Description of Services
The Core for Translational Research in Imaging @ Maryland (C-TRIM) was established with the goal to advance state of the art technology for animal imaging at the molecular, cellular and system level, to serve as resource for medical research, biotechnology advances and pharmaceutical development, and for probing in vivo gene function, disease processes and therapeutic applications including drug delivery and trials. The goal of this core is to facilitate inter-institutional collaboration between Academic Institutions in Maryland and technology transfer to Industry.
A major objective of C-TRIM is to provide services for in-vivo and ex-vivo cross-sectional and functional imaging using MRI, PET, and CT. The center will provide consultation on advanced imaging techniques and will also provide all necessary image-processing support to investigators. Capabilities also exist within the center to build custom made coils for specific applications.
Brief Description of Equipment
The small animal MRI is a 7.0 Tesla 31 cm bore magnet from Bruker Biospec and is located in HH 645. This intermediate bore spectrometer/imaging system is suitable for localized spectroscopic investigations of rodents and small animals (such as rabbits and cats) and perfused organs (e.g. dog heart, dog pancreas and pig lung).
The Siemens Inveon small animal PET-CT imaging system is located in a 578 square foot imaging suite in Howard Hall Room 644.
The Inveon imager consists of PET and CT subsystems that can be docked together for combined functional and anatomic imaging with implicit registration between the modalities or the systems can be separated for independent operation. Post-acquisition image analysis can be performed with the Inveon Research Workplace (IRW) software for viewing, image fusion and quantitative analysis.
The small animal CT system has a variable focus x-ray source with an adjustable voltage potential of 20-130 kVp and a maximum anode current of 0.5 mA. The focal spot size is dependent on system power and is between 6 microns (µm) at 8 W and 60 microns (µm) at 65 W. The CCD detector has 4064x4064 pixels with detector element size 32 microns (µm). System magnification is 1.2-3.3 with a maximum field of view of 10.8x10.8 cm2. Image reconstruction is performed with a modified Feldkamp algorithm. Typical reconstructed image resolution is 50 microns (μm), with best achievable resolution of 15 microns (μm).
The C-TRIM is directed by Dr. Rao Gullapalli who chairs the steering committee that sets policy and provides scientific and financial oversight for the core. Dr. Su Xu manages the day-to-day operations and provides guidance and assistance with core activities. She provides consultancy to investigators wishing to embark on MR imaging projects. Dr. Mark Smith provides consultancy and assistance on PET/CT related imaging projects. The C-TRIM provides a full array of cross-sectional structural and functional imaging services.