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Center for Fluorescence Spectroscopy

Fluorescence01MISSION:

The Center for Fluorescence Spectroscopy (CFS) provides state-of-the-art fluorescence instrumentation for studies of structure, function, and dynamics of biological macromolecules. CFS also provides the expertise on applications of fluorescence for bioassays and cellular imaging.


Fluorescence02SERVICES:

The CFS makes available state-of-the art spectroscopic instrumentation and techniques for fluorometric bioassay development and cellular imaging.

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Techniques include:

  • Fluorescence energy transfer (FRET)
  • Fluorescence polarization (FP)
  • Fluorescence correlation spectroscopy (FCS)
  • Single molecule detection (SMD)
  • Time-resolved spectroscopy
  • Fluorescence lifetime imaging microscopy (FLIM)

Facility also provides technical expertise on all aspects of fluorescence techniques used in basic science and biological/medical applications.

Cell imaging and studies of biomolecule interactions of assemble molecules and on single molecule basis are available with fluorescence microscopies.


Fluorescence04CORE INSTRUMENTATION:

Fluorescence Lifetime imaging Microscope

State-of-the-art imaging system, Alba V (FLIM and FCS) is designed for cellular imaging and bioassay readout and quantitative analysis. The system is equipped with multiple lasers, multiple channels, dual scanners and dual lifetime imaging capability (TD and FD).

Single Molecule Fluorescence Microscope

  • Multiple lasers
  • Lifetime capability
  • FCS

Time-Resolved Fluorescence s pectrometer

  • Super Continuum Laser
  • Automated system

Atomic Force Microscope and NOSOM W ITec alpha300S

  • Contact Mode
  • AC Mode
  • Confocal capability

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CONTACT:

Joseph R. Lakowicz, PhD

Director

Krishanu Ray, PhD

Associate Director

 

Henryk Szmacinski, PhD


LOCATION:

Rooms N-241
Insitute of Human Virology
725 West Lombard Street
Baltimore, MD 21201


HOURS:

Monday through Friday
7:00am - 5:00pm


PHONE:

Office: 410-706-7500

Fax: 410-706-8408


 

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