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Liron Boyman, PhD

Academic Title:

Research Associate

Primary Appointment:

Physiology

Location:

Mailing Address : BioMET Building, 111 S. Penn St., Suite 104 Office: Pharmacy Hall S544

Education and Training

  • B.Sc., Medical and Life Sciences, Tel Aviv University School of Medicine and the Faculty of Life Sciences, Israel, 2004
  • Ph.D., Physiology and Pharmacology, Tel Aviv University School of Medicine, Israel, 2010

  • Postdoctoral Fellowship, BioMET-Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD, 2010-2015 

 

 

Biosketch

Dr. Boyman's work centers on investigating cardiac calcium signaling and has been the discoverer of important features in cardiac muscle physiology, including the regulation of calcium efflux from cardiac cells and the quantitative aspects of calcium movement in cardiac mitochondria.

He has developed and implemented novel imaging technologies, most of which are designed for investigating calcium signals at high temporal and spatial resolution in cardiac cells. This includes developing tools to carry out quantitative measurements of mitochondrial Ca2+ signals in real-time using genetically targeted probes, new oxygen micro sensors to investigate the effect of ischemia on mitochondrial Ca2+, and new biochemical fluorescent applications to quantify mitochondrial Ca2+ fluxes through specific ion channels and exchangers. In addition to the effort to develop new tools he has extensively collaborated with many other investigators to implement these new tools in their ongoing investigation.  

Research/Clinical Keywords

Calcium Signaling, Calcium Sparks, Calcium-Dependent Arrhythmogenesis, Excitation-Contraction (EC) Coupling, Sodium Calcium Exchange Mechanisms, Cardiac Hypertrophy, Heart Failure, Cardiac Myocytes, Cardiac Mitochondria, Cardiac Cellular Physiology, Computational Biology, Super-Resolution Imaging, Confocal Imaging

Highlighted Publications

Boyman, L., Williams, G.S., Khananshvili, D., Sekler, I., Lederer, W.J. (2013). NCLX: The mitochondrial sodium calcium exchanger. J Mol Cell Cardiol. 59:205-213. PMID: 23538132.

Williams, G.S., Boyman, L., Chikando, A.C., Khairallah, R., Lederer, W.J. (2013) Mitochondrial Calcium Uptake. Proc Natl Acad Sci USA. 25;110(26):10479-86. PMID: 23759742.

Boyman, L., Chikando, A.C.,  Williams, G.S., Khairallah, R., Kettlewell, S., Ward, C.W., Smith, G.L., Kao, J.P., Lederer, W.J. (2014). Calcium Movement in Cardiac Mitochondria. Biophys J. 107(6):1289-301. PMID: 25229137.

Williams, G.S., Boyman, L., Lederer, W.J. (2015). Mitochondrial calcium and the regulation of metabolism in the heart. J Mol Cell Cardiol. 78:35-45. PMID: 25450609

Additional Publication Citations

Shpak, B., Shpak, C., Hiller, R., Boyman, L., Khananshvili, D. (2004). Inotropic and lusitropic effects induced by the inhibitory factor of the Na/Ca exchanger are not mediated by the beta-adrenergic activation.J Cardiovasc Pharmacol. 44(4), 466-472. PMID: 15454855.

Shpak, C., Hiller, R., Shpak, B., Boyman, L., Khananshvili, D. (2004). The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion- transport site of the Na/Ca exchanger. Biochem Biophys Res Commun. 324(4):1346- 1351. PMID: 15504362

Boyman, L., Hiller, R., Shpak, B., Yomtov, E., Shpak, C., Khananshvili, D. (2005). Advanced procedures for separation and analysis of low molecular weight inhibitor (NCXIF) of the cardiac sodium-calcium exchanger. Biochem Biophys Res Commun. 337(3):936-943. PMID: 16226722.

Boyman, L., Hiller, R., Shpak, B., Shpak, C., Khananshvili, D. (2006). Purified endogenousinhibitor of the Na/Ca exchanger can enhance the cardiomyocytes contractility andcalcium transients. Biochem Biophys Res Commun. 346(3):1100-1107. PMID: 16782052.

Shpak, B., Gofman, Y., Shpak, C., Hiller, R., Boyman, L., Khananshvili, D. (2006). Effects ofpurified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig. Eur J Pharmacol. 553(1- 3):196-204. PMID: 17078946.

Boyman, L., Hiller, R., Lederer, W.J., Khananshvili, D. (2008). Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein. Biochemistry. 47(25):6602-6611. PMID: 18507397.

Boyman, L., Mikhasenko, H., Hiller, R., Khananshvili, D. (2009). Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein. J Biol Chem. 284(10):6185- 6193. PMID: 19141619.

Giladi, M., Boyman, L., Mikhasenko, H., Hiller, R., Khananshvili, D. (2010). Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1. J Biol Chem. 285(36):28117-28125. PMID: 20587421.

Boyman, L., Hagen, B.M., Giladi, M., Hiller, R., Lederer, W.J., Khananshvili, D. (2011). Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger. J Biol Chem. 286(33):28811-28820. PMID: 21680748.Hagen, B.M., Boyman, L., Kao, J.P., Lederer. W.J. (2012). A comparative assessment of fluo Ca2+ indicators in rat ventricular myocytes. Cell Calcium. 52(2):170-181. PMID: 22721780.

Sunan, L., Shan, X., Roelofs, BA., Boyman, L., Lederer, WJ., Sesaki, H., Karbowski, M., (2015). Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J Cell Biology. PMID: 25547155

Boyman, L., Williams, G.S., Lederer, W.J. (2015) The Growing Importance of Mitochondrial Calcium in Health and Disease. Proc Natl Acad Sci USA. 112(36):11150-1. PMID: 26311848. 

Shan, X., Cherok, E., Das, S., Li, S., Roelofs, BA., Ge, SX., Polster, BM., Boyman, L., Lederer, W.J., Wang, C., Karbowski, M.(2016). Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein. Mol Biol Cell. 27(2):349-59. PMID: 26564796

Book Chapters 
Boyman, L., Williams, G.S., Lederer, W.J., Mitochondrial Calcium and Ischemia Reperfusion Injury in Heart, Mitochondria and Cell Death, Edited by David M, New York, Springer Science 2015, DOI 10.1007/978-1-4939-3612-0_2. 

 

 

Awards and Affiliations

Affiliations:

2015-present:  Research Associate, University of Maryland School of Medicine.

Awards:

2004 –2010: Ph.D. Stipend Award, Dr. Miriam and Sheldon G. Edelson Foundation.

2008: Katzir-Katchalsky Award, Student Travel Fellowships, For Distinguished Under Graduate Performances.

2009: Shtacher Award, For Research Excellency in the Fields of Physiology and Pharmacology.

2014: Scientist Development Grant Award, American Heart Association. AHA Award Number: 15SDG22100002.

Grants and Contracts

01/01/15 - 12/31/18  “Mitochondrial Calcium Signaling in Heart; Physiological and Pathophysiological Implications ” American Heart Association Award Number: 15SDG22100002.