/2016 – 02/28/2021      

“Elucidating causes of vaginal symptoms using a multi-omics approach”

NIH / NINR R01 NR015495

Role: Co-I                          

PI: Ravel J and Forney LJ

 

02/05/2016 – 01/31/2021      

“Lubricant Use and the Vaginal Microbiome”

NIH / NIAID R01-AI119012

Role: PI

 

05/01/2015 – 04/30/2020      

“Longitudinal study of the vaginal microbiome prior to incident STI”

NIH / NIAID R01-AI116799

Role: PI

 

09/1/2014- 8/31/2019            

“Ecopathogenomics of sexually transmitted infections (EPSTI)”

Project 3: Genital microbiome-pathogen interactions in a sexual transmission network”

Sexually Transmitted Infections Cooperative Research Centers, U19 (RFA-AI-13-043)

NIH / NIAID U19-AI084044

Role: Co-I        

PI: Ravel J and Bavoil P

 

3/1/2011- 2/29/2017                              

“Duration of Hormonal Contraceptive Use: Immune Responses & Vaginal Microbiota”

NIH / NIAID R01-AI089878

Role: Co-I          

PI: Ghanem KG         

 

08/15/2013—7/31/2016        

“Vaginal microbiota, immune responses and vulvovaginal symptoms during menopause”

NIH R21-AI107224

PAS-10-226, Advancing Novel Science in Women’s Health Research (ANSWHR)

Role: PI