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Transgenic Resources

MISSION:

Our mission is to study the characterization of animal models of human disease; provide accredited services for laboratory animal care through collaborative research, professional development of veterinarians through specialty training with American College of Laboratory Animal Medicine (ACLAM); achieve continuous certification through compliance with The Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi), the United States Department of Agriculture (USDA); and the Office of Laboratory Animal Welfare (Public Health Service, NIH) and to act as a resource for information and instruction on the use of laboratory animals.

The University School of Medicine Program in Comparative Medicine was established in 1989. All Program faculty members hold joint appointments in other departments; conduct independent and collaborative research; and have expertise in the fields of clinical laboratory animal medicine, surgery, comparative pathology, microbiology, immunology, genetics and infectious diseases.

Comparative Medicine faculty members are available for consultation on animal research protocols, laboratory animal management and development of grant applications proposing the use of animals. Members participate in the teaching of medical students, graduate students, and postdoctoral fellows and provide postdoctoral residency and graduate training programs for veterinarians in the fields of Laboratory Animal Medicine and Veterinary Pathology.

As members of the University of Maryland School of Medicine’s Veterinary Resources, we also provide veterinary supervision for husbandry and health care related to facilities management, diagnosis, treatment and prevention of intercurrent disease in research animals.


SERVICES:

  • Wide range of animal models from mice to non-human primates for biomedical research
  • GLP support for FDA/EPA- regulated studies
  • Generation of polyclonal/ monoclonal antibodies and induced pluripotent stem cells
  • Maintain mouse colonies (SCID-NOD/NSG/NRG, nude, C57BL/6)
  • Pre-research consultations with researchers on development of animal models
  • Technical services provided for rodent procedures such as: blood withdrawal, anesthetic support, and weaning
  • Hands on training course to investigators and staff on humane handling of laboratory animals

TRANSGENIC RESOURCES:

The new, as of 2015, Transgenic Resources and the University of Maryland School of Medicine exists to facilitate all aspects of customized production of genetically engineered rodent models. Transgenic Resources has developed a partnership with Jackson Laboratories (JAX) (you may contact George Scheer, UMB, Senior Buyer, 410-706-8305, for Terms & Conditions, Pricing) which is a proven leader in conducting transgenic knockout rodent services. The services offered are extensive and include standard transgenics, nuclease- mediated (CRISPR) knockout and knock-in mouse services, as well as ES cell injections. The mission of Transgenic Resources is to ensure that these established partnerships provide the best pricing, customization and the highest product quality to support our world class research. Lou DeTolla, VMD, PhD, will serve as Director, Transgenic Resources. Lou’s Ph.D. is in immunogenetics and he has directed transgenic core facilities previously, both at UMB and Merck Sharp and Dohme Laboratories.

Researchers may directly contact the following vendors (listed below) for information and quotes for generation of their transgenic model(s).

TRANSGENIC VENDORS:

Jackson Laboratory
Susan Kolocotronis
Opportunity Development Manager
410-926-2620
susan.kolocotronis@jax.org

The Harvard Clinical and Translational Science Center
Arlene H. Sharpe, MD, PhD
Director, BWH Transgenic Mouse Facility
617-432-6569
asharpe@rics.bwh.harvard.edu

University of Michigan
Thom Saunders, PhD
734-647-2910
tsaunder@umich.edu

Ingenious Targeting Laboratory
Michael Castelli
Scientific Strategy Consultant
631-468-8530 ext. 103

Cyagen Biosciences Inc.
Marvin Y. Ouyang, PhD
Vice President, Technologies
800-921-8930
marvinouyang@cyagen.com

CONTACT:

Louis J. DeTolla, VMD, MS, PhD, DACLAM

Professor and Director
Comparative Medicine Chief
Veterinary Resources Professor of Pathology, Medicine
(Infectious Diseases) and
Epidemiology and Public Health

E. Douglas Allen, BS, LATg

Deputy Director


LOCATION:

Room G-100, MSTF
10 South Pine Street
Baltimore, MD 21201


HOURS:

Monday through Friday
7:00am - 5:00pm


PHONE:

Office: 410-706-8536
or 410-706-8537

Fax: 410-706-8538

 

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