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Cytogenetics Laboratory

MISSION:

Our laboratory offers cytogenetic and molecular genomic diagnosis for both constitutional and acquired chromosome abnormalities. We focus on the detection and characterization of subtle chromosome abnormalities in hematological malignancies/ stem cells, as well as roles of telomere biology in cancer and human aging.


SERVICES:

The Cytogenetics Laboratory is a CLIA-certified and CAP accredited facility that offers comprehensive cytogenetic diagnosis for both constitutional and acquired chromosome abnormalities. It provides conventional karyotype analysis and fluorescence in situ hybridization (FISH) studies for the detection and characterization of chromosome abnormalities in clinical specimens and in established cell lines. The Cytogenetics Laboratory includes an American Board of Medical Genetics-certified clinical cytogeneticist/clinical molecular geneticist, highly knowledgeable laboratory supervisors, and wellexperienced staff.

  • Chromosome Studies on multiple sample types including peripheral blood, bone marrow, fibroblasts and solid tissues (Karyotype).
  • FISH testing
  • Microarray analyses (Data analyses)

INSTRUMENTATION:

Automatic Interphase and Metaphase Finder:

Metasystems Metafer Slide Scanner and Ikaros/Isis Analysis Software are powerful tools.

Metafer

  • Automatic export of high resolution images for analysis

Major equipment available:

  • Metasystems Metafer Slide Scanner and Ikaros/Isis Analysis Software
  • Nikon TMS microscope w/Fluorescence
  • Olympus AX-70 microscope
  • Olympus BHSM microscope
  • Olympus BX-41 microscope
  • Olympus BX-41 w/Fluorescence
  • Zeiss Axiophot microscope
  • Zeiss Axioskop microscope

Chromosome Studies (Karyotype):

Chromosome

FISH Testing

FISH Testing:

  • Whole chromosome painting
  • Centromere probes
  • Subtelomere probes
  • Microdeletion probes
  • Cancer probes
  • Other locus-specific probes

Cytogenomic Microarray Analyses:

Cytogenetic Microarray


CONTACT:

Ying Zou, MD, PhD, FACMG

Ying Zou, MD, PhD, FACMG

Associate Professor
Department of Pathology
Director, Cytogenetics Laboratory
University of Maryland Pathology Associates, P.A.

Elizabeth Waters
Supervisor
410-706-4063

Melody Butler
Supervisor
410-706-2809


LOCATION:

Room 7-049, Bressler Research Building
655 West Baltimore Street
Baltimore, MD 21201
410-706-2809


HOURS:

Monday through Friday
7:00am - 5:00pm


PHONE:

410-706-2809


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