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Neville Brookes, PhD

Academic Title:

Associate Professor

Primary Appointment:

Pharmacology

Education and Training

-  Bristol School of Pharmacy (now Bath University, School of Pharmacy), U.K.
   M.R.Pharm.S. (Membership, Royal Pharmaceutical Society), 1962

-  Leeds University, School of Medicine, U.K.
    Ph.D. in Pharmacology, 1967

-  Birmingham University, Medical School, U.K.
    Postdoctoral Fellowship in Neuropharmacology, 1967-68

 

Biosketch

Dr. Brookes' laboratory studied how brain cells integrate and coordinate the membrane transport activities controlling the fluxes and compartmentation of amino acid neurotransmitters and their metabolic precursors. The goal was to understand how these fluxes are normally regulated and how their perturbation may underlie neurodegenerative disorders associated with aging and exposure to environmental neurotoxicants. Dr. Brookes applied expertise in neural cell culture, acquired in the laboratory of Dr. Philip Nelson at NICHD, to elucidate the role of astrocytes in the glutamate-glutamine cycle. These studies were funded by NIEHS, and involved collaborations with Dr. R. J. Turner at NIDR and with Dr. S. Broer at Australian National University. Currently, Dr. Brookes is course director of GPLS 607 (Principles of Pharmacology) and GPLS 623 (Molecular Neurotoxicology), is a section leader for GPLS 601 (Core Course), and he contributes several pharmacology classes in the 'Foundations of Disease' and 'Pathophysiology & Therapeutics I' courses for the sophomore medical class.

Research/Clinical Keywords

amino acid transport, astrocytes, pH regulation, glutamate-glutamine cycle

Highlighted Publications

Brookes, N. and Turner, R.J. (1994) K+-induced alkalinization in mouse cerebral astrocytes mediated by reversal of electrogenic Na+-HCO3- cotransport. American Journal of Physiology 267 (Cell Physiol. 36): C1633-C1640.

Brookes, N. (1997) Intracellular pH as a regulatory signal in astrocyte metabolism. Glia 21: 64-73.

Bröer, S. and Brookes, N. (2001) Review - Glutamine transfer between astrocytes and neurons. Journal of Neurochemistry 77: 705-719.