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Glaser Prize in Imaging

Glazer Prize 2016 Image 03

This image features a renal organoid, cultured from primary mouse nephron cells, in a three dimensional matrix. This cyst-like organoid demonstrates a canonical cyst structure with a hollow lumen, highlighted in red by Dolichos biflorus agglutinin to mark distal tubule origin. The wall of the organoid is decorated with a DAPI stain, in blue, to demonstrate the nuclei, and Na+/K+-ATPase, in green, to exhibit basolateral organization. The culture is manipulated with the addition of specific growth factors for development of cysts and tubules, and represents part of a larger attempt to design a novel in vitro model system for cystogenesis in autosomal dominant polycystic kidney disease.

Ed GlaserThe Department has re-established The Glaser Prize in Imaging.

This prize was established to honor Dr. Edmund Glaser when he retired from the Department of Physiology in 1997. Dr. Glaser and his colleague, Dr. Hendrick Van der Loos, made a seminal contribution in the 1960’s by creating the first computer-assisted neuron reconstruction system - Neurolucida. He went on to found a company, MBF Bioscience in Williston, Vermont, to further develop and market software for neuroscience imaging in 1988 with his son Jack Glaser, the current company president.

The prize is awarded for the most visually attractive scientific image submitted by a student working in the current academic year in the laboratory of a faculty member with a primary or secondary appointment in the Department of Physiology. Images may be obtained with any instrument, may be of any cell or tissue type, and may be subjected to any form of post-acquisition modification.

 

Glazer Prize 2016 Image 02Eryn Dixon, a Program in Toxicology PhD student, is the winner of the 2016 Glaser Prize in Imaging.

Her image shows a kidney organoid that has been grown in culture and has spontaneously formed a fluid-filled cyst, like those characterizing polycystic kidney disease.

The growing of so-called mini-organs outside of the body, rather than just dispersed cells in a dish, is revolutionizing our ability to understand the biological basis of a variety of diseases and develop effective therapies. For example, they were used to discover that the Zika virus infects brain stem cells to cause microencephaly.‌

Glazer Prize 2016 Image 01

Pictured above: Eryn Dixon, Program in Toxicology PhD student and Owen M. Woodward, PhD.