Skip to main content

Translational Laboratory Shared Service

Watch a video about the Translational Laboratory Shared Service >>

The University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) Translational Shared Service (TLSS) offers pre-clinical and clinical experimental support to basic researchers and physicians in the UMGCC community. We work in areas across the entire spectrum: cell biology, in vitro, in vivo and human trials. 

In Vitro Assays 

  • IC50 generation
  • Cell cycle (propidium iodide)
  • Viability (trypan blue exclusion)
  • Apoptosis
  • Potentiation/Synergy
  • ROS
  • Western Analysis
  • Angiogenesis
  • Mycoplasma testing


  • Real time proliferation/invasion/migration

In Vivo Assays 

  • IACUC approved umbrella protocol
  • Tolerability:
  • Tumor Growth
  • Pharmacokinetics: generation of plasma
  • Efficacy (flank models)
  • Efficacy (orthotopic models)
  • Pharmacodynamic Endpoints
  • Imaging of cells with Xenogen System

Clinical Trial Support 

We isolate:

  • Plasma
  • Serum
  • Tumor Biopsy
  • Whole Blood (isolation of PBMC,
  • DNA, RNA, protein)
  • Bone Marrow (isolation of marrow
  • Buccal Mucosa

Pharmacodynamic (PD) Endpoints 

  • in patient samples, tumor or surrogate tissues, preclinical samples
  • endpoint dependent on target (e.g., ELISA, flow cytometry, Western, unique assay)

renaRena Lapidus, Ph.D.

Room 7-010, Bressler Research Building
655 West Baltimore Street
Baltimore, MD 21201

Services We Offer

  • Access to 50+ human cell lines
  • Luciferase-expressing breasts and prostate cancer cell lines
  • IACUC approved umbrella protocol
  • Access/ knowledge in using Xenogen/ IVIS image mice
  • Primary Xenograft Models
    • Breast
    • Leukemia (under development)
    • Ovarian (under development)
  • Access to IRB approved protocol for tissue acquisition

Get pricing & info