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Research

Center for Sports Medicine, Health and Human Performance (CSMHHP)

The new CSMHHP will advance the discovery of innovative solutions to improve human health, performance, and injury recovery while increasing access to world-class sports medicine and occupational health services. The University of Maryland School of Medicine at the University of Maryland, Baltimore (UMB) will lead the facility’s clinical programs and will collaborate with the University of Maryland, College Park (UMCP) on research at the center. 

CSMHHP pairs the strong academic and educational programs in neuroscience at both UMB and UMCP, and joins engineers, imaging experts, and physicians to solve problems related to neurological injury identification, treatment, recovery, and prevention.

Initial research efforts will focus on nervous system injury and related neuroscience in three general areas:

  1. Identify transcriptomic-based mechanisms and modulation in experimental central nervous system injury and recovery.
  2. Develop novel brain injury models, brain imaging methodologies, non-invasive biomarkers, and therapeutic interventions.
  3. Examine multi-modal performance enhancement strategies (basic and clinical) including effects of training, exercise, and diet.

CSMHHP will be part of a larger, cutting-edge academic, research, and athletic facility at UMCP located within the renovated and expanded Cole Field House. During the next several years, broader CSMHHP initiatives will be developed and space within Cole will be devoted to clinical evaluation and care (orthopaedics and concussion) as well as clinical and basic research. Cole also will include a new program to educate undergraduate students about innovation and entrepreneurism. http://colefieldhouse.umd.edu.


Our Focus

Our major focus is basic and translational neuroscience related to central nervous system (CNS) injury and recovery. Projects are listed by broad theme and include likely partnering groups. The goal in each area is to generate at least one joint publication and material for a competitive grant application within the first 12 to 18 months.

  1. Identify transcriptomic-based mechanisms and modulation in experimental CNS injury and recovery. BSRCU, IGS, SON, CHIB, CBCB, UMIACS.
    1. Elucidating microRNA changes in CNS injury for cell death and inflammation
    2. Using RNAseq in traumatic brain injury (TBI) to address regeneration/neurorestoration mechanisms
    3. Studying microbiome alterations in TBI: brain-gut interactions, effects of immune modulation, and probiotic treatments
  2. Develop novel brain injury models, brain imaging methodologies, non-invasive biomarkers, and therapeutic interventions. BSRCU, SOP; BBI, Bioengineering, Physics, Neuroimaging Center, NanoCenter, CHIB, UMIACS.
    1. Testing new biomarkers in animal and human injury: repeated vs. single injury, training effects, age and sex/gender differences.
    2. Developing and evaluating new brain imaging methods (including magnetic-resonance based inflammatory imaging)
    3. Evaluating modulatory effects of focused ultrasound on neuroinflammation, neurogenesis, and recovery
    4. Characterizing a non-human primate (Marmoset) TBI model (behavior, histology, imaging)
    5. Developing new physiological monitoring devices (including portable) tools to assess risk, and therapeutic success
    6. Evaluating novel therapeutic interventions (including nanoscale drug delivery)
  3. Multi-modal performance enhancement (basic and clinical): effects of training, exercise, and diet. Kinesiology, Engineering (Aeronautical, Bioengineering), Center for Advanced Study of Language, Nutrition, BSRCU, STAR ORC, Center for Alternative Medicine.
    1. Facilitating recovery after experimental TBI: interactions of exercise, dietary restriction/modulation and environmental enrichment.
    2. Enhancing human performance: interactions across training, diet and exercise
    3. Examining experimental models at systems, cellular, and molecular levels: risk factors and predictors of outcome
    4. Evaluating training effects: muscle-brain interactions; microbiome and injury susceptibility; cognition, movement, and language
    5. Examining training variables and neurorestoration: growth factors, immune regulation, neurogenesis, and neural plasticity; age effects
    6. Evaluating new therapies (e.g., neuro-feedback) to optimize recovery

Glossary of Acronyms:

  • BBI: Brain Behavior Institute
  • BSRCU: Brain Sciences Research Consortium Unit
  • CBCB: Center for Bioinformatics and Computational Biology
  • CHIB: Center for Health-Related Informatics and Bioimaging
  • IGS: Institute for Genome Sciences
  • SON: School of Nursing
  • SOP: School of Pharmacy
  • STAR ORC: Shock Trauma & Anesthesiology Research Organized Research Center
  • UMIACS: University of Maryland Institute for Advanced Computer Studies