Paul Welling, MD, Professor, Department of Physiology was named Chair of the Finance Committee for the American Physiological Society. Dr. Welling will serve a three-year term.
Grants and Contracts
Tami Kingsbury, PhD, Assistant Professor of Physiology, Center for Stem Cell Biology & Regenerative Medicine, received an 18-month Momentum Fellowship in the amount of $75,000 from The Mark Foundation for Cancer Research for “Molecular Interactions of PSEDN Members in Cancer.”
Matthew Trudeau, PhD, Associate Professor and Andrea Meredith, PhD, Associate Professor, both from the Department of Physiology, received a five-year, $1,044,840 competing renewal T32 training grant from the National Institute of General Medical Sciences. This inter-departmental training grant will continue support for the Training Program in Integrative Membrane Biology, incepted in 1987 and now in its 31st year of continuous funding. The grant provides support for pre-doctoral training in the biophysics, biochemistry, structure, cell and molecular biology, and physiology of biological membranes, through the Graduate Program in Life Sciences.
Tami Kingsbury, PhD, Assistant Professor of Physiology, Center for Stem Cell Biology, was last author of “Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae,” published in Genetics on May 7, 2018.
Melissa Konopko, PhD, Allison Densmore, Laboratory Research Technician, and Bruce Krueger, PhD, Professor, all from the Department of Physiology, co-authored “Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder,” published in Developmental Neuroscience on October 27, 2017.
In the News
Thomas Blanpied, PhD, Associate Professor, Department of Physiology, was invited to present the keynote lecture at the Annual Meeting of the Philadelphia Chapter of the Society for Neuroscience on April 26 at Temple University. His talk was titled, “Molecular Nanopositioning and Alignment Control Function of Single Synapses.”
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, presented a talk on “Immune Modulation of the Gut Innervation” on April 23 at Experimental Biology 2018 in San Diego, CA.
Grants and Contracts
Michele Vitolo, PhD, Assistant Professor, Department of Physiology, received a 4-year, $779,000 American Cancer Society Research Scholars Award for “Targeting Cytoskeletal Aberrations to Prevent Breast Cancer Metastasis.”
Thomas Blanpied, PhD, Associate Professor, Department of Physiology, was senior author of “Transcellular Nanoalignment of Synaptic Function,” published in Neuron on November 1, 2017. The article also appeared in print at the annual meeting of the Society for Neuroscience on November 11, 2017.
In the News
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, presented “The Alternative Life of Macrophages” on March 12 to the Division of Biomedical Sciences at the University of California, Riverside.
In the News
Thomas Blanpied, PhD, Associate Professor, Department of Physiology, presented a symposium titled, “Molecular Nanopositioning and Alignment Control Synaptic Function” at the 62nd Annual Meeting of the Biophysical Society, held in San Francisco in February.
Mordecai Blaustein, MD, Professor, and John Hamlyn, PhD, Professor, both from the Department of Physiology, were among the co-authors on “Update on Angiotensin II: New Endocrine Connections Between the Brain, Adrenal Glands and the Cardiovascular System” in Endocrine Connections, 2017 Aug 30. Dr. Blaustein, also authored “The Pump, the Exchanger and the Holy Spirit: Origins and 40-Year Evolution of Ideas About the Ouabain-Na+ Pump Endocrine System” in the American Journal of Physiology Cell Physiology, 2018 Jan 1. This article, accompanied by an editorial written by the editors of the journal, describes the origins of Dr. Blaustein’s 1977 hypothesis and the subsequent discoveries that led to the elucidation of a novel endocrine system. More recently, Drs. Blaustein and Hamlyn were among the co-authors on “Central and Peripheral Slow-Pressor Mechanisms Contributing to Angiotensin II-Salt Hypertension in Rats” in Cardiovascular Research, 2018 Feb 1.
Andrea Meredith, PhD, Associate Professor, Josh Whitt and Beth McNally, PhD, Research Associate, all from the Department of Physiology, were co-authors on “Differential Contribution of Ca2+ Sources to Day and Night BK Current Activation in the Circadian Clock” in The Journal of General Physiology, 2017 Dec 13.
In the News
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, delivered a keynote presentation on “Novel Therapeutic Targets for Type 2 Diabetes” on November 3 at the International Congress on Diabetes and Its Complications in Linthicum, MD.
Margaret McCarthy, PhD, Professor and Chair of the Department of Pharmacology, was elected as a fellow of American Association for the Advancement of Science (AAAS).
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the co-authors of “Bidirectional Brain-Gut Interactions and Chronic Pathological Changes After Traumatic Brain Injury in Mice” in Brain, Behavior, and Immunity, 2017 Jul 1 [Epub].
Grants and Contracts
Toni Antalis, PhD, Professor of Physiology, Center for Vascular and Inflammatory Diseases, received a five-year, $1,767,095 new R01 grant from the National Institute of Health (NIH)/National Cancer Institute (NCI). Dr. Antalis’ study, “Protease Activated Receptor-2 (PAR-2) Signaling and Metastatic Ovarian Cancer,” will elucidate a newly discovered proteolytic pathway that regulates ovarian tumor angiogenesis. It is anticipated that data generated from this study will bring better understanding of which could provide new strategies for controlling this devastating disease.
