Dr. Goldberg received his medical training at SUNY-Downstate Medical Center in Brooklyn NYC and did residency training in internal Medicine at NYU-Bellevue Medical center from 1972-74. He completed a fellowship in Endocrinology-Metabolism, Nutrition, and Gerontology at the University of Washington and Seattle VA from 1974-77 where he was mentored in the conduct of clinical investigation in nutrition and metabolism by Drs. John Brunzell and Edwin Bierman. He moved to Washington University in St. Louis Missouri as an Assistant Professor in the Departments of Medicine and Preventive Medicine to conduct research with Dr. John Holloszy in exercise, metabolism and nutrition research in chronic renal disease, obesity and diabetes. In 1983 he joined William Hazzard, MD as Director of Research in the Johns Hopkins University Division of Gerontology and Geriatric Medicine as PI of the Johns Hopkins Academic Teaching Nursing Home Program Project, director of the new Bayview-Johns Hopkins General Clinical Research Center, and PI on RO1’s and the T32 training grant in gerontology and geriatrics until 1990.
Dr. Goldberg was recruited to the University of Maryland in 1990, and established the Division of Gerontology and Geriatric Medicine, the Baltimore VA Geriatric Research Education and Clinical Center (GRECC) and the T32 NIA Training Grant in “The Biology of Exercise, Nutrition and Metabolism in Aging” in 1992, which have been continuously renewed through 2015. He received RO1 and VA grants, and in 1994 was awarded a Claude D. Pepper Older Americans Independence Center from the NIA, which he renewed 3 times (1994- 2016). In 2005 a Clinical Nutrition Research Unit, and in 2010 the Nutrition Obesity Research Center were awarded to GRECC investigators Drs. Friedand Shuldiner with Dr. Goldberg as Co-Director, and in 2005-2015 a VA Rehabilitation Center of Excellence in Robotics and Neurological Diseases was awarded to Dr. Macko.
Dr. Goldberg has been continuously funded for 38 years by NIA and VA center grants and program projects, R01’s and VA Merit Awards, and has published >200 peer-reviewed manuscripts and book chapters. He has extensive experience in research training, having mentored >55 pre- and postdoctoral fellows on T32 and T35 training grants and 20 junior faculty on NIH/VA Career Development Awards in translational exercise rehabilitation, nutrition and metabolism clinical research in aging. He is currently PI of the UM Claude D. Pepper Older Americans Independence Center, NIA T32 Training Grant in Exercise, Nutrition and Metabolism in Aging, and Co-Director of the Mid-Atlantic Nutrition and Obesity Research Center and UM Center for Research on Aging. These prestigious Research Centers, Training Grants, VA and RO1 Grants fostered the growth of translational bedside to bench research in the Division by coalescing the efforts of an interdisciplinary team of MD and PhD investigators, exercise physiologists, dietitians and nurses in the conduct of exercise, nutrition, metabolism and cardiovascular disease – related clinical research in aging.
Dr. Goldberg leads research programs in the Baltimore VA GRECC, NIH RO1 grants and UMB Claude D. Pepper Older American Independence Center that investigate the hypothesis that some of the functional declines and medical diseases associated with aging in Western society are contributed to significantly by physical deconditioning and the development of obesity, i.e. lifestyle habits, as well as genetic and ethnic factors, not aging per se. Aging and obesity have many medically-related similarities, and there is a progressive relationship between obesity, physical deconditioning and risk for diabetes, hypertension, hyperlipidemia and their arteriosclerotic-thrombotic complications.
The Goldberg laboratory examines the mechanisms by which exercise and weight loss affect obesity and its glucose and lipid metabolic complications. His studies show that the combined effects of exercise and weight loss are synergistic in reducing central obesity and raising VO2 max to reduce CVD risk factors associated with the metabolic syndrome. These and other studies confirm that exercise and weight loss increase insulin sensitivity and reduce lipid profiles, hyperinsulinemia and glucose intolerance more than either do independently in obese men and women. This work shows that mechanisms in both adipose tissue and muscle contribute to the metabolic complications associated with central obesity and are modifiable by exercise and weight loss. His current research assesses the cellular mechanisms by which weight loss and exercise improve the metabolic dysfunction associated with obesity. The addition of a moderate intensity exercise to weight loss seems to partition nutrients to muscle for oxidation, in contrast to weight loss alone which does not increase lipoprotein lipase, the rate limiting enzyme for lipid uptake by muscle. The influence of gene polymorphisms on metabolic and body fat responses to weight loss and exercise training are being studied to test the hypothesis that obese subjects with certain gene variants may respond better to exercise than weight loss.