Marguerite Buzza, PhD, Research Associate, Department of Physiology; Subhradip Mukhopadhyay, PhD, Fellow, Center for Vascular and Inflammatory Diseases; Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, and Toni Antalis, PhD, Professor, Department of Physiology, were among the co-authors on“Inflammatory Cytokines Down-Regulate The Barrier Protective Prostasin-Matriptase Proteolytic Cascade Early in Experimental Colitis” in Journal of Biological Chemistry, 2017 Jun 30;292(26):10801-10812.
Alan Shuldiner, MD, the John L. Whitehurst Professor of Medicine and Director of the Program for Pharmacogenomics and Genomic Medicine, and Braxton Mitchell, PhD, Professor, Department of Epidemiology and Public Health, were among the co-authors on “Heritability of Plasma Neopterin Levels in the Old Order Amish” in Journal of Neuroimmunology, 2017 Jun 15;307:37-41. Dr. Mitchell was also among the co-authors on “Aneurysms with Persistent Patency After Treatment with the Pipeline Embolization Device” in Journal of Neurosurgery, 2017 Jun;126(6):1894-1898.
In the News
Thomas Blanpied, PhD, Associate Professor, Department of Physiology, presented an invited lecture on “How Nanostructure Controls Synapse Function” at the Gordon Research Conference “Excitatory Synapses and Brain Function,” held in Les Diablerets, Switzerland in early June.
Subhradip Mukhopadhyay, PhD, Postdoctoral Fellow, Center for Vascular and Inflammatory Diseases, and Toni Antalis, PhD, Professor, and Rajabrata Sarkar, MD, PhD, Professor, both from the Departments of Physiology and Surgery, were among the co-authors on “Myeloid p53 Regulates Macrophage Polarization and Venous Thrombus Resolution by Inflammatory Vascular Remodeling in Mice” in Blood, 2017 Mar 20 [Epub ahead of print].
Honors and Awards
Nevins Todd, MD, Associate Professor, Departments of Medicine and Physiology, received the Student Council Preclinical Faculty Award at the 2017 School of Medicine graduation ceremony on May 18.
Grants and Contracts
Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor of Pediatrics and Physiology, received a subcontract from the University of Maryland, College Park (UMCP) to participate and advise on stem cell and molecular biology in the new NIH P41-funded “Center for Engineering Complex Tissues” (CECT; PI: John Fisher PhD, Chair, Department of BioEngineering, UMCP). Total five-year funding for the Center is $6,302,200. Collaborators also include Rice University and Wake Forest Institute for Regenerative Medicine. CECT will oversee six collaborative projects, six service projects, and multiple training programs to foster expert collaborations for the advancement of tissue engineering.
In the News
Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Director of the Center for Stem Cell Biology and Regenerative Medicine, and Associate Dean for Research; Tami Kingsbury, PhD, Assistant Professor of Physiology, Center for Stem Cell Biology & Regenerative Medicine; and Nancy Hardy, MD, Associate Professor of Medicine, University of Maryland Greenebaum Comprehensive Cancer Center, spoke at and led a CASSS Scientific Society symposium organized by NIST, IBBR and MedImmune entitled “Release Criteria for Hematopoietic Stem Cell Therapies” on February 9 in Rockville, MD.
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the co-authors on “Parasites, Nutrition, Immune Responses, and Biology of Metabolic Tissues” in Parasite Immunology, 2017 Feb 24 [Epub ahead of print].
Grants and Contracts
Dudley Strickland, PhD, Professor of Surgery and Physiology, Director of the Center for Vascular and Inflammatory Diseases, and Associate Dean of Graduate and Postdoctoral Studies, received a seven-year, $5,405,872 new award from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI). This “Outstanding Investigator Award (R35 grant)” is designed to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced principal investigators, and is the first time this prestigious award has been issued by NHLBI. Dr. Strickland’s study, “Role of LDL Receptor Family Members in Protecting the Vasculature,” will use a well-developed mice model to investigate the mechanisms associated with aneurysm formation and define the role of LDL-receptor family members in this process. It is anticipated that data generated from this study will give insight into how members of the LDL receptor superfamily protect the vasculature from disease and may eventually allow intervention prior to rupture of the vessels and prevent death.
Andrea Meredith, PhD, Associate Professor, Department of Physiology, was appointed to a three-year term on the Advisory Board for the Biophysical Society and the Institute of Physics ebook publications series on biophysics, providing expertise in ion channels and systems biophysics.
Andrea Meredith, PhD, Associate Professor, Department of Physiology, co-authored “BK Channels are Required For Multisensory Plasticity In the Oculomotor System” in Neuron, 2016 Dec 2 [Epub ahead of print].
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the co-authors on “Neuroimmune Modulation Of Gut Function” in Handbook of Experimental Pharmacology, 2016 Dec 30 [Epub ahead of print].
Lawrence Goldman, PhD, Emeritus Professor, Department of Physiology
The Department of Physiology regrets the passing of Emeritus Professor, Dr. Lawrence Goldman, on November 28, 2016.
Dr. Goldman earned his BS in Chemistry and Physics from Tufts University in 1958. He received his PhD degree in Zoology and Biophysics at UCLA in 1964. From 1964 to 1965, he obtained postdoctoral training in the Department of Neurology, College of Physicians and Surgeons at Columbia University in New York, before accepting a position as Assistant Professor in the Department of Zoology at the University of Maryland, College Park in 1965. In 1967, he joined the University of Maryland School of Medicine as an Assistant Professor in the Department of Biophysics (later incorporated into the Department of Physiology). Dr. Goldman rose through the ranks to become Associate Professor with Tenure in 1970 and Professor in 1977. Dr. Goldman was also a Fulbright Senior Professor at the University of Saarlandes in Homburg, Germany, from 1987 to 1988.
Over his 41 year career at UM SOM, Dr. Goldman and his trainees made major contributions to our understanding of the ways in which ion channels open and close, particularly those gated by the voltage across the cell membrane. His research career was focused on the study of the fundamental physical mechanisms underlying generation and conduction of the action potential- the electrical unit of information flow in the nervous system. Among his many scientific contributions, Dr. Goldman provided experimental evidence explaining the proportionality between action potential conduction velocity and the square root of fiber diameter in nerve fibers. He also made significant contributions to our understanding of the biological underpinnings of the mathematical descriptions of ion channel gating made by Alan Hodgkin and Andrew Huxley in their Nobel Prize-winning work.
Dr. Goldman’s contributions to our understanding of membrane biophysics have been widely recognized by his peers, as demonstrated by the many invited presentations of his work he made around the world. He will be missed by his colleagues in the Department of Physiology and the University of Maryland School of Medicine.
Events, Lectures and Workshops
Andrea Meredith, PhD, Associate Professor, Department of Physiology, and Mark Nelson, PhD, a former Department of Physiology trainee, co-organized the 70th Annual Society of General Physiologists Meeting and Symposium “Genetic Models for Ion Channel Function in Physiology and Disease,” held at the Marine Biological Laboratory in Woods Hole, MA, September 7–11, 2016. The scientific program brought together 130 prominent scientists using genetic, electrophysiological, and imaging techniques to elucidate the molecular, cellular, and integrated physiology of ion channels in a variety of human disease models. Dr. Meredith also presented a talk entitled “Circadian Regulation of BK Channel Splice Variant Expression.”
Honors and Awards
Eryn Dixon, a PhD student in the laboratory of Owen Woodward, PhD, Assistant Professor, Department of Physiology, was awarded The Glaser Prize in Imaging for 2016 for her image showing a mini-kidney grown in a dish that has been induced to form a cyst resembling those characterizing polycystic kidney disease. The Glaser Prize was established to honor Dr. Edmund Glaser when he retired from the Department of Physiology. Dr. Glaser and his colleague, Dr. Hendrick Van der Loos, made a seminal contribution in the 1960’s by creating the first computer-assisted neuron reconstruction system - Neurolucida. He went on to found a company, MBF Bioscience, to further develop and market software for neuroscience imaging in 1988. The prize is awarded annually for the most visually attractive scientific image submitted by a student working in the laboratory of a faculty member in the Department of Physiology.
Stephen Davis, MBBS, FACE, FRCP, MACP, the Theodore E. Woodward Professor of Medicine and Chairman, Department of Medicine, has been elected to Mastership in the American College of Physicians (ACP). Election to Mastership recognizes outstanding and extraordinary career accomplishments. Masters must have made notable contributions to medicine. This includes, but is not limited to, teaching, outstanding work in clinical medicine (research or practice), contributions to preventive medicine, improvements in the delivery of health care, and/or contributions to the medical literature. According to ACP bylaws, Masters are elected “on account of personal character, positions of honor, contributions toward furthering the purposes of the ACP, eminence in practice or in medical research, or other attainments in science or in the art of medicine.” ACP activities are also taken into consideration for all candidates. This includes service to the ACP in an official capacity, participation in chapter activities, and involvement in the development of College products and educational programs. Volunteer and community service is also taken into consideration. Dr. Davis will formally be honored at a Convocation during the Internal Medicine Meeting 2017, ACP’s annual scientific conference, which will be held in San Diego, March 30–April 1.
Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the co-authors on “The Synthesis of OspD3 (ShET2) in Shigella flexneri is Independent of OspC1” in Gut Microbes, 2016 Nov;7(6):486-502. She also was among the co-authors on “A Critical Role for IL-25 In Host Protective Th2 Memory Response Against Heligmosomoides polygyrus bakeri” in Infection and Immunity, 2016 Nov 18;84(12):3328-3337